Browsing HMS Scholarly Articles by Title
Now showing items 4312-4331 of 17918
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Differential regulation of mesodermal gene expression by Drosophila cell type-specific Forkhead transcription factors
(Company of Biologists, 2012)A common theme in developmental biology is the repeated use of the same gene in diverse spatial and temporal domains, a process that generally involves transcriptional regulation mediated by multiple separate enhancers, ... -
Differential regulation of myeloid leukemias by the bone marrow microenvironment
(2013)Like their normal hematopoietic stem cell counterparts, leukemia stem cells (LSC) in chronic myelogenous leukemia (CML) and acute myeloid leukemia (AML) are presumed to reside in specific niches in the bone marrow ... -
Differential regulation of neurexin at glutamatergic and GABAergic synapses
(Frontiers Media S.A., 2013)Neurexins (Nrxs) have emerged as potential determinants of synaptic specificity, but little is known about their localization at central synapses. Here we show that Nrxs have a remarkably selective localization at distinct ... -
Differential Requirement for PBP1a and PBP1b in in Vivo and in Vitro Fitness of Vibrio cholerae
(American Society for Microbiology, 2014)We investigated the roles of the Vibrio cholerae high-molecular-weight bifunctional penicillin binding proteins, PBP1a and PBP1b, in the fitness of this enteric pathogen. Using a screen for synthetic lethality, we found ... -
Differential responses to high-frequency electrical stimulation in ON and OFF retinal ganglion cells
(IOP Publishing, 2014-02-21)Objective The field of retinal prosthetics for artificial vision has advanced considerably in recent years, however clinical outcomes remain inconsistent. The performance of retinal prostheses is likely limited by the ... -
Differential Risk of Death in Older Residents in Nursing Homes Prescribed Specific Antipsychotic Drugs: Population Based Cohort Study
(BMJ Publishing Group Ltd., 2012)Objective: To assess risks of mortality associated with use of individual antipsychotic drugs in elderly residents in nursing homes. Design Population based cohort study with linked data from Medicaid, Medicare, the Minimum ... -
Differential role of nonhomologous end joining factors in the generation, DNA damage response, and myeloid differentiation of human induced pluripotent stem cells
(National Academy of Sciences, 2014)Nonhomologous end-joining (NHEJ) is a key pathway for efficient repair of DNA double-strand breaks (DSBs) and V(D)J recombination. NHEJ defects in humans cause immunodeficiency and increased cellular sensitivity to ionizing ... -
Differential Roles of Direct and Indirect Allorecognition Pathways in the Rejection of Skin and Corneal Transplants
(Ovid Technologies (Wolters Kluwer Health), 2009)Background It is generally accepted that all transplants are not rejected in the same fashion. However, the extrinsic and intrinsic factors that control the recognition and rejection of a particular allograft by the ... -
Differential roles of microglia and monocytes in the inflamed central nervous system
(The Rockefeller University Press, 2014)In the human disorder multiple sclerosis (MS) and in the model experimental autoimmune encephalomyelitis (EAE), macrophages predominate in demyelinated areas and their numbers correlate to tissue damage. Macrophages may ... -
Differential Roles of the Pseudomonas aeruginosa PA14 rpoN Gene in Pathogenicity in Plants, Nematodes, Insects, and Mice
(American Society for Microbiology, 2001)We cloned the rpoN (ntrA, glnF) gene encoding the alternate sigma factor sigma (54) from the opportunistic multihost pathogen Pseudomonas aeruginosa strain PA14. A marker exchange protocol was used to construct the PA14 ... -
Differential Sensitivities of Retroviruses to Integrase Strand Transfer Inhibitors
(American Society for Microbiology, 2011)Integrase inhibitors are emerging anti-human immunodeficiency virus (HIV) drugs, and multiple retroviruses and transposable elements were evaluated here for susceptibilities to raltegravir (RAL) and elvitegravir (EVG). All ... -
Differential Sensitivity of Melanoma Cell Lines with BRAFV600E Mutation to the Specific Raf Inhibitor PLX4032
(BioMed Central, 2010)Blocking oncogenic signaling induced by the BRAFV600E mutation is a promising approach for melanoma treatment. We tested the anti-tumor effects of a specific inhibitor of Raf protein kinases, PLX4032/RG7204, in melanoma ... -
Differential Stem and Progenitor Cell Trafficking by Prostaglandin E2
(2013)SUMMARY To maintain lifelong production of blood cells, hematopoietic stem cells (HSC) are tightly regulated by inherent programs and extrinsic regulatory signals received from their microenvironmental niche. Long-term ... -
Differential strand separation at critical temperature: A minimally disruptive enrichment method for low-abundance unknown DNA mutations
(Oxford University Press, 2012)Detection of low-level DNA variations in the presence of wild-type DNA is important in several fields of medicine, including cancer, prenatal diagnosis and infectious diseases. PCR-based methods to enrich mutations during ... -
Differential Time Trends of Outcomes and Costs of Care for Acute Myocardial Infarction Hospitalizations by ST Elevation and Type of Intervention in the United States, 2001–2011
(Blackwell Publishing Ltd, 2015)Background: Little is known whether time trends of in‐hospital mortality and costs of care for acute myocardial infarction (AMI) differ by type of AMI (ST‐elevation myocardial infarction [STEMI] vs. non‐ST‐elevation [NSTEMI]) ... -
Differential, Phosphorylation Dependent Trafficking of AQP2 in LLC-PK1 Cells
(Public Library of Science, 2012)The kidney maintains water homeostasis by modulating aquaporin 2 (AQP2) on the plasma membrane of collecting duct principal cells in response to vasopressin (VP). VP mediated phosphorylation of AQP2 at serine 256 is critical ... -
Differentially Charged Hollow Core/Shell Lipid-Polymer-Lipid Hybrid Nanoparticles for Small Interfering RNA Delivery
(Wiley-Blackwell, 2011)Speedy delivery: Biodegradable and biocompatible polymers and lipids form hybrid core/shell nanoparticles (see picture, left) that show promising in vitro and in vivo results for delivering siRNA. The unique lipid–polymer–lipid ... -
Differentially Expressed Alternatively Spliced Genes in Malignant Pleural Mesothelioma Identified Using Massively Parallel Transcriptome Sequencing
(BioMed Central, 2009)Background: Analyses of Expressed Sequence Tags (ESTs) databases suggest that most human genes have multiple alternative splice variants. The alternative splicing of pre-mRNA is tightly regulated during development and in ... -
Differentiating Branch Duct and Mixed IPMN in Endoscopically Collected Pancreatic Cyst Fluid via Cytokine Analysis
(Hindawi Publishing Corporation, 2012)Background: Differentiating branch duct from mixed intraductal papillary mucinous neoplasm (BD-IPMN) is problematic, but clinically important as mixed IPMNs are managed surgically, while some BD-IPMN may be followed. ... -
Differentiating Cognitive Impairment from Symptoms of Anxiety in Postcoronary Artery Bypass Grafting Encephalopathy: A Case Report
(Dove Medical Press, 2006)Post-coronary artery bypass grafting encephalopathy (CABGE) is associated with cognitive decline in a significant number of post-cardiac surgery cases. Patients may experience this condition as a result of being maintained ...