Browsing HMS Scholarly Articles by Title

Now showing items 45-64 of 17922

    • 5-Fluorouracil upregulates cell surface B7-H1 (PD-L1) expression in gastrointestinal cancers 

      Van Der Kraak, Lauren; Goel, Gaurav; Ramanan, Krishnaveni; Kaltenmeier, Christof; Zhang, Lin; Normolle, Daniel P.; Freeman, Gordon J.; Tang, Daolin; Nason, Katie S.; Davison, Jon M.; Luketich, James D.; Dhupar, Rajeev; Lotze, Michael T. (BioMed Central, 2016)
      Background: Resistance to chemotherapy is a major obstacle in the effective treatment of cancer patients. B7-homolog 1, also known as programmed death ligand-1 (PD-L1), is an immunoregulatory protein that is overexpressed ...

    • 5-HT\(_{\text{2C}}\)Rs Expressed by Pro-Opiomelanocortin Neurons Regulate Energy Homeostasis 

      Xu, Yong; Jones, Juli E.; Kohno, Daisuke; Williams, Kevin W.; Choi, Michelle J.; Anderson, Jason G.; Heisler, Lora K.; Zigman, Jeffrey M.; Elmquist, Joel K.; Lee, Charlotte E.; Lowell, Bradford Barr (Cell Press, 2008)
      Drugs activating 5-hydroxytryptamine 2C receptors (5-HT\(_{\text{2C}}\)Rs) potently suppress appetite, but the underlying mechanisms for these effects are not fully understood. To tackle this issue, we generated mice with ...

    • 5-Hydroxymethylcytosine Expression in Metastatic Melanoma versus Nodal Nevus in Sentine Lymph Node Biopsies 

      Lee, Jonathan J.; Granter, Scott R.; Laga, Alvaro C.; Saavedra, Arturo; Zhan, Qian; Guo, Weimin; Xu, Shuyun; Murphy, George F.; Lian, Christine G. (2014)
      Sentinel lymph node biopsies are conducted to stage patients with newly-diagnosed melanomas that have histopathologic attributes conferring defined levels of metastatic potential. Because benign nevic cells may also form ...

    • 5-SPICE: the application of an original framework for community health worker program design, quality improvement and research agenda setting 

      Palazuelos, Daniel; Ellis, Kyla; DaEun Im, Dana; Peckarsky, Matthew; Schwarz, Dan; Farmer, Didi Bertrand; Dhillon, Ranu; Johnson, Ari; Orihuela, Claudia; Hackett, Jill; Bazile, Junior; Berman, Leslie; Ballard, Madeleine; Panjabi, Rajesh Ramesh; Ternier, Ralph; Slavin, Samuel Dennis; Lee, Scott; Selinsky, Steve; Mitnick, Carole Diane (Co-Action Publishing, 2013)
      Introduction: Despite decades of experience with community health workers (CHWs) in a wide variety of global health projects, there is no established conceptual framework that structures how implementers and researchers ...

    • 52-kDa Ro/SSA Epitopes Preferentially Recognized by Antibodies from Mothers of Children with Neonatal Lupus and Congenital Heart Block 

      Fritsch, Christine; Hoebeke, Johan; Dali, Hayet; Ricchiuti, Vincent; Isenberg, David A; Meyer, Olivier; Muller, Sylviane (BioMed Central, 2005)
      Neonatal lupus erythematosus is a rare disorder caused by the transplacental passage of maternal autoantibodies. The 52-kDa Ro/SSA antigen (Ro52) ribonucleoprotein represents an antigenic target strongly associated with ...

    • 53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis 

      Morales, Julio C.; Franco, Sonia; Murphy, Michael M.; Bassing, Craig H.; Mills, Kevin D.; Adams, Melissa M.; Walsh, Nicole C.; Manis, John P.; Rassidakis, George Z.; Alt, Frederick W.; Carpenter, Phillip B. (National Academy of Sciences, 2006)
      p53-binding protein 1 (53BP1) participates in the cellular response to DNA double-stranded breaks where it associates with various DNA repair/cell cycle factors including the H2AX histone variant. Mice deficient for 53BP1 ...

    • 53BP1 Protects against CtIP-Dependent Capture of Ectopic Chromosomal Sequences at the Junction of Distant Double-Strand Breaks 

      Guirouilh-Barbat, Josée; Gelot, Camille; Xie, Anyong; Dardillac, Elodie; Scully, Ralph; Lopez, Bernard S. (Public Library of Science, 2016)
      DNA double-strand breaks (DSB) are very harmful lesions that can generate genome rearrangements. In this study, we used intrachromosomal reporters to compare both the efficiency and accuracy of end-joining occurring with ...

    • 5mC and 5hmC dynamics during PGC reprogramming and role of Tet1 in female meiosis 

      Yamaguchi, Shinpei; Hong, Kwonho; Liu, Rui; Shen, Li; Inoue, Azusa; Diep, Dinh; Zhang, Kun; Zhang, Yi (BioMed Central, 2013)

    • A 600 kb Deletion Syndrome at 16p11.2 Leads to Energy Imbalance and Neuropsychiatric Disorders 

      Zufferey, Flore; Sherr, Elliott H; Beckmann, Noam D; Hanson, Ellen M.; Maillard, Anne M; Hippolyte, Loyse; Macé, Aurélien; Ferrari, Carina; Kutalik, Zoltán; Andrieux, Joris; Aylward, Elizabeth; Barker, Mandy; Bernier, Raphael; Bouquillon, Sonia; Conus, Philippe; Delobel, Bruno; Faucett, W Andrew; Goin-Kochel, Robin P; Grant, Ellen; Harewood, Louise; Hunter, Jill V; Lebon, Sébastien; Ledbetter, David H; Martin, Christa Lese; Männik, Katrin; Martinet, Danielle; Mukherjee, Pratik; Ramocki, Melissa B; Spence, Sarah J; Steinman, Kyle J; Tjernagel, Jennifer; Spiro, John E; Reymond, Alexandre; Beckmann, Jacques S; Chung, Wendy K; Jacquemont, Sébastien (BMJ Publishing Group, 2012)
      Background: The recurrent ∼600 kb 16p11.2 BP4-BP5 deletion is among the most frequent known genetic aetiologies of autism spectrum disorder (ASD) and related neurodevelopmental disorders. Objective: To define the medical, ...

    • 7T MRI of spinal cord injury 

      Cohen-Adad, J.; Zhao, Wei Chen; Wald, Lawrence Leroy; Oaklander, Anne Louise (Ovid Technologies (Wolters Kluwer Health), 2012)
      A man with 25 years of mild left neck, arm, and leg paresthesias had initial MRI in 1996 identifying a left C3-4 dorsal horn cavernous hemangioma. In 1997, hemorrhage (C3-7) and resection induced left arm > leg proprioceptive ...

    • 89 Zr-Labeled Dextran Nanoparticles Allow in Vivo Macrophage Imaging 

      Keliher, Edmund J.; Yoo, Jeongsoo; Nahrendorf, Matthias; Lewis, Jason S.; Marinelli, Brett; Newton, Andita; Pittet, Mikael J.; Weissleder, Ralph (American Chemical Society, 2011)
      Tissue macrophages play a critical role both in normal physiology and in disease states. However, because of a lack of specific imaging agents, we continue to have a poor understanding of their absolute numbers, flux rates, ...

    • The 8q24 Cancer Risk Variant Rs6983267 Shows Long-Range Interaction With MYC in Colorectal Cancer 

      Pomerantz, Mark; Ahmadiyeh, Nasim; Jia, Li; Herman, Paula; Verzi, Michael; Doddapaneni, Harshavardhan; Beckwith, Christine A.; Chan, Jennifer A.; Hills, Adam; Davis, Matt; Yao, Keluo; Kehoe, Sarah M.; Lenz, Heinz-Josef; Haiman, Christopher A.; Yan, Chunli; Henderson, Brian E.; Frenkel, Baruch; Barretina, Jordi; Bass, Adam; Tabernero, Josep; Baselga, Jose; Regan, Meredith; Manak, J. Robert; Shivdasani, Ramesh; Coetzee, Gerhard A.; Freedman, Matthew (Springer Science and Business Media LLC, 2009-06-28)
      An inherited variant on chromosome 8q24, rs6983267, is significantly associated with cancer pathogenesis. We present evidence that this region is a transcriptional enhancer, that the risk region physically interacts with ...

    • The 8th Annual Computational and Systems Neuroscience (Cosyne) Meeting 

      Histed, Mark; Pillow, Jonathan W (BioMed Central, 2011)

    • 8th international conference on management and rehabilitation of chronic respiratory failure: the long summaries – part 1 

      Ambrosino, Nicolino; Casaburi, Richard; Chetta, Alfredo; Clini, Enrico; Donner, Claudio F.; Dreher, Michael; Goldstein, Roger; Jubran, Amal; Nici, Linda; Owen, Caroline A.; Rochester, Carolyn; Tobin, Martin J.; Vagheggini, Guido; Vitacca, Michele; ZuWallack, Richard (BioMed Central, 2015)
      This paper summarizes the Part 1 of the proceedings of the 8th International Conference on Management and Rehabilitation of Chronic Respiratory Failure, held in Pescara, Italy, on 7 and 8 May, 2015. It summarizes the ...

    • 8th International conference on management and rehabilitation of chronic respiratory failure: the long summaries – part 2 

      Ambrosino, Nicolino; Casaburi, Richard; Chetta, Alfredo; Clini, Enrico; Donner, Claudio F.; Dreher, Michael; Goldstein, Roger; Jubran, Amal; Nici, Linda; Owen, Caroline A.; Rochester, Carolyn; Tobin, Martin J.; Vagheggini, Guido; Vitacca, Michele; ZuWallack, Richard (BioMed Central, 2015)
      This paper summarizes the Part 2 of the proceedings of the 8th International Conference on Management and Rehabilitation of Chronic Respiratory Failure, held in Pescara, Italy, on 7 and 8 May, 2015. It summarizes the ...

    • 8th International conference on management and rehabilitation of chronic respiratory failure: the long summaries – Part 3 

      Ambrosino, Nicolino; Casaburi, Richard; Chetta, Alfredo; Clini, Enrico; Donner, Claudio F.; Dreher, Michael; Goldstein, Roger; Jubran, Amal; Nici, Linda; Owen, Caroline A.; Rochester, Carolyn; Tobin, Martin J.; Vagheggini, Guido; Vitacca, Michele; ZuWallack, Richard (BioMed Central, 2015)
      This paper summarizes the Part 3 of the proceedings of the 8th International Conference on Management and Rehabilitation of Chronic Respiratory Failure, held in Pescara, Italy, on 7 and 8 May, 2015. It summarizes the ...

    • A 12-Residue-long Polyleucine Tail Is Sufficient to Anchor Synaptobrevin to the Endoplasmic Reticulum Membrane 

      Whitley, Paul; Grahn, Elin; Kutay, Ulrike; Rapoport, Tom A.; von Heijne, Gunnar (American Society for Biochemistry and Molecular Biology, 1996)

    • A 200-kb region of human chromosome 22q11.2 confers antipsychotic-responsive behavioral abnormalities in mice 

      Hiroi, Noboru; Zhu, Hongwen; Lee, MoonSook; Funke, Birgit; Arai, Makoto; Itokawa, Masanari; Kucherlapati, Raju; Morrow, Bernice; Sawamura, Takehito; Agatsuma, Soh (National Academy of Sciences, 2005)

    • A broad-spectrum antiviral targeting entry of enveloped viruses 

      Wolf, Mike C.; Freiberg, Alexander N.; Zhang, Tinghu; Akyol-Ataman, Zeynep; Grock, Andrew; Hong, Patrick W.; Li, Jianrong; Watson, Natalya F.; Fang, Angela Q.; Aguilar, Hector C.; Porotto, Matteo; Honko, Anna N.; Damoiseaux, Robert; Miller, John P.; Woodson, Sara E.; Chantasirivisal, Steven; Fontanes, Vanessa; Negrete, Oscar A.; Krogstad, Paul; Dasgupta, Asim; Moscona, Anne; Hensley, Lisa E.; Whelan, Sean P.; Faull, Kym F.; Holbrook, Michael R.; Jung, Michael E.; Lee, Benhur (National Academy of Sciences, 2010)
      We describe an antiviral small molecule, LJ001, effective against numerous enveloped viruses including Influenza A, filoviruses, poxviruses, arenaviruses, bunyaviruses, paramyxoviruses, flaviviruses, and HIV-1. In sharp ...

    • A cell wall damage response mediated by a sensor kinase/response regulator pair enables beta-lactam tolerance 

      Dörr, Tobias; Alvarez, Laura; Delgado, Fernanda; Davis, Brigid; Cava, Felipe; Waldor, Matthew (National Academy of Sciences, 2016)
      The bacterial cell wall is critical for maintenance of cell shape and survival. Following exposure to antibiotics that target enzymes required for cell wall synthesis, bacteria typically lyse. Although several cell envelope ...