Browsing HMS Scholarly Articles by Title

Now showing items 4520-4539 of 17922

    • Distinct functional determinants of influenza hemagglutinin-mediated membrane fusion 

      Ivanovic, Tijana; Harrison, Stephen C (eLife Sciences Publications, Ltd, 2015)
      Membrane fusion is the critical step for infectious cell penetration by enveloped viruses. We have previously used single-virion measurements of fusion kinetics to study the molecular mechanism of influenza-virus envelope ...

    • Distinct Functional Networks Within the Cerebellum and Their Relation to Cortical Systems Assessed With Independent Component Analysis 

      Dobromyslin, Vitaly I.; Salat, David; Fortier, Catherine; Leritz, Elizabeth; Beckmann, Christian F.; Milberg, William; McGlinchey, Regina (Elsevier BV, 2012-05-01)
      Cerebellar functional circuitry has been examined in several prior studies using resting fMRI data and seed-based procedures, as well as whole-brain independent component analysis (ICA). Here, we hypothesized that ICA ...

    • Distinct Malignant Behaviors of Mouse Myogenic Tumors Induced by Different Oncogenetic Lesions 

      Hettmer, Simone; Bronson, Roderick T.; Wagers, Amy J. (Frontiers Media S.A., 2015)
      Rhabdomyosarcomas (RMS) are heterogeneous cancers with myogenic differentiation features. The cytogenetic and mutational aberrations in RMS are diverse. This study examined differences in the malignant behavior of two ...

    • Distinct Metabolomic Signatures Are Associated with Longevity in Humans 

      Cheng, Susan; Larson, Martin G.; McCabe, Elizabeth L.; Murabito, Joanne M.; Rhee, Eugene P.; Ho, Jennifer E.; Jacques, Paul F.; Ghorbani, Anahita; Magnusson, Martin; Souza, Amanda L.; Deik, Amy A.; Pierce, Kerry A.; Bullock, Kevin; O’Donnell, Christopher J.; Melander, Olle; Clish, Clary B.; Vasan, Ramachandran S.; Gerszten, Robert E.; Wang, Thomas J. (2015)
      Alterations in metabolism influence lifespan in experimental models, but data in humans are lacking. Here we use liquid chromatography/mass spectrometry to quantify 217 plasma metabolites and examine their relation to ...

    • Distinct Neuroblastoma-associated Alterations of PHOX2B Impair Sympathetic Neuronal Differentiation in Zebrafish Models 

      Pei, Desheng; Luther, William; Wang, Wenchao; Paw, Barry H.; Stewart, Rodney A.; George, Rani E. (Public Library of Science, 2013)
      Heterozygous germline mutations and deletions in PHOX2B, a key regulator of autonomic neuron development, predispose to neuroblastoma, a tumor of the peripheral sympathetic nervous system. To gain insight into the oncogenic ...

    • Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: An in vivo analysis in MIRKO mice 

      Yechoor, Vijay; Patti, Mary-Elizabeth; Ueki, Kohjiro; Laustsen, Palle; Saccone, Robert; Rauniyar, Ravi; Kahn, C. Ronald (National Academy of Sciences, 2004)
      Diabetes mellitus is a complex metabolic disorder accompanied by alterations in cellular physiology, metabolism, and gene expression. These alterations can be primary (due to loss of direct insulin action) or secondary ...

    • Distinct patterns of expression of fibroblast growth factors and their receptors in human atheroma and nonatherosclerotic arteries. Association of acidic FGF with plaque microvessels and macrophages 

      Brogi, E; Winkles, J A; Underwood, R; Clinton, S K; Alberts, G F; Libby, Peter (American Society for Clinical Investigation, 1993)
      Because fibroblast growth factors (FGFs) modulate important functions of endothelial cells (EC) and smooth muscle cells (SMC), we studied FGF expression in human vascular cells and control or atherosclerotic arteries. All ...

    • Distinct Patterns of IFITM-Mediated Restriction of Filoviruses, SARS Coronavirus, and Influenza A Virus 

      Radoshitzky, Sheli R.; Becker, Michelle M.; Chi, Xiaoli; Dong, Lian; Longobardi, Lindsay E.; Boltz, Dutch; Kuhn, Jens H.; Bavari, Sina; Denison, Mark R.; Baric, Ralph S.; Huang, I-Chueh; Bailey, Charles; Weyer, Jessica; Chiang, Jessica; Brass, Abraham L.; Ahmed, Asim Aminsharif; Elledge, Stephen J.; Choe, Hyeryun; Farzan, Michael Reynolds (Public Library of Science, 2011)
      Interferon-inducible transmembrane proteins 1, 2, and 3 (IFITM1, 2, and 3) are recently identified viral restriction factors that inhibit infection mediated by the influenza A virus (IAV) hemagglutinin (HA) protein. Here ...

    • Distinct patterns of lipoproteins with apoB defined by presence of apoE or apoC-III in hypercholesterolemia and hypertriglyceridemia. 

      Campos, Hannia; Perlov, Dan; Khoo, Christina; Sacks, Frank Martin (American Society for Biochemistry and Molecular Biology, 2001)
      Apolipoprotein (apo) E and apoC-III concentrations in VLDL and LDL are associated with coronary heart disease. We studied the relationship between apoE and apoC-III and the abnormal concentrations and distribution of apoB ...

    • Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas 

      Campbell, Joshua D.; Alexandrov, Anton; Kim, Jaegil; Wala, Jeremiah; Berger, Alice H.; Pedamallu, Chandra Sekhar; Shukla, Sachet A.; Guo, Guangwu; Brooks, Angela N.; Murray, Bradley A.; Imielinski, Marcin; Hu, Xin; Ling, Shiyun; Akbani, Rehan; Rosenberg, Mara; Cibulskis, Carrie; Ramachandran, Aruna; Collisson, Eric A.; Kwiatkowski, David J.; Lawrence, Michael S.; Weinstein, John N.; Verhaak, Roel G. W.; Wu, Catherine J.; Hammerman, Peter S.; Cherniack, Andrew D.; Getz, Gad; Artyomov, Maxim N.; Schreiber, Robert; Govindan, Ramaswamy; Meyerson, Matthew (2016)
      To compare lung adenocarcinoma (ADC) and lung squamous cell carcinoma (SqCC) and to identify new drivers of lung carcinogenesis, we examined exome sequences and copy number profiles of 660 lung ADC and 484 lung SqCC ...

    • Distinct plasma immune signatures in ME/CFS are present early in the course of illness 

      Hornig, M.; Montoya, J. G.; Klimas, N. G.; Levine, S.; Felsenstein, Donna; Bateman, L.; Peterson, D. L.; Gottschalk, C. G.; Schultz, A. F.; Che, X.; Eddy, M. L.; Komaroff, Anthony L.; Lipkin, W. I. (American Association for the Advancement of Science (AAAS), 2015)
      Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is an unexplained incapacitating illness that may affect up to 4 million people in the United States alone. There are no validated laboratory tests for diagnosis ...

    • Distinct Populations of HCN Pacemaker Channels Produce Voltage-dependent and Voltage-independent Currents 

      Proenza, Catherine; Yellen, Gary (Rockefeller University Press, 2006)
      Hyperpolarization-activated HCN pacemaker channels are critical for the generation of spontaneous activity and the regulation of excitability in the heart and in many types of neurons. These channels produce both a ...

    • Distinct Processes and Transcriptional Targets Underlie CDX2 Requirements in Intestinal Stem Cells and Differentiated Villus Cells 

      San Roman, Adrianna K.; Tovaglieri, Alessio; Breault, David T.; Shivdasani, Ramesh A. (Elsevier, 2015)
      Summary Lgr5-expressing intestinal stem cells (ISCs) renew the adult gut epithelium by producing mature villus cells (VCs); the transcriptional basis for ISC functions remains unclear. RNA sequencing analysis identified ...

    • Distinct Recognition of Complement iC3b by Integrins αXβ2 and αMβ2 

      Wang, Jia-Huai; Xu, Shutong; Wang, Jianchuan; Springer, Timothy (Proceedings of the National Academy of Sciences, 2017-03-14)
      Recognition by the leukocyte integrins αXβ2 and αMβ2 of complement iC3b-opsonized targets is essential for effector functions including phagocytosis. The integrin-binding sites on iC3b remain incompletely characterized. ...

    • Distinct roles of XRCC4 and Ku80 in non-homologous end-joining of endonuclease- and ionizing radiation-induced DNA double-strand breaks 

      Schulte-Uentrop, Leonie; El-Awady, Raafat A.; Schliecker, Lena; Willers, Henning; Dahm-Daphi, Jochen (Oxford University Press, 2008)
      Non-homologous end-joining (NHEJ) of DNA double-strand breaks (DSBs) is mediated by two protein complexes comprising Ku80/Ku70/DNA-PKcs/Artemis and XRCC4/LigaseIV/XLF. Loss of Ku or XRCC4/LigaseIV function compromises the ...

    • Distinct Spatiotemporal Activity in Principal Neurons of the Mouse Olfactory Bulb in Anesthetized and Awake States 

      Blauvelt, David Gregory; Sato, Tomokazu F.; Wienisch, Martin; Murthy, Venkatesh N. (Frontiers Media S.A., 2013)
      The acquisition of olfactory information and its early processing in mammals are modulated by brain states through sniffing behavior and neural feedback. We imaged the spatiotemporal pattern of odor-evoked activity in a ...

    • Distinct transcriptional changes in non-small cell lung cancer patients associated with multi-antigenic RNActive® CV9201 immunotherapy 

      Hong, Henoch S.; Koch, Sven D.; Scheel, Birgit; Gnad-Vogt, Ulrike; Schröder, Andreas; Kallen, Karl-Josef; Wiegand, Volker; Backert, Linus; Kohlbacher, Oliver; Hoerr, Ingmar; Fotin-Mleczek, Mariola; Billingsley, James M. (Taylor & Francis, 2016)
      ABSTRACT We recently completed a phase I/IIa trial of RNActive® CV9201, a novel mRNA-based therapeutic vaccine targeting five tumor-associated antigens in non-small cell lung cancer (NSCLC) patients. The aim of the study ...

    • Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation 

      Foudi, Adlen; Kramer, Daniel J.; Qin, Jinzhong; Ye, Denise; Behlich, Anna-Sophie; Mordecai, Scott; Preffer, Frederic I.; Amzallag, Arnaud; Ramaswamy, Sridhar; Hochedlinger, Konrad; Orkin, Stuart H.; Hock, Hanno (The Rockefeller University Press, 2014)
      The zinc finger transcriptional repressor Gfi-1b is essential for erythroid and megakaryocytic development in the embryo. Its roles in the maintenance of bone marrow erythropoiesis and thrombopoiesis have not been defined. ...

    • Distinctive Expansion of Potential Virulence Genes in the Genome of the Oomycete Fish Pathogen Saprolegnia parasitica 

      Jiang, Rays H. Y.; de Bruijn, Irene; Haas, Brian J.; Belmonte, Rodrigo; Löbach, Lars; Christie, James; van den Ackerveken, Guido; Bottin, Arnaud; Bulone, Vincent; Díaz-Moreno, Sara M.; Dumas, Bernard; Fan, Lin; Gaulin, Elodie; Govers, Francine; Grenville-Briggs, Laura J.; Horner, Neil R.; Levin, Joshua Z.; Mammella, Marco; Meijer, Harold J. G.; Morris, Paul; Nusbaum, Chad; Oome, Stan; Phillips, Andrew J.; van Rooyen, David; Rzeszutek, Elzbieta; Saraiva, Marcia; Secombes, Chris J.; Seidl, Michael F.; Snel, Berend; Stassen, Joost H. M.; Sykes, Sean; Tripathy, Sucheta; van den Berg, Herbert; Vega-Arreguin, Julio C.; Wawra, Stephan; Young, Sarah K.; Zeng, Qiandong; Dieguez-Uribeondo, Javier; Russ, Carsten; Tyler, Brett M.; van West, Pieter (Public Library of Science, 2013)
      Oomycetes in the class Saprolegniomycetidae of the Eukaryotic kingdom Stramenopila have evolved as severe pathogens of amphibians, crustaceans, fish and insects, resulting in major losses in aquaculture and damage to aquatic ...

    • Distinctive Mesenchymal-Parenchymal Cell Pairings Govern B Cell Differentiation in the Bone Marrow 

      Yu, Vionnie W.C.; Lymperi, Stefania; Oki, Toshihiko; Jones, Alexandra; Swiatek, Peter; Vasic, Radovan; Ferraro, Francesca; Scadden, David T. (Elsevier, 2016)
      Summary Bone marrow niches for hematopoietic progenitor cells are not well defined despite their critical role in blood homeostasis. We previously found that cells expressing osteocalcin, a marker of mature osteolineage ...