Now showing items 4526-4545 of 17918

    • Distinct patterns of expression of fibroblast growth factors and their receptors in human atheroma and nonatherosclerotic arteries. Association of acidic FGF with plaque microvessels and macrophages 

      Brogi, E; Winkles, J A; Underwood, R; Clinton, S K; Alberts, G F; Libby, Peter (American Society for Clinical Investigation, 1993)
      Because fibroblast growth factors (FGFs) modulate important functions of endothelial cells (EC) and smooth muscle cells (SMC), we studied FGF expression in human vascular cells and control or atherosclerotic arteries. All ...
    • Distinct Patterns of IFITM-Mediated Restriction of Filoviruses, SARS Coronavirus, and Influenza A Virus 

      Radoshitzky, Sheli R.; Becker, Michelle M.; Chi, Xiaoli; Dong, Lian; Longobardi, Lindsay E.; Boltz, Dutch; Kuhn, Jens H.; Bavari, Sina; Denison, Mark R.; Baric, Ralph S.; Huang, I-Chueh; Bailey, Charles; Weyer, Jessica; Chiang, Jessica; Brass, Abraham L.; Ahmed, Asim Aminsharif; Elledge, Stephen J.; Choe, Hyeryun; Farzan, Michael Reynolds (Public Library of Science, 2011)
      Interferon-inducible transmembrane proteins 1, 2, and 3 (IFITM1, 2, and 3) are recently identified viral restriction factors that inhibit infection mediated by the influenza A virus (IAV) hemagglutinin (HA) protein. Here ...
    • Distinct patterns of lipoproteins with apoB defined by presence of apoE or apoC-III in hypercholesterolemia and hypertriglyceridemia. 

      Campos, Hannia; Perlov, Dan; Khoo, Christina; Sacks, Frank Martin (American Society for Biochemistry and Molecular Biology, 2001)
      Apolipoprotein (apo) E and apoC-III concentrations in VLDL and LDL are associated with coronary heart disease. We studied the relationship between apoE and apoC-III and the abnormal concentrations and distribution of apoB ...
    • Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas 

      Campbell, Joshua D.; Alexandrov, Anton; Kim, Jaegil; Wala, Jeremiah; Berger, Alice H.; Pedamallu, Chandra Sekhar; Shukla, Sachet A.; Guo, Guangwu; Brooks, Angela N.; Murray, Bradley A.; Imielinski, Marcin; Hu, Xin; Ling, Shiyun; Akbani, Rehan; Rosenberg, Mara; Cibulskis, Carrie; Ramachandran, Aruna; Collisson, Eric A.; Kwiatkowski, David J.; Lawrence, Michael S.; Weinstein, John N.; Verhaak, Roel G. W.; Wu, Catherine J.; Hammerman, Peter S.; Cherniack, Andrew D.; Getz, Gad; Artyomov, Maxim N.; Schreiber, Robert; Govindan, Ramaswamy; Meyerson, Matthew (2016)
      To compare lung adenocarcinoma (ADC) and lung squamous cell carcinoma (SqCC) and to identify new drivers of lung carcinogenesis, we examined exome sequences and copy number profiles of 660 lung ADC and 484 lung SqCC ...
    • Distinct plasma immune signatures in ME/CFS are present early in the course of illness 

      Hornig, M.; Montoya, J. G.; Klimas, N. G.; Levine, S.; Felsenstein, Donna; Bateman, L.; Peterson, D. L.; Gottschalk, C. G.; Schultz, A. F.; Che, X.; Eddy, M. L.; Komaroff, Anthony L.; Lipkin, W. I. (American Association for the Advancement of Science (AAAS), 2015)
      Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is an unexplained incapacitating illness that may affect up to 4 million people in the United States alone. There are no validated laboratory tests for diagnosis ...
    • Distinct Populations of HCN Pacemaker Channels Produce Voltage-dependent and Voltage-independent Currents 

      Proenza, Catherine; Yellen, Gary (Rockefeller University Press, 2006)
      Hyperpolarization-activated HCN pacemaker channels are critical for the generation of spontaneous activity and the regulation of excitability in the heart and in many types of neurons. These channels produce both a ...
    • Distinct Processes and Transcriptional Targets Underlie CDX2 Requirements in Intestinal Stem Cells and Differentiated Villus Cells 

      San Roman, Adrianna K.; Tovaglieri, Alessio; Breault, David T.; Shivdasani, Ramesh A. (Elsevier, 2015)
      Summary Lgr5-expressing intestinal stem cells (ISCs) renew the adult gut epithelium by producing mature villus cells (VCs); the transcriptional basis for ISC functions remains unclear. RNA sequencing analysis identified ...
    • Distinct Recognition of Complement iC3b by Integrins αXβ2 and αMβ2 

      Wang, Jia-Huai; Xu, Shutong; Wang, Jianchuan; Springer, Timothy (Proceedings of the National Academy of Sciences, 2017-03-14)
      Recognition by the leukocyte integrins αXβ2 and αMβ2 of complement iC3b-opsonized targets is essential for effector functions including phagocytosis. The integrin-binding sites on iC3b remain incompletely characterized. ...
    • Distinct roles of XRCC4 and Ku80 in non-homologous end-joining of endonuclease- and ionizing radiation-induced DNA double-strand breaks 

      Schulte-Uentrop, Leonie; El-Awady, Raafat A.; Schliecker, Lena; Willers, Henning; Dahm-Daphi, Jochen (Oxford University Press, 2008)
      Non-homologous end-joining (NHEJ) of DNA double-strand breaks (DSBs) is mediated by two protein complexes comprising Ku80/Ku70/DNA-PKcs/Artemis and XRCC4/LigaseIV/XLF. Loss of Ku or XRCC4/LigaseIV function compromises the ...
    • Distinct Spatiotemporal Activity in Principal Neurons of the Mouse Olfactory Bulb in Anesthetized and Awake States 

      Blauvelt, David Gregory; Sato, Tomokazu F.; Wienisch, Martin; Murthy, Venkatesh N. (Frontiers Media S.A., 2013)
      The acquisition of olfactory information and its early processing in mammals are modulated by brain states through sniffing behavior and neural feedback. We imaged the spatiotemporal pattern of odor-evoked activity in a ...
    • Distinct transcriptional changes in non-small cell lung cancer patients associated with multi-antigenic RNActive® CV9201 immunotherapy 

      Hong, Henoch S.; Koch, Sven D.; Scheel, Birgit; Gnad-Vogt, Ulrike; Schröder, Andreas; Kallen, Karl-Josef; Wiegand, Volker; Backert, Linus; Kohlbacher, Oliver; Hoerr, Ingmar; Fotin-Mleczek, Mariola; Billingsley, James M. (Taylor & Francis, 2016)
      ABSTRACT We recently completed a phase I/IIa trial of RNActive® CV9201, a novel mRNA-based therapeutic vaccine targeting five tumor-associated antigens in non-small cell lung cancer (NSCLC) patients. The aim of the study ...
    • Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation 

      Foudi, Adlen; Kramer, Daniel J.; Qin, Jinzhong; Ye, Denise; Behlich, Anna-Sophie; Mordecai, Scott; Preffer, Frederic I.; Amzallag, Arnaud; Ramaswamy, Sridhar; Hochedlinger, Konrad; Orkin, Stuart H.; Hock, Hanno (The Rockefeller University Press, 2014)
      The zinc finger transcriptional repressor Gfi-1b is essential for erythroid and megakaryocytic development in the embryo. Its roles in the maintenance of bone marrow erythropoiesis and thrombopoiesis have not been defined. ...
    • Distinctive Expansion of Potential Virulence Genes in the Genome of the Oomycete Fish Pathogen Saprolegnia parasitica 

      Jiang, Rays H. Y.; de Bruijn, Irene; Haas, Brian J.; Belmonte, Rodrigo; Löbach, Lars; Christie, James; van den Ackerveken, Guido; Bottin, Arnaud; Bulone, Vincent; Díaz-Moreno, Sara M.; Dumas, Bernard; Fan, Lin; Gaulin, Elodie; Govers, Francine; Grenville-Briggs, Laura J.; Horner, Neil R.; Levin, Joshua Z.; Mammella, Marco; Meijer, Harold J. G.; Morris, Paul; Nusbaum, Chad; Oome, Stan; Phillips, Andrew J.; van Rooyen, David; Rzeszutek, Elzbieta; Saraiva, Marcia; Secombes, Chris J.; Seidl, Michael F.; Snel, Berend; Stassen, Joost H. M.; Sykes, Sean; Tripathy, Sucheta; van den Berg, Herbert; Vega-Arreguin, Julio C.; Wawra, Stephan; Young, Sarah K.; Zeng, Qiandong; Dieguez-Uribeondo, Javier; Russ, Carsten; Tyler, Brett M.; van West, Pieter (Public Library of Science, 2013)
      Oomycetes in the class Saprolegniomycetidae of the Eukaryotic kingdom Stramenopila have evolved as severe pathogens of amphibians, crustaceans, fish and insects, resulting in major losses in aquaculture and damage to aquatic ...
    • Distinctive Mesenchymal-Parenchymal Cell Pairings Govern B Cell Differentiation in the Bone Marrow 

      Yu, Vionnie W.C.; Lymperi, Stefania; Oki, Toshihiko; Jones, Alexandra; Swiatek, Peter; Vasic, Radovan; Ferraro, Francesca; Scadden, David T. (Elsevier, 2016)
      Summary Bone marrow niches for hematopoietic progenitor cells are not well defined despite their critical role in blood homeostasis. We previously found that cells expressing osteocalcin, a marker of mature osteolineage ...
    • Distinguishing direct versus indirect transcription factor–DNA interactions 

      Gordân, Raluca; Hartemink, Alexander J.; Bulyk, Martha L. (Cold Spring Harbor Laboratory Press, 2009)
      Transcriptional regulation is largely enacted by transcription factors (TFs) binding DNA. Large numbers of TF binding motifs have been revealed by ChIP-chip experiments followed by computational DNA motif discovery. However, ...
    • Distinguishing social and cultural features of cholera in urban and rural areas of Western Kenya: Implications for public health 

      Nyambedha, Erick Otieno; Sundaram, Neisha; Schaetti, Christian; Akeyo, Lilian; Chaignat, Claire-Lise; Hutubessy, Raymond; Weiss, Mitchell Gralnick (Informa UK Limited, 2013)
      Urban and rural areas have distinctive health problems, which require consideration. To examine sociocultural features of cholera and its community context, a semi-structured explanatory model interview based on vignettes ...
    • Distinguishing Untreated Osteoblastic Metastases From Enostoses Using CT Attenuation Measurements 

      Ulano, Adam; Bredella, Miriam A.; Burke, Patrick J; Chebib, Ivan Adel; Simeone, Frank J; Huang, Ambrose J.; Torriani, Martin P.; Chang, Connie Y. (American Roentgen Ray Society, 2016)
      Purpose: To determine if CT density thresholds of osteoblastic bone lesions can be used to distinguish untreated osteoblastic metastases from enostoses. Materials and Methods: The study group comprised 62 patients (37 ...
    • A distributed cell division counter reveals growth dynamics in the gut microbiota 

      Myhrvold, Cameron; Kotula, Jonathan W.; Hicks, Wade M.; Conway, Nicholas J.; Silver, Pamela A. (Nature Pub. Group, 2015)
      Microbial population growth is typically measured when cells can be directly observed, or when death is rare. However, neither of these conditions hold for the mammalian gut microbiota, and, therefore, standard approaches ...
    • Distributed Data Processing for Public Health Surveillance 

      Lazarus, Ross; Yih, Katherine Katherine; Platt, Richard (BioMed Central, 2006)
      Background: Many systems for routine public health surveillance rely on centralized collection of potentially identifiable, individual, identifiable personal health information (PHI) records. Although individual, identifiable ...
    • Distributed Health Data Networks 

      Brown, Jeffrey Stuart; Holmes, John H.; Shah, Kiran; Hall, Ken; Lazarus, Ross; Platt, Richard (Ovid Technologies (Wolters Kluwer Health), 2010)
      Background: Comparative effectiveness research, medical product safety evaluation, and quality measurement will require the ability to use electronic health data held by multiple organizations. There is no consensus about ...