Browsing HMS Scholarly Articles by Title
Now showing items 4669-4688 of 17921
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Does stroke location predict walk speed response to gait rehabilitation?
(John Wiley and Sons Inc., 2015)Abstract Objectives: Recovery of independent ambulation after stroke is a major goal. However, which rehabilitation regimen best benefits each individual is unknown and decisions are currently made on a subjective basis. ... -
Does Symptom Type Moderate the Relationship Between Insight and Outcome in Cognitive Behavioral Therapy for Psychosis? A Preliminary Investigation
(Informa UK Limited, 2012)Insight has emerged as a potential predictor variable in cognitive behavioral therapy for psychosis (CBTp). However, previous research has produced mixed results. The present study aimed to clarify whether symptom type is ... -
Does the Computerized Display of Charges Affect Inpatient Ancillary Test Utilization?
(American Medical Association (AMA), 1997-11-24)Background: The computerized display of charges for ancillary tests in outpatients has been found to affect physician-ordering behavior, but this issue has not been studied in inpatients. Objective: To assess whether ... -
Does the Mechanism of Lymph Node Invasion Affect Survival in Patients with Pancreatic Ductal Adenocarcinoma?
(Springer Science + Business Media, 2010)Background: Lymph node metastases are prognostically significant in pancreatic ductal adenocarcinoma. Little is known about the significance of direct lymph node invasion. Aim: The aim of this study is to find out whether ... -
Does Weather Matter? The Effect of Weather Patterns and Temporal Factors on Pediatric Orthopedic Trauma Volume
(Bentham Open, 2016)Objectives: Orthopaedists often speculate how weather and school schedule may influence pediatric orthopedic trauma volume, but few studies have examined this. This study aims to determine: how do weather patterns, day, ... -
The Dohner fluorescence in situ hybridization prognostic classification of chronic lymphocytic leukaemia (CLL): the CLL Research Consortium experience
(2016)Summary This study revisited the Dohner prognostic hierarchy in a cohort of 1585 well-documented patients with chronic lymphocytic leukaemia. The duration of both time to first treatment (TTFT) and overall survival (OS) ... -
Doing Research on the Ethics of Doing Research
(BioMed Central, 2007)In the previous issue of Critical Care Chenaud and colleagues found that most intensive care unit patients who had given informed consent for their participation in a clinical trial could not recall either the purpose of ... -
DOK2 Inhibits EGFR-Mutated Lung Adenocarcinoma
(Public Library of Science, 2013)Somatic mutations in the EGFR proto-oncogene occur in ~15% of human lung adenocarcinomas and the importance of EGFR mutations for the initiation and maintenance of lung cancer is well established from mouse models and ... -
Domestication Reprogrammed the Budding Yeast Life Cycle
(Cold Spring Harbor Laboratory, 2022-02-24) -
Dominance of Deleterious Alleles Controls the Response to a Population Bottleneck
(Public Library of Science, 2015)Population bottlenecks followed by re-expansions have been common throughout history of many populations. The response of alleles under selection to such demographic perturbations has been a subject of great interest in ... -
Dominant Sequences of Human Major Histocompatibility Complex Conserved Extended Haplotypes from HLA-DQA2 to DAXX
(Public Library of Science, 2014)We resequenced and phased 27 kb of DNA within 580 kb of the MHC class II region in 158 population chromosomes, most of which were conserved extended haplotypes (CEHs) of European descent or contained their centromeric ... -
Don't Wear Your New Shoes (Yet): Taking the Right Steps to Become a Successful Principal Investigator
(Public Library of Science, 2013)You finished your PhD, have been a postdoc for a while, and you start wondering, “What's next?” Suppose you come to the conclusion that you want to stay in academia, and move up the ladder to become a principal investigator ... -
Donor Bone Marrow-Derived T Cells Inhibit GVHD Induced by Donor Lymphocyte Infusion in Established Mixed Allogeneic Hematopoietic Chimeras
(Public Library of Science, 2012)Delayed administration of donor lymphocyte infusion (DLI) to established mixed chimeras has been shown to achieve anti-tumor responses without graft-vs.-host disease (GVHD). Herein we show that de novo donor BM-derived T ... -
Door‐to‐Puncture: A Practical Metric for Capturing and Enhancing System Processes Associated With Endovascular Stroke Care, Preliminary Results From the Rapid Reperfusion Registry
(Blackwell Publishing Ltd, 2014)Background: In 2011, the Brain Attack Coalition proposed door‐to‐treatment times of 2 hours as a benchmark for patients undergoing intra‐arterial therapy (IAT). We designed the Rapid Reperfusion Registry to capture the ... -
Dopa-Responsive Dystonia: Functional Analysis of Single Nucleotide Substitutions within the 5’ Untranslated GCH1 Region
(Public Library of Science, 2013)Background: Mutations in the GCH1 gene are associated with childhood onset, dopa-responsive dystonia (DRD). Correct diagnosis of DRD is crucial, given the potential for complete recovery once treated with L-dopa. The ... -
Dopamine D1 signaling organizes network dynamics underlying working memory
(American Association for the Advancement of Science, 2016)Local prefrontal dopamine signaling supports working memory by tuning pyramidal neurons to task-relevant stimuli. Enabled by simultaneous positron emission tomography–magnetic resonance imaging (PET-MRI), we determined ... -
Dopamine Genetic Risk Score Predicts Depressive Symptoms in Healthy Adults and Adults with Depression
(Public Library of Science, 2014)Background: Depression is a common source of human disability for which etiologic insights remain limited. Although abnormalities of monoamine neurotransmission, including dopamine, are theorized to contribute to the ... -
Dopamine Receptor and Gα(olf) Expression in DYT1 Dystonia Mouse Models during Postnatal Development
(Public Library of Science, 2015)Background: DYT1 dystonia is a heritable, early-onset generalized movement disorder caused by a GAG deletion (ΔGAG) in the DYT1 gene. Neuroimaging studies and studies using mouse models suggest that DYT1 dystonia is ... -
Dopamine Transporter 3'UTR VNTR Genotype is a Marker of Performance on Executive Function Tasks in Children with ADHD
(BioMed Central, 2008)Background: Attention-Deficit/Hyperactivity Disorder (ADHD) is a heterogeneous disorder from both clinical and pathogenic viewpoints. Executive function deficits are considered among the most important pathogenic pathways ...