Now showing items 4678-4697 of 17918

    • Domestication Reprogrammed the Budding Yeast Life Cycle 

      De Chiara, Matteo; Barré, Benjamin; Persson, Karl; Irizar, Agurtzane; Vischioni, Chiara; Khaiwal, Sakshi; Stenberg, Simon; Chioma Amadi, Onyetugo; Zun, Gasper; Dobersek, Katja; Taccioli, Cristian; Schacherer, Joseph; Petrovic, Uros; Warringer, Jonas; Liti, Gianni (Cold Spring Harbor Laboratory, 2022-02-24)
    • Dominance of Deleterious Alleles Controls the Response to a Population Bottleneck 

      Balick, Daniel J.; Do, Ron; Cassa, Christopher A.; Reich, David; Sunyaev, Shamil R. (Public Library of Science, 2015)
      Population bottlenecks followed by re-expansions have been common throughout history of many populations. The response of alleles under selection to such demographic perturbations has been a subject of great interest in ...
    • Dominant Sequences of Human Major Histocompatibility Complex Conserved Extended Haplotypes from HLA-DQA2 to DAXX 

      Larsen, Charles E.; Alford, Dennis R.; Trautwein, Michael R.; Jalloh, Yanoh K.; Tarnacki, Jennifer L.; Kunnenkeri, Sushruta K.; Fici, Dolores A.; Yunis, Edmond J.; Awdeh, Zuheir L.; Alper, Chester A. (Public Library of Science, 2014)
      We resequenced and phased 27 kb of DNA within 580 kb of the MHC class II region in 158 population chromosomes, most of which were conserved extended haplotypes (CEHs) of European descent or contained their centromeric ...
    • Don't Wear Your New Shoes (Yet): Taking the Right Steps to Become a Successful Principal Investigator 

      de Ridder, Jeroen; Abeel, Thomas; Michaut, Magali; Satagopam, Venkata P.; Gehlenborg, Nils (Public Library of Science, 2013)
      You finished your PhD, have been a postdoc for a while, and you start wondering, “What's next?” Suppose you come to the conclusion that you want to stay in academia, and move up the ladder to become a principal investigator ...
    • Donor Bone Marrow-Derived T Cells Inhibit GVHD Induced by Donor Lymphocyte Infusion in Established Mixed Allogeneic Hematopoietic Chimeras 

      Wang, Hui; Yang, Yanping; Wang, Guanjun; Wang, Shumei; Yeap, Beow Yong; Sykes, Megan; Yang, Yong-Guang (Public Library of Science, 2012)
      Delayed administration of donor lymphocyte infusion (DLI) to established mixed chimeras has been shown to achieve anti-tumor responses without graft-vs.-host disease (GVHD). Herein we show that de novo donor BM-derived T ...
    • Door‐to‐Puncture: A Practical Metric for Capturing and Enhancing System Processes Associated With Endovascular Stroke Care, Preliminary Results From the Rapid Reperfusion Registry 

      Sun, Chung‐Huan J.; Ribo, Marc; Goyal, Mayank; Yoo, Albert J.; Jovin, Tudor; Cronin, Carolyn A.; Zaidat, Osama; Nogueira, Raul; Nguyen, Thanh; Hussain, M. Shazam; Menon, Bijoy K.; Mehta, Brijesh; Jindal, Gaurav; Horev, Anat; Norbash, Alexander; Leslie‐Mazwi, Thabele; Wisco, Dolora; Gupta, Rishi (Blackwell Publishing Ltd, 2014)
      Background: In 2011, the Brain Attack Coalition proposed door‐to‐treatment times of 2 hours as a benchmark for patients undergoing intra‐arterial therapy (IAT). We designed the Rapid Reperfusion Registry to capture the ...
    • Dopa-Responsive Dystonia: Functional Analysis of Single Nucleotide Substitutions within the 5’ Untranslated GCH1 Region 

      Armata, Ioanna A.; Balaj, Leonora; Kuster, John K.; Zhang, Xuan; Tsai, Shelun; Armatas, Andreas A.; Multhaupt-Buell, Trisha J.; Soberman, Roy; Breakefield, Xandra O.; Ichinose, Hiroshi; Sharma, Nutan (Public Library of Science, 2013)
      Background: Mutations in the GCH1 gene are associated with childhood onset, dopa-responsive dystonia (DRD). Correct diagnosis of DRD is crucial, given the potential for complete recovery once treated with L-dopa. The ...
    • Dopamine D1 signaling organizes network dynamics underlying working memory 

      Roffman, Joshua L.; Tanner, Alexandra S.; Eryilmaz, Hamdi; Rodriguez-Thompson, Anais; Silverstein, Noah J.; Ho, New Fei; Nitenson, Adam Z.; Chonde, Daniel B.; Greve, Douglas N.; Abi-Dargham, Anissa; Buckner, Randy L.; Manoach, Dara S.; Rosen, Bruce R.; Hooker, Jacob M.; Catana, Ciprian (American Association for the Advancement of Science, 2016)
      Local prefrontal dopamine signaling supports working memory by tuning pyramidal neurons to task-relevant stimuli. Enabled by simultaneous positron emission tomography–magnetic resonance imaging (PET-MRI), we determined ...
    • Dopamine Genetic Risk Score Predicts Depressive Symptoms in Healthy Adults and Adults with Depression 

      Pearson-Fuhrhop, Kristin M.; Dunn, Erin C.; Mortero, Sarah; Devan, William J.; Falcone, Guido J.; Lee, Phil; Holmes, Avram J.; Hollinshead, Marisa O.; Roffman, Joshua L.; Smoller, Jordan W.; Rosand, Jonathan; Cramer, Steven C. (Public Library of Science, 2014)
      Background: Depression is a common source of human disability for which etiologic insights remain limited. Although abnormalities of monoamine neurotransmission, including dopamine, are theorized to contribute to the ...
    • Dopamine Receptor and Gα(olf) Expression in DYT1 Dystonia Mouse Models during Postnatal Development 

      Zhang, Lin; McCarthy, Deirdre M.; Sharma, Nutan; Bhide, Pradeep G. (Public Library of Science, 2015)
      Background: DYT1 dystonia is a heritable, early-onset generalized movement disorder caused by a GAG deletion (ΔGAG) in the DYT1 gene. Neuroimaging studies and studies using mouse models suggest that DYT1 dystonia is ...
    • Dopamine Transporter 3'UTR VNTR Genotype is a Marker of Performance on Executive Function Tasks in Children with ADHD 

      Karama, Sherif; Grizenko, Natalie; Sonuga-Barke, Edmund; Mbekou, Valentin; Polotskaia, Anna; Ter-Stepanian, Marina; De Guzman, Rosherrie; Bellingham, Johanne; Sengupta, Sarojini; Joober, Ridha; Doyle, Alysa Emily; Biederman, Joseph (BioMed Central, 2008)
      Background: Attention-Deficit/Hyperactivity Disorder (ADHD) is a heterogeneous disorder from both clinical and pathogenic viewpoints. Executive function deficits are considered among the most important pathogenic pathways ...
    • Dopamine-enabled anti-Hebbian timing-dependent plasticity in prefrontal circuitry 

      Ruan, Hongyu; Saur, Taixiang; Yao, Wei-Dong (Frontiers Media S.A., 2014)
      Spike timing-dependent plasticity (STDP) of glutamatergic synapses is a Hebbian associative plasticity that may underlie certain forms of learning. A cardinal feature of STDP is its dependence on the temporal order of ...
    • Dopamine-Induced Conformational Changes in Alpha-Synuclein 

      Outeiro, Tiago F.; Klucken, Jochen; Bercury, Kathryn; Tetzlaff, Julie; Putcha, Preeti; Oliveira, Luis M. A.; Quintas, Alexandre; McLean, Pamela June; Hyman, Bradley Theodore (Public Library of Science, 2009)
      Background: Oligomerization and aggregation of α-synuclein molecules play a major role in neuronal dysfunction and loss in Parkinson's disease [1]. However, α-synuclein oligomerization and aggregation have mostly been ...
    • Dopaminergic neurons inhibit striatal output via non-canonical release of GABA 

      Tritsch, Nicolas X.; Ding, Jun B.; Sabatini, Bernardo L. (2012)
      The substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) contain the two largest populations of dopamine (DA)-releasing neurons in the mammalian brain. These neurons extend elaborate projections in striatum, ...
    • Dorsal Anterior Cingulate Thickness Is Related to Alexithymia in Childhood Trauma-Related PTSD 

      Demers, Lauren A.; Olson, Elizabeth A.; Crowley, David J.; Rauch, Scott L.; Rosso, Isabelle M. (Public Library of Science, 2015)
      Alexithymia, or “no words for feelings”, is highly prevalent in samples with childhood maltreatment and posttraumatic stress disorder (PTSD). The dorsal anterior cingulate cortex (dACC) has been identified as a key region ...
    • Dorsalizing and Neuralizing Properties of Xdsh, a Maternally Expressed Xenopus Homolog of Dishevelled 

      Sokol, Sergei Y.; Klingensmith, John; Perrimon, Norbert; Itoh, Keiji (The Company of Biologists, 1995-06-01)
      Signaling factors of the Wnt proto-oncogene family are implicated in dorsal axis formation during vertebrate development, but the molecular mechanism of this process is not known. Studies in Drosophila have indicated that ...
    • The dorsomedial striatum encodes net expected return, critical for energizing performance vigor 

      Wang, Alice Y.; Miura, Keiji; Uchida, Naoshige (2013)
      Decision making requires an actor to not only steer behavior towards specific goals, but also determine the optimal vigor of performance. Current research and models have largely focused on the former problem of how actions ...
    • Dorsomorphin, a Selective Small Molecule Inhibitor of BMP Signaling, Promotes Cardiomyogenesis in Embryonic Stem Cells 

      Hao, Jijun; Daleo, Marie A.; Murphy, Clare K.; Yu, Paul B.; Ho, Joshua N.; Hu, Jianyong; Peterson, Randall Theodore; Hatzopoulos, Antonis K.; Hong, Charles C. (Public Library of Science, 2008)
      Background: Pluripotent embryonic stem (ES) cells, which have the capacity to give rise to all tissue types in the body, show great promise as a versatile source of cells for regenerative therapy. However, the basic ...
    • Dorsoventral Patterning in Hemichordates: Insights into Early Chordate Evolution 

      Lowe, Christopher J; Terasaki, Mark; Runft, Linda; Kwan, Kristen; Haigo, Saori; Aronowicz, Jochanan; Gruber, Chris; Gerhart, John; Wu, Michael; Freeman, Robert M; Lander, Eric Steven; Smith, Mark; Kirschner, Marc W. (Public Library of Science, 2006)
      We have compared the dorsoventral development of hemichordates and chordates to deduce the organization of their common ancestor, and hence to identify the evolutionary modifications of the chordate body axis after the ...
    • Dosage Compensation in the Mouse Balances Up-Regulation and Silencing of X-Linked Genes 

      Gupta, Vibhor; VerMilyea, Matthew D; Falciani, Francesco; O'Neill, Laura P; Turner, Bryan M; Reik, Wolf; Lin, Hong; Lee, Jeannie T. (Public Library of Science, 2007)
      Dosage compensation in mammals involves silencing of one X chromosome in XX females and requires expression, in cis, of Xist RNA. The X to be inactivated is randomly chosen in cells of the inner cell mass (ICM) at the ...