Browsing HMS Scholarly Articles by Title
Now showing items 4782-4801 of 17922
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Dry Eye Disease Patients with Xerostomia Report Higher Symptom Load and Have Poorer Meibum Expressibility
(Public Library of Science, 2016)The purpose of the study was to investigate if xerostomia (dry mouth) is associated with symptoms and signs of dry eye disease (DED). At the Norwegian Dry Eye Clinic, patients with symptomatic DED with different etiologies ... -
Dry Eye Disease: an immune-mediated ocular surface disorder
(American Medical Association (AMA), 2012)Dry eye disease is a multifactorial disorder of the tears and ocular surface characterized by symptoms of dryness and irritation. Although the pathogenesis of dry eye disease is not fully understood, it is recognized that ... -
DSD and Professionalism from a Multilateral View: Supplementing the Consensus Statement on the Basis of a Qualitative Survey
(Hindawi Publishing Corporation, 2012)Treatment and support of a child with DSD calls for experience and expertise in diagnosis, surgical techniques, understanding of psychosocial issues, and recognizing and accepting the significance of individual values of ... -
DTI and MTR abnormalities in schizophrenia: Analysis of white matter integrity
(Elsevier BV, 2005)Diffusion tensor imaging (DTI) studies in schizophrenia demonstrate lower anisotropic diffusion within white matter due either to loss of coherence of white matter fiber tracts, to changes in the number and/or density of ... -
A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice
(2016)Many genetic liver diseases present in newborns with repeated, often lethal, metabolic crises. Gene therapy using non-integrating viruses such as AAV is not optimal in this setting because the non-integrating genome is ... -
Dual Adaptive Filtering by Optimal Projection Applied to Filter Muscle Artifacts on EEG and Comparative Study
(Hindawi Publishing Corporation, 2014)Muscle artifacts constitute one of the major problems in electroencephalogram (EEG) examinations, particularly for the diagnosis of epilepsy, where pathological rhythms occur within the same frequency bands as those of ... -
Dual CD4-based CAR T cells with distinct costimulatory domains mitigate HIV pathogenesis in vivo
(Springer Science and Business Media LLC, 2020-08-31)A potent and sustained antiviral T cell response will likely be a critical component of an effective HIV cure strategy. Here, we explored the utility of CD4-based Chimeric Antigen Receptor (CAR) T cells to mitigate HIV-induced ... -
Dual defensin strategy for targeting Enterococcus faecalis
(Proceedings of the National Academy of Sciences, 2013) -
Dual DNA and Protein Tagging of Open Chromatin Unveils Dynamics of Epigenomic Landscapes in Leukemia
(Springer Science and Business Media LLC, 2021-03-01)The architecture of chromatin specifies eukaryotic cell identity by controlling transcription factor access to sites of gene regulation. Here we describe a dual transposase/peroxidase approach, integrative DNA And Protein ... -
Dual Function of CD81 in Influenza Virus Uncoating and Budding
(Public Library of Science, 2013)As an obligatory pathogen, influenza virus co-opts host cell machinery to harbor infection and to produce progeny viruses. In order to characterize the virus-host cell interactions, several genome-wide siRNA screens and ... -
Dual Function of Ras in Raf Activation
(The Company of Biologists, 1998-12-15)The small guanine nucleotide binding protein p21(Ras) plays an important role in the activation of the Raf kinase. However, the precise mechanism by which Raf is activated remains unclear. It has been proposed that the ... -
Dual Functions of Wingless in the Drosophila Leg Imaginal Disc
(The Company of Biologists, 1995-02-01)The Drosophila gene wingless is a member of the Wnt gene family, a group of genes that are involved in embryonic development and the regulation of cell proliferation. wingless encodes a secreted glycoprotein that plays a ... -
Dual Host-Virus Arms Races Shape an Essential Housekeeping Protein
(Public Library of Science, 2013)Transferrin Receptor (TfR1) is the cell-surface receptor that regulates iron uptake into cells, a process that is fundamental to life. However, TfR1 also facilitates the cellular entry of multiple mammalian viruses. We use ... -
Dual inhibition of AKT/FLT3-ITD by A674563 overcomes FLT3 ligand-induced drug resistance in FLT3-ITD positive AML
(Impact Journals LLC, 2016)The FLT3-ITD mutation is one of the most prevalent oncogenic mutations in AML. Several FLT3 kinase inhibitors have shown impressive activity in clinical evaluation, however clinical responses are usually transient and ... -
Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages
(National Academy of Sciences, 2016)Glioblastomas (GBMs) rapidly become refractory to anti-VEGF therapies. We previously demonstrated that ectopic overexpression of angiopoietin-2 (Ang-2) compromises the benefits of anti-VEGF receptor (VEGFR) treatment in ... -
Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type
(John Wiley & Sons, Ltd, 2015)Abstract Small cell carcinoma of the ovary, hypercalcaemic type (SCCOHT) is a lethal and sometimes familial ovarian tumour of young women and children. We and others recently discovered that over 90% of SCCOHTs harbour ... -
Dual phosphorylation of Sin1 at T86 and T398 negatively regulates mTORC2 complex integrity and activity
(Higher Education Press, 2014)Mammalian target of rapamycin (mTOR) plays essential roles in cell proliferation, survival and metabolism by forming at least two functional distinct multi-protein complexes, mTORC1 and mTORC2. External growth signals can ... -
Dual Regulation of the lin-14 Target mRNA by the lin-4 miRNA
(Public Library of Science, 2013)microRNAs (miRNAs) are ∼22 nt regulatory RNAs that in animals typically bind with partial complementarity to sequences in the 3′ untranslated (UTR) regions of target mRNAs, to induce a decrease in the production of the ... -
A Dual Regulator of Neutrophil Recruitment
(American Society of Hematology, 2014) -
A Dual Role for Corneal Dendritic Cells in Herpes Simplex Keratitis: Local Suppression of Corneal Damage and Promotion of Systemic Viral Dissemination
(Public Library of Science, 2015)The cornea is the shield to the foreign world and thus, a primary site for peripheral infections. However, transparency and vision are incompatible with inflammation and scarring that may result from infections. Thus, the ...