Now showing items 4791-4810 of 17918

    • Dual Function of CD81 in Influenza Virus Uncoating and Budding 

      He, Jiang; Sun, Eileen; Bujny, Miriam V.; Kim, Doory; Davidson, Michael W.; Zhuang, Xiaowei (Public Library of Science, 2013)
      As an obligatory pathogen, influenza virus co-opts host cell machinery to harbor infection and to produce progeny viruses. In order to characterize the virus-host cell interactions, several genome-wide siRNA screens and ...
    • Dual Function of Ras in Raf Activation 

      Li, Willis X.; Melnick, Michael; Perrimon, Norbert (The Company of Biologists, 1998-12-15)
      The small guanine nucleotide binding protein p21(Ras) plays an important role in the activation of the Raf kinase. However, the precise mechanism by which Raf is activated remains unclear. It has been proposed that the ...
    • Dual Functions of Wingless in the Drosophila Leg Imaginal Disc 

      Wilder, Elizabeth L.; Perrimon, Norbert (The Company of Biologists, 1995-02-01)
      The Drosophila gene wingless is a member of the Wnt gene family, a group of genes that are involved in embryonic development and the regulation of cell proliferation. wingless encodes a secreted glycoprotein that plays a ...
    • Dual Host-Virus Arms Races Shape an Essential Housekeeping Protein 

      Demogines, Ann; Abraham, Jonathan; Choe, Hyeryun; Farzan, Michael; Sawyer, Sara L. (Public Library of Science, 2013)
      Transferrin Receptor (TfR1) is the cell-surface receptor that regulates iron uptake into cells, a process that is fundamental to life. However, TfR1 also facilitates the cellular entry of multiple mammalian viruses. We use ...
    • Dual inhibition of AKT/FLT3-ITD by A674563 overcomes FLT3 ligand-induced drug resistance in FLT3-ITD positive AML 

      Wang, Aoli; Wu, Hong; Chen, Cheng; Hu, Chen; Qi, Ziping; Wang, Wenchao; Yu, Kailin; Liu, Xiaochuan; Zou, Fengming; Zhao, Zheng; Wu, Jiaxin; Liu, Juan; Liu, Feiyang; Wang, Li; Stone, Richard M.; Galinksy, Ilene A.; Griffin, James D.; Zhang, Shanchun; Weisberg, Ellen L.; Liu, Jing; Liu, Qingsong (Impact Journals LLC, 2016)
      The FLT3-ITD mutation is one of the most prevalent oncogenic mutations in AML. Several FLT3 kinase inhibitors have shown impressive activity in clinical evaluation, however clinical responses are usually transient and ...
    • Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages 

      Peterson, Teresa; Kirkpatrick, Nathaniel; Huang, Yuhui; Farrar, Christian; Marijt, Koen; Kloepper, Jonas; Datta, Meenal; Amoozgar, Zohreh; Seano, Giorgio; Jung, Keehoon; Kamoun, Walid; Vardam, Trupti; Snuderl, Matija; Goveia, Jermaine; Chatterjee, Sampurna; Batista, Ana; Muzikansky, Alona; Leow, Ching Ching; Xu, Lei; Batchelor, Tracy; Duda, Dan; Fukumura, Dai; Jain, Rakesh (National Academy of Sciences, 2016)
      Glioblastomas (GBMs) rapidly become refractory to anti-VEGF therapies. We previously demonstrated that ectopic overexpression of angiopoietin-2 (Ang-2) compromises the benefits of anti-VEGF receptor (VEGFR) treatment in ...
    • Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type 

      Karnezis, Anthony N; Wang, Yemin; Ramos, Pilar; Hendricks, William PD; Oliva, Esther; D'Angelo, Emanuela; Prat, Jaime; Nucci, Marisa R; Nielsen, Torsten O; Chow, Christine; Leung, Samuel; Kommoss, Friedrich; Kommoss, Stefan; Silva, Annacarolina; Ronnett, Brigitte M; Rabban, Joseph T; Bowtell, David D; Weissman, Bernard E; Trent, Jeffrey M; Gilks, C Blake; Huntsman, David G (John Wiley & Sons, Ltd, 2015)
      Abstract Small cell carcinoma of the ovary, hypercalcaemic type (SCCOHT) is a lethal and sometimes familial ovarian tumour of young women and children. We and others recently discovered that over 90% of SCCOHTs harbour ...
    • Dual phosphorylation of Sin1 at T86 and T398 negatively regulates mTORC2 complex integrity and activity 

      Liu, Pengda; Guo, Jianping; Gan, Wenjian; Wei, Wenyi (Higher Education Press, 2014)
      Mammalian target of rapamycin (mTOR) plays essential roles in cell proliferation, survival and metabolism by forming at least two functional distinct multi-protein complexes, mTORC1 and mTORC2. External growth signals can ...
    • Dual Regulation of the lin-14 Target mRNA by the lin-4 miRNA 

      Shi, Zhen; Hayes, Gabriel; Ruvkun, Gary (Public Library of Science, 2013)
      microRNAs (miRNAs) are ∼22 nt regulatory RNAs that in animals typically bind with partial complementarity to sequences in the 3′ untranslated (UTR) regions of target mRNAs, to induce a decrease in the production of the ...
    • A Dual Regulator of Neutrophil Recruitment 

      Luo, Hongbo (American Society of Hematology, 2014)
    • A Dual Role for Corneal Dendritic Cells in Herpes Simplex Keratitis: Local Suppression of Corneal Damage and Promotion of Systemic Viral Dissemination 

      Hu, Kai; Harris, Deshea L.; Yamaguchi, Takefumi; von Andrian, Ulrich H.; Hamrah, Pedram (Public Library of Science, 2015)
      The cornea is the shield to the foreign world and thus, a primary site for peripheral infections. However, transparency and vision are incompatible with inflammation and scarring that may result from infections. Thus, the ...
    • Dual roles for hepatic lectin receptors in the clearance of chilled platelets 

      Rumjantseva, Viktoria; Grewal, Prabhjit K.; Wandall, Hans H.; Josefsson, Emma C.; Sørensen, Anne Louise; Larson, Göran; Marth, Jamey D.; Hartwig, John H.; Hoffmeister, Karin M. (2015)
      Chilling rapidly (<4 h) clusters Glycoprotein - (GP)Ib receptors on blood platelets, and ß2-integrins of hepatic macrophages bind ßGlcNAc residues in the clusters leading to rapid clearance of acutely chilled platelets ...
    • Dual Suppression of the Cyclin-Dependent Kinase Inhibitors CDKN2C and CDKN1A in Human Melanoma 

      Jalili, Ahmad; Wagner, Christine; Pashenkov, Mikhail; Pathria, Gaurav; Mertz, Kirsten D.; Widlund, Hans R.; Lupien, Mathieu; Brunet, Jean- Philippe; Golub, Todd R.; Stingl, Georg; Fisher, David Erich; Ramaswamy, Sridhar; Wagner, Stephan N. (Oxford University Press, 2012)
      Resistance to BRAFV600E inhibitors is associated with reactivation of mitogen-activated protein kinase (MAPK) signaling at different levels in melanoma. To identify downstream effectors of MAPK signaling that could be used ...
    • A Dual TLR Agonist Adjuvant Enhances the Immunogenicity and Protective Efficacy of the Tuberculosis Vaccine Antigen ID93 

      Orr, Mark T.; Beebe, Elyse A.; Hudson, Thomas E.; Moon, James J.; Fox, Christopher B.; Reed, Steven G.; Coler, Rhea N. (Public Library of Science, 2014)
      With over eight million cases of tuberculosis each year there is a pressing need for the development of new vaccines against Mycobacterium tuberculosis. Subunit vaccines consisting of recombinant proteins are an attractive ...
    • A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing 

      Grünewald, Julian; Zhou, Ronghao; Lareau, Caleb A.; Garcia, Sara P.; Iyer, Sowmya; Miller, Bret R.; Langner, Lukas M.; Hsu, Jonathan Y.; Aryee, Martin; Joung, J. Keith (Springer Science and Business Media LLC, 2020-06-01)
    • Dual-Modality Fluorescence and Full-Field Optical Coherence Microscopy for Biomedical Imaging Applications 

      Auksorius, Egidijus; Bromberg, Yaron; Motiejūnaitė, Rūta; Pieretti, Alberto Christian; Liu, Linbo; Coron, Emmanuel; Aranda, Jorge; Goldstein, Allan Moises; Bouma, Brett; Kazlauskas, Andrius; Tearney, Guillermo James (Optical Society of America, 2012)
      Full-field optical coherence microscopy (FFOCM) is a high-resolution interferometric technique that is particularly attractive for biomedical imaging. Here we show that combining it with structured illumination fluorescence ...
    • Dual-Phase Cardiac Diffusion Tensor Imaging with Strain Correction 

      Stoeck, Christian T.; Kalinowska, Aleksandra; von Deuster, Constantin; Harmer, Jack; Chan, Rachel W.; Niemann, Markus; Manka, Robert; Atkinson, David; Sosnovik, David E.; Mekkaoui, Choukri; Kozerke, Sebastian (Public Library of Science, 2014)
      Purpose In this work we present a dual-phase diffusion tensor imaging (DTI) technique that incorporates a correction scheme for the cardiac material strain, based on 3D myocardial tagging. Methods: In vivo dual-phase cardiac ...
    • Duality of n-3 Polyunsaturated Fatty Acids on Mcp-1 Expression in Vascular Smooth Muscle: A Potential Role of 4-Hydroxy Hexenal 

      Nagayama, Kohji; Morino, Katsutaro; Sekine, Osamu; Nakagawa, Fumiyuki; Ishikado, Atsushi; Iwasaki, Hirotaka; Okada, Takashi; Tawa, Masashi; Sato, Daisuke; Imamura, Takeshi; Nishio, Yoshihiko; Ugi, Satoshi; Kashiwagi, Atsunori; Okamura, Tomio; Maegawa, Hiroshi (MDPI, 2015)
      N-3 polyunsaturated fatty acids such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have protective effects against atherosclerosis. Monocyte chemotactic protein (MCP)-1 is a major inflammatory mediator in ...
    • Duarte galactose-1-phosphate uridyl transferase genotypes are not associated with ovarian cancer risk 

      Merritt, Melissa A.; Kotsopoulos, Joanne; Cramer, Daniel William; Hankinson, Susan Elizabeth; Terry, Kathryn Lynne; Tworoger, Shelley Slate (Elsevier BV, 2012)
      Objective To investigate whether Galactose-1-phosphate uridyl transferase (GALT) variant genotypes were associated with epithelial ovarian cancer risk and to determine if this association was modified by lactose ...
    • Duloxetine in the Treatment of Major Depressive Disorder: An Open-Label Study 

      Hudson, James I; Perahia, David G.; Gilaberte, Inmaculada; Wang, Fujun; Watkin, John G.; Detke, Michael J. (BioMed Central, 2007)
      Background: Major depressive disorder (MDD) is a chronic and highly disabling condition. Existing pharmacotherapies produce full remission in only 30% to 40% of treated patients. Antidepressants exhibiting dual reuptake ...