Browsing HMS Scholarly Articles by Title

Now showing items 4813-4832 of 17922

    • Duration of Lactation and Maternal Adipokines at 3 Years Postpartum 

      Stuebe, Alison M.; Mantzoros, Christos; Kleinman, Ken Paul; Gillman, Matthew William; Rifas-Shiman, Sheryl Lynn; Gunderson, Erica P.; Rich-Edwards, Janet Wilson (American Diabetes Association, 2011)
      Objective: Lactation has been associated with reduced maternal risk of type 2 diabetes, the metabolic syndrome, and cardiovascular disease. We examined the relationship between breastfeeding duration and maternal adipokines ...

    • Duration of Postoperative Atrial Fibrillation After Cardiac Surgery Is Associated With Worsened Long-Term Survival 

      Sigurdsson, Martin I.; Longford, Nicholas T.; Heydarpour, Mahyar; Saddic, Louis; Chang, Tzuu-Wang; Fox, Amanda A.; Collard, Charles D.; Aranki, Sary Fouad; Shekar, Prem; Shernan, Stanton K.; Muehlschlegel, Jochen Daniel; Body, Simon Christopher (Elsevier BV, 2016)
      Background. Studies of the effects of postoperative atrial fibrillation (poAF) on long-term survival are con- flicting, likely because of comorbidities that occur with poAF and the patient populations studied. Furthermore, ...

    • During Muscle Atrophy, Thick, but not Thin, Filament Components are Degraded by MuRF1-Dependent Ubiquitylation 

      Cohen, Shenhav Orit; Brault, Jeffrey J.; Gygi, Steven P.; Glass, David Jonathan; Valenzuela, David M.; Gartner, Carlos; Latres, Esther; Goldberg, Alfred L. (Rockefeller University Press, 2009)
      Loss of myofibrillar proteins is a hallmark of atrophying muscle. Expression of muscle RING-finger 1 (MuRF1), a ubiquitin ligase, is markedly induced during atrophy, and MuRF1 deletion attenuates muscle wasting. We generated ...

    • Dynamic 1H-MRS assessment of brain tumors: A novel approach for differential diagnosis of glioma 

      Tong, Tong; Yang, Zhong; Chen, John W.; Zhu, Jianming; Yao, Zhenwei (Impact Journals LLC, 2015)
      Purpose To determine whether the changes of [Cho/NAA] ratio in patients with glioma, measured by dynamic 1H-MRS can be used to differentiate between high-grade and low-grade gliomas. Materials and Methods This prospective ...

    • Dynamic 3-Dimensional Echocardiographic Assessment of Mitral Annular Geometry in Patients With Functional Mitral Regurgitation 

      Khabbaz, Kamal; Mahmood, Feroze-Ud-Den; Shakil, Omair; Warraich, Haider J.; Gorman, Joseph H.; Gorman, Robert C.; Matyal, Robina; Panzica, Peter J.; Hess, Philip E. (Elsevier BV, 2013)
      Background: Mitral valve (MV) annular dynamics have been well described in animal models of functional mitral regurgitation (FMR). Despite this little, if any, data exists regarding the dynamic MV annular geometry in humans ...

    • Dynamic 31P–MRSI using spiral spectroscopic imaging can map mitochondrial capacity in muscles of the human calf during plantar flexion exercise at 7 T 

      Valkovič, Ladislav; Chmelík, Marek; Meyerspeer, Martin; Gagoski, Borjan; Rodgers, Christopher T.; Krššák, Martin; Andronesi, Ovidiu C.; Trattnig, Siegfried; Bogner, Wolfgang (John Wiley and Sons Inc., 2016)
      Abstract Phosphorus MRSI (31P–MRSI) using a spiral‐trajectory readout at 7 T was developed for high temporal resolution mapping of the mitochondrial capacity of exercising human skeletal muscle. The sensitivity and ...

    • Dynamic and Nucleolin-Dependent Localization of Human Cytomegalovirus UL84 to the Periphery of Viral Replication Compartments and Nucleoli 

      Bender, Brian; Coen, Donald; Strang, Blair (American Society for Microbiology, 2014)
      Protein-protein and protein-nucleic acid interactions within subcellular compartments are required for viral genome replication. To understand the localization of the human cytomegalovirus viral replication factor UL84 ...

    • Dynamic Associations of Change in Physical Activity and Change in Cognitive Function: Coordinated Analyses of Four Longitudinal Studies 

      Lindwall, Magnus; Cimino, Cynthia R.; Gibbons, Laura E.; Mitchell, Meghan B.; Benitez, Andreana; Brown, Cassandra L.; Kennison, Robert F.; Shirk, Steven D.; Atri, Alireza; Robitaille, Annie; MacDonald, Stuart W. S.; Zelinski, Elizabeth M.; Willis, Sherry L.; Schaie, K. Warner; Johansson, Boo; Praetorius, Marcus; Dixon, Roger A.; Mungas, Dan M.; Hofer, Scott M.; Piccinin, Andrea M. (Hindawi Publishing Corporation, 2012)
      The present study used a coordinated analyses approach to examine the association of physical activity and cognitive change in four longitudinal studies. A series of multilevel growth models with physical activity included ...

    • Dynamic Balance of Excitation and Inhibition in Human and Monkey Neocortex 

      Dehghani, Nima; Peyrache, Adrien; Telenczuk, Bartosz; Le Van Quyen, Michel; Halgren, Eric; Cash, Sydney S.; Hatsopoulos, Nicholas G.; Destexhe, Alain (Nature Publishing Group, 2016)
      Balance of excitation and inhibition is a fundamental feature of in vivo network activity and is important for its computations. However, its presence in the neocortex of higher mammals is not well established. We investigated ...

    • Dynamic Cardiovagal Response to Motion Sickness: A Point-Process Heart Rate Variability Study 

      LaCount, Lauren; Napadow, Vitaly; Kuo, Braden; Park, K.; Kim, J.; Brown, Emery; Barbieri, Riccardo (IEEE, 2009)
      A visual display of stripes was used to examine cardio-vagal response to motion sickness. Heart rate variability (HRV) was investigated using dynamic methods to discern instantaneous fluctuations in reaction to stimulus ...

    • Dynamic Chromatin Modification Sustains Epithelial-Mesenchymal Transition following Inducible Expression of Snail-1 

      Javaid, Sarah; Zhang, Jianmin; Anderssen, Endre; Black, Josh C.; Wittner, Ben S.; Tajima, Ken; Ting, David T.; Smolen, Gromoslaw A.; Zubrowski, Matthew; Desai, Rushil; Maheswaran, Shyamala; Ramaswamy, Sridhar; Whetstine, Johnathan R.; Haber, Daniel A. (2014)
      SUMMARY Epithelial-mesenchymal transition (EMT) is thought to contribute to cancer metastasis, but its underlying mechanisms are not well understood. To define early steps in this cellular transformation, we analyzed human ...

    • Dynamic Clinical Data Mining: Search Engine-Based Decision Support 

      Celi, Leo Anthony; Zimolzak, Andrew J; Stone, David J (Gunther Eysenbach, 2014)
      The research world is undergoing a transformation into one in which data, on massive levels, is freely shared. In the clinical world, the capture of data on a consistent basis has only recently begun. We propose an operational ...

    • Dynamic computational phenotyping of human cognition 

      Schurr, Roey; Reznik, Daniel; Hillman, Hanna; Bhui, Rahul; Gershman, Samuel J. (Springer Science and Business Media LLC, 2024-02-08)
      Computational phenotyping has emerged as a powerful tool for characterizing individual variability across a variety of cognitive domains. An individual's computational phenotype is defined as a set of mechanistically ...

    • Dynamic development of the pancreas from birth to adulthood 

      Bonner-Weir, Susan; Weir, Gordon C.; Aguayo-Mazzucato, Cristina (Taylor & Francis, 2016)
      After birth the endocrine pancreas continues its development, a complex process that involves both the maturation of islet cells and a marked expansion of their numbers. New beta cells are formed both by duplication of ...

    • Dynamic Eye Tracking Based Metrics for Infant Gaze Patterns in the Face-Distractor Competition Paradigm 

      Ahtola, Eero; Stjerna, Susanna; Yrttiaho, Santeri; Nelson, Charles A.; Leppänen, Jukka M.; Vanhatalo, Sampsa (Public Library of Science, 2014)
      Objective: To develop new standardized eye tracking based measures and metrics for infants’ gaze dynamics in the face-distractor competition paradigm. Method Eye tracking data were collected from two samples of healthy ...

    • Dynamic GATA4 enhancers shape the chromatin landscape central to heart development and disease 

      He, Aibin; Gu, Fei; Hu, Yong; Ma, Qing; Ye, Lillian Yi; Akiyama, Jennifer A.; Visel, Axel; Pennacchio, Len A.; Pu, William T. (Springer Science and Business Media LLC, 2014-09-24)
      How stage-specific enhancer dynamics modulate gene expression patterns essential for organ development, homesostasis, and disease is not well understood. Here, we addressed this question by mapping chromatin occupancy of ...

    • Dynamic in vivo mutations within the ica operon during persistence of Staphylococcus aureus in the airways of cystic fibrosis patients 

      Schwartbeck, Bianca; Birtel, Johannes; Treffon, Janina; Langhanki, Lars; Mellmann, Alexander; Kale, Devika; Kahl, Janina; Hirschhausen, Nina; Neumann, Claudia; Lee, Jean C.; Götz, Friedrich; Rohde, Holger; Henke, Hanae; Küster, Peter; Peters, Georg; Kahl, Barbara C. (Public Library of Science, 2016)
      Cystic fibrosis (CF) is associated with chronic bacterial airway infections leading to lung insufficiency and decreased life expectancy. Staphylococcus aureus is one of the most prevalent pathogens isolated from the airways ...

    • Dynamic Macrophage "Probing" Is Required For The Efficient Capture Of Phagocytic Targets 

      Flannagan, Ronald S.; Harrison, Rene E.; Yip, Christopher M.; Jaqaman, Khuloud; Grinstein, Sergio (The Rockefeller University Press, 2010)
      Binding of ligands by immunoreceptors is thought to be a passive, stochastic process. Contrary to this notion, we found that binding of IgG-opsonized particles by Fcγ receptors was inhibited in macrophages, dendritic and ...

    • Dynamic Magnetic Fields Remote-Control Apoptosis via Nanoparticle Rotation 

      Zhang, Enming; Kircher, Moritz F.; Koch, Martin; Eliasson, Lena; Goldberg, S. Nahum; Renström, Erik (American Chemical Society, 2014)
      The ability to control the movement of nanoparticles remotely and with high precision would have far-reaching implications in many areas of nanotechnology. We have designed a unique dynamic magnetic field (DMF) generator ...