Browsing HMS Scholarly Articles by Title
Now showing items 4888-4907 of 17922
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Early Detection and Prediction of Cardiotoxicity in Chemotherapy-Treated Patients
(Elsevier BV, 2011)As breast cancer survival increases, cardiotoxicity associated with chemotherapeutic regimens such as anthracyclines and trastuzumab becomes a more significant issue. Assessment of the left ventricular (LV) ejection fraction ... -
Early detection of cryptic memory and glucose uptake deficits in pre-pathological APP mice
(Nature Publishing Group, 2016)Earlier diagnosis and treatment of Alzheimer's disease would greatly benefit from the identification of biomarkers at the prodromal stage. Using a prominent animal model of aspects of the disease, we here show using ... -
Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
(MyJove Corporation, 2016)The kidney normally functions to maintain hemodynamic homeostasis and is a major site of damage caused by drug toxicity. Drug-induced nephrotoxicity is estimated to contribute to 19- 25% of all clinical cases of acute ... -
Early Detection of Erlotinib Treatment Response in NSCLC by 3′-Deoxy-3′-[\(^{18}F\)]-Fluoro-L-Thymidine ([\(^{18}F\)]FLT) Positron Emission Tomography (PET)
(Public Library of Science, 2008)Background: Inhibition of the epidermal growth factor receptor (EGFR) has shown clinical success in patients with advanced non-small cell lung cancer (NSCLC). Somatic mutations of EGFR were found in lung adenocarcinoma ... -
Early Detection of Poor Adherers to Statins: Applying Individualized Surveillance to Pay for Performance
(Public Library of Science, 2013)Background: Medication nonadherence costs $300 billion annually in the US. Medicare Advantage plans have a financial incentive to increase medication adherence among members because the Centers for Medicare and Medicaid ... -
Early Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia
(Elsevier, 2016)Summary Patients with an HNF1BS148L/+ mutation (MODY5) typically exhibit pancreatic hypoplasia. However, the molecular mechanisms are unknown due to inaccessibility of patient material and because mouse models do not fully ... -
Early Diagnosis of Peripheral Nervous System Involvement in Fabry Disease and Treatment of Neuropathic Pain: The Report of an Expert Panel
(BioMed Central, 2011)Background: Fabry disease is an inherited metabolic disorder characterized by progressive lysosomal accumulation of lipids in a variety of cell types, including neural cells. Small, unmyelinated nerve fibers are particularly ... -
Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE
(BioMed Central, 2016)Prior to 2001 there was no standard for early management of severe sepsis and septic shock in the emergency department. In the presence of standard or usual care, the prevailing mortality was over 40-50 %. In response, a ... -
Early hematopoietic lineage restrictions directed by Ikaros
(Nature Publishing Group, 2006)Ikaros is expressed in early hematopoietic progenitors and is required for lymphoid differentiation. In the absence of Ikaros, there is a lack of markers defining fate restriction along lympho-myeloid pathways, but it is ... -
Early hyperactivity and precocious maturation of corticostriatal circuits in Shank3B−/− mice
(2016)Some autistic individuals exhibit abnormal development of the caudate nucleus and associative cortical areas, suggesting potential dysfunction of cortico-basal ganglia (BG) circuits. Using optogenetic and electrophysiological ... -
Early Increases in Multiple Biomarkers Predict Subsequent Cardiotoxicity in Patients With Breast Cancer Treated With Doxorubicin, Taxanes, and Trastuzumab
(Elsevier BV, 2014)Objectives: The aim of this study was to determine if individual or multiple biomarkers are associated with cardiotoxicity in patients with breast cancer undergoing cancer therapy. Background: Current methods to identify ... -
An early indicator of drug success: Top Journal Selectivity Index
(Dove Medical Press, 2013)The Top Journal Selectivity Index (TJSI) is a scientometric index reflecting the potential importance of a new drug. It represents the ratio of the number of all types of articles on a particular drug in the top 20 journals ... -
Early inflammatory mediator gene expression in two models of traumatic brain injury: ex vivo cortical slice in mice and in vivo cortical impact in piglets
(BioMed Central, 2015)Background: The immunological response during the first 24 hours after traumatic brain injury (TBI) may be a critical therapeutic interval for limiting the secondary neuronal damage that is influenced by enhanced inflammatory ... -
Early Interactions of Murine Macrophages with Francisella tularensis Map to Mouse Chromosome 19
(American Society of Microbiology, 2016)ABSTRACT Differences among individuals in susceptibility to infectious diseases can be modulated by host genetics. Much of the research in this field has aimed to identify loci within the host genome that are associated ... -
Early life environment and natural history of inflammatory bowel diseases
(BioMed Central, 2014)Background: Early life exposures may modify risk of inflammatory bowel diseases (IBD; Crohn’s disease (CD), ulcerative colitis (UC)). However, the relationship between early life exposures and natural history of IBD has ... -
Early life-course socioeconomic position, adult work-related factors and oral health disparities: cross-sectional analysis of the J-SHINE study
(BMJ Publishing Group, 2014)Objectives: We examined the association between socioeconomic position (SEP) and oral health, and the associations of economic difficulties in childhood and workplace-related factors on these parameters. Design: Cross-sectional ... -
Early maternal depressive symptoms and child growth trajectories: a longitudinal analysis of a nationally representative US birth cohort
(BioMed Central, 2014)Background: Maternal depressive symptoms are negatively associated with early child growth in developing countries; however, few studies have examined this relation in developed countries or used a longitudinal design with ... -
Early Maternal Withdrawal and Nonverbal Childhood IQ as Precursors for Substance Use Disorder in Young Adulthood: Results of a 20-Year Prospective Study
(Springer Nature, 2012)The relation between early mother–infant interaction and later socio-emotional development has been well established. The present study addresses the more recent interest in the impact of maternal caregiving on cognitive ... -
An early modern human from Romania with a recent Neanderthal ancestor
(2015)Neanderthals are thought to have disappeared in Europe ~39,000–41,000 years ago but they have contributed one to three percent of the DNA of present-day people in Eurasia1. Here, we analyze DNA from a 37,000–42,000-year-old2 ...