Browsing HMS Scholarly Articles by Title
Now showing items 5023-5042 of 17922
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Effect of Inhibition of Angiotensin-Converting Enzyme and/or Neutral Endopeptidase on Neuropathy in High-Fat-Fed C57Bl/6J Mice
(Hindawi Publishing Corporation, 2012)We have demonstrated that treating diet-induced obese (DIO) mice with the vasopeptidase inhibitor ilepatril improved neural function. Vasopeptidase inhibitors block angiotensin-converting enzyme (ACE) and neutral endopeptidase ... -
Effect of Insulin Resistance on Monounsaturated Fatty Acid Levels: A Multi-cohort Non-targeted Metabolomics and Mendelian Randomization Study
(Public Library of Science, 2016)Insulin resistance (IR) and impaired insulin secretion contribute to type 2 diabetes and cardiovascular disease. Both are associated with changes in the circulating metabolome, but causal directions have been difficult to ... -
The effect of intramuscular interferon beta-1a on spinal cord volume in relapsing-remitting multiple sclerosis
(BioMed Central, 2016)Background: Spinal cord atrophy occurs early in multiple sclerosis (MS) and impacts disability. The therapeutic effect of interferon beta-1a (IFNβ-1a) on spinal cord atrophy in patients with relapsing-remitting (RR) MS has ... -
The effect of intrapartum antibiotics on early-onset neonatal sepsis in Dhaka, Bangladesh: a propensity score matched analysis
(BioMed Central, 2014)Background: We estimate the effect of antibiotics given in the intrapartum period on early-onset neonatal sepsis in Dhaka, Bangladesh using propensity score techniques. Methods: We followed 600 mother-newborn pairs as part ... -
Effect of Late Gadolinium Enhancement on the Recovery of Left Ventricular Systolic Function After Pulmonary Vein Isolation
(John Wiley and Sons Inc., 2016)Background: The factors that predict recovery of left ventricular (LV) systolic dysfunction among patients with atrial fibrillation (AF) are not completely understood. Late gadolinium enhancement (LGE) of the LV has been ... -
Effect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin gene
(BioMed Central, 2015)Background: Nemaline myopathy (NM), the most common non-dystrophic congenital myopathy, is characterized by generalized skeletal muscle weakness, often from birth. To date, no therapy exists that enhances the contractile ... -
Effect of Lipid Head Groups on Double-Layered Two-Dimensional Crystals Formed by Aquaporin-0
(Public Library of Science, 2015)Aquaporin-0 (AQP0) is a lens-specific water channel that also forms membrane junctions. Reconstitution of AQP0 with dimyristoyl phosphatidylcholine (DMPC) and E. coli polar lipids (EPL) yielded well-ordered, double-layered ... -
Effect of Lipid Raft Disruption on Ethanol Inhibition of L1 Adhesion
(BlackWell Publishing Ltd, 2014)Background: Alcohol causes fetal alcohol spectrum disorders in part by disrupting the function of the neural cell adhesion molecule L1. Alcohol inhibits L1-mediated cell–cell adhesion in diverse cell types and inhibits ... -
Effect of Local Medical Opinion Leaders on Quality of Care for Acute Myocardial Infarction
(American Medical Association (AMA), 1998)Context.— The effectiveness of recruiting local medical opinion leaders to improve quality of care is poorly understood. Objective.— To evaluate a guideline-implementation intervention of clinician education by local ... -
Effect of Low Refocusing Angle in T1-Weighted Spin Echo and Fast Spin Echo MRI on Low-Contrast Detectability: A Comparative Phantom Study at 1.5 and 3 Tesla
(Hindawi Publishing Corporation, 2013)MRI tissue contrast is not well preserved at high field. In this work, we used a phantom with known, intrinsic contrast (3.6%) for model tissue pairs to test the effects of low angle refocusing pulses and magnetization ... -
Effect of Low-Fat vs. Other Diet Interventions on Long-Term Weight Change in Adults: A Systematic Review and Meta-Analysis
(2015)Background: The effectiveness of low-fat diets for long-term weight loss has been debated for decades, with dozens of randomized trials (RCTs) and recent reviews giving mixed results. Methods: We conducted a random effects ... -
Effect of lung compliance and endotracheal tube leakage on measurement of tidal volume
(BioMed Central, 2004)Introduction: The objective of this laboratory study was to measure the effect of decreased lung compliance and endotracheal tube (ETT) leakage on measured exhaled tidal volume at the airway and at the ventilator, in a ... -
The effect of Massachusetts health reform on 30 day hospital readmissions: retrospective analysis of hospital episode statistics
(BMJ Publishing Group Ltd., 2014)Objectives: To analyse changes in overall readmission rates and disparities in such rates, among patients aged 18-64 (those most likely to have been affected by reform), using all payer inpatient discharge databases (hospital ... -
Effect of Massachusetts healthcare reform on racial and ethnic disparities in admissions to hospital for ambulatory care sensitive conditions: retrospective analysis of hospital episode statistics
(BMJ Publishing Group Ltd., 2015)Objectives: To examine the impact of Massachusetts healthcare reform on changes in rates of admission to hospital for ambulatory care sensitive conditions (ACSCs), which are potentially preventable with good access to ... -
Effect of Menopausal Status on Carotid Intima-Media Thickness and Presence of Carotid Plaque in Chinese Women Generation Population
(Nature Publishing Group, 2015)Menopause is an important physiological stage in women's life. The potential association of menopause with carotid intima-media thickness as well as with occurrence and stability of carotid plaque in Chinese female population ... -
Effect of Mineralocorticoid Receptor Blockade on Hippocampal-Dependent Memory in Obese Adults
(2015)Objective: The hippocampus is crucial for paired-associate learning. Obesity is associated with increased MR activity in peripheral and possibly central tissues, decreased hippocampal size in humans and impaired hippocampal ... -
Effect of monthly vitamin D3 supplementation in healthy adults on adverse effects of earthquakes: randomised controlled trial
(BMJ Publishing Group Ltd., 2014)Objective: To determine whether supplementation with vitamin D improves resilience to the adverse effects of earthquakes. Design: Opportunistic addition to an established randomised double blind placebo controlled trial. ... -
The effect of musical expertise on the representation of space
(Frontiers Media S.A., 2014)Consistent evidence suggests that pitch height may be represented in a spatial format, having both a vertical and a horizontal representation. The spatial representation of pitch height results into response compatibility ... -
Effect of Natalizumab Treatment on Circulating Plasmacytoid Dendritic Cells: A Cross-Sectional Observational Study in Patients with Multiple Sclerosis
(Public Library of Science, 2014)Objectives: Dendritic cells (DCs) serve a critical role both in promoting and inhibiting adaptive immunity. The goal of this study was to investigate the effect of natalizumab (NTZ) treatment on DC numbers, phenotype, and ... -
Effect of negative pressure wound therapy on wound healing
(Elsevier BV, 2014)