Browsing HMS Scholarly Articles by Title
Now showing items 5053-5072 of 17918
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Effect of Phage on the Infectivity of Vibrio cholerae and Emergence of Genetic Variants
(American Society for Microbiology, 2008)Seasonal epidemics of cholera in Bangladesh are self-limited in nature, presumably due to phage predation of the causative Vibrio cholerae during the late stage of an epidemic, when cholera patients excrete large quantities ... -
Effect of pharmacologic agents on the function of the ischemic heart
(Elsevier BV, 1973)Since isoproterenol, tachycardia induced by atrial pacing, propranolol and Hyaluronidase alter the extent and severity of cardiac damage after coronary occlusion, their effects on the function of the severely ischemic heart ... -
Effect of Phosphodiesterase Inhibition on Insulin Resistance in Obese Individuals
(Blackwell Publishing Ltd, 2014)Background: Obesity is associated with cardiometabolic disease, including insulin resistance (IR) and diabetes. Cyclic guanosine monophosphate (cGMP) signaling affects energy balance, IR, and glucose metabolism in experimental ... -
Effect of Portal Glucose Sensing on Systemic Glucose Levels in SD and ZDF Rats
(Public Library of Science, 2016)Background: The global epidemic of Type-2-Diabetes (T2D) highlights the need for novel therapeutic targets and agents. Roux-en-Y-Gastric-Bypass (RYGB) is the most effective treatment. Studies investigating the mechanisms ... -
Effect of Preterm Birth on Postnatal Apolipoprotein and Adipocytokine Profiles
(S. Karger AG, 2015)BACKGROUND: Critical metabolic changes preparing for ex utero life may occur at the fetal age of approximately 28-32 weeks, and preterm birth <28 weeks postmenstrual age (PMA) may affect these pathways. Children born <28 ... -
The effect of primary organic particles on emergency hospital admissions among the elderly in 3 US cities
(BioMed Central, 2013)Background: Fine particle (PM2.5) pollution related to combustion sources has been linked to a variety of adverse health outcomes. Although poorly understood, it is possible that organic carbon (OC) species, particularly ... -
Effect of processing time and storage on fibrinogen content of EDTA plasma assayed by radial immunodiffusion.
(American Association for Clinical Chemistry, 1992) -
Effect of Progestin-Dominant Combined Oral Contraception on Uterine Fibroid Development
(Austin Publishing Group, 2017-11-29)Background: Combined oral contraception blocks the endogenous ovarian steroid secretion that stabilizes the hormonal environment. Monophasic, progestin-dominant, contraceptives may lead to regression of estrogendependent ... -
The Effect of Race and Chronic Obstructive Pulmonary Disease on Long-Term Survival after Coronary Artery Bypass Grafting
(Frontiers Media S.A., 2013)Background: Chronic obstructive pulmonary disease (COPD) is a known predictor of decreased long-term survival after coronary artery bypass grafting (CABG). Differences in survival by race have not been examined. Methods: ... -
Effect of Rare Variants in ADRB2 on Risk of Severe Exacerbations and Symptom Control During Longacting β Agonist Treatment in a Multiethnic Asthma Population: A Genetic Study
(Elsevier BV, 2014-03)Background Severe adverse life-threatening events associated with long-acting beta agonists (LABA) use have caused the FDA to review LABA safety which has resulted in a boxed warning and a mandatory LABA safety study in ... -
Effect of Reducing Interns' Work Hours on Serious Medical Errors in Intensive Care Units
(Massachusetts Medical Society, 2004-10-28)BACKGROUND Although sleep deprivation has been shown to impair neurobehavioral performance, few studies have measured its effects on medical errors. METHODS We conducted a prospective, randomized study comparing the ... -
Effect of Roux-en-Y Gastric Bypass Surgery on Bile Acid Metabolism in Normal and Obese Diabetic Rats
(Public Library of Science, 2015)In addition to classic functions of facilitating hepatobiliary secretion and intestinal absorption of lipophilic nutrients, bile acids (BA) are also endocrine factors and regulate glucose and lipid metabolism. Recent data ... -
Effect of Ruboxistaurin on Blood–Retinal Barrier Permeability in Relation to Severity of Leakage in Diabetic Macular Edema
(Association for Research in Vision and Ophthalmology (ARVO), 2005)Purpose. The purpose of the study was to investigate the effect of orally administered ruboxistaurin (RBX, LY333531), a selective protein kinase C β inhibitor, on the permeability of the blood–retinal barrier in patients ... -
Effect of Ruboxistaurin on the Visual Acuity Decline Associated with Long-standing Diabetic Macular Edema
(Association for Research in Vision and Ophthalmology (ARVO), 2009)Purpose. To compare relationships between severity and duration of diabetic macular edema (DME) and visual acuity (VA) observed in the PKC-DRS2 with those from the Early Treatment Diabetic Retinopathy Study (ETDRS) and to ... -
The Effect of Salsalate Therapy on Endothelial Function in a Broad Range of Subjects
(Blackwell Publishing Ltd, 2014)Background: Inflammation is fundamental to the development of atherosclerosis. We examined the effect of anti‐inflammatory doses of salicylate on endothelium‐dependent vasodilation, a biomarker of cardiovascular risk, in ... -
Effect of Serotype on Pneumococcal Competition in a Mouse Colonization Model
(American Society of Microbiology, 2015)ABSTRACT Competitive interactions between Streptococcus pneumoniae strains during host colonization could influence the serotype distribution in nasopharyngeal carriage and pneumococcal disease. We evaluated the competitive ... -
Effect of Single-stranded DNA-binding Proteins on the Helicase and Primase Activities of the Bacteriophage T7 Gene 4 Protein
(American Society for Biochemistry and Molecular Biology, 2004)Gene 4 protein (gp4) of bacteriophage T7 provides two essential functions at the T7 replication fork, primase and helicase activities. Previous studies have shown that the single-stranded DNA-binding protein of T7, encoded ... -
Effect of Sleep Apnea and Continuous Positive Airway Pressure on Cardiac Structure and Recurrence of Atrial Fibrillation
(Blackwell Publishing Ltd, 2013)Background: Sleep apnea (SA) is associated with an increased risk of atrial fibrillation (AF). We sought to determine the effect of SA on cardiac structure in patients with AF, whether therapy for SA was associated with ... -
The effect of sleep deficiency on esophageal acid exposure of healthy controls and patients with gastroesophageal reflux disease
(Wiley, 2019-11-07)Background: Studies have demonstrated a bi-directional relationship between sleep deficiency and gastroesophageal reflux disease (GERD). However, there is limited data on how sleep deficiency affects esophageal acid ...