Browsing HMS Scholarly Articles by Title
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Effects of Particulate Matter on Genomic DNA Methylation Content and iNOS Promoter Methylation
(National Institute of Environmental Health Sciences, 2008)Background: Altered patterns of gene expression mediate the effects of particulate matter (PM) on human health, but mechanisms through which PM modifies gene expression are largely undetermined.Objectives We aimed at ... -
Effects of placebos without deception compared with no treatment: protocol for a systematic review and meta-analysis
(BMJ Publishing Group, 2015)Introduction: Placebos have long provided a robust control for evaluating active pharmacological preparations, but frequently demonstrate a variable therapeutic effect when delivered in double-blinded placebo-controlled ... -
Effects of Postmenopausal Estrogen Replacement on the Concentrations and Metabolism of Plasma Lipoproteins
(Massachusetts Medical Society, 1991-10-24)BACKGROUND. Postmenopausal estrogen-replacement therapy may reduce the risk of cardiovascular disease, and this beneficial effect may be mediated in part by favorable changes in plasma lipid levels. However, the effects ... -
Effects of postmenopausal hormone replacement with oral and transdermal estrogen on high density lipoprotein metabolism
(ASBMB, 1994)Estrogen treatment raises plasma high density lipoprotein (HDL) levels, which may reduce cardiovascular risk. To identify the responsible mechanisms as well as the importance of the route of administration, we treated eight ... -
Effects of Posture and Stimulus Spectral Composition on Peripheral Physiological Responses to Loud Sounds
(Public Library of Science, 2016)In the “loud-tone” procedure, a series of brief, loud, pure-tone stimuli are presented in a task-free situation. It is an established paradigm for measuring autonomic sensitization in posttraumatic stress disorder (PTSD). ... -
Effects of Protein, Monounsaturated Fat, and Carbohydrate Intake on Blood Pressure and Serum Lipids
(American Medical Association (AMA), 2005) -
Effects of Qigong on Depression: A Systemic Review
(Hindawi Publishing Corporation, 2013)Physical exercises and relaxation have been found to be beneficial for depression. However, there is little evidence on the use of Qigong, a mind-body practice integrating gentle exercise and relaxation, in the management ... -
Effects of recombinant human growth hormone (rhGH) administration on body composition and cardiovascular risk factors in obese adolescent girls
(BioMed Central, 2014)Background: Obesity is associated with a relative deficiency of growth hormone, which is predictive of greater visceral fat and markers of cardiovascular risk. The study’s purpose was to use recombinant human growth hormone ... -
Effects of Removing Gatekeeping on Specialist Utilization by Children in a Health Maintenance Organization
(American Medical Association (AMA), 2002)Background: The "gatekeeping" model of access to specialty care has been an essential managed care tool, intended to control costs of care and promote coordination between generalists and specialists. Objective: To ... -
Effects of Sensory Behavioral Tasks on Pain Threshold and Cortical Excitability
(Public Library of Science, 2013)Background/objective: Transcutaneous electrical stimulation has been proven to modulate nervous system activity, leading to changes in pain perception, via the peripheral sensory system, in a bottom up approach. We tested ... -
Effects of sex hormones on bronchial reactivity during the menstrual cycle
(BioMed Central, 2014)Background: Many asthmatic women complain of symptom exacerbations in particular periods, i.e. during pregnancy and menstrual cycles (perimenstrual asthma: PMA)". The goal of this study was to study the effect of the luteal ... -
Effects of Sleep Deprivation on Brain Bioenergetics, Sleep, and Cognitive Performance in Cocaine-Dependent Individuals
(Hindawi Publishing Corporation, 2013)In cocaine-dependent individuals, sleep is disturbed during cocaine use and abstinence, highlighting the importance of examining the behavioral and homeostatic response to acute sleep loss in these individuals. The current ... -
Effects of Sleep Patterns and Obesity on Increases in Blood Pressure in a 5-Year Period: Report from the Tucson Children's Assessment of Sleep Apnea Study
(Elsevier BV, 2012-07)Objectives To determine associations between body mass index (BMI) and sleep on blood pressure over a 5-year period from childhood to adolescence. Study design A longitudinal, community-based sample of 334 children ... -
Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study
(BioMed Central, 2013)Background: Although smoking behavior is known to affect body mass index (BMI), the potential for smoking to influence genetic associations with BMI is largely unexplored. Methods: As part of the ‘Population Architecture ... -
The effects of socioeconomic status and indices of physical environment on reduced birth weight and preterm births in Eastern Massachusetts
(BioMed Central, 2008)Background: Air pollution and social characteristics have been shown to affect indicators of health. While use of spatial methods to estimate exposure to air pollution has increased the power to detect effects, questions ... -
The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies
(Public Library of Science, 2013)Broadly neutralizing HIV antibodies (bnAbs) are typically highly somatically mutated, raising doubts as to whether they can be elicited by vaccination. We used 454 sequencing and designed a novel phylogenetic method to ... -
The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies
(Public Library of Science (PLoS), 2013-11-21)Broadly neutralizing HIV antibodies (bnAbs) are typically highly somatically mutated, raising doubts as to whether they can be elicited by vaccination. We used 454 sequencing and designed a novel phylogenetic method to ... -
Effects of Sorafenib on Intra-Tumoral Interstitial Fluid Pressure and Circulating Biomarkers in Patients with Refractory Sarcomas (NCI Protocol 6948)
(Public Library of Science, 2012)Purpose: Jain Sorafenib is a multi-targeted tyrosine kinase inhibitor with therapeutic efficacy in several malignancies. Sorafenib may exert its anti-neoplastic effect in part by altering vascular permeability and reducing ... -
The effects of spinal anaesthesia for elective caesarean section on uterine and umbilical arterial pulsatility indexes in normotensive and chronic hypertensive pregnant women: a prospective, longitudinal study
(BioMed Central, 2014)Background: Despite the known effects of neuraxial blockade on major vessel function and the rapid decrease in uterine vascular impedance, it is unclear how the blockade affects the utero-placental circulation in the ... -
The Effects of Stress and Trauma on Brain and Memory: A View from Developmental Cognitive Neuroscience
(Cambridge University Press (CUP), 1998)Many aspects of brain development depend on experience. Because the major macro-morphological events of brain development occur over the first 2–3 years of postnatal life, this time period can be considered both a period ...