Browsing HMS Scholarly Articles by Title
Now showing items 5289-5308 of 17918
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Efficacy of cilostazol on platelet reactivity and cardiovascular outcomes in patients undergoing percutaneous coronary intervention: insights from a meta-analysis of randomised trials
(BMJ Publishing Group, 2014)Background: Cilostazol overcomes high on-treatment platelet reactivity (HTPR) and reduces adverse cardiovascular (CV) outcomes after percutaneous coronary intervention (PCI). However, the role for triple antiplatelet therapy ... -
Efficacy of Epidural Injections in the Treatment of Lumbar Central Spinal Stenosis: A Systematic Review
(Kowsar, 2015)Context: Lumbar central spinal stenosis is common and often results in chronic persistent pain and disability, which can lead to multiple interventions. After the failure of conservative treatment, either surgical or ... -
Efficacy of Esketamine Augmentation in Major Depressive Disorder: A Meta-Analysis
(Physicians Postgraduate Press, Inc, 2020-05-26)Objective: Esketamine, the s-enantiomer of ketamine, was recently approved as a rapid-acting intranasal therapy for depression and is currently under development for suicidality. The authors sought to determine the efficacy ... -
Efficacy of Infection Control Interventions in Reducing the Spread of Multidrug-Resistant Organisms in the Hospital Setting
(Public Library of Science, 2012)Multidrug-resistant organisms (MDRO) continue to spread in hospitals globally, but the population-level impact of recommended preventive strategies and the relative benefit of individual strategies targeting all MDRO in ... -
Efficacy of Metreleptin in Obese Patients With Type 2 Diabetes: Cellular and Molecular Pathways Underlying Leptin Tolerance
(American Diabetes Association, 2011)Objective: Metreleptin has been efficacious in improving metabolic control in patients with lipodystrophy, but its efficacy has not been tested in obese patients with type 2 diabetes. Research Design and Methods: We studied ... -
The Efficacy of Paroxetine and Placebo in Treating Anxiety and Depression: A Meta-Analysis of Change on the Hamilton Rating Scales
(Public Library of Science, 2014)Background: Previous meta-analyses of published and unpublished trials indicate that antidepressants provide modest benefits compared to placebo in the treatment of depression; some have argued that these benefits are not ... -
Efficacy of Sunitinib and Radiotherapy in Genetically Engineered Mouse Model of Soft-tissue Sarcoma
(Elsevier, 2009)Purpose: Sunitinib (SU) is a multitargeted receptor tyrosine kinase inhibitor of the vascular endothelial growth factor and platelet-derived growth factor receptors. The present study examined SU and radiotherapy (RT) in ... -
The efficacy of the Cook-Swartz implantable Doppler in the detection of free-flap compromise: a systematic review protocol
(BMJ, 2014)Introduction The Cook-Swartz implantable Doppler monitors venous or arterial blood flow from free flaps and can detect free-flap compromise. Previous studies have shown that the use of this Doppler can improve detection ... -
Efficacy of Topical Blockade of Interleukin-1 in Experimental Dry Eye Disease
(Elsevier BV, 2012)PURPOSE To evaluate the therapeutic efficacy of topical IL-1Ra in the treatment of Dry Eye Disease (DED). DESIGN Laboratory Investigation. METHODS DED was induced in C57BL/6 female mice through exposure to a ... -
Efficacy of WHO recommendation for continued breastfeeding and maternal cART for prevention of perinatal and postnatal HIV transmission in Zambia
(International AIDS Society, 2015)Introduction: To prevent mother-to-child transmission (MTCT) of HIV in developing countries, new World Health Organization (WHO) guidelines recommend maternal combination antiretroviral therapy (cART) during pregnancy, ... -
Efficacy, Safety, and Biomarkers of Neoadjuvant Bevacizumab, Radiation Therapy, and Fluorouracil in Rectal Cancer: A Multidisciplinary Phase II Study
(American Society of Clinical Oncology (ASCO), 2009)PURPOSE: To assess the safety and efficacy of neoadjuvant bevacizumab with standard chemoradiotherapy in locally advanced rectal cancer and explore biomarkers for response. PATIENTS AND METHODS: In a phase I/II study, 32 ... -
Efficacy, Safety, and Tolerability of Pregabalin Treatment for Painful Diabetic Peripheral Neuropathy
(American Diabetes Association, 2008)OBJECTIVE—To evaluate the efficacy, safety, and tolerability of pregabalin across the effective dosing range, to determine differences in the efficacy of three times daily (TID) versus twice daily (BID) dosage schedules, ... -
Efficiency and Cost of Primary Care by Nurses and Physician Assistants
(Massachusetts Medical Society, 1978-02-09)We conducted a prospective study in a prepaid primary-care practice (health-maintenance organization) of a system in which nurses and physician assistants used protocols, and compared the efficiency and costs of this ... -
Efficiency and Power as a Function of Sequence Coverage, SNP Array Density, and Imputation
(Public Library of Science, 2012)High coverage whole genome sequencing provides near complete information about genetic variation. However, other technologies can be more efficient in some settings by (a) reducing redundant coverage within samples and (b) ... -
Efficiency of CD19 chimeric antigen receptor-modified T cells for treatment of B cell malignancies in phase I clinical trials: a meta-analysis
(Impact Journals LLC, 2015)Chimeric antigen receptor (CAR) modified T cells targeted CD19 showed promising clinical outcomes in treatment of B cell malignances such as chronic lymphocytic leukemia (CLL), acute lymphoblastic leukemia (ALL) and other ... -
Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling
(2013)Despite substantial efforts to understand the interactions between nanoparticles and cells, the cellular processes that determine the efficiency of intracellular drug delivery remain largely unclear. Here we examined ... -
Efficient 18F-Labeling of Synthetic Exendin-4 Analogues for Imaging Beta Cells
(Wiley Open Access, 2012) -
Efficient Ablation of Genes in Human Hematopoietic Stem and Effector Cells using CRISPR/Cas9
(Elsevier BV, 2014)Genome editing via CRISPR/Cas9 has rapidly become the tool of choice by virtue of its efficacy and ease of use. However, CRISPR/Cas9-mediated genome editing in clinically relevant human somatic cells remains untested. Here, ... -
Efficient and specific gene knockdown by small interfering RNAs produced in bacteria
(2013)Synthetic small interfering RNAs (siRNAs) are an indispensable tool to investigate gene function in eukaryotic cells1,2 and may be used for therapeutic purposes to knockdown genes implicated in disease3. Thus far, most ...