Browsing HMS Scholarly Articles by Title
Now showing items 534-553 of 17922
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An AICD-based functional screen to identify APP metabolism regulators
(BioMed Central, 2007)Background: A central event in Alzheimer's disease (AD) is the regulated intramembraneous proteolysis of the β-amyloid precursor protein (APP), to generate the β-amyloid (Aβ) peptide and the APP intracellular domain (AICD). ... -
AIDA and UCP1 Snuggle Up to Prevent Hypothermia
(Springer Science and Business Media LLC, 2021-03-09)In response to cold stress, mammals release norepinephrine from the sympathetic nervous system to elevate thermogenesis in brown adipose tissue (BAT) in order to maintain body temperature. This study reveals that the protein ... -
AIF Downregulation and Its Interaction with STK3 in Renal Cell Carcinoma
(Public Library of Science, 2014)Apoptosis-inducing factor (AIF) plays a crucial role in caspase-independent programmed cell death by triggering chromatin condensation and DNA fragmentation. Therefore, it might be involved in cell homeostasis and tumor ... -
AIG1 and ADTRP are Atypical Integral Membrane Hydrolases that Degrade Bioactive FAHFAs
(2016)Enzyme classes may contain outlier members that share mechanistic, but not sequence or structural relatedness with more common representatives. The functional annotation of such exceptional proteins can be challenging. ... -
Air conditioning and source-specific particles as modifiers of the effect of PM(10) on hospital admissions for heart and lung disease.
(National Institute of Environmental Health Sciences, 2002)Studies on acute effects of particulate matter (PM) air pollution show significant variability in exposure-effect relations among cities. Recent studies have shown an influence of ventilation on personal/indoor-outdoor ... -
Air Pollution and ST-Segment Depression in Elderly Subjects
(National Institue of Environmental Health Sciences, 2005)Increased levels of daily ambient particle pollution have been associated with increased risk of cardiovascular morbidity. Black carbon (BC) is a measure of the traffic-related component of particles. We investigated ... -
Air pollution attributable postneonatal infant mortality in U.S. metropolitan areas: a risk assessment study
(BioMed Central, 2004)Background: The impact of outdoor air pollution on infant mortality has not been quantified. Methods: Based on exposure-response functions from a U.S. cohort study, we assessed the attributable risk of postneonatal infant ... -
Air Pollution Exposure and Abnormal Glucose Tolerance during Pregnancy: The Project Viva Cohort
(National Institute of Environmental Health Sciences, 2014)Background: Exposure to fine particulate matter (PM with diameter ≤ 2.5 μm; PM2.5) has been linked to type 2 diabetes mellitus, but associations with hyperglycemia in pregnancy have not been well studied. Methods: We studied ... -
Air pollution exposure and gestational diabetes mellitus among pregnant women in Massachusetts: a cohort study
(BioMed Central, 2016)Background: Rodent and human studies suggest an association between air pollution exposure and type 2 diabetes mellitus, but the extent to which air pollution is associated with gestational diabetes mellitus (GDM) is less ... -
Air pollution exposure and lung function in highly exposed subjects in Beijing, China: a repeated-measure study
(BioMed Central, 2014)Background: Exposure to ambient particulate matter (PM) has been associated with reduced lung function. Elemental components of PM have been suggested to have critical roles in PM toxicity, but their contribution to ... -
Air Pollution Exposures During Adulthood and Risk of Endometriosis in the Nurses’ Health Study II
(National Institute of Environmental Health Sciences, 2013)Background: Particulate matter and proximity to large roadways may promote disease mechanisms, including systemic inflammation, hormonal alteration, and vascular proliferation, that may contribute to the development and ... -
Air Pollution, Smoking, and Plasma Homocysteine
(National Institute of Environmental Health Sciences, 2006)Background: Mild hyperhomocysteinemia is independently associated with an increased risk of cardiovascular disease. Air pollution exposure induces short-term inflammatory changes that may determine hyperhomocysteinemia, ... -
Air Travel and the Spread of Influenza: Authors' Reply
(Public Library of Science, 2006) -
Air-Stimulated ATP Release from Keratinocytes Occurs through Connexin Hemichannels
(Public Library of Science, 2013)Cutaneous ATP release plays an important role in both epidermal stratification and chronic pain, but little is known about ATP release mechanisms in keratinocytes that comprise the epidermis. In this study, we analyzed ATP ... -
Airborne Particulate Matter and Mitochondrial Damage: A Cross-Sectional Study
(BioMed Central, 2010)Background: Oxidative stress generation is a primary mechanism mediating the effects of Particulate Matter (PM) on human health. Although mitochondria are both the major intracellular source and target of oxidative stress, ... -
Aire controls gene expression in the thymic epithelium with ordered stochasticity
(2015)Aire controls immunologic tolerance by inducing the ectopic thymic expression of many tissue-specific genes, acting broadly by removing stops on the transcriptional machinery. To better understand Aire’s specificity, we ... -
Airplane pilot mental health and suicidal thoughts: a cross-sectional descriptive study via anonymous web-based survey
(BioMed Central, 2016)Background: The Germanwings Flight 9525 crash has brought the sensitive subject of airline pilot mental health to the forefront in aviation. Globally, 350 million people suffer from depression–a common mental disorder. ... -
Airway \(CD8^+\) T Cells Induced by Pulmonary DNA Immunization Mediate Protective Anti-Viral Immunity
(Nature Publishing Group, 2013)Vaccination strategies for protection against a number of respiratory pathogens must induce T-cell populations in both the pulmonary airways and peripheral lymphoid organs. In this study, we show that pulmonary immunization ... -
Airway and Parenchymal Strains during Bronchoconstriction in the Precision Cut Lung Slice
(Frontiers Media S.A., 2016)The precision-cut lung slice (PCLS) is a powerful tool for studying airway reactivity, but biomechanical measurements to date have largely focused on changes in airway caliber. Here we describe an image processing tool ... -
Airway Epithelial Progenitors Are Region Specific and Show Differential Responses to Bleomycin-Induced Lung Injury
(Wiley, 2012-09)Mechanisms that regulate regional epithelial cell diversity and pathologic remodeling in airways are poorly understood. We hypothesized that regional differences in cell composition and injury-related tissue remodeling ...