Browsing HMS Scholarly Articles by Title
Now showing items 5492-5511 of 17922
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Endoscopic Ultrasound-Guided Pancreatobiliary Endoscopy in Surgically Altered Anatomy
(Korean Society of Gastrointestinal Endoscopy, 2016)Endoscopic retrograde cholangiopancreatography (ERCP) has become the mainstay of therapy for pancreatobiliary diseases. While ERCP is safe and highly effective in the general population, the procedure remains challenging ... -
Endoscopic ultrasound-guided techniques for diagnosing pancreatic mass lesions: Can we do better?
(Baishideng Publishing Group Inc, 2016)The diagnostic approach to a possible pancreatic mass lesion relies first upon various non-invasive imaging modalities, including computed tomography, ultrasound, and magnetic resonance imaging techniques. Once a suspect ... -
Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase
(2014)The PTH receptor is one of the first GPCR found to sustain cAMP signaling after internalization of the ligand–receptor complex in endosomes. This unexpected model is adding a new dimension on how we think about GPCR ... -
Endothelial cell mitogens derived from retina and hypothalamus: biochemical and biological similarities
(Rockefeller University Press, 1984)Bovine retina and hypothalamus contain anionic endothelial cell mitogens that display unusual affinities for the negatively charged glycosaminoglycan heparin. Both growth factor activities are acidic polypeptides (pl's of ... -
Endothelial Differentiation Gene-1, a New Downstream Gene Is Involved in RTEF-1 Induced Angiogenesis in Endothelial Cells
(Public Library of Science, 2014)Related Transcriptional Enhancer Factor-1 (RTEF-1) has been suggested to induce angiogenesis through regulating target genes. Whether RTEF-1 has a direct role in angiogenesis and what specific genes are involved in RTEF-1 ... -
Endothelial glycocalyx conditions influence nanoparticle uptake for passive targeting
(Dove Medical Press, 2016)Cardiovascular diseases are facilitated by endothelial cell (EC) dysfunction and coincide with EC glycocalyx coat shedding. These diseases may be prevented by delivering medications to affected vascular regions using ... -
Endothelial, platelet, and macrophage microparticle levels do not change acutely following transcatheter aortic valve replacement
(BioMed Central, 2016)Background: Patients with severe aortic stenosis have increased levels of prothrombotic and proinflammatory microparticles (MP), and MPs actively regulate pathological processes that lead to atherothrombotic cardiovascular ... -
Endothelin A Receptor Antagonist, Atrasentan, Attenuates Renal and Cardiac Dysfunction in Dahl Salt-Hypertensive Rats in a Blood Pressure Independent Manner
(Public Library of Science, 2015)Proteinuria is a hallmark of chronic kidney disease (CKD) and cardiovascular disease (CVD), and a good predictor of clinical outcome. Selective endothelin A (ETA) receptor antagonist used with renin-angiotensin system (RAS) ... -
Endothelin-1 and Endothelin Receptor mRNA Expression in Normal and Atherosclerotic Human Arteries
(Elsevier BV, 1993)Endothelin-1 (ET-1) is a potent vasoconstrictor peptide implicated in a number of human diseases including atherosclerosis. ET-1 binds to two distinct G protein-coupled receptors, known as the ETA and ETB receptor subtypes. ... -
Engaging older patients in cardiovascular research: observational analysis of the ICON-1 study
(BMJ Publishing Group, 2016)Background: As a consequence of population ageing, the number of older patients presenting with acute coronary syndrome (ACS) is increasing. The historical underrepresentation of older patients in many pivotal ACS clinical ... -
Engineered ascorbate peroxidase as a genetically-encoded reporter for electron microscopy
(2013)Electron microscopy (EM) is the standard method for imaging cellular structures with nanometer resolution, but existing genetic tags are inactive in most cellular compartments1 or require light and are difficult to use2. ... -
Engineered CRISPR-Cas9 nucleases with altered PAM specificities
(2015)Although CRISPR-Cas9 nucleases are widely used for genome editing1, 2, the range of sequences that Cas9 can recognize is constrained by the need for a specific protospacer adjacent motif (PAM)3–6. As a result, it can often ... -
An Engineered Enzyme That Targets Circulating Lactate to Alleviate Intracellular NADH:NAD+ Imbalance
(Springer Science and Business Media LLC, 2020-01-13)An elevated intracellular NADH/NAD+ ratio, or “reductive stress,” has been associated with multiple diseases, including disorders of the mitochondrial electron transport chain (ETC). As the intracellular NADH/NAD+ ratio ... -
Engineered Hyperactive Integrase for Concerted HIV-1 DNA Integration
(Public Library of Science, 2014)The DNA cutting and joining reactions of HIV-1 integration are catalyzed by integrase (IN), a viral protein that functions as a tetramer bridging the two viral DNA ends (intasome). Two major obstacles for biochemical and ... -
Engineered Microneedle Arrays for Transcutaneous HIV Vaccine Delivery
(BioMed Central, 2012) -
An engineered multicomponent bone marrow niche for the recapitulation of hematopoiesis at ectopic transplantation sites
(BioMed Central, 2016)Background: Bone marrow (BM) niches are often inaccessible for controlled experimentation due to their difficult accessibility, biological complexity, and three-dimensional (3D) geometry. Methods: Here, we report the ... -
Engineered Trehalose Permeable to Mammalian Cells
(Public Library of Science, 2015)Trehalose is a naturally occurring disaccharide which is associated with extraordinary stress-tolerance capacity in certain species of unicellular and multicellular organisms. In mammalian cells, presence of intra- and ... -
Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects
(Oxford University Press, 2012)Engineered zinc finger nucleases (ZFNs) induce DNA double-strand breaks at specific recognition sequences and can promote efficient introduction of desired insertions, deletions or substitutions at or near the cut site via ...