Browsing HMS Scholarly Articles by Title

Now showing items 5531-5550 of 17922

    • Enhanced Fidelity to Treatment for Bipolar Disorder: Results From a Randomized Controlled Implementation Trial 

      Waxmonsky, Jeanette; Kilbourne, Amy M.; Goodrich, David E.; Nord, Kristina M.; Lai, Zongshan; Laird, Christina; Clogston, Julia; Kim, Hyungjin Myra; Miller, Christopher Joseph; Bauer, Mark S (American Psychiatric Publishing, 2014)
      Background We determined whether application of a novel implementation intervention (Enhanced Replicating Effective Programs-REP) versus its standard, dissemination-focused version (REP) improved fidelity to bipolar ...

    • Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants 

      Klein, Florian; Nogueira, Lilian; Nishimura, Yoshiaki; Phad, Ganesh; West, Anthony P.; Halper-Stromberg, Ariel; Horwitz, Joshua A.; Gazumyan, Anna; Liu, Cassie; Eisenreich, Thomas R.; Lehmann, Clara; Fätkenheuer, Gerd; Williams, Constance; Shingai, Masashi; Martin, Malcolm A.; Bjorkman, Pamela J.; Seaman, Michael S.; Zolla-Pazner, Susan; Karlsson Hedestam, Gunilla B.; Nussenzweig, Michel C. (The Rockefeller University Press, 2014)
      Antibody-mediated immunotherapy is effective in humanized mice when combinations of broadly neutralizing antibodies (bNAbs) are used that target nonoverlapping sites on the human immunodeficiency virus type 1 (HIV-1) ...

    • Enhanced Identification of Postoperative Infections among Inpatients 

      Noskin, Gary A.; Cunningham, Susan M.; Plaskett, Theresa; Fraser, Victoria J.; Olsen, Margaret A.; Tokars, Jerome I.; Solomon, Steven; Perl, Trish M.; Cosgrove, Sara E.; Tilson, Richard S.; Greenbaum, Maurice; Herwaldt, Loreen A.; Diekema, Daniel J.; Climo, Michael; Yokoe, Deborah Stephanie; Zuccotti, Gianna; Hooper, David Crittenden; Sands, Kenneth Eliot Frederick; Tully, John Lawrence; Wong, Edward S.; Platt, Richard (Centers for Disease Control and Prevention, 2004)
      We evaluated antimicrobial exposure, discharge diagnoses, or both to identify surgical site infections (SSI). This retrospective cohort study in 13 hospitals involved weighted, random samples of records from 8,739 coronary ...

    • Enhanced Identification of Postoperative Infections among Outpatients 

      Miner, Andrew L.; Sands, Kenneth Eliot Frederick; Yokoe, Deborah Stephanie; Freedman, John; Thompson, Kristin; Livingston, James Michael; Platt, Richard (Centers for Disease Control and Prevention, 2004)
      We investigated using administrative claims data to identify surgical site infections (SSI) after breast surgery and cesarean section. Postoperative diagnosis codes, procedure codes, and pharmacy information were automatically ...

    • Enhanced in vivo imaging of metabolically biotinylated cell surface reporters 

      Niers, Johanna M.; Chen, John W.; Weissleder, Ralph; Tannous, Bakhos A. (American Chemical Society, 2011)
      Metabolic biotinylation of intracellular and secreted proteins as well as surface receptors in mammalian cells provides a versatile way to monitor gene expression; to purify and target viral vectors; to monitor cell and ...

    • Enhanced Macrophage Tropism of HIV in Brain and Lymphoid Tissues is Associated with Sensitivity to the Broadly Neutralizing CD4 Binding Site Antibody b12 

      Dunfee, Rebecca L; Thomas, Elaine R; Gabuzda, Dana Helga (BioMed Central, 2009)
      Macrophages in the central nervous system (CNS) and other tissues are an important cellular reservoir for human immunodeficiency virus type 1 (HIV) infection, particularly in the later stages of disease. Macrophage-tropic ...

    • Enhanced multiplex genome engineering through co-operative oligonucleotide co-selection 

      Carr, Peter A.; Wang, Harris He; Sterling, Bram; Isaacs, Farren J.; Lajoie, Marc Joseph; Xu, George Jing; Church, George McDonald; Jacobson, Joseph M. (Oxford University Press, 2012)
      Genome-scale engineering of living organisms requires precise and economical methods to efficiently modify many loci within chromosomes. One such example is the directed integration of chemically synthesized single-stranded ...

    • Enhanced Nigrostriatal Neuron-specific, Long-term Expression by Using Neural-specific Promoters in Combination with Targeted Gene Transfer by Modified Helper Virus-free HSV-1 Vector Particles 

      Cao, Haiyan; Zhang, Guo-Rong; Wang, Xiaodan; Kong, Lingxin; Geller, Alfred I. (BioMed Central, 2008)
      Background: Direct gene transfer into neurons has potential for developing gene therapy treatments for specific neurological conditions, and for elucidating neuronal physiology. Due to the complex cellular composition of ...

    • Enhanced Rb/E2F and TSC/mTOR Pathways Induce Synergistic Inhibition in PDGF-Induced Proliferation in Vascular Smooth Muscle Cells 

      Li, Yue; Li, Xuan; Liu, Jie; Guo, Wei; Zhang, Hongchao; Wang, Jianchang (Public Library of Science, 2017)
      Platelet-derived growth factor (PDGF) plays an essential role in proliferation of vascular smooth muscle cells (VSMCs). The Rb/E2F and TSC/mTOR pathways contribute to the proliferation of VSMCs, but its exact roles in ...

    • Enhanced reactivity to pain in patients with rheumatoid arthritis 

      Edwards, Robert R; Wasan, Ajay D.; Bingham, Clifton O. III; Bathon, Joan; Haythornthwaite, Jennifer A.; Smith, Michael T.; Page, Gayle G. (BioMed Central, 2009)
      Introduction: Maladaptive physiological responses to stress appear to play a role in chronic inflammatory diseases such as rheumatoid arthritis (RA). However, relatively little stress research in RA patients has involved ...

    • Enhanced Susceptibility to Infections in a Diabetic Wound Healing Model 

      Hirsch, Tobias; Spielmann, Malte; Zuhaili, Baraa; Koehler, Till; Fossum, Magdalena; Steinau, Hans-Ulrich; Yao, Feng; Steinstraesser, Lars; Onderdonk, Andrew Bruce; Eriksson, Elof (BioMed Central, 2008)
      Background: Wound infection is a common complication in diabetic patients. The progressive spread of infections and development of drug-resistant strains underline the need for further insights into bacterial behavior in ...

    • Enhanced Syllable Discrimination Thresholds in Musicians 

      Zuk, Jennifer; Ozernov-Palchik, Ola; Kim, Heesoo; Lakshminarayanan, Kala; Gabrieli, John D. E.; Tallal, Paula; Gaab, Nadine (Public Library of Science, 2013)
      Speech processing inherently relies on the perception of specific, rapidly changing spectral and temporal acoustic features. Advanced acoustic perception is also integral to musical expertise, and accordingly several studies ...

    • Enhanced TLR-MYD88 Signaling Stimulates Autoinflammation in SH3BP2 Cherubism Mice and Defines the Etiology of Cherubism 

      Yoshitaka, Teruhito; Mukai, Tomoyuki; Kittaka, Mizuho; Alford, Lisa M.; Masrani, Salome; Ishida, Shu; Yamaguchi, Ken; Yamada, Motohiko; Mizuno, Noriyoshi; Olsen, Bjorn; Reichenberger, Ernst J.; Ueki, Yasuyoshi (Elsevier BV, 2014-09-25)
      Cherubism is caused by mutations in SH3BP2. Studies of cherubism mice showed that TNF-α-dependent autoinflammation is a major cause for the disorder, but failed to explain why human cherubism lesions are restricted to jaws ...

    • Enhanced Transduction of Colonic Cell Lines In Vitro and the Inflamed Colon in Mice by Viral Vectors, Derived from Adeno-associated Virus Serotype 2, Using Virus-Microbead Conjugates Bearing Lectin 

      Farlow, Samuel J; Jerusalmi, Alan; Sano, Takeshi (BioMed Central, 2007)
      Background: Virus-mediated delivery of therapeutic transgenes to the inflamed colon holds a great potential to serve as an effective therapeutic strategy for inflammatory bowel disease, since local, long-term expression ...

    • Enhancement of anti-leukemia activity of NK cells in vitro and in vivo by inhibition of leukemia cell-induced NK cell damage 

      Arriga, Roberto; Caratelli, Sara; Coppola, Andrea; Spagnoli, Giulio Cesare; Venditti, Adriano; Amadori, Sergio; Lanzilli, Giulia; Lauro, Davide; Palomba, Patrizia; Sconocchia, Tommaso; Del Principe, Maria Ilaria; Maurillo, Luca; Buccisano, Francesco; Capuani, Barbara; Ferrone, Soldano; Sconocchia, Giuseppe (Impact Journals LLC, 2016)
      Acute myeloid leukemia (AML) cells induce, in vitro, NK cell abnormalities (NKCAs) including apoptosis and activating receptor down-regulation. The potential negative impact of AML cells on the therapeutic efficacy of NK ...

    • Enhancement of CURB65 Score with Proadrenomedullin (CURB65-A) for Outcome Prediction in Lower Respiratory Tract Infections: Derivation of a Clinical Algorithm 

      Albrich, Werner C; Dusemund, Frank; Christ-Crain, Mirjam; Zimmerli, Werner; Bregenzer, Thomas; Irani, Sarosh; Buergi, Ulrich; Mueller, Beat; Ruegger, Kristina; Reutlinger, Barbara; Schuetz, Philipp (BioMed Central, 2011)
      Background: Proadrenomedullin (ProADM) confers additional prognostic information to established clinical risk scores in lower respiratory tract infections (LRTI). We aimed to derive a practical algorithm combining the ...

    • Enhancement of E. coli acyl-CoA synthetase FadD activity on medium chain fatty acids 

      Ford, Tyler J.; Way, Jeffrey C. (PeerJ Inc., 2015)
      FadD catalyses the first step in E. coli beta-oxidation, the activation of free fatty acids into acyl-CoA thioesters. This activation makes fatty acids competent for catabolism and reduction into derivatives like alcohols ...

    • Enhancement of Naringenin Bioavailability by Complexation with Hydroxypropoyl-β-Cyclodextrin 

      Shulman, Maria; Cohen, Merav; Soto-Gutierrez, Alejandro; Yagi, Hiroshi; Wang, Hongyun; Goldwasser, Jonathan; Lee-Parsons, Carolyn W.; Benny-Ratsaby, Ofra; Yarmush, Martin Leon; Nahmias, Yaakov (Public Library of Science, 2011)
      The abundant flavonoid aglycone, naringenin, which is responsible for the bitter taste in grapefruits, has been shown to possess hypolipidemic and anti-inflammatory effects both in vitro and in vivo. Recently, our group ...

    • Enhancement of Notch Receptor Maturation and Signaling Sensitivity by Cripto-1 

      Watanabe, Kazuhide; Nagaoka, Tadahiro; Bianco, Caterina; Gonzales, Monica; Castro, Nadia P.; Rangel, Maria Cristina; Sakamoto, Kei; Callahan, Robert; Salomon, David S.; Lee, Joseph M.; Sun, Youping (The Rockefeller University Press, 2009)
      Nodal and Notch signaling pathways play essential roles in vertebrate development. Through a yeast two-hybrid screening, we identified Notch3 as a candidate binding partner of the Nodal coreceptor Cripto-1. Coimmunoprecipitation ...

    • Enhancement of SMN protein levels in a mouse model of spinal muscular atrophy using novel drug-like compounds 

      Cherry, Jonathan J; Osman, Erkan Y; Evans, Matthew C; Choi, Sungwoon; Xing, Xuechao; Cuny, Gregory D; Glicksman, Marcie A; Lorson, Christian L; Androphy, Elliot J (Blackwell Publishing Ltd, 2013)
      Spinal muscular atrophy (SMA) is a neurodegenerative disease that causes progressive muscle weakness, which primarily targets proximal muscles. About 95% of SMA cases are caused by the loss of both copies of the SMN1 gene. ...