Browsing HMS Scholarly Articles by Title

Now showing items 5607-5626 of 17922

    • The Epidemiology of Major Depressive Episode in the Iraqi General Population 

      Al-Hamzawi, Ali Obaid; Bruffaerts, Ronny; Bromet, Evelyn J.; AlKhafaji, Abdulzahra Mohammed; Kessler, Ronald C. (Public Library of Science, 2015)
      Objective: To assess the prevalence, symptom severity, functional impairment, and treatment of major depressive episode (MDE) in the Iraqi general population. Methods: The Iraq Mental Health Survey is a nationally ...

    • Epidemiology of musculoskeletal upper extremity ambulatory surgery in the United States 

      Jain, Nitin B; Higgins, Laurence D; Losina, Elena; Collins, Jamie; Blazar, Philip E; Katz, Jeffrey N (BioMed Central, 2014)
      Background: Musculoskeletal disorders of the upper extremity are common reasons for patients to seek care and undergo ambulatory surgery. The objective of our study was to assess the overall and age-adjusted utilization ...

    • Epidemiology, Risk Factors, and Outcomes of Out-of-Hospital Cardiac Arrest Caused by Stroke: A Population-Based Study 

      Fukuda, Tatsuma; Ohashi-Fukuda, Naoko; Kondo, Yutaka; Sera, Toshiki; Doi, Kent; Yahagi, Naoki (Wolters Kluwer Health, 2016)
      Abstract Limited information is available regarding stroke-related out-of-hospital cardiac arrest (OHCA). We aimed to assess the clinical characteristics of stroke-related OHCA and to identify the factors associated with ...

    • Epidermal Growth Factor Gene Functional Polymorphism and the Risk of Hepatocellular Carcinoma in Patients With Cirrhosis 

      Tanabe, Kenneth Kenji; Lemoine, Antoinette; Finkelstein, Dianne Madelyn; Kawasaki, Hiroshi; Fujii, Tsutomu; Chung, Raymond Taeyong; Lauwers, Gregory Y.; Kulu, Yakup; Muzikansky, Alona; Kuruppu, Darshini; Lanuti, Michael; Goodwin, Jonathan M.; Azoulay, Daniel; Fuchs, Bryan C. (American Medical Association (AMA), 2008)
      Context: Overexpression of epidermal growth factor (EGF) in the liver induces transformation to hepatocellular carcinoma in animal models. Polymorphisms in the EGF gene modulate EGF levels. Objective: To assess the ...

    • Epidermal Growth Factor Receptor Activation in Glioblastoma through Novel Missense Mutations in the Extracellular Domain 

      Vivanco, Igor; Feng, Whei L; Yoshimoto, Koji; King, Jennifer C; Nghiemphu, Phioanh; Yuza, Yuki; Xu, Qing; Thomas, Roman K; Peck, Timothy C; Linhart, David J; Glatt, Karen A; Getz, Gad; Onofrio, Robert; Ziaugra, Liuda; Levine, Ross L; Gabriel, Stacey; Kawaguchi, Tomohiro; O'Neill, Keith; Khan, Haumith; Liau, Linda M; Nelson, Stanley F; Rao, P. Nagesh; Mischel, Paul; Pieper, Russell O; Cloughesy, Tim; Leahy, Daniel J; Sellers, William R; Sawyers, Charles L; Mellinghoff, Ingo K; Lee, Jeffrey C.; Beroukhim, Rameen; Huang, Julie; DeBiasi, Ralph Michael; Greulich, Heidi E.; Paez, J. Guillermo; Meyerson, Matthew Langer (Public Library of Science, 2006)
      Background: Protein tyrosine kinases are important regulators of cellular homeostasis with tightly controlled catalytic activity. Mutations in kinase-encoding genes can relieve the autoinhibitory constraints on kinase ...

    • Epidermal growth factor receptor and Ink4a/Arf: Convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis 

      Bachoo, Robert M.; Maher, Elizabeth A.; Ligon, Keith L.; Sharpless, Norman E.; Chan, Suzanne S.; You, Mingjian James; Tang, Yi; DeFrances, Jessica; Stover, Elizabeth; Weissleder, Ralph; Rowitch, David H.; Louis, David N.; DePinho, Ronald A. (Elsevier (Cell Press), 2002)

    • Epidermal Growth Factor Receptor Gene Amplification in Atypical Adenomatous Hyperplasia of the Lung 

      McIntire, Maria G.; Santagata, Sandro; Ligon, Keith; Chirieac, Lucian (e-Century Publishing, 2010-05-16)
      Atypical adenomatous hyperplasia (AAH) is postulated to be the earliest morphologic precursor lesion in lung carcinogenesis. The epidermal growth factor receptor (EGFR), one of the members of the Erb-2 family of receptors, ...

    • Epidural Needle with Embedded Optical Fibers for Spectroscopic Differentiation of Tissue: Ex Vivo Feasibility Study 

      Desjardins, Adrien E.; Hendriks, Benno H.W.; van der Voort, Marjolein; Bierhoff, Walter; Braun, Guus; Babic, Drazenko; Holmin, Staffan; Rathmell, James Phillip; Nachabé, Rami; Söderman, Michael; Holmström, Björn (Optical Society of America, 2011)
      Epidural injection is commonly used to provide intraoperative anesthesia, postoperative and obstetric analgesia, and to treat acute radicular pain. Identification of the epidural space is typically carried out using the ...

    • EpiFire: An Open Source C++ Library and Application for Contact Network Epidemiology 

      Hladish, Thomas; Melamud, Eugene; Barrera, Luis Alberto; Galvani, Alison; Meyers, Lauren Ancel (BioMed Central, 2012)
      Background: Contact network models have become increasingly common in epidemiology, but we lack a flexible programming framework for the generation and analysis of epidemiological contact networks and for the simulation ...

    • Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer 

      Shen, Hui; Fridley, Brooke L.; Song, Honglin; Lawrenson, Kate; Cunningham, Julie M.; Ramus, Susan J.; Cicek, Mine S.; Tyrer, Jonathan; Stram, Douglas; Larson, Melissa C.; Köbel, Martin; Ziogas, Argyrios; Zheng, Wei; Yang, Hannah P.; Wu, Anna H.; Wozniak, Eva L.; Ling Woo, Yin; Winterhoff, Boris; Wik, Elisabeth; Whittemore, Alice S.; Wentzensen, Nicolas; Palmieri Weber, Rachel; Vitonis, Allison F.; Vincent, Daniel; Vierkant, Robert A.; Vergote, Ignace; Van Den Berg, David; Van Altena, Anne M.; Tworoger, Shelley Slate; Thompson, Pamela J.; Tessier, Daniel C.; Terry, Kathryn Lynne; Teo, Soo-Hwang; Templeman, Claire; Stram, Daniel O.; Southey, Melissa C.; Sieh, Weiva; Siddiqui, Nadeem; Shvetsov, Yurii B.; Shu, Xiao-Ou; Shridhar, Viji; Wang-Gohrke, Shan; Severi, Gianluca; Schwaab, Ira; Salvesen, Helga B.; Rzepecka, Iwona K.; Runnebaum, Ingo B.; Anne Rossing, Mary; Rodriguez-Rodriguez, Lorna; Risch, Harvey A.; Renner, Stefan P.; Poole, Elizabeth M.; Pike, Malcolm C.; Phelan, Catherine M.; Pelttari, Liisa M.; Pejovic, Tanja; Paul, James; Orlow, Irene; Zawiah Omar, Siti; Olson, Sara H.; Odunsi, Kunle; Nickels, Stefan; Nevanlinna, Heli; Ness, Roberta B.; Narod, Steven A.; Nakanishi, Toru; Moysich, Kirsten B.; Monteiro, Alvaro N.A.; Moes-Sosnowska, Joanna; Modugno, Francesmary; Menon, Usha; McLaughlin, John R.; McGuire, Valerie; Matsuo, Keitaro; Mat Adenan, Noor Azmi; Massuger, Leon F.A.G; Lurie, Galina; Lundvall, Lene; Lubiński, Jan; Lissowska, Jolanta; Levine, Douglas A.; Leminen, Arto; Lee, Alice W.; Le, Nhu D.; Lambrechts, Sandrina; Lambrechts, Diether; Kupryjanczyk, Jolanta; Krakstad, Camilla; Konecny, Gottfried E.; Krüger Kjaer, Susanne; Kiemeney, Lambertus A.; Kelemen, Linda E.; Keeney, Gary L.; Karlan, Beth Y.; Karevan, Rod; Kalli, Kimberly R.; Kajiyama, Hiroaki; Ji, Bu-Tian; Jensen, Allan; Jakubowska, Anna; Iversen, Edwin; Hosono, Satoyo; Høgdall, Claus K.; Høgdall, Estrid; Hoatlin, Maureen; Hillemanns, Peter; Heitz, Florian; Hein, Rebecca; Harter, Philipp; Halle, Mari K.; Hall, Per; Gronwald, Jacek; Gore, Martin; Goodman, Marc T.; Giles, Graham G.; Gentry-Maharaj, Aleksandra; Garcia-Closas, Montserrat; Flanagan, James M.; Fasching, Peter A.; Ekici, Arif B.; Edwards, Robert; Eccles, Diana; Easton, Douglas F.; Dürst, Matthias; du Bois, Andreas; Dörk, Thilo; Doherty, Jennifer A.; Despierre, Evelyn; Dansonka-Mieszkowska, Agnieszka; Cybulski, Cezary; Cramer, Daniel William; Cook, Linda S.; Chen, Xiaoqing; Charbonneau, Bridget; Chang-Claude, Jenny; Campbell, Ian; Butzow, Ralf; Bunker, Clareann H.; Brueggmann, Doerthe; Brown, Robert; Brooks-Wilson, Angela; Brinton, Louise A.; Bogdanova, Natalia; Block, Matthew S.; Benjamin, Elizabeth; Beesley, Jonathan; Beckmann, Matthias W.; Bandera, Elisa V.; Baglietto, Laura; Bacot, François; Armasu, Sebastian M.; Antonenkova, Natalia; Anton-Culver, Hoda; Aben, Katja K.; Liang, Dong; Wu, Xifeng; Lu, Karen; Hildebrandt, Michelle A.T.; Schildkraut, Joellen M.; Sellers, Thomas A.; Huntsman, David; Berchuck, Andrew; Chenevix-Trench, Georgia; Gayther, Simon A.; Pharoah, Paul D.P.; Laird, Peter W.; Goode, Ellen L.; Leigh Pearce, Celeste (Nature Publishing Group, 2013)
      HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing in serous epithelial ovarian cancer, leading us to hypothesize that variation in this gene differentially associates with ...

    • An Epigenetic Blockade of Cognitive Functions in the Neurodegenerating Brain 

      Gräff, Johannes; Rei, Damien; Guan, Ji-Song; Wang, Wen-Yuan; Seo, Jinsoo; Fass, Daniel M.; Kao, Patricia F.; Kahn, Martin; Su, Susan C.; Joseph, Nadine; Delalle, Ivana; Tsai, Li-Huei; Hennig, Krista M.; Nieland, Thomas; Samiei, Alireza; Haggarty, Stephen John (Nature Publishing Group, 2012)
      Cognitive decline is a debilitating feature of most neurodegenerative diseases of the central nervous system, including Alzheimer’s disease. The causes leading to such impairment are only poorly understood and effective ...

    • An epigenetic clock for gestational age at birth based on blood methylation data 

      Knight, Anna K.; Craig, Jeffrey M.; Theda, Christiane; Bækvad-Hansen, Marie; Bybjerg-Grauholm, Jonas; Hansen, Christine S.; Hollegaard, Mads V.; Hougaard, David M.; Mortensen, Preben B.; Weinsheimer, Shantel M.; Werge, Thomas M.; Brennan, Patricia A.; Cubells, Joseph F.; Newport, D. Jeffrey; Stowe, Zachary N.; Cheong, Jeanie L. Y.; Dalach, Philippa; Doyle, Lex W.; Loke, Yuk J.; Baccarelli, Andrea A.; Just, Allan C.; Wright, Robert O.; Téllez-Rojo, Mara M.; Svensson, Katherine; Trevisi, Letizia; Kennedy, Elizabeth M.; Binder, Elisabeth B.; Iurato, Stella; Czamara, Darina; Räikkönen, Katri; Lahti, Jari M. T.; Pesonen, Anu-Katriina; Kajantie, Eero; Villa, Pia M.; Laivuori, Hannele; Hämäläinen, Esa; Park, Hea Jin; Bailey, Lynn B.; Parets, Sasha E.; Kilaru, Varun; Menon, Ramkumar; Horvath, Steve; Bush, Nicole R.; LeWinn, Kaja Z.; Tylavsky, Frances A.; Conneely, Karen N.; Smith, Alicia K. (BioMed Central, 2016)
      Background: Gestational age is often used as a proxy for developmental maturity by clinicians and researchers alike. DNA methylation has previously been shown to be associated with age and has been used to accurately ...

    • Epigenetic Encoding, Heritability and Plasticity of Glioma Transcriptional Cell States 

      Chaligne, Ronan; Gaiti, Federico; Silverbush, Dana; Schiffman, Joshua S.; Weisman, Hannah R.; Kluegel, Lloyd; Gritsch, Simon; Deochand, Sunil D.; Gonzalez Castro, L. Nicolas; Richman, Alyssa R.; Klughammer, Johanna; Biancalani, Tommaso; Muus, Christoph; Sheridan, Caroline; Alonso, Alicia; Izzo, Franco; Park, Jane; Rozenblatt-Rosen, Orit; Regev, Aviv; Suvà, Mario L.; Landau, Dan A. (Springer Science and Business Media LLC, 2021-09-30)
      Single cell RNA-sequencing revealed extensive transcriptional cell state diversity in cancer, often observed independently from genetic heterogeneity, raising the central question of how malignant cell states are encoded ...

    • Epigenetic evolution and lineage histories of chronic lymphocytic leukaemia 

      Gaiti, Federico; Chaligne, Ronan; Brand, Ryan M.; Kothen-Hill, Steven; Schulman, Rafael C.; Grigorev, Kirill; Risso, Davide; Kim, Kyu-Tae; Pastore, Alessandro; Huang, Kevin Y.; Alonso, Alicia; Sheridan, Caroline; Omans, Nathaniel D.; Biederstedt, Evan; Clement, Kendell; Wang, Lili; Felsenfeld, Joshua A.; Bhavsar, Erica B.; Allan, John N.; Furman, Richard; Meissner, Alexander; Landau, Dan A.; Gu, Hongcang; Aryee, Martin; Gnirke, Andreas; Wu, Catherine (Springer Science and Business Media LLC, 2019-05-15)

    • Epigenetic Hierarchy Governing Nestin Expression 

      Han, Dong Wook; Do, Jeong Tae; Arauzo-Bravo, Marcos J.; Lee, Sung Ho; Meissner, Alexander; Lee, Hoon Taek; Jaenisch, Rudolf; Scholer, Hans R. (Wiley-Blackwell, 2009)
      Nestin is an intermediate filament protein expressed specifically in neural stem cells and progenitor cells of the central nervous system. DNA demethylation and histone modifications are two types of epigenetic modifications ...

    • Epigenetic Influences on Associations between Air Pollutants and Lung Function in Elderly Men: The Normative Aging Study 

      Lepeule, Johanna; Bind, Marie-Abele Catherine; Baccarelli, Andrea A.; Koutrakis, Petros; Tarantini, Letizia; Litonjua, Augusto; Sparrow, David; Vokonas, Pantel; Schwartz, Joel D. (NLM-Export, 2014)
      Background: Few studies have been performed on pulmonary effects of air pollution in the elderly—a vulnerable population with low reserve capacity—and mechanisms and susceptibility factors for potential effects are unclear. ...

    • Epigenetic Inheritance of a Cocaine Resistance Phenotype 

      Vassoler, Fair M.; White, Samantha L.; Schmidt, Heath D.; Sadri-Vakili, Ghazaleh; Pierce, R. Christopher (2012)
      A heritable phenotype resulting from the self-administration of cocaine in rats was delineated. We observed delayed acquisition and reduced maintenance of cocaine self-administration in male, but not female, offspring of ...

    • Epigenetic Landscapes Explain Partially Reprogrammed Cells and Identify Key Reprogramming Genes 

      Lang, Alex H.; Li, Hu; Collins, James J.; Mehta, Pankaj (Public Library of Science, 2014)
      A common metaphor for describing development is a rugged “epigenetic landscape” where cell fates are represented as attracting valleys resulting from a complex regulatory network. Here, we introduce a framework for explicitly ...

    • Epigenetic memory in induced pluripotent stem cells 

      Kim, K.; Doi, A.; Wen, B.; Ng, K.; Zhao, R.; Cahan, P.; Kim, J.; Aryee, M. J.; Ji, H.; Ehrlich, L.; Yabuuchi, A.; Takeuchi, A.; Cunniff, K. C.; Hongguang, H.; Mckinney-Freeman, S.; Naveiras, O.; Yoon, T. J.; Irizarry, R. A.; Jung, N.; Seita, J.; Hanna, J.; Murakami, P.; Jaenisch, R.; Weissleder, R.; Orkin, S. H.; Weissman, I. L.; Feinberg, A. P.; Daley, G. Q. (Nature Research (part of Springer Nature), 2010)
      Somatic cell nuclear transfer and transcription-factor-based reprogramming revert adult cells to an embryonic state, and yield pluripotent stem cells that can generate all tissues. Through different mechanisms and kinetics, ...

    • Epigenetic modifications: basic mechanisms and role in cardiovascular disease (2013 Grover Conference series) 

      Loscalzo, Joseph; Handy, Diane E. (University of Chicago Press, 2014)
      Abstract Epigenetics refers to heritable traits that are not a consequence of DNA sequence. Three classes of epigenetic regulation exist: DNA methylation, histone modification, and noncoding RNA action. In the cardiovascular ...