Browsing HMS Scholarly Articles by Title
Now showing items 5649-5668 of 17918
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Epitope-Based Vaccines: SARS – A Model
(BioMed Central, 2006) -
Epoxyeicosanoids Promote Organ and Tissue Regeneration
(National Academy of Sciences, 2013-07-29)Epoxyeicosatrienoic acids (EETs), lipid mediators produced by cytochrome P450 epoxygenases, regulate inflammation, angiogenesis, and vascular tone. Despite pleiotropic effects on cells, the role of these epoxyeicosanoids ... -
Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice
(American Society for Clinical Investigation, 2012)Epoxyeicosatrienoic acids (EETs) are small molecules produced by cytochrome P450 epoxygenases. They are lipid mediators that act as autocrine or paracrine factors to regulate inflammation and vascular tone. As a result, ... -
Epoxyeicosatrienoic Acids Enhance Embryonic Haematopoiesis and Adult Marrow Engraftment
(2015)Haematopoietic stem and progenitor cell (HSPC) transplant is a widely used treatment for life-threatening conditions including leukemia; however, the molecular mechanisms regulating HSPC engraftment of the recipient niche ... -
Epstein-Barr Virus (EBV) SM Protein Induces and Recruits Cellular Sp110b to Stabilize mRNAs and Enhance EBV Lytic Gene Expression
(American Society for Microbiology, 2004)Promyelocytic leukemia protein (PML) nuclear bodies or nuclear domain 10s (ND10s) are multiprotein nuclear structures implicated in transcriptional and posttranscriptional gene regulation that are disrupted during replication ... -
An Epstein-Barr Virus Encoded Inhibitor of Colony Stimulating Factor-1 Signaling Is an Important Determinant for Acute and Persistent EBV Infection
(Public Library of Science, 2012)Acute Epstein-Barr virus (EBV) infection is the most common cause of Infectious Mononucleosis. Nearly all adult humans harbor life-long, persistent EBV infection which can lead to development of cancers including Hodgkin ... -
Epstein–Barr Virus and Rheumatoid Arthritis: Is There a Link?
(BioMed Central, 2006)Rheumatoid arthritis is a systemic autoimmune disease characterized by chronic, destructive, debilitating arthritis. Its etiology is unknown; it is presumed that environmental factors trigger development in the genetically ... -
Epstein–Barr Virus Infection of Mammary Epithelial Cells Promotes Malignant Transformation☆
(Elsevier, 2016)Whether the human tumor virus, Epstein–Barr Virus (EBV), promotes breast cancer remains controversial and a potential mechanism has remained elusive. Here we show that EBV can infect primary mammary epithelial cells (MECs) ... -
Epstein–Barr virus latent genes
(Nature Publishing Group, 2015)Latent Epstein–Barr virus (EBV) infection has a substantial role in causing many human disorders. The persistence of these viral genomes in all malignant cells, yet with the expression of limited latent genes, is consistent ... -
Epstein–Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKKα-dependent noncanonical NF-κB activation
(National Academy of Sciences, 2004)Epstein-Barr virus (EBV) latent infection membrane protein 1 (LMP1)-induced NF-kappaB activation is important for infected cell survival. LMP1 activates NF-kappaB, in part, by engaging tumor necrosis factor (TNF) ... -
Epstein–Barr Virus MicroRNAs Are Evolutionarily Conserved and Differentially Expressed
(Public Library of Science, 2006)The pathogenic lymphocryptovirus Epstein–Barr virus (EBV) is shown to express at least 17 distinct microRNAs (miRNAs) in latently infected cells. These are arranged in two clusters: 14 miRNAs are located in the introns of ... -
Epstein–Barr virus super-enhancer eRNAs are essential for MYC oncogene expression and lymphoblast proliferation
(National Academy of Sciences, 2016)Epstein-Barr virus (EBV) super-enhancers (ESEs) are essential for lymphoblastoid cell (LCL) growth and survival. Reanalyses of LCL global run-on sequencing (Gro-seq) data found abundant enhancer RNAs (eRNAs) being transcribed ... -
ER stress and unfolded protein response in amyotrophic lateral sclerosis—a controversial role of protein disulphide isomerase
(Frontiers Media S.A., 2014)Accumulation of proteins in aberrant conformation occurs in many neurodegenerative diseases. Furthermore, dysfunctions in protein handling in endoplasmic reticulum (ER) and the following ER stress have been implicated in ... -
ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells
(The Rockefeller University Press, 2013)Unresolved endoplasmic reticulum (ER) stress in the epithelium can provoke intestinal inflammation. Hypomorphic variants of ER stress response mediators, such as X-box–binding protein 1 (XBP1), confer genetic risk for ... -
Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals
(National Academy of Sciences, 2012)During Mycobacterium tuberculosis infection, a population of bacteria likely becomes refractory to antibiotic killing in the absence of genotypic resistance, making treatment challenging. We describe an in vitro model ... -
Eradication of Multidrug-Resistant Pseudomonas Biofilm With Pulsed Electric Fields
(Wiley, 2015-09-09)Biofilm formation is a significant problem, accounting for over eighty percent of microbial infections in the body. Biofilm eradication is problematic due to increased resistance to antibiotics and antimicrobials as compared ... -
ErbB2, EphrinB1, Src Kinase and PTPN13 Signaling Complex Regulates MAP Kinase Signaling in Human Cancers
(Public Library of Science, 2012)In non-cancerous cells, phosphorylated proteins exist transiently, becoming de-phosphorylated by specific phosphatases that terminate propagation of signaling pathways. In cancers, compromised phosphatase activity and/or ... -
Erectile Dysfunction in Heme-Deficient Nitric Oxide–Unresponsive Soluble Guanylate Cyclase Knock-In Mice
(Elsevier BV, 2017)Introduction: The nitric oxide (NO), soluble guanylate cyclase (sGC), and cyclic guanosine monophosphate (cGMP) pathway is the leading pathway in penile erection. Aim: To assess erectile function in a mouse model in which ... -
ERG is Required for the Differentiation of Embryonic Stem Cells along the Endothelial Lineage
(BioMed Central, 2009)Background: The molecular mechanisms that govern stem cell differentiation along the endothelial lineage remain largely unknown. Ets related gene (ERG) has recently been shown to participate in the transcriptional regulation ...