Browsing HMS Scholarly Articles by Title
Now showing items 5926-5945 of 17922
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Exacerbation of signs and symptoms of allergic conjunctivitis by a controlled adverse environment challenge in subjects with a history of dry eye and ocular allergy
(Dove Medical Press, 2013)Background: The goal of this study was to assess the effect of a controlled adverse environment (CAE) challenge on subjects with both allergic conjunctivitis and dry eye. Methods: Thirty-three subjects were screened and ... -
Examining Product Risk in Context. Market Withdrawal of Zomepirac as a Case Study
(American Medical Association (AMA), 1993)Objective. —To examine changes in the prescribing of analgesics after the market entry and subsequent withdrawal of zomepirac sodium, a nonsteroidal anti-inflammatory drug (NSAID), following repeated reports of zomepirac-related ... -
Examining the Interface Between Substance Misuse and Intimate Partner Violence
(Libertas Academica, 2009)There is considerable theoretical and empirical support for a link between substance misuse and perpetration and victimization of intimate partner violence. This review briefly summarizes this literature and highlights ... -
Excellent clinical outcomes and retention in care for adults with HIV-associated Kaposi sarcoma treated with systemic chemotherapy and integrated antiretroviral therapy in rural Malawi
(International AIDS Society, 2015)Introduction: HIV-associated Kaposi sarcoma (HIV-KS) is the most common cancer in Malawi. In 2008, the non-governmental organization, Partners In Health, and the Ministry of Health established the Neno Kaposi Sarcoma Clinic ... -
Exceptional Molecular and Coreceptor-requirement Properties of Molecular Clones Isolated from an Human Immunodeficiency Virus Type-1 Subtype C Infection
(BioMed Central, 2008)Background: The pathogenic significance of coreceptor switch in the viral infection of HIV-1 is not completely understood. This situation is more complex in subtype C infection where coreceptor switch is either absent or ... -
Excess cancer incidence among workers exposed to fluoride
(Nordic Association of Occupational Safety and Health, 1993) -
Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans
(Public Library of Science, 2006)Background: Acute respiratory distress syndrome (ARDS) is a devastating complication of numerous underlying conditions, most notably sepsis. Although pathologic vascular leak has been implicated in the pathogenesis of ARDS ... -
Excess cost of non-remission among outpatients with major depressive disorder
(BioMed Central, 2014)Background: The purpose of this study was to assess the economic benefit of achieving remission among outpatients with major depressive disorder (MDD) who are currently employed in Korea. Methods: Cross-sectional observational ... -
Excess HB-EGF, which promotes VEGF signaling, leads to hydrocephalus
(Nature Publishing Group, 2016)Heparin binding epidermal growth factor-like growth factor (HB-EGF) is an angiogenic factor mediating radial migration of the developing forebrain, while vascular endothelial growth factor (VEGF) is known to influence ... -
Excess of Deleterious Mutations around HLA Genes Reveals Evolutionary Cost of Balancing Selection
(Oxford University Press, 2016)Deleterious mutations are expected to evolve under negative selection and are usually purged from the population. However, deleterious alleles segregate in the human population and some disease-associated variants are ... -
Excessive activation of ionotropic glutamate receptors induces apoptotic hair-cell death independent of afferent and efferent innervation
(Nature Publishing Group, 2017)Accumulation of excess glutamate plays a central role in eliciting the pathological events that follow intensely loud noise exposures and ischemia-reperfusion injury. Glutamate excitotoxicity has been characterized in ... -
Excessive diagnostic testing in acute kidney injury
(BioMed Central, 2016)Background: The patterns, performance characteristics, and yield of diagnostic tests ordered for the evaluation of acute kidney injury (AKI) have not been rigorously evaluated. Methods: We characterized the frequency of ... -
Excessive Extracellular Volume Reveals a Neurodegenerative Pattern in Schizophrenia Onset
(Society for Neuroscience, 2012)Diffusion MRI has been successful in identifying the existence of white matter abnormalities in schizophrenia in vivo. However, the role of these abnormalities in the etiology of schizophrenia is not well understood. ... -
Exchange of DNA polymerases at the replication fork of bacteriophage T7
(National Academy of Sciences, 2007)T7 gene 5 DNA polymerase (gp5) and its processivity factor, Escherichia coli thioredoxin, together with the T7 gene 4 DNA helicase, catalyze strand displacement synthesis on duplex DNA processively (> 17,000 nucleotides ... -
Excitatory Neurotransmitters in Brain Regions in Interictal Migraine Patients
(BioMed Central, 2009)Objective: To examine biochemical differences in the anterior cingulate cortex (ACC) and insula during the interictal phase of migraine patients. We hypothesized that there may be differences in levels of excitatory amino ... -
Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress
(eLife Sciences Publications, Ltd, 2016)The cJun NH2-terminal kinase (JNK) signaling pathway is implicated in the response to metabolic stress. Indeed, it is established that the ubiquitously expressed JNK1 and JNK2 isoforms regulate energy expenditure and insulin ... -
Exclusion of Elderly People from Randomized Clinical Trials of Drugs for Ischemic Heart Disease
(Wiley-Blackwell, 2017)Objectives To measure exclusion of elderly adults from randomized trials studying drug interventions for ischemic heart disease (IHD) and describe the characteristics of these trials. Design Cross-sectional ... -
Exclusion of Polymorphisms in Carnosinase Genes (CNDP1 and CNDP2) as a Cause of Diabetic Nephropathy in Type 1 Diabetes
(American Diabetes Association, 2008)Objectives: Recently, an association was found between diabetic nephropathy and the D18S880 microsatellite, located in the carnosinase gene (CNDP1) on chromosome 18q. Alleles of this microsatellite encode for a variable ... -
Exclusive Breastfeeding and Developmental and Behavioral Status in Early Childhood
(MDPI, 2013)Breastfeeding during infancy may have beneficial effects on various developmental outcomes in childhood. In this study, exclusively breastfed infants were randomly assigned to receive complementary foods from the age of 4 ... -
Executive Function and Falls in Older Adults: New Findings from a Five-Year Prospective Study Link Fall Risk to Cognition
(Public Library of Science, 2012)Background: Recent findings suggest that executive function (EF) plays a critical role in the regulation of gait in older adults, especially under complex and challenging conditions, and that EF deficits may, therefore, ...