Browsing HMS Scholarly Articles by Title
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Expectation versus Reality: The Impact of Utility on Emotional Outcomes after Returning Individualized Genetic Research Results in Pediatric Rare Disease Research, a Qualitative Interview Study
(Public Library of Science, 2016)Purpose Much information on parental perspectives on the return of individual research results (IRR) in pediatric genomic research is based on hypothetical rather than actual IRR. Our aim was to understand how the expected ... -
Expedited mapping of the ligandable proteome using fully functionalized enantiomeric probe pairs
(Springer Science and Business Media LLC, 2019-10-28)A fundamental challenge in chemical biology and medicine is to understand and expand the fraction of the human proteome that can be targeted by small molecules. We recently described a strategy that integrates fragment-based ... -
Experience and Lessons From Health Impact Assessment for Human Rights Impact Assessment
(Springer Science and Business Media LLC, 2015-09-16)As globalisation has opened remote parts of the world to foreign investment, global leaders at the United Nations and beyond have called on multinational companies to foresee and mitigate negative impacts on the communities ... -
Experience of Pleasure and Emotional Expression in Individuals with Schizotypal Personality Features
(Public Library of Science, 2012)Difficulties in feeling pleasure and expressing emotions are one of the key features of schizophrenia spectrum conditions, and are significant contributors to constricted interpersonal interactions. The current study ... -
Experience Playing a Musical Instrument and Overnight Sleep Enhance Performance on a Sequential Typing Task
(Public Library of Science, 2016)The smooth, coordinated fine motor movements required to play a musical instrument are not only highly valued in our society; they also predict academic success in areas that generalize beyond the motor domain, including ... -
Experience with targeted next generation sequencing for the care of lung cancer: Insights into promises and limitations of genomic oncology in day-to-day practice
(Elsevier BV, 2015)Introduction Tumor genotyping using single gene assays (SGAs) is standard practice in advanced non-small-cell lung cancer (NSCLC). We evaluated how the introduction of next generation sequencing (NGS) into day-to-day ... -
Experiences and Attitudes of Genome Investigators Regarding Return of Individual Genetic Test Results
(2014)Purpose Whether and how to return individual genetic results to study participants is among the most contentious policy issues in contemporary genomic research. Methods: We surveyed corresponding authors of genome-wide ... -
Experiences applying for and understanding health insurance under Massachusetts health care reform
(BioMed Central, 2016)Background: The Affordable Care Act was modeled on the Massachusetts Health Reform of 2006, which reduced the number of uninsured largely through a Medicaid expansion and the provision of publicly subsidized insurance ... -
Experiences of health care transition voiced by young adults with type 1 diabetes: a qualitative study
(Dove Medical Press, 2014)Objective: This qualitative study aimed to explore the experience of transition from pediatric to adult diabetes care reported by posttransition emerging adults with type 1 diabetes (T1D), with a focus on preparation for ... -
Experimental Comparison of Parametric Versus Nonparametric Analyses of Data From the Cold Pressor Test
(Elsevier BV, 2015)Parametric statistical methods are common in human pain research. They require normally distributed data, but this assumption is rarely tested. The current study analyzes the appropriateness of parametric testing for ... -
Experimental discovery of sRNAs in Vibrio cholerae by direct cloning, 5S/tRNA depletion and parallel sequencing
(Oxford University Press, 2009)Direct cloning and parallel sequencing, an extremely powerful method for microRNA (miRNA) discovery, has not yet been applied to bacterial transcriptomes. Here we present sRNA-Seq, an unbiased method that allows for ... -
Experimental Glaucoma Induced by Ocular Injection of Magnetic Microspheres
(MyJove Corporation, 2015)Progress in understanding the pathophysiology, and providing novel treatments for glaucoma is dependent on good animal models of the disease. We present here a protocol for elevating intraocular pressure (IOP) in the rat, ... -
Experimental Models for Analysis of Oligodendrocyte Pathophysiology in Stroke
(BioMed Central, 2009)White matter damage is a clinically important part of stroke. However, compared to the mechanisms of neuronal injury in gray matter, white matter pathophysiology remains relatively understudied and poorly understood. This ... -
Expired Nitric Oxide after Bronchoprovocation and Repeated Spirometry in Patients with Asthma
(American Thoracic Society, 1998-03)Compared with normal individuals, subjects with asthma have elevated levels of expired nitric oxide (NO). These levels are hypothesized to reflect the degree of airway inflammation. Expired NO levels rise during the late ... -
An explainable deep-learning algorithm for the detection of acute intracranial haemorrhage from small datasets
(Springer Science and Business Media LLC, 2018-12-17)Owing to improvements in image recognition via deep learning, machine-learning algorithms could eventually be applied to automated medical diagnoses that can guide clinical decision-making. However, these algorithms remain ... -
Explaining Adherence Success in Sub-Saharan Africa: An Ethnographic Study
(Public Library of Science, 2009)Background: Individuals living with HIV/AIDS in sub-Saharan Africa generally take more than 90% of prescribed doses of antiretroviral therapy (ART). This number exceeds the levels of adherence observed in North America and ... -
Explaining geographic patterns of suicide in the US: the role of firearms and antidepressants
(Springer International Publishing, 2014)Background: Suicide rates vary more than 3-fold across the fifty states. Previous ecological studies have pointed, separately, to covariation of suicide mortality with rates of a) household firearm ownership, and b) ... -
Explaining Suicide in an Urban Slum of Mumbai, India
(Hogrefe & Huber, 2009)Background: Health demographic mortality studies use verbal autopsies to identify suicide as a cause of death. Psychological autopsies focus almost exclusively on associated high-risk psychiatric disorders. New approaches ... -
Explaining suicide: Identifying common themes and diverse perspectives in an urban Mumbai slum
(Elsevier BV, 2012)Rates, demographics and diagnostics, which are the focus of many studies of suicide, may provide an insufficient account without adequate consideration of psychological, social and cultural contexts and motives. Furthermore, ... -
Explaining, not just predicting, drives interest in personal genomics
(BioMed Central, 2015)Background: There is a widespread assumption that risk prediction is the major driver of customer interest in personal genomic testing (PGT). However, some customers may also be motivated by finding out whether their ...