Browsing HMS Scholarly Articles by Title
Now showing items 602-621 of 17922
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Alpha-CTLA-4 mAb-associated Panenteritis: A Histologic and Immunohistochemical Analysis
(Ovid Technologies (Wolters Kluwer Health), 2008)Monoclonal antibodies (mAbs) against the cytotoxic T lymphocyte antigen-4 (CTLA-4) molecule are used as an adjuvant to experimental tumor immunization protocols in the treatment of malignant melanomas and ovarian cancers. ... -
Alpha-synuclein in cutaneous small nerve fibers
(Dove Medical Press, 2016)Despite progression in the development of pharmacological therapy, treatment of alpha synucleinopathies, such as Parkinson’s disease (PD) and some atypical parkinsonism syndromes, is still challenging. To date, our knowledge ... -
ALS-causative mutations in FUS/TLS confer gain- and loss-of-function by altered association with SMN and U1-snRNP
(2015)The RNA-binding protein FUS/TLS, mutation in which is causative of the fatal motor neuron disease ALS, is demonstrated to directly bind to the U1-snRNP and SMN complexes. ALS-causative mutations in FUS/TLS are shown to ... -
Alteration of Galectin-3 in Tears of Patients With Dry Eye Disease
(Elsevier BV, 2015)Purpose To investigate the expression, release, and proteolytic degradation of galectin-3 in patients with dry eye disease. Design Observational case series with a comparison group. Methods Tear washes and ... -
Alteration of Innate Immunity by Donor IL-6 Deficiency in a Presensitized Heart Transplant Model
(Public Library of Science, 2013)Engraftment of IL-6 deficient donor into wild-type recipient could significantly improve allograft survival through T cell lineage particularly regulatory T cells (Tregs) in non-sensitized transplant host. However, its ... -
ALTERATION OF THE EPHA2/EPHRIN-A SIGNALING AXIS IN PSORIATIC EPIDERMIS
(2012)EphA2 is a receptor tyrosine kinase (RTK) that triggers keratinocyte differentiation upon activation and subsequently down-regulation by ephrin-A1 ligand. The objective for this study was to determine if the EphA2/ephrin-A1 ... -
Alterations in brain structures underlying language function in young adults at high familial risk for schizophrenia
(Elsevier BV, 2012)Introduction—Neuroanatomical and cognitive alterations typical of schizophrenia (SZ) patients are observed to a lesser extent in their adolescent and adult first-degree relatives, likely reflecting neurodevelopmental ... -
Alterations in Brain-Derived Neurotrophic Factor in the Mouse Hippocampus Following Acute but Not Repeated Benzodiazepine Treatment
(Public Library of Science, 2013)Benzodiazepines (BZs) are safe drugs for treating anxiety, sleep, and seizure disorders, but their use also results in unwanted effects including memory impairment, abuse, and dependence. The present study aimed to reveal ... -
Alterations in Corneal Stromal Dendritic Cell Phenotype and Distribution in Inflammation
(American Medical Association (AMA), 2003)Background The normal corneal stroma is endowed with large numbers of resident dendritic cells (DCs). The purpose of this study was to examine the phenotype and distribution of these cells in inflammation. Methods ... -
Alterations in Energy/Redox Metabolism Induced by Mitochondrial and Environmental Toxins: A Specific Role for Glucose-6-Phosphate-Dehydrogenase and the Pentose Phosphate Pathway in Paraquat Toxicity
(American Chemical Society, 2014)Parkinson’s disease (PD) is a multifactorial disorder with a complex etiology including genetic risk factors, environmental exposures, and aging. While energy failure and oxidative stress have largely been associated with ... -
Alterations in gray matter volume due to unilateral hearing loss
(Nature Publishing Group, 2016)Although extensive research on neural plasticity resulting from hearing deprivation has been conducted, the direct influence of compromised audition on the auditory cortex and the potential impact of long durations of ... -
Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia
(2014)Many neurodegenerative diseases, such as frontotemporal dementia (FTD), are associated with behavioral deficits, but the anatomical and molecular bases remain poorly understood. Here we show that forebrain-specific expression ... -
Alterations of Serum Levels of BDNF-Related miRNAs in Patients with Depression
(Public Library of Science, 2013)Depression is a serious and potentially life-threatening mental disorder with unknown etiology. Emerging evidence shows that brain-derived neurotrophic factor (BDNF) and microRNAs (miRNAs) play critical roles in the etiology ... -
Alterations of the human gut microbiome in multiple sclerosis
(Nature Publishing Group, 2016)The gut microbiome plays an important role in immune function and has been implicated in several autoimmune disorders. Here we use 16S rRNA sequencing to investigate the gut microbiome in subjects with multiple sclerosis ... -
Alterations of tumor microenvironment by carbon monoxide impedes lung cancer growth
(Impact Journals LLC, 2016)We hypothesized that tumor-associated macrophages (TAMs) are controlled by the diffusible gas carbon monoxide (CO). We demonstrate that induction of apoptosis in lung tumors treated with low doses of CO is associated with ... -
Altered biochemical specificity of G-quadruplexes with mutated tetrads
(Oxford University Press, 2016)A fundamental motif in canonical nucleic acid structure is the base pair. Mutations that disrupt base pairs are typically destabilizing, but stability can often be restored by a second mutation that replaces the original ... -
Altered brain morphometry in carpal tunnel syndrome is associated with median nerve pathology☆☆☆
(Elsevier, 2013)Objective: Carpal tunnel syndrome (CTS) is a common median nerve entrapment neuropathy characterized by pain, paresthesias, diminished peripheral nerve conduction velocity (NCV) and maladaptive functional brain neuroplasticity. ... -
Altered Cholesterol Homeostasis in Aged Macrophages Linked to Neovascular Macular Degeneration
(Elsevier BV, 2013)Abnormal lipid metabolism has been linked to age-related macular degeneration (AMD); choroidal neovascularization in late AMD commonly causes blindness. Sene et al. (2013) now demonstrate that in aged macrophages decreased ... -
Altered Chromatin Occupancy of Master Regulators Underlies Evolutionary Divergence in the Transcriptional Landscape of Erythroid Differentiation
(Public Library of Science, 2014)Erythropoiesis is one of the best understood examples of cellular differentiation. Morphologically, erythroid differentiation proceeds in a nearly identical fashion between humans and mice, but recent evidence has shown ... -
Altered Chromosomal Topology Drives Oncogenic Programs in SDH-Deficient GISTs
(Springer Science and Business Media LLC, 2019-10-16)Epigenetic aberrations are widespread in cancer, yet the underlying mechanisms and causality remain poorly understood1-3. A subset of gastrointestinal stromal tumors (GISTs) lack canonical kinase mutations but instead have ...