Browsing HMS Scholarly Articles by Title

Now showing items 6289-6308 of 17922

    • The First 500 Registrations to the Research Registry®: Advancing Registration of Under-Registered Study Types 

      Agha, Riaz; Fowler, Alexander J.; Limb, Christopher; Al Omran, Yasser; Sagoo, Harkiran; Koshy, Kiron; Jafree, Daniyal J.; Anwar, Mohammed Omer; McCullogh, Peter; Orgill, Dennis Paul (Frontiers Media S.A., 2016)
      Introduction: The Declaration of Helsinki 2013 encourages the registration of all research studies involving human participants. However, emphasis has been placed on prospective clinical trials, and it is estimated that ...

    • The First International Mini-Symposium on Methionine Restriction and Lifespan 

      Ables, Gene P.; Brown-Borg, Holly M.; Buffenstein, Rochelle; Church, Christopher D.; Elshorbagy, Amany K.; Gladyshev, Vadim N.; Huang, Tsang-hai; Miller, Richard A.; Mitchell, James R.; Richie, John P.; Rogina, Blanka; Stipanuk, Martha H.; Orentreich, David S.; Orentreich, Norman (Frontiers Media S.A., 2014)
      It has been 20 years since the Orentreich Foundation for the Advancement of Science, under the leadership Dr. Norman Orentreich, first reported that low methionine (Met) ingestion by rats extends lifespan (Orentreich et ...

    • The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy 

      McKee, Ann C.; Cairns, Nigel J.; Dickson, Dennis W.; Folkerth, Rebecca D.; Dirk Keene, C.; Litvan, Irene; Perl, Daniel P.; Stein, Thor D.; Vonsattel, Jean-Paul; Stewart, William; Tripodis, Yorghos; Crary, John F.; Bieniek, Kevin F.; Dams-O’Connor, Kristen; Alvarez, Victor E.; Gordon, Wayne A. (Springer Berlin Heidelberg, 2015)
      Chronic traumatic encephalopathy (CTE) is a neurodegeneration characterized by the abnormal accumulation of hyperphosphorylated tau protein within the brain. Like many other neurodegenerative conditions, at present, CTE ...

    • First Results From the IllustrisTNG Simulations: Matter and Galaxy Clustering 

      Springel, Volker; Pakmor, Rüdiger; Pillepich, Annalisa; Weinberger, Rainer; Nelson, Dylan; Hernquist, Lars; Vogelsberger, Mark; Genel, Shy; Torrey, Paul; Marinacci, Federico; Naiman, Jill (Oxford University Press (OUP), 2017-12-22)
      Hydrodynamical simulations of galaxy formation have now reached sufficient volume to make precision predictions for clustering on cosmologically relevant scales. Here, we use our new IllustrisTNG simulations to study the ...

    • First translational ‘Think Tank’ on cerebrovascular disease, cognitive impairment and dementia 

      Barone, Frank C.; Gustafson, Deborah; Crystal, Howard A.; Moreno, Herman; Adamski, Mateusz G.; Arai, Ken; Baird, Alison E.; Balucani, Clotilde; Brickman, Adam M.; Cechetto, David; Gorelick, Philip; Biessels, Geert Jan; Kiliaan, Amanda; Launer, Lenore; Schneider, Julie; Sorond, Farzaneh A.; Whitmer, Rachel; Wright, Clinton; Zhang, Zheng Gang (BioMed Central, 2016)
      Abstract and introduction to the workshop As the human population continues to age, an increasing number of people will exhibit significant deficits in cognitive function and dementia. It is now recognized that cerebrovascular, ...

    • First-Episode of Synthetic Cannabinoid-Induced Psychosis in a Young Adult, Successfully Managed with Hospitalization and Risperidone 

      Roberto, Aaron J.; Lorenzo, Aileen; Li, Kevin J.; Young, Jonathan; Mohan, Abhishek; Pinnaka, Subhash; Lapidus, Kyle A. B. (Hindawi Publishing Corporation, 2016)
      Synthetic cannabinoids- (SCs-) induced psychosis is a growing public health concern. It leads to significant impairment, including emotional distress, difficulty communicating, and other debilitating symptoms. In this case ...

    • First-Episode Schizophrenic Psychosis Differs From First-Episode Affective Psychosis and Controls in P300 Amplitude Over Left Temporal Lobe 

      Salisbury, Dean F.; Shenton, Martha Elizabeth; Sherwood, Andrea R.; Fischer, Iris A.; Yurgelun-Todd, Deborah; Tohen, Mauricio; McCarley, Robert William (American Medical Association (AMA), 1998)
      Background: Schizophrenia is associated with central (sagittal) midline reductions of the P300 cognitive event-related potential and topographic asymmetry of P300, with reduced left temporal voltage. This P300 asymmetry ...

    • A First-Generation Multi-Functional Cytokine for Simultaneous Optical Tracking and Tumor Therapy 

      Hingtgen, Shawn; Kasmieh, Randa; Elbayly, Elizabeth; Nesterenko, Irina; Figueiredo, Jose-Luiz; Dash, Rupesh; Sarkar, Devanand; Hall, David; Kozakov, Dima; Vajda, Sandor; Fisher, Paul B.; Shah, Khalid A. (Public Library of Science, 2012)
      Creating new molecules that simultaneously enhance tumor cell killing and permit diagnostic tracking is vital to overcoming the limitations rendering current therapeutic regimens for terminal cancers ineffective. Accordingly, ...

    • First-principles simulations of ionic molecular solids: The phase transitions inK2SeO4 

      Lu, Hsiao-ming; Hardy, J. R. (American Physical Society (APS), 1990)
      We present a new approach to first-principles simulations of the statics and dynamics of ionic molecular crystals. It is shown that the new method gives very realistic simulations of the phase transitions in K2Se04 and ...

    • First-principles study of phase transitions inKNO3 

      Lu, Hsiao-ming; Hardy, J. R. (American Physical Society (APS), 1991)
      We report a first-principles simulation study of phase transitions in KNO3, using our recently developed method for treating ionic molecular solids. With the interionic potentials calculated from ab initio electron charge ...

    • First-principles study of the lattice dynamics ofK2SO4 

      Liu, D.; Lu, Hsiao-ming; Ullman, F. G.; Hardy, J. R. (American Physical Society (APS), 1991)
      Using a newly developed first-principles approach to simulations of ionic molecular crystals, we performed static relaxation, molecular-dynamics simulation, and lattice-dynamics calculations, and measurements of the Raman ...

    • First-Trimester Follistatin-Like-3 Levels in Pregnancies Complicated by Subsequent Gestational Diabetes Mellitus 

      Thadhani, Ravi Ishwar; Powe, Camille Elise; Tjoa, May Lee; Khankin, Eliyahu; Ye, Jun; Ecker, Jeffrey Lawrence; Schneyer, Alan; Karumanchi, Subbian Ananth (American Diabetes Association, 2009)
      Objective: To determine whether maternal levels of follistatin-like-3 (FSTL3), an inhibitor of activin and myostatin involved in glucose homeostasis, are altered in the first trimester of pregnancies complicated by subsequent ...

    • First-Trimester Urine Concentrations of Phthalate Metabolites and Phenols and Placenta miRNA Expression in a Cohort of U.S. Women 

      LaRocca, Jessica; Binder, Alexandra M.; McElrath, Thomas F.; Michels, Karin B. (National Institute of Environmental Health Sciences, 2015)
      Background: There is increasing concern that early-life exposure to endocrine-disrupting chemicals (EDCs) can influence the risk of disease development. Phthalates and phenols are two classes of suspected EDCs that are ...

    • Fiscal difficulties of cities, the labor market, and health care 

      Hsu, John; Newhouse, Joseph; Overhage, Lindsay Nicole; Zuvekas, Samuel (Cambridge University Press (CUP), 2018-12-19)
      We investigated labor force and health outcomes in cities experiencing fiscal difficulties to assess how those difficulties might impact their employees. We matched 23 cities with bond downgrades and 31 cities with stable ...

    • FishFace: interactive atlas of zebrafish craniofacial development at cellular resolution 

      Eames, B Frank; DeLaurier, April; Ullmann, Bonnie; Huycke, Tyler R; Nichols, James T; Dowd, John; McFadden, Marcie; Sasaki, Mark M; Kimmel, Charles B (BioMed Central, 2013)
      Background: The vertebrate craniofacial skeleton may exhibit anatomical complexity and diversity, but its genesis and evolution can be understood through careful dissection of developmental programs at cellular resolution. ...

    • The Fission Yeast COP9/signalosome Is Involved in Cullin Modification by Ubiquitin-related Ned8p 

      Zhou, Chunshui; Seibert, Volker; Geyer, Rory; Rhee, Edward; Lyapina, Svetlana; Cope, Greg; Deshaies, Raymond J; Wolf, Dieter A (BioMed Central, 2001)
      Background: The function of the fission yeast cullins Pcu1p and Pcu4p requires modification by the ubiquitin-related peptide Ned8p. A recent report by Lyapina et al. shows that the COP9/signalosome (CSN), a multifunctional ...

    • A Fit-Fat Index for Predicting Incident Diabetes in Apparently Healthy Men: A Prospective Cohort Study 

      Sloan, Robert A; Haaland, Benjamin A; Sawada, Susumu S; Lee, I-Min; Sui, Xuemei; Lee, Duck-chul; Ridouane, Yassine; Müller-Riemenschneider, Falk; Blair, Steven N (Public Library of Science, 2016)
      Background: The purpose of this study was to examine the impact of combined cardiorespiratory fitness and waist-to-height ratio in the form of a fit-fat index on incident diabetes risk. Additionally, the independent ...

    • A Fitness Index for Transplantation of Machine-Perfused Cadaveric Rat Livers 

      Tolboom, Herman; Perk, Sinem; Izamis, Maria Louisa; Uygun, Basak E.; Yarmush, Martin Leon; Uygun, Mustafa (BioMed Central, 2012)
      Background: The 110,000 patients currently on the transplant waiting list reflect the critical shortage of viable donor organs. However, a large pool of unused organs, from donors after cardiac death (DCD) that are ...

    • The Fitness Landscape of HIV-1 Gag: Advanced Modeling Approaches and Validation of Model Predictions by In Vitro Testing 

      Mann, Jaclyn K.; Barton, John P.; Ferguson, Andrew L.; Omarjee, Saleha; Walker, Bruce D.; Chakraborty, Arup; Ndung'u, Thumbi (Public Library of Science, 2014)
      Viral immune evasion by sequence variation is a major hindrance to HIV-1 vaccine design. To address this challenge, our group has developed a computational model, rooted in physics, that aims to predict the fitness landscape ...

    • Five components of the ethylene-response pathway identified in a screen for weak ethylene-insensitive mutants in Arabidopsis 

      Alonso, Jose M.; Stepanova, Anna N.; Solano, Roberto; Wisman, Ellen; Ferrari, Simone; Ausubel, Frederick M.; Ecker, Joseph R. (National Academy of Sciences, 2003)
      Five ethylene-insensitive loci (wei1-wei5) were identified by using a low-dose screen for "weak" ethylene-insensitive mutants. wei1, wei2, and wei3 seedlings showed hormone insensitivity only in roots, whereas wei4 and ...