Browsing HMS Scholarly Articles by Title

Now showing items 6784-6803 of 17922

    • Genetic contribution to postpartum haemorrhage in Swedish population: cohort study of 466 686 births 

      Oberg, Anna Sara; Hernandéz-Diaź, Sonia; Frisell, Thomas; Greene, Michael F; Almqvist, Catarina; Bateman, Brian T (BMJ Publishing Group Ltd., 2014)
      Objective: To investigate the familial clustering of postpartum haemorrhage in the Swedish population, and to quantify the relative contributions of genetic and environmental effects. Design: Register based cohort study. ...

    • Genetic contributions to changes of fiber tracts of ventral visual stream in 22q11.2 deletion syndrome 

      Kikinis, Zora; Makris, Nikos; Finn, Christine; Bouix, Sylvain; Lucia, Diandra; Coleman, Michael James; Tworog-Dube, Erica; Kikinis, Ron; Kucherlapati, Raju; Shenton, Martha Elizabeth; Kubicki, Marek R. (Springer Science + Business Media, 2013)
      Patients with 22q11.2 deletion syndrome (22q11.2DS) represent a population at high risk for developing schizophrenia, as well as learning disabilities. Deficits in visuo-spatial memory are thought to underlie some of the ...

    • Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949) 

      Davies, G; Armstrong, N; Bis, J C; Bressler, J; Chouraki, V; Giddaluru, S; Hofer, E; Ibrahim-Verbaas, C A; Kirin, M; Lahti, J; van der Lee, S J; Le Hellard, S; Liu, T; Marioni, R E; Oldmeadow, C; Postmus, I; Smith, A V; Smith, J A; Thalamuthu, A; Thomson, R; Vitart, V; Wang, J; Yu, L; Zgaga, L; Zhao, W; Boxall, R; Harris, S E; Hill, W D; Liewald, D C; Luciano, M; Adams, H; Ames, D; Amin, N; Amouyel, P; Assareh, A A; Au, R; Becker, J T; Beiser, A; Berr, C; Bertram, L; Boerwinkle, E; Buckley, B M; Campbell, H; Corley, J; De Jager, P L; Dufouil, C; Eriksson, J G; Espeseth, T; Faul, J D; Ford, I; Scotland, Generation; Gottesman, R F; Griswold, M E; Gudnason, V; Harris, T B; Heiss, G; Hofman, A; Holliday, E G; Huffman, J; Kardia, S L R; Kochan, N; Knopman, D S; Kwok, J B; Lambert, J-C; Lee, T; Li, G; Li, S-C; Loitfelder, M; Lopez, O L; Lundervold, A J; Lundqvist, A; Mather, K A; Mirza, S S; Nyberg, L; Oostra, B A; Palotie, A; Papenberg, G; Pattie, A; Petrovic, K; Polasek, O; Psaty, B M; Redmond, P; Reppermund, S; Rotter, J I; Schmidt, H; Schuur, M; Schofield, P W; Scott, R J; Steen, V M; Stott, D J; van Swieten, J C; Taylor, K D; Trollor, J; Trompet, S; Uitterlinden, A G; Weinstein, G; Widen, E; Windham, B G; Jukema, J W; Wright, A F; Wright, M J; Yang, Q; Amieva, H; Attia, J R; Bennett, D A; Brodaty, H; de Craen, A J M; Hayward, C; Ikram, M A; Lindenberger, U; Nilsson, L-G; Porteous, D J; Räikkönen, K; Reinvang, I; Rudan, I; Sachdev, P S; Schmidt, R; Schofield, P R; Srikanth, V; Starr, J M; Turner, S T; Weir, D R; Wilson, J F; van Duijn, C; Launer, L; Fitzpatrick, A L; Seshadri, S; Mosley, T H; Deary, I J (Nature Publishing Group, 2015)
      General cognitive function is substantially heritable across the human life course from adolescence to old age. We investigated the genetic contribution to variation in this important, health- and well-being-related trait ...

    • Genetic Correlates of Longevity and Selected Age-related Phenotypes: A Genome-wide Association Study in the Framingham Study 

      Lunetta, Kathryn L; D'Agostino, Ralph B; Benjamin, Emelia J; Govindaraju, Raju; Kelly-Hayes, Margaret; Massaro, Joseph M; Pencina, Michael J; Seshadri, Sudha; Murabito, Joanne M; Karasik, David; Guo, Chao-yu; Kiel, Douglas P. (BioMed Central, 2007)
      Background: Family studies and heritability estimates provide evidence for a genetic contribution to variation in the human life span. Methods: We conducted a genome wide association study (Affymetrix 100K SNP GeneChip) ...

    • A Genetic Deconstruction of Neurocognitive Traits in Schizophrenia and Bipolar Disorder 

      Fernandes, Carla P. D.; Christoforou, Andrea; Giddaluru, Sudheer; Ersland, Kari M.; Djurovic, Srdjan; Mattheisen, Manuel; Lundervold, Astri J.; Reinvang, Ivar; Nöthen, Markus M.; Rietschel, Marcella; Ophoff, Roel A.; Hofman, Albert; Uitterlinden, André G.; Werge, Thomas; Cichon, Sven; Espeseth, Thomas; Andreassen, Ole A.; Steen, Vidar M.; Le Hellard, Stephanie (Public Library of Science, 2013)
      Background: Impairments in cognitive functions are common in patients suffering from psychiatric disorders, such as schizophrenia and bipolar disorder. Cognitive traits have been proposed as useful for understanding the ...

    • Genetic Deficiency of Glycogen Synthase Kinase-3β Corrects Diabetes in Mouse Models of Insulin Resistance 

      Tanabe, Katsuya; Liu, Zhonghao; Patel, Satish; Doble, Bradley W; Cras-Méneur, Corentin; Martinez, Sara C; Welling, Cris M; Bernal-Mizrachi, Ernesto; Woodgett, James R; Permutt, M. Alan; Li, Lin; White, Morris Francis (Public Library of Science, 2008)
      Despite treatment with agents that enhance β-cell function and insulin action, reduction in β-cell mass is relentless in patients with insulin resistance and type 2 diabetes mellitus. Insulin resistance is characterized ...

    • Genetic Deletion of SEPT7 Reveals a Cell Type-Specific Role of Septins in Microtubule Destabilization for the Completion of Cytokinesis 

      Menon, Manoj B.; Sawada, Akihiro; Chaturvedi, Anuhar; Mishra, Pooja; Schuster-Gossler, Karin; Galla, Melanie; Schambach, Axel; Gossler, Achim; Förster, Reinhold; Heuser, Michael; Kotlyarov, Alexey; Kinoshita, Makoto; Gaestel, Matthias (Public Library of Science, 2014)
      Cytokinesis terminates mitosis, resulting in separation of the two sister cells. Septins, a conserved family of GTP-binding cytoskeletal proteins, are an absolute requirement for cytokinesis in budding yeast. We demonstrate ...

    • Genetic Determinant for Amino Acid Metabolites and Changes in Body Weight and Insulin Resistance in Response to Weight-Loss Diets: The Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) Trial 

      Xu, M.; Qi, Q.; Liang, J; Bray, G. A.; Hu, Frank B.; Sacks, Frank Martin; Qi, Lu (Ovid Technologies (Wolters Kluwer Health), 2013)
      BACKGROUND: Circulating branched-chain amino acids and aromatic amino acids were recently related to insulin resistance and diabetes mellitus in prospective cohorts. We tested the effects of a genetic determinant of ...

    • Genetic Determinants for Body Iron Store and Type 2 Diabetes Risk in US Men and Women 

      He, Meian; Workalemahu, Tsegaselassie; Manson, JoAnn Elisabeth; Hu, Frank B.; Qi, Lu (Public Library of Science, 2012)
      Background: High body iron store has been associated with an increased risk of type 2 diabetes (T2D); it remains unknown whether the genetic variants related to body iron status affect T2D risk. We aimed at comprehensively ...

    • Genetic Determinants of Phosphate Response in Drosophila 

      Bergwitz, Clemens; Wee, Mark J.; Sinha, Sumi; Huang, Joanne Hyunjung; DeRobertis, Charles; Mensah, Lawrence; Cohen, Jonathan Brewer; Friedman, Adam Amiel Laufer; Kulkarni, Meghana; Hu, Yanhui; Vinayagam, Arunachalam; Schnall-Levin, Michael; Berger, Bonnie; Perkins, Lizabeth A.; Mohr, Stephanie; Perrimon, Norbert (Public Library of Science, 2013)
      Phosphate is required for many important cellular processes and having too little phosphate or too much can cause disease and reduce life span in humans. However, the mechanisms underlying homeostatic control of extracellular ...

    • Genetic determinants of telomere length and risk of common cancers: a Mendelian randomization study 

      Zhang, Chenan; Doherty, Jennifer A.; Burgess, Stephen; Hung, Rayjean J.; Lindström, Sara; Kraft, Peter; Gong, Jian; Amos, Christopher I.; Sellers, Thomas A.; Monteiro, Alvaro N.A.; Chenevix-Trench, Georgia; Bickeböller, Heike; Risch, Angela; Brennan, Paul; Mckay, James D.; Houlston, Richard S.; Landi, Maria Teresa; Timofeeva, Maria N.; Wang, Yufei; Heinrich, Joachim; Kote-Jarai, Zsofia; Eeles, Rosalind A.; Muir, Ken; Wiklund, Fredrik; Grönberg, Henrik; Berndt, Sonja I.; Chanock, Stephen J.; Schumacher, Fredrick; Haiman, Christopher A.; Henderson, Brian E.; Amin Al Olama, Ali; Andrulis, Irene L.; Hopper, John L.; Chang-Claude, Jenny; John, Esther M.; Malone, Kathleen E.; Gammon, Marilie D.; Ursin, Giske; Whittemore, Alice S.; Hunter, David J.; Gruber, Stephen B.; Knight, Julia A.; Hou, Lifang; Le Marchand, Loic; Newcomb, Polly A.; Hudson, Thomas J.; Chan, Andrew T.; Li, Li; Woods, Michael O.; Ahsan, Habibul; Pierce, Brandon L. (Oxford University Press, 2015)
      Epidemiological studies have reported inconsistent associations between telomere length (TL) and risk for various cancers. These inconsistencies are likely attributable, in part, to biases that arise due to post-diagnostic ...

    • Genetic Differences between the Determinants of Lipid Profile Phenotypes in African and European Americans: The Jackson Heart Study 

      Deo, Rahul Chandrakant; Reich, David Emil; Tandon, Arti; Akylbekova, Ermeg; Patterson, Nick; Waliszewska, Alicja; Kathiresan, Sekar; Sarpong, Daniel; Taylor, Herman A., Jr.; Wilson, James G. (Public Library of Science, 2009)
      Genome-wide association analysis in populations of European descent has recently found more than a hundred genetic variants affecting risk for common disease. An open question, however, is how relevant the variants discovered ...

    • Genetic Diversity among Enterococcus faecalis 

      McBride, Shonna M.; Fischetti, Vincent A.; LeBlanc, Donald J.; Moellering, Robert Charles; Gilmore, Michael S. (Public Library of Science, 2007)
      Enterococcus faecalis, a ubiquitous member of mammalian gastrointestinal flora, is a leading cause of nosocomial infections and a growing public health concern. The enterococci responsible for these infections are often ...

    • Genetic diversity is a predictor of mortality in humans 

      Bihlmeyer, Nathan A; Brody, Jennifer A; Smith, Albert Vernon; Lunetta, Kathryn L; Nalls, Mike; Smith, Jennifer A; Tanaka, Toshiko; Davies, Gail; Yu, Lei; Mirza, Saira Saeed; Teumer, Alexander; Coresh, Josef; Pankow, James S; Franceschini, Nora; Scaria, Anish; Oshima, Junko; Psaty, Bruce M; Gudnason, Vilmundur; Eiriksdottir, Gudny; Harris, Tamara B; Li, Hanyue; Karasik, David; Kiel, Douglas P; Garcia, Melissa; Liu, Yongmei; Faul, Jessica D; Kardia, Sharon LR; Zhao, Wei; Ferrucci, Luigi; Allerhand, Michael; Liewald, David C; Redmond, Paul; Starr, John M; De Jager, Philip L; Evans, Denis A; Direk, Nese; Ikram, Mohammed Arfan; Uitterlinden, André; Homuth, Georg; Lorbeer, Roberto; Grabe, Hans J; Launer, Lenore; Murabito, Joanne M; Singleton, Andrew B; Weir, David R; Bandinelli, Stefania; Deary, Ian J; Bennett, David A; Tiemeier, Henning; Kocher, Thomas; Lumley, Thomas; Arking, Dan E (BioMed Central, 2014)
      Background: It has been well-established, both by population genetics theory and direct observation in many organisms, that increased genetic diversity provides a survival advantage. However, given the limitations of both ...

    • Genetic encoding of DNA nanostructures and their self-assembly in living bacteria 

      Elbaz, Johann; Yin, Peng; Voigt, Christopher A. (Nature Publishing Group, 2016)
      The field of DNA nanotechnology has harnessed the programmability of DNA base pairing to direct single-stranded DNAs (ssDNAs) to assemble into desired 3D structures. Here, we show the ability to express ssDNAs in Escherichia ...

    • A genetic epidemiology approach to cyber-security 

      Gil, Santiago; Kott, Alexander; Barabási, Albert-László (Nature Publishing Group, 2014)
      While much attention has been paid to the vulnerability of computer networks to node and link failure, there is limited systematic understanding of the factors that determine the likelihood that a node (computer) is ...

    • The Genetic Etiology of Tourette Syndrome: Large-Scale Collaborative Efforts on the Precipice of Discovery 

      Georgitsi, Marianthi; Willsey, A. Jeremy; Mathews, Carol A.; State, Matthew; Scharf, Jeremiah M.; Paschou, Peristera (Frontiers Media S.A., 2016)
      Gilles de la Tourette Syndrome (TS) is a childhood-onset neurodevelopmental disorder that is characterized by multiple motor and phonic tics. It has a complex etiology with multiple genes likely interacting with environmental ...

    • Genetic Evidence for a Normal-Weight “Metabolically Obese” Phenotype Linking Insulin Resistance, Hypertension, Coronary Artery Disease, and Type 2 Diabetes 

      Yaghootkar, Hanieh; Scott, Robert A.; White, Charles C.; Zhang, Weihua; Speliotes, Elizabeth; Munroe, Patricia B.; Ehret, Georg B.; Bis, Joshua C.; Fox, Caroline S.; Walker, Mark; Borecki, Ingrid B.; Knowles, Joshua W.; Yerges-Armstrong, Laura; Ohlsson, Claes; Perry, John R.B.; Chambers, John C.; Kooner, Jaspal S.; Franceschini, Nora; Langenberg, Claudia; Hivert, Marie-France; Dastani, Zari; Richards, J. Brent; Semple, Robert K.; Frayling, Timothy M. (American Diabetes Association, 2014)
      The mechanisms that predispose to hypertension, coronary artery disease (CAD), and type 2 diabetes (T2D) in individuals of normal weight are poorly understood. In contrast, in monogenic primary lipodystrophy—a reduction ...

    • Genetic evidence for two founding populations of the Americas 

      Skoglund, Pontus; Mallick, Swapan; Bortolini, Maria Cátira; Chennagiri, Niru; Hünemeier, Tábita; Petzl-Erler, Maria Luiza; Salzano, Francisco Mauro; Patterson, Nick; Reich, David (2015)
      Genetic studies have been consistent with a single common origin of Native American groups from Central and South America1-4. However, some morphological studies have suggested a more complex picture, whereby the northeast ...

    • Genetic evidence of serum phosphate-independent functions of FGF-23 on bone 

      Sitara, Despina; Kim, Somi; Razzaque, Mohammed Shawkat; Bergwitz, Clemens; Taguchi, Takashi; Schüler, Christiane; Erben, Reinhold G.; Lanske, Beate Klara Maria (Public Library of Science, 2008)
      Maintenance of physiologic phosphate balance is of crucial biological importance, as it is fundamental to cellular function, energy metabolism, and skeletal mineralization. Fibroblast growth factor-23 (FGF-23) is a master ...