Browsing HMS Scholarly Articles by Title

Now showing items 6871-6890 of 17922

    • Genetic variants in CETP increase risk of intracerebral hemorrhage 

      Anderson, Christopher D.; Falcone, Guido J.; Phuah, Chia‐Ling; Radmanesh, Farid; Brouwers, H. Bart; Battey, Thomas W. K.; Biffi, Alessandro; Peloso, Gina M.; Liu, Dajiang J.; Ayres, Alison M.; Goldstein, Joshua N.; Viswanathan, Anand; Greenberg, Steven M.; Selim, Magdy; Meschia, James F.; Brown, Devin L.; Worrall, Bradford B.; Silliman, Scott L.; Tirschwell, David L.; Flaherty, Matthew L.; Kraft, Peter; Jagiella, Jeremiasz M.; Schmidt, Helena; Hansen, Björn M.; Jimenez‐Conde, Jordi; Giralt‐Steinhauer, Eva; Elosua, Roberto; Cuadrado‐Godia, Elisa; Soriano, Carolina; van Nieuwenhuizen, Koen M.; Klijn, Catharina J. M.; Rannikmae, Kristiina; Samarasekera, Neshika; Salman, Rustam Al‐Shahi; Sudlow, Catherine L.; Deary, Ian J.; Morotti, Andrea; Pezzini, Alessandro; Pera, Joanna; Urbanik, Andrzej; Pichler, Alexander; Enzinger, Christian; Norrving, Bo; Montaner, Joan; Fernandez‐Cadenas, Israel; Delgado, Pilar; Roquer, Jaume; Lindgren, Arne; Slowik, Agnieszka; Schmidt, Reinhold; Kidwell, Chelsea S.; Kittner, Steven J.; Waddy, Salina P.; Langefeld, Carl D.; Abecasis, Goncalo; Willer, Cristen J.; Kathiresan, Sekar; Woo, Daniel; Rosand, Jonathan (John Wiley and Sons Inc., 2016)
      Objective: In observational epidemiologic studies, higher plasma high‐density lipoprotein cholesterol (HDL‐C) has been associated with increased risk of intracerebral hemorrhage (ICH). DNA sequence variants that decrease ...

    • Genetic Variants in FGFR2 and FGFR4 Genes and Skin Cancer Risk in the Nurses' Health Study 

      Nan, Hongmei; Qureshi, Abrar A; Hunter, David J.; Han, Jiali (BioMed Central, 2009)
      Background: The human fibroblast growth factor (FGF) and its receptor (FGFR) play an important role in tumorigenesis. Deregulation of the FGFR2 gene has been identified in a number of cancer sites. Overexpression of the ...

    • Genetic Variants in GAPDH Confer Susceptibility to Sporadic Parkinson’s Disease in a Chinese Han Population 

      Liu, Ling; Xiong, Nian; Zhang, Ping; Chen, Chunnuan; Huang, Jinsha; Zhang, Guoxin; Xu, Xiaoyun; Shen, Yan; Lin, Zhicheng; Wang, Tao (Public Library of Science, 2015)
      Background: Accumulating evidence has demonstrated that the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a part of Lewy body inclusions and involves the pathogenesis of Parkinson’s disease (PD). However, it remains ...

    • Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets 

      Rahmioglu, Nilufer; Nyholt, Dale R.; Morris, Andrew P.; Missmer, Stacey A.; Montgomery, Grant W.; Zondervan, Krina T. (Oxford University Press, 2014)
      BACKGROUND Endometriosis is a heritable common gynaecological condition influenced by multiple genetic and environmental factors. Genome-wide association studies (GWASs) have proved successful in identifying common genetic ...

    • Genetic variation in catechol-O-methyltransferase modifies effects of clonidine treatment in chronic fatigue syndrome 

      Hall, Kathryn T.; Kossowsky, Joe; Oberlander, Tim F.; Kaptchuk, Ted J.; Saul, J. Philip; Wyller, Vegard Bruun; Fagermoen, Even; Sulheim, Dag; Gjerstad, Johannes; Winger, Anette; Mukamal, Kenneth J. (2016)
      Clonidine, an α2-adrenergic receptor agonist, decreases circulating norepinephrine and epinephrine, attenuating sympathetic activity. Although catechol-O-methyltransferase (COMT) metabolizes catecholamines, main effectors ...

    • Genetic Variation in DNA Repair Pathways and Risk of Non-Hodgkin's Lymphoma 

      Rendleman, Justin; Antipin, Yevgeniy; Reva, Boris; Adaniel, Christina; Przybylo, Jennifer A.; Dutra-Clarke, Ana; Hansen, Nichole; Heguy, Adriana; Huberman, Kety; Borsu, Laetitia; Paltiel, Ora; Ben-Yehuda, Dina; Brown, Jennifer R.; Freedman, Arnold S.; Sander, Chris; Zelenetz, Andrew; Klein, Robert J.; Shao, Yongzhao; Lacher, Mortimer; Vijai, Joseph; Offit, Kenneth; Kirchhoff, Tomas (Public Library of Science, 2014)
      Molecular and genetic evidence suggests that DNA repair pathways may contribute to lymphoma susceptibility. Several studies have examined the association of DNA repair genes with lymphoma risk, but the findings from these ...

    • Genetic variation in telomere maintenance genes in relation to ovarian cancer survival 

      Harris, Holly Ruth; De Vivo, Immaculata; Titus, Linda J.; Vitonis, Allison F.; Wong, Jason; Cramer, Daniel William; Terry, Kathryn Lynne (e-Century Publishing, 2012)
      Telomeres are repetitive non-coding DNA sequences at the ends of chromosomes that provide protection against chromosomal instability. Telomere length and stability are influenced by proteins, including telomerase which is ...

    • Genetic Variation in the Estrogen Metabolic Pathway and Mammographic Density as an Intermediate Phenotype of Breast Cancer 

      Li, Jingmei; Eriksson, Louise; Humphreys, Keith; Czene, Kamila; Liu, Jianjun; Lindström, Sara; Vachon, Celine M; Couch, Fergus J; Scott, Christopher G; Hall, Per; Tamimi, Rulla May; Hunter, David J.; Lagiou, Pagona (BioMed Central, 2010)
      Introduction: Several studies have examined the effect of genetic variants in genes involved in the estrogen metabolic pathway on mammographic density, but the number of loci studied and the sample sizes evaluated have ...

    • Genetic Variation in the HSD17B1 Gene and Risk of Prostate Cancer 

      Kraft, Peter; Pharoah, Paul; Chanock, Stephen J; Albanes, Demetrius; Kolonel, Laurence N; Hayes, Richard B; Andriole, Gerald; Berg, Christine; Boeing, Heiner; Burtt, Noel P; Bueno-de-Mesquita, Bas; Calle, Eugenia E; Cann, Howard; Canzian, Federico; Crawford, David E; Dunning, Alison M; Feigelson, Heather S; Gonzalez, Carlos Alberto; Haiman, Christopher A; Hallmans, Goran; Henderson, Brian E; Kaaks, Rudolf; Key, Timothy; Marchand, Loic Le; Overvad, Kim; Palli, Domenico; Pike, Malcolm C; Riboli, Elio; Rodriguez, Carmen; Setiawan, Wendy V; Stram, Daniel O; Thomas, Gilles; Thun, Michael J; Travis, Ruth; Trichopoulou, Antonia; Virtamo, Jarmo; Wacholder, Sholom; Altshuler, David Matthew; Chen, Yin-Ching Iris; Freedman, Matthew Lawrence; Gaziano, John Michael; Giovannucci, Edward L.; Hirschhorn, Joel Naom; Hunter, David J.; Ma, Jing; Stampfer, Meir (Public Library of Science, 2005)
      Steroid hormones are believed to play an important role in prostate carcinogenesis, but epidemiological evidence linking prostate cancer and steroid hormone genes has been inconclusive, in part due to small sample sizes ...

    • Genetic Variation in TYMS in the One-Carbon Transfer Pathway Is Associated with Ovarian Carcinoma Types in the Ovarian Cancer Association Consortium 

      Kelemen, L. E.; Goodman, M. T.; McGuire, V.; Rossing, M. A.; Webb, P. M.; Kobel, M.; Anton-Culver, H.; Beesley, J.; Berchuck, A.; Brar, S.; Carney, M. E.; Chang-Claude, J.; Chenevix-Trench, G.; Cramer, Daniel William; Cunningham, J. M.; DiCioccio, R. A.; Doherty, J. A.; Easton, D. F.; Fredericksen, Z. S.; Fridley, B. L.; Gates, M. A.; Gayther, S. A.; Gentry-Maharaj, A.; Hogdall, E.; Kjaer, S. K.; Lurie, G.; Menon, U.; Moorman, P. G.; Moysich, K.; Ness, R. B.; Palmieri, R. T.; Pearce, C. L.; Pharoah, P. D. P.; Ramus, S. J.; Song, H.; Stram, D. O.; Tworoger, Shelley Slate; Van Den Berg, D.; Vierkant, R. A.; Wang-Gohrke, S.; Whittemore, A. S.; Wilkens, L. R.; Wu, A. H.; Schildkraut, J. M.; Sellers, T. A.; Goode, E. L. (American Association for Cancer Research (AACR), 2010)
      Background We previously reported risks of ovarian carcinoma for common polymorphisms in one-carbon (1-C) transfer genes. We sought to replicate associations for DPYD rs1801265, DNMT3A rs13420827, MTHFD1 rs1950902, MTHFS ...

    • Genetic variation of a bacterial pathogen within individuals with cystic fibrosis provides a record of selective pressures 

      Lieberman, Tami D.; Flett, Kelly B.; Yelin, Idan; Martin, Thomas R.; McAdam, Alexander J.; Priebe, Gregory P.; Kishony, Roy (2014)
      Advances in sequencing have enabled the identification of mutations acquired by bacterial pathogens during infection1-10. However, it remains unclear whether adaptive mutations fix in the population or lead to pathogen ...

    • Genetic variation of aldolase from Korean isolates of Plasmodium vivax and its usefulness in serodiagnosis 

      Kim, Jung-Yeon; Shin, Hyun-ll; Sohn, Youngjoo; Kim, Hyuck; Lee, Sang-Wook; Lee, Won-Ja; Lee, Hyeong-Woo; Kim, Hyung-Hwan (BioMed Central, 2012)
      Background: The malaria aldolase is widely used as rapid diagnostic test (RDT), but the efficacy in aspect of its serological effectiveness in diagnosis is not known. The genetic variation of Korean isolates was analysed ...

    • Genetic variation of fasting glucose and changes in glycemia in response to 2-year weight-loss diet intervention: the POUNDS Lost trial 

      Wang, Tiange; Huang, Tao; Zheng, Yan; Rood, Jennifer; Bray, George A.; Sacks, Frank M.; Qi, Lu (2016)
      Objective: Weight loss intervention through diet modification has been widely used to improve obesity-related hyperglycemia; however, little is known about whether genetic variation modifies the intervention effect. We ...

    • Genetic Variations in HSPA8 Gene Associated with Coronary Heart Disease Risk in a Chinese Population 

      He, Meian; Guo, Huan; Yang, Xiaobo; Zhou, Li; Zhang, Xiaomin; Cheng, Longxian; Zeng, Hesong; Hu, Frank B.; Tanguay, Robert M.; Wu, Tangchun (Public Library of Science, 2010)
      Background: There is ample evidence that Hsp70 takes part in the progress of coronary heart disease (CHD). This implies that genetic variants of Hsp70 genes such as HSPA8 (HSC70) gene might contribute to the development ...

    • A genetically defined asymmetry underlies the inhibitory control of flexor–extensor locomotor movements 

      Britz, Olivier; Zhang, Jingming; Grossmann, Katja S; Dyck, Jason; Kim, Jun C; Dymecki, Susan; Gosgnach, Simon; Goulding, Martyn (eLife Sciences Publications, Ltd, 2015)
      V1 and V2b interneurons (INs) are essential for the production of an alternating flexor–extensor motor output. Using a tripartite genetic system to selectively ablate either V1 or V2b INs in the caudal spinal cord and ...

    • Genetically Elevated Fetuin-A Levels, Fasting Glucose Levels, and Risk of Type 2 Diabetes: The Cardiovascular Health Study* 

      Jensen, Majken K.; Bartz, Traci M.; Djoussé, Luc; Kizer, Jorge R.; Zieman, Susan J.; Rimm, Eric B.; Siscovick, David S.; Psaty, Bruce M.; Ix, Joachim H.; Mukamal, Kenneth J. (American Diabetes Association, 2013)
      OBJECTIVE Fetuin-A levels are associated with higher risk of type 2 diabetes, but it is unknown if the association is causal. We investigated common (>5%) genetic variants in the fetuin-A gene (AHSG) fetuin-A levels, fasting ...

    • Genetically Encoded Calcium Indicators for Ulti-Color Neural Activity Imaging and Combination With Optogenetics 

      Akerboom, Jasper; Carreras Calderón, Nicole; Tian, Lin; Wabnig, Sebastian; Prigge, Matthias; Tolö, Johan; Gordus, Andrew; Orger, Michael B.; Severi, Kristen E.; Macklin, John J.; Patel, Ronak Bhailal; Pulver, Stefan R.; Wardill, Trevor J.; Fischer, Elisabeth; Schüler, Christina; Chen, Tsai-Wen; Sarkisyan, Karen S.; Marvin, Jonathan S.; Bargmann, Cornelia I.; Kim, Douglas S.; Kügler, Sebastian; Lagnado, Leon; Hegemann, Peter; Gottschalk, Alexander; Schreiter, Eric R.; Looger, Loren L. (Frontiers Media S.A., 2013)
      Genetically encoded calcium indicators (GECIs) are powerful tools for systems neuroscience. Here we describe red, single-wavelength GECIs, “RCaMPs,” engineered from circular permutation of the thermostable red fluorescent ...

    • Genetically encoded short peptide tag for versatile protein labeling by Sfp phosphopantetheinyl transferase 

      Yin, Jun; Straight, Paul D.; McLoughlin, Shaun M.; Zhou, Zhe; Lin, Alison J.; Golan, David E.; Kelleher, Neil L.; Kolter, Roberto; Walsh, Christopher T. (National Academy of Sciences, 2005)
      An 11-residue peptide with the sequence DSLEFIASKLA was identified from a genomic library of Bacillus subtilis by phage display as an efficient substrate for Sfp phosphopantetheinyl transferase-catalyzed protein labeling ...

    • Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth 

      Mizrak, Arda; Bolukbasi, Mehmet Fatih; Ozdener, Gokhan Baris; Brenner, Gary Jay; Madlener, Sibylle; Erkan, Erdogan Pekcan; Ströbel, Thomas; Breakefield, Xandra Owens; Saydam, Okay (Nature Publishing Group, 2013)
      Microvesicles (MVs) play an important role in intercellular communication by carrying mRNAs, microRNAs (miRNAs), non-coding RNAs, proteins, and DNA from cell to cell. To our knowledge, this is the first report of delivery ...

    • Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases 

      Zhou, Weihua; Wei, Wenyi; Sun, Yi (Nature Publishing Group, 2013)
      The SCF (SKP1 (S-phase-kinase-associated protein 1), Cullin-1, F-box protein) E3 ubiquitin ligases, the founding member of Cullin-RING ligases (CRLs), are the largest family of E3 ubiquitin ligases in mammals. Each individual ...