Browsing HMS Scholarly Articles by Title
Now showing items 6922-6941 of 17922
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A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control
(eLife Sciences Publications, Ltd, 2013)HIV-1 sequence diversity is affected by selection pressures arising from host genomic factors. Using paired human and viral data from 1071 individuals, we ran >3000 genome-wide scans, testing for associations between host ... -
Genome-wide 5-hydroxymethylcytosine modification pattern is a novel epigenetic feature of globozoospermia
(Impact Journals LLC, 2015)Discovery of 5-hydroxymethylcytosine (5hmC) in mammalian genomes has excited the field of epigenetics, but information on the genome-wide distribution of 5hmC is limited. Globozoospermia is a rare but severe cause of male ... -
Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B
(BioMed Central, 2013)Background: Canine osteosarcoma is clinically nearly identical to the human disease, but is common and highly heritable, making genetic dissection feasible. Results: Through genome-wide association analyses in three breeds ... -
Genome-wide Analysis Identifies Novel Loci Associated with Ovarian Cancer Outcomes: Findings from the Ovarian Cancer Association Consortium
(American Association for Cancer Research (AACR), 2015)PURPOSE: Chemotherapy resistance remains a major challenge in the treatment of ovarian cancer. We hypothesize that germline polymorphisms might be associated with clinical outcome. EXPERIMENTAL DESIGN: We analyzed ... -
Genome-Wide Analysis of Copy Number Variants in Attention Deficit Hyperactivity Disorder: The Role of Rare Variants and Duplications at 15q13.3
(American Psychiatric Publishing, 2013)Objective: Attention deficit hyperactivity disorder (ADHD) is a common, highly heritable psychiatric disorder. Because of its multifactorial etiology, however, identifying the genes involved has been difficult. The authors ... -
Genome-Wide Analysis of DNA Methylation and Cigarette Smoking in a Chinese Population
(National Institute of Environmental Health Sciences, 2016)Background: Smoking is a risk factor for many human diseases. DNA methylation has been related to smoking, but genome-wide methylation data for smoking in Chinese populations is limited. Objectives: We aimed to investigate ... -
Genome-Wide Analysis of ETS-Family DNA-Binding In Vitro and In Vivo
(Nature Publishing Group, 2010)Members of the large ETS family of transcription factors (TFs) have highly similar DNA-binding domains (DBDs)—yet they have diverse functions and activities in physiology and oncogenesis. Some differences in DNA-binding ... -
Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci
(Nature Publishing Group, 2016)Neuroticism is a personality trait of fundamental importance for psychological well-being and public health. It is strongly associated with major depressive disorder (MDD) and several other psychiatric conditions. Although ... -
Genome-Wide Analysis of Survival in Early-Stage Non–Small-Cell Lung Cancer
(American Society of Clinical Oncology (ASCO), 2009-06-01)Purpose Lung cancer, of which 85% is non–small-cell (NSCLC), is the leading cause of cancer-related death in the United States. We used genome-wide analysis of tumor tissue to investigate whether single nucleotide ... -
A Genome-wide analysis of the response to inhaled beta2-agonists in Chronic Obstructive Pulmonary Disease
(2015)Short-acting β2-agonist bronchodilators are the most common medications used in treating chronic obstructive pulmonary disease (COPD). Genetic variants determining bronchodilator responsiveness (BDR) in COPD have not been ... -
Genome-wide Analysis of YY2 Versus YY1 Target Genes
(Oxford University Press, 2010)Yin Yang 1 (YY1) is a critical transcription factor controlling cell proliferation, development and DNA damage responses. Retrotranspositions have independently generated additional YY family members in multiple species. ... -
Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease
(National Academy of Sciences, 2010)Dysregulation of autophagy, a cellular catabolic mechanism essential for degradation of misfolded proteins, has been implicated in multiple neurodegenerative diseases. However, the mechanisms that lead to the autophagy ... -
Genome-wide analysis reveals TET-and TDG-mediated 5-methylcytosine oxidation dynamics
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Genome-Wide and Candidate Gene Association Study of Cigarette Smoking Behaviors
(Public Library of Science, 2009)The contribution of common genetic variation to one or more established smoking behaviors was investigated in a joint analysis of two genome wide association studies (GWAS) performed as part of the Cancer Genetic Markers ... -
Genome-wide Association Analysis Identifies 14 New Risk Loci for Schizophrenia
(2013)Schizophrenia is a heritable disorder with substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases, 6,243 ... -
Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank
(Nature Publishing Group, 2016)Our sleep timing preference, or chronotype, is a manifestation of our internal biological clock. Variation in chronotype has been linked to sleep disorders, cognitive and physical performance, and chronic disease. Here we ... -
Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open angle glaucoma
(2015)Primary open angle glaucoma (POAG) is a leading cause of blindness world-wide. To identify new susceptibility loci, we meta-analyzed GWAS results from 8 independent studies from the United States (3,853 cases and 33,480 ... -
Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits
(Public Library of Science, 2011)Nonalcoholic fatty liver disease (NAFLD) clusters in families, but the only known common genetic variants influencing risk are near PNPLA3. We sought to identify additional genetic variants influencing NAFLD using genome-wide ... -
Genome-Wide Association Analysis in Asthma Subjects Identifies SPATS2L as a Novel Bronchodilator Response Gene
(Public Library of Science, 2012)Bronchodilator response (BDR) is an important asthma phenotype that measures reversibility of airway obstruction by comparing lung function (i.e. FEV1) before and after the administration of a short-acting β2-agonist, the ... -
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer
(2015)Genome wide association studies (GWAS) and large scale replication studies have identified common variants in 79 loci associated with breast cancer, explaining ~14% of the familial risk of the disease. To identify new ...