Browsing HMS Scholarly Articles by Title

Now showing items 6945-6964 of 17922

    • Genome-Wide Association and Trans-ethnic Meta-Analysis for Advanced Diabetic Kidney Disease: Family Investigation of Nephropathy and Diabetes (FIND) 

      Iyengar, Sudha K.; Sedor, John R.; Freedman, Barry I.; Kao, W. H. Linda; Kretzler, Matthias; Keller, Benjamin J.; Abboud, Hanna E.; Adler, Sharon G.; Best, Lyle G.; Bowden, Donald W.; Burlock, Allison; Chen, Yii-Der Ida; Cole, Shelley A.; Comeau, Mary E.; Curtis, Jeffrey M.; Divers, Jasmin; Drechsler, Christiane; Duggirala, Ravi; Elston, Robert C.; Guo, Xiuqing; Huang, Huateng; Hoffmann, Michael Marcus; Howard, Barbara V.; Ipp, Eli; Kimmel, Paul L.; Klag, Michael J.; Knowler, William C.; Kohn, Orly F.; Leak, Tennille S.; Leehey, David J.; Li, Man; Malhotra, Alka; März, Winfried; Nair, Viji; Nelson, Robert G.; Nicholas, Susanne B.; O’Brien, Stephen J.; Pahl, Madeleine V.; Parekh, Rulan S.; Pezzolesi, Marcus G.; Rasooly, Rebekah S.; Rotimi, Charles N.; Rotter, Jerome I.; Schelling, Jeffrey R.; Seldin, Michael F.; Shah, Vallabh O.; Smiles, Adam M.; Smith, Michael W.; Taylor, Kent D.; Thameem, Farook; Thornley-Brown, Denyse P.; Truitt, Barbara J.; Wanner, Christoph; Weil, E. Jennifer; Winkler, Cheryl A.; Zager, Philip G.; Igo, Robert P.; Hanson, Robert L.; Langefeld, Carl D. (Public Library of Science, 2015)
      Diabetic kidney disease (DKD) is the most common etiology of chronic kidney disease (CKD) in the industrialized world and accounts for much of the excess mortality in patients with diabetes mellitus. Approximately 45% of ...

    • Genome-Wide Association for Abdominal Subcutaneous and Visceral Adipose Reveals a Novel Locus for Visceral Fat in Women 

      Liu, Yongmei; White, Charles C.; Feitosa, Mary; Smith, Albert V.; Heard-Costa, Nancy; Lohman, Kurt; Foster, Meredith C.; Greenawalt, Danielle M.; Griffin, Paula; Ding, Jinghong; Newman, Anne B.; Tylavsky, Fran; Miljkovic, Iva; Kritchevsky, Stephen B.; Launer, Lenore; Garcia, Melissa; Eiriksdottir, Gudny; Gudnason, Vilmunder; Harris, Tamara B.; Cupples, L. Adrienne; Borecki, Ingrid B.; Fox, Caroline; Johnson, Andrew D.; Carr, Jeffrey J. (Public Library of Science, 2012)
      Body fat distribution, particularly centralized obesity, is associated with metabolic risk above and beyond total adiposity. We performed genome-wide association of abdominal adipose depots quantified using computed ...

    • A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study 

      Hwang, Shih-Jen; Yang, Qiong; Meigs, James Benjamin; Pearce, Elizabeth N; Fox, Caroline (BioMed Central, 2007)
      Background: Glomerular filtration rate (GFR) and urinary albumin excretion (UAE) are markers of kidney function that are known to be heritable. Many endocrine conditions have strong familial components. We tested for ...

    • Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes 

      Strawbridge, Rona J.; Dupuis, Josée; Prokopenko, Inga; Barker, Adam; Ahlqvist, Emma; Rybin, Denis; Petrie, John R.; Travers, Mary E.; Bouatia-Naji, Nabila; Dimas, Antigone S.; Nica, Alexandra; Wheeler, Eleanor; Chen, Han; Voight, Benjamin F.; Taneera, Jalal; Kanoni, Stavroula; Peden, John F.; Turrini, Fabiola; Gustafsson, Stefan; Zabena, Carina; Almgren, Peter; Barker, David J.P.; Barnes, Daniel; Dennison, Elaine M.; Eriksson, Johan G.; Eriksson, Per; Eury, Elodie; Folkersen, Lasse; Fox, Caroline; Frayling, Timothy M.; Goel, Anuj; Gu, Harvest F.; Horikoshi, Momoko; Isomaa, Bo; Jackson, Anne U.; Jameson, Karen A.; Kajantie, Eero; Kerr-Conte, Julie; Kuulasmaa, Teemu; Kuusisto, Johanna; Loos, Ruth J.F.; Luan, Jian'an; Makrilakis, Konstantinos; Manning, Alisa K; Martínez-Larrad, María Teresa; Narisu, Narisu; Nastase Mannila, Maria; Öhrvik, John; Osmond, Clive; Pascoe, Laura; Payne, Felicity; Sayer, Avan A.; Sennblad, Bengt; Silveira, Angela; Stančáková, Alena; Stirrups, Kathy; Swift, Amy J.; Syvänen, Ann-Christine; Tuomi, Tiinamaija; van 't Hooft, Ferdinand M.; Walker, Mark; Weedon, Michael N.; Xie, Weijia; Zethelius, Björn; Ongen, Halit; Mälarstig, Anders; Hopewell, Jemma C.; Saleheen, Danish; Chambers, John; Parish, Sarah; Danesh, John; Kooner, Jaspal; Östenson, Claes-Göran; Lind, Lars; Cooper, Cyrus C.; Serrano-Ríos, Manuel; Ferrannini, Ele; Forsen, Tom J.; Clarke, Robert; Franzosi, Maria Grazia; Seedorf, Udo; Watkins, Hugh; Froguel, Philippe; Johnson, Paul; Deloukas, Panos; Collins, Francis S.; Laakso, Markku; Dermitzakis, Emmanouil T.; Boehnke, Michael; McCarthy, Mark I.; Wareham, Nicholas J.; Groop, Leif; Pattou, François; Gloyn, Anna L.; Dedoussis, George V.; Lyssenko, Valeriya; Meigs, James Benjamin; Barroso, Inês; Watanabe, Richard M.; Ingelsson, Erik; Langenberg, Claudia; Hamsten, Anders; Florez, Jose Carlos (American Diabetes Association, 2011)
      OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). ...

    • Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility 

      Landi, Maria Teresa; Bishop, D. Timothy; MacGregor, Stuart; Machiela, Mitchell J.; Stratigos, Alexander J.; Ghiorzo, Paola; Brossard, Myriam; Calista, Donato; Choi, Jiyeon; Fargnoli, Maria Concetta; Zhang, Tongwu; Rodolfo, Monica; Trower, Adam J.; Menin, Chiara; Martinez, Jacobo; Hadjisavvas, Andreas; Song, Lei; Stefanaki, Irene; Scolyer, Richard; Yang, Rose; Goldstein, Alisa M.; Potrony, Miriam; Kypreou, Katerina P.; Pastorino, Lorenza; Queirolo, Paola; Pellegrini, Cristina; Cattaneo, Laura; Zawistowski, Matthew; Gimenez-Xavier, Pol; Rodriguez, Arantxa; Elefanti, Lisa; Manoukian, Siranoush; Rivoltini, Licia; Smith, Blair H.; Loizidou, Maria A.; Del Regno, Laura; Massi, Daniela; Mandala, Mario; Khosrotehrani, Kiarash; Akslen, Lars A.; Amos, Christopher I.; Andresen, Per A.; Avril, Marie-Françoise; Azizi, Esther; Soyer, H. Peter; Bataille, Veronique; Dalmasso, Bruna; Bowdler, Lisa M.; Burdon, Kathryn P.; Chen, Wei V.; Codd, Veryan; Craig, Jamie E.; Dębniak, Tadeusz; Falchi, Mario; Fang, Shenying; Friedman, Eitan; Simi, Sarah; Galan, Pilar; Garcia-Casado, Zaida; Gillanders, Elizabeth M.; Gordon, Scott; Green, Adele; Gruis, Nelleke A.; Hansson, Johan; Harland, Mark; Harris, Jessica; Helsing, Per; Henders, Anjali; Hočevar, Marko; Höiom, Veronica; Hunter, David; Ingvar, Christian; Kumar, Rajiv; Lang, Julie; Lathrop, G. Mark; Lee, Jeffrey E.; Li, Xin; Lubiński, Jan; Mackie, Rona M.; Malt, Maryrose; Malvehy, Josep; McAloney, Kerrie; Mohamdi, Hamida; Molven, Anders; Moses, Eric K.; Neale, Rachel E.; Novaković, Srdjan; Nyholt, Dale R.; Olsson, Håkan; Orr, Nicholas; Fritsche, Lars G.; Puig-Butille, Joan Anton; Qureshi, Abrar A.; Radford-Smith, Graham L.; Randerson-Moor, Juliette; Requena, Celia; Rowe, Casey; Samani, Nilesh J.; Sanna, Marianna; Schadendorf, Dirk; Schulze, Hans-Joachim; Simms, Lisa A.; Smithers, Mark; Song, Fengju; Swerdlow, Anthony J.; van der Stoep, Nienke; Kukutsch, Nicole A.; Visconti, Alessia; Wallace, Leanne; Ward, Sarah V.; Wheeler, Lawrie; Sturm, Richard A.; Hutchinson, Amy; Jones, Kristine; Malasky, Michael; Vogt, Aurelie; Zhou, Weiyin; Pooley, Karen A.; Elder, David E.; Han, Jiali; Hicks, Belynda; Hayward, Nicholas K.; Kanetsky, Peter A.; Brummett, Chad; Montgomery, Grant W.; Olsen, Catherine M.; Hayward, Caroline; Dunning, Alison M.; Martin, Nicholas G.; Evangelou, Evangelos; Mann, Graham J.; Long, Georgina; Pharoah, Paul D. P.; Easton, Douglas F.; Barrett, Jennifer H.; Cust, Anne E.; Abecasis, Goncalo; Duffy, David L.; Whiteman, David C.; Gogas, Helen; De Nicolo, Arcangela; Tucker, Margaret A.; Newton-Bishop, Julia A.; Peris, Ketty; Chanock, Stephen J.; Demenais, Florence; Brown, Kevin M.; Puig, Susana; Nagore, Eduardo; Shi, Jianxin; Iles, Mark M.; Law, Matthew H. (Springer Science and Business Media LLC, 2020-04-27)

    • Genome-wide Association Meta-analysis Identifies New Endometriosis Risk Loci 

      Nyholt, Dale R.; Low, Siew-Kee; Anderson, Carl A.; Painter, Jodie N.; Uno, Satoko; Morris, Andrew P.; MacGregor, Stuart; Gordon, Scott D.; Henders, Anjali K.; Martin, Nicholas G.; Attia, John; Holliday, Elizabeth G.; McEvoy, Mark; Scott, Rodney J.; Kennedy, Stephen M; Treloar, Susan A.; Missmer, Stacey Ann; Adachi, Sosuke; Tanaka, Kenichi; Nakamura, Yusuke; Zondervan, Krina T.; Zembutsu, Hitoshi; Montgomery, Grant W. (2012)
      We conducted a genome-wide association (GWA) meta-analysis of 4,604 endometriosis cases and 9,393 controls of Japanese and European ancestry. We show that rs12700667 on chromosome 7p15.2, previously found in Europeans, ...

    • A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation 

      Coviello, Andrea D.; Haring, Robin; Wellons, Melissa; Vaidya, Dhananjay; Lehtimäki, Terho; Keildson, Sarah; Lunetta, Kathryn L.; He, Chunyan; Fornage, Myriam; Lagou, Vasiliki; Mangino, Massimo; Onland-Moret, N. Charlotte; Eriksson, Joel; Garcia, Melissa; Liu, Yong Mei; Koster, Annemarie; Lohman, Kurt; Lyytikäinen, Leo-Pekka; Petersen, Ann-Kristin; Stolk, Lisette; Vandenput, Liesbeth; Wood, Andrew R.; Zhuang, Wei Vivian; Ruokonen, Aimo; Hartikainen, Anna-Liisa; Pouta, Anneli; Bandinelli, Stefania; Biffar, Reiner; Brabant, Georg; Chen, Yuhui; Cummings, Steven; Ferrucci, Luigi; Gunter, Marc J.; Martikainen, Hannu; Homuth, Georg; Illig, Thomas; Jansson, John-Olov; Karlsson, Magnus; Kettunen, Johannes; Liu, Jingmin; Ljunggren, Östen; Lorentzon, Mattias; Maggio, Marcello; Markus, Marcello R. P.; Mellström, Dan; Miljkovic, Iva; Mirel, Daniel; Morin Papunen, Laure; Peeters, Petra H. M.; Prokopenko, Inga; Raffel, Leslie; Reincke, Martin; Reiner, Alex P.; Rivadeneira, Fernando; Schwartz, Stephen M.; Siscovick, David; Soranzo, Nicole; Stöckl, Doris; Uitterlinden, André G.; van Gils, Carla H.; Vasan, Ramachandran S.; Wichmann, H.-Erich; Zhai, Guangju; Bhasin, Shalender; Bidlingmaier, Martin; Chanock, Stephen J.; Harris, Tamara B.; Kähönen, Mika; Liu, Simin; Ouyang, Pamela; Spector, Tim D.; van der Schouw, Yvonne T.; Viikari, Jorma; Wallaschofski, Henri; McCarthy, Mark I.; Frayling, Timothy M.; Murray, Anna; Franks, Steve; Järvelin, Marjo-Riitta; de Jong, Frank H.; Raitakari, Olli; Teumer, Alexander; Ohlsson, Claes; Murabito, Joanne M.; Perry, John R. B.; Chen, Brian; Prescott, Jennifer; Cox, David G.; Hankinson, Susan Elizabeth; Hofman, Albert; Johnson, Andrew D.; Karasik, David; Kiel, Douglas P.; Nelson, Sarah; Rexrode, Kathryn Marian; Tworoger, Shelley Slate; De Vivo, Immaculata; Hunter, David J.; Kraft, Peter (Public Library of Science, 2012)
      Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases ...

    • Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias 

      Beecham, Gary W.; Hamilton, Kara; Naj, Adam C.; Martin, Eden R.; Huentelman, Matt; Myers, Amanda J.; Corneveaux, Jason J.; Hardy, John; Vonsattel, Jean-Paul; Younkin, Steven G.; Bennett, David A.; De Jager, Philip L.; Larson, Eric B.; Crane, Paul K.; Kamboh, M. Ilyas; Kofler, Julia K.; Mash, Deborah C.; Duque, Linda; Gilbert, John R.; Gwirtsman, Harry; Buxbaum, Joseph D.; Kramer, Patricia; Dickson, Dennis W.; Farrer, Lindsay A.; Frosch, Matthew P.; Ghetti, Bernardino; Haines, Jonathan L.; Hyman, Bradley T.; Kukull, Walter A.; Mayeux, Richard P.; Pericak-Vance, Margaret A.; Schneider, Julie A.; Trojanowski, John Q.; Reiman, Eric M.; Schellenberg, Gerard D.; Montine, Thomas J. (Public Library of Science, 2014)
      Alzheimer's disease (AD) and related dementias are a major public health challenge and present a therapeutic imperative for which we need additional insight into molecular pathogenesis. We performed a genome-wide association ...

    • Genome-Wide Association of Body Fat Distribution in African Ancestry Populations Suggests New Loci 

      Liu, Ching-Ti; Monda, Keri L.; Taylor, Kira C.; Lange, Leslie; Demerath, Ellen W.; Palmas, Walter; Wojczynski, Mary K.; Ellis, Jaclyn C.; Vitolins, Mara Z.; Liu, Simin; Papanicolaou, George J.; Irvin, Marguerite R.; Xue, Luting; Griffin, Paula J.; Nalls, Michael A.; Adeyemo, Adebowale; Liu, Jiankang; Li, Guo; Ruiz-Narvaez, Edward A.; Chen, Wei-Min; Chen, Fang; Henderson, Brian E.; Millikan, Robert C.; Ambrosone, Christine B.; Strom, Sara S.; Guo, Xiuqing; Andrews, Jeanette S.; Sun, Yan V.; Mosley, Thomas H.; Yanek, Lisa R.; Shriner, Daniel; Haritunians, Talin; Rotter, Jerome I.; Speliotes, Elizabeth K.; Smith, Megan; Rosenberg, Lynn; Mychaleckyj, Josyf; Nayak, Uma; Spruill, Ida; Garvey, W. Timothy; Pettaway, Curtis; Nyante, Sarah; Bandera, Elisa V.; Britton, Angela F.; Zonderman, Alan B.; Rasmussen-Torvik, Laura J.; Chen, Yii-Der Ida; Ding, Jingzhong; Lohman, Kurt; Kritchevsky, Stephen B.; Zhao, Wei; Peyser, Patricia A.; Kardia, Sharon L. R.; Kabagambe, Edmond; Broeckel, Ulrich; Chen, Guanjie; Zhou, Jie; Wassertheil-Smoller, Sylvia; Neuhouser, Marian L.; Rampersaud, Evadnie; Psaty, Bruce; Kooperberg, Charles; Manson, JoAnn E.; Kuller, Lewis H.; Ochs-Balcom, Heather M.; Johnson, Karen C.; Sucheston, Lara; Ordovas, Jose M.; Palmer, Julie R.; Haiman, Christopher A.; McKnight, Barbara; Howard, Barbara V.; Becker, Diane M.; Bielak, Lawrence F.; Liu, Yongmei; Allison, Matthew A.; Grant, Struan F. A.; Burke, Gregory L.; Patel, Sanjay R.; Schreiner, Pamela J.; Borecki, Ingrid B.; Evans, Michele K.; Taylor, Herman; Sale, Michele M.; Howard, Virginia; Carlson, Christopher S.; Rotimi, Charles N.; Cushman, Mary; Harris, Tamara B.; Reiner, Alexander P.; Cupples, L. Adrienne; North, Kari E.; Fox, Caroline S. (Public Library of Science, 2013)
      Central obesity, measured by waist circumference (WC) or waist-hip ratio (WHR), is a marker of body fat distribution. Although obesity disproportionately affects minority populations, few studies have conducted genome-wide ...

    • Genome-wide Association of Lipid-lowering Response to Statins in Combined Study Populations 

      Barber, Mathew J.; Mangravite, Lara M.; Hyde, Craig L.; McCarty, Catherine A.; Li, Xiaohui; Wilke, Russell A.; Rieder, Mark J.; Williams, Paul T.; Chatterjee, Aurobindo; Rotter, Jerome I.; Nickerson, Deborah A.; Stephens, Matthew; Krauss, Ronald M.; Zanger, Ulrich; Chasman, Daniel Ian; Smith, Joshua D.; Ridker, Paul M. (Public Library of Science, 2010)
      Background: Statins effectively lower total and plasma LDL-cholesterol, but the magnitude of decrease varies among individuals. To identify single nucleotide polymorphisms (SNPs) contributing to this variation, we performed ...

    • Genome-Wide Association of Pericardial Fat Identifies a Unique Locus for Ectopic Fat 

      White, Charles C.; Lohman, Kurt; Heard-Costa, Nancy; Emilsson, Valur; Liu, Ching-Ti; Taylor, Kent D.; Allison, Matthew; Budoff, Matthew; Rotter, Jerome I.; Ding, Jingzhong; Cupples, L. Adrienne; Liu, Yongmei; Fox, Caroline; Cohen, Paul; Zhang, Yingying; Johnson, Andrew D.; Chen, Y.-D. Ida; Carr, Jeffrey J.; Hoffmann, Udo (Public Library of Science, 2012)
      Pericardial fat is a localized fat depot associated with coronary artery calcium and myocardial infarction. We hypothesized that genetic loci would be associated with pericardial fat independent of other body fat depots. ...

    • Genome-Wide Association Scan for Diabetic Nephropathy Susceptibility Genes in Type 1 Diabetes 

      Poznik, G. David; Mychaleckyj, Josyf C.; Barati, Michelle T.; Klein, Jon B.; Ng, Daniel P.K.; Placha, Grzegorz; Canani, Luis H.; Bochenski, Jacek; Waggott, Daryl; Merchant, Michael L.; Mirea, Lucia; Wanic, Krzysztof; Katavetin, Pisut; Kure, Masahiko; Wolkow, Pawel; Dunn, Jonathon S.; Smiles, Adam; Boright, Andrew P.; Bull, Shelley B.; Rich, Stephen S.; Warram, James H.; Pezzolesi, Marcus Guy; Paterson, Andrew D.; Krolewski, Bozena Krystyna; DCCT/EDIC Research Group; Krolewski, Andrzej Stefan; Walker, William H.; Doria, Alessandro; Rogus, John Joseph (American Diabetes Association, 2009)
      OBJECTIVE—Despite extensive evidence for genetic susceptibility to diabetic nephropathy, the identification of susceptibility genes and their variants has had limited success. To search for genes that contribute to ...

    • Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution 

      Lindgren, Cecilia M.; Heid, Iris M.; Randall, Joshua C.; Lamina, Claudia; Steinthorsdottir, Valgerdur; Speliotes, Elizabeth K.; Thorleifsson, Gudmar; Willer, Cristen J.; Herrera, Blanca M.; Jackson, Anne U.; Lim, Noha; Scheet, Paul; Soranzo, Nicole; Amin, Najaf; Aulchenko, Yurii S.; Chambers, John C.; Drong, Alexander; Luan, Jian'an; Rivadeneira, Fernando; Sanna, Serena; Timpson, Nicholas J.; Zillikens, M. Carola; Almgren, Peter; Bandinelli, Stefania; Bennett, Amanda J.; Bergman, Richard N.; Bonnycastle, Lori L.; Bumpstead, Suzannah J.; Chanock, Stephen J.; Cherkas, Lynn; Chines, Peter; Coin, Lachlan; Cooper, Cyrus; Crawford, Gabriel; Doering, Angela; Dominiczak, Anna; Doney, Alex S. F.; Ebrahim, Shah; Elliott, Paul; Erdos, Michael R.; Estrada, Karol; Ferrucci, Luigi; Fischer, Guido; Forouhi, Nita G.; Gieger, Christian; Grallert, Harald; Groves, Christopher J.; Grundy, Scott; Guiducci, Candace; Hadley, David; Hamsten, Anders; Havulinna, Aki S.; Holle, Rolf; Holloway, John W.; Illig, Thomas; Isomaa, Bo; Jacobs, Leonie C.; Jameson, Karen; Jousilahti, Pekka; Karpe, Fredrik; Kuusisto, Johanna; Laitinen, Jaana; Lathrop, G. Mark; Lawlor, Debbie A.; Mangino, Massimo; McArdle, Wendy L.; Meitinger, Thomas; Morken, Mario A.; Morris, Andrew P.; Munroe, Patricia; Narisu, Narisu; Nordström, Anna; Nordström, Peter; Oostra, Ben A.; Palmer, Colin N. A.; Payne, Felicity; Peden, John F.; Prokopenko, Inga; Renström, Frida; Ruokonen, Aimo; Salomaa, Veikko; Sandhu, Manjinder S.; Scuteri, Angelo; Silander, Kaisa; Song, Kijoung; Stringham, Heather M.; Swift, Amy J.; Tuomi, Tiinamaija; Uda, Manuela; Vollenweider, Peter; Waeber, Gerard; Wallace, Chris; Walters, G. Bragi; Weedon, Michael N.; Witteman, Jacqueline C. M.; Zhang, Cuilin; Zhang, Weihua; Caulfield, Mark J.; Collins, Francis S.; Davey Smith, George; Day, Ian N. M.; Franks, Paul W.; Hattersley, Andrew T.; Jarvelin, Marjo-Riitta; Kong, Augustine; Kooner, Jaspal S.; Laakso, Markku; Lakatta, Edward; Mooser, Vincent; Morris, Andrew D.; Peltonen, Leena; Samani, Nilesh J.; Spector, Timothy D.; Strachan, David P.; Tanaka, Toshiko; Tuomilehto, Jaakko; Uitterlinden, André G.; van Duijn, Cornelia M.; Wareham, Nicholas J.; Waterworth, Dawn M.; Boehnke, Michael; Deloukas, Panos; Groop, Leif; Thorsteinsdottir, Unnur; Schlessinger, David; Wichmann, H.-Erich; Frayling, Timothy M.; Abecasis, Gonçalo R.; Loos, Ruth J. F.; Stefansson, Kari; Mohlke, Karen L.; Barroso, Inês; Hirschhorn, Joel Naom; McCarthy, Mark I.; Watkins, Hugh; The Wellcome Trust Case Control Consortium; Hunter, David J.; Hu, Frank B.; Yuan, Xin; Scott, Laura J.; Hofman, Albert; Zhao, Jing Hua; Lyon, Helen N; Qi, Lu (Public Library of Science, 2009)
      To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist–hip ...

    • Genome-wide association studies in ADHD 

      Franke, Barbara; Neale, Benjamin M.; Faraone, Stephen V. (Springer-Verlag, 2009)
      Attention-deficit/hyperactivity disorder, ADHD, is a common and highly heritable neuropsychiatric disorder that is seen in children and adults. Although heritability is estimated at around 76%, it has been hard to find ...

    • Genome-Wide Association Studies in an Isolated Founder Population from the Pacific Island of Kosrae 

      Lowe, Jennifer K.; Maller, Julian B.; Pe'er, Itsik; Neale, Benjamin M.; Salit, Jacqueline; Kenny, Eimear E.; Shea, Jessica L.; Burkhardt, Ralph; Ji, Weizhen; Noel, Martha; Foo, Jia Nee; Blundell, Maude L.; Skilling, Vita; Garcia, Laura; Sullivan, Marcia L.; Lee, Heather E.; Labek, Anna; Ferdowsian, Hope; Auerbach, Steven B.; Lifton, Richard P.; Breslow, Jan L.; Stoffel, Markus; Smith, J. Gustav; Newton-Cheh, Christopher Holmes; Daly, Mark Joseph; Altshuler, David Matthew; Friedman, Jeffrey M. (Public Library of Science, 2009)
      It has been argued that the limited genetic diversity and reduced allelic heterogeneity observed in isolated founder populations facilitates discovery of loci contributing to both Mendelian and complex disease. A strong ...

    • Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes 

      Imamura, Minako; Takahashi, Atsushi; Yamauchi, Toshimasa; Hara, Kazuo; Yasuda, Kazuki; Grarup, Niels; Zhao, Wei; Wang, Xu; Huerta-Chagoya, Alicia; Hu, Cheng; Moon, Sanghoon; Long, Jirong; Kwak, Soo Heon; Rasheed, Asif; Saxena, Richa; Ma, Ronald C. W.; Okada, Yukinori; Iwata, Minoru; Hosoe, Jun; Shojima, Nobuhiro; Iwasaki, Minaka; Fujita, Hayato; Suzuki, Ken; Danesh, John; Jørgensen, Torben; Jørgensen, Marit E.; Witte, Daniel R.; Brandslund, Ivan; Christensen, Cramer; Hansen, Torben; Mercader, Josep M.; Flannick, Jason; Moreno-Macías, Hortensia; Burtt, Noël P.; Zhang, Rong; Kim, Young Jin; Zheng, Wei; Singh, Jai Rup; Tam, Claudia H. T.; Hirose, Hiroshi; Maegawa, Hiroshi; Ito, Chikako; Kaku, Kohei; Watada, Hirotaka; Tanaka, Yasushi; Tobe, Kazuyuki; Kawamori, Ryuzo; Kubo, Michiaki; Cho, Yoon Shin; Chan, Juliana C. N.; Sanghera, Dharambir; Frossard, Philippe; Park, Kyong Soo; Shu, Xiao-Ou; Kim, Bong-Jo; Florez, Jose C.; Tusié-Luna, Teresa; Jia, Weiping; Tai, E Shyong; Pedersen, Oluf; Saleheen, Danish; Maeda, Shiro; Kadowaki, Takashi (Nature Publishing Group, 2016)
      Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis ...

    • Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA 

      Ramasamy, Adaikalavan; Kuokkanen, Mikko; Vedantam, Sailaja; Gajdos, Zofia Katherine; Couto Alves, Alexessander; Lyon, Helen N.; Ferreira, Manuel A. R.; Strachan, David P.; Zhao, Jing Hua; Abramson, Michael J.; Brown, Matthew A.; Coin, Lachlan; Dharmage, Shyamali C.; Duffy, David L.; Haahtela, Tari; Heath, Andrew C.; Janson, Christer; Kähönen, Mika; Khaw, Kay-Tee; Laitinen, Jaana; Le Souef, Peter; Lehtimäki, Terho; Madden, Pamela A. F.; Marks, Guy B.; Martin, Nicholas G.; Matheson, Melanie C.; Palmer, Cameron Douglas; Palotie, Aarno; Pouta, Anneli; Robertson, Colin F.; Viikari, Jorma; Widen, Elisabeth; Wjst, Matthias; Jarvis, Deborah L.; Montgomery, Grant W.; Thompson, Philip J.; Wareham, Nick; Eriksson, Johan; Jousilahti, Pekka; Laitinen, Tarja; Pekkanen, Juha; Raitakari, Olli T.; O'Connor, George T.; Salomaa, Veikko; Jarvelin, Marjo-Riitta; Hirschhorn, Joel Naom (Public Library of Science, 2012)
      Rationale: Asthma has substantial morbidity and mortality and a strong genetic component, but identification of genetic risk factors is limited by availability of suitable studies. Objectives: To test if population-based ...

    • Genome-Wide Association Studies of Multiple Keratinocyte Cancers 

      Pardo, Luba M.; Li, Wen-Qing; Hwang, Shih-Jen; Verkouteren, Joris A. C.; Hofman, Albert; Uitterlinden, André G.; Kraft, Peter; Turman, Constance; Han, Jiali; Cho, Eunyoung; Murabito, Joanne M.; Levy, Daniel; Qureshi, Abrar A.; Nijsten, Tamar (Public Library of Science, 2017)
      There is strong evidence for a role of environmental risk factors involved in susceptibility to develop multiple keratinocyte cancers (mKCs), but whether genes are also involved in mKCs susceptibility has not been thoroughly ...

    • Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers 

      Stein, Murray B.; Chen, Chia-Yen; Ursano, Robert J.; Cai, Tianxi; Gelernter, Joel; Heeringa, Steven G.; Jain, Sonia; Jensen, Kevin P.; Maihofer, Adam X.; Mitchell, Colter; Nievergelt, Caroline M.; Nock, Matthew K.; Neale, Benjamin Michael; Polimanti, Renato; Ripke, Stephan; Sun, Xiaoying; Thomas, Michael; Wang, Qian; Ware, Erin B.; Borja, Susan; Kessler, Ronald; Smoller, Jordan W; undefined, undefined (American Medical Association (AMA), 2016)
      Importance Posttraumatic stress disorder (PTSD) is a prevalent, serious public health concern, particularly in the military. The identification of genetic risk factors for PTSD may provide important insights into the ...

    • Genome-Wide Association Studies of Serum Magnesium, Potassium, and Sodium Concentrations Identify Six Loci Influencing Serum Magnesium Levels 

      Meyer, Tamra E.; Verwoert, Germaine C.; Hwang, Shih-Jen; Glazer, Nicole L.; Smith, Albert V.; van Rooij, Frank J. A.; Ehret, Georg B.; Boerwinkle, Eric; Felix, Janine F.; Leak, Tennille S.; Harris, Tamara B.; Yang, Qiong; Dehghan, Abbas; Aspelund, Thor; Katz, Ronit; Homuth, Georg; Kocher, Thomas; Rettig, Rainer; Ried, Janina S.; Gieger, Christian; Prucha, Hanna; Pfeufer, Arne; Meitinger, Thomas; Coresh, Josef; Sarnak, Mark J.; Chen, Yii-Der Ida; Uitterlinden, André G.; Chakravarti, Aravinda; Psaty, Bruce M.; van Duijn, Cornelia M.; Witteman, Jacqueline C. M.; Gudnason, Vilmundur; Siscovick, David S.; Köttgen, Anna; Hofman, Albert; Kao, W. H. Linda; Fox, Caroline (Public Library of Science, 2010)
      Magnesium, potassium, and sodium, cations commonly measured in serum, are involved in many physiological processes including energy metabolism, nerve and muscle function, signal transduction, and fluid and blood pressure ...