Browsing HMS Scholarly Articles by Title

Now showing items 7070-7089 of 17922

    • A Genome-Wide “Pleiotropy Scan” Does Not Identify New Susceptibility Loci for Estrogen Receptor Negative Breast Cancer 

      Campa, Daniele; Barrdahl, Myrto; Tsilidis, Konstantinos K.; Severi, Gianluca; Diver, W. Ryan; Siddiq, Afshan; Chanock, Stephen; Hoover, Robert N.; Ziegler, Regina G.; Berg, Christine D.; Buys, Saundra S.; Haiman, Christopher A.; Henderson, Brian E.; Schumacher, Fredrick R.; Le Marchand, Loïc; Flesch-Janys, Dieter; Lindström, Sara; Hunter, David J.; Hankinson, Susan E.; Willett, Walter C.; Kraft, Peter; Cox, David G.; Khaw, Kay-Tee; Tjønneland, Anne; Dossus, Laure; Trichopoulos, Dimitrios; Panico, Salvatore; van Gils, Carla H.; Weiderpass, Elisabete; Barricarte, Aurelio; Sund, Malin; Gaudet, Mia M.; Giles, Graham; Southey, Melissa; Baglietto, Laura; Chang-Claude, Jenny; Kaaks, Rudolf; Canzian, Federico (Public Library of Science, 2014)
      Approximately 15–30% of all breast cancer tumors are estrogen receptor negative (ER−). Compared with ER-positive (ER+) disease they have an earlier age at onset and worse prognosis. Despite the vast number of risk variants ...

    • Genomewide Association Study for Onset Age in Parkinson Disease 

      Latourelle, Jeanne C; Pankratz, Nathan; Dumitriu, Alexandra; Wilk, Jemma B; Goldwurm, Stefano; Pezzoli, Gianni; Mariani, Claudio B; DeStefano, Anita L; Halter, Cheryl; Nichols, William C; Foroud, Tatiana; Gusella, James Francis; Myers, Richard Hepworth (BioMed Central, 2009)
      Background: Age at onset in Parkinson disease (PD) is a highly heritable quantitative trait for which a significant genetic influence is supported by multiple segregation analyses. Because genes associated with onset age ...

    • Genomewide meta‐analysis identifies loci associated with IGF‐I and IGFBP‐3 levels with impact on age‐related traits 

      Teumer, Alexander; Qi, Qibin; Nethander, Maria; Aschard, Hugues; Bandinelli, Stefania; Beekman, Marian; Berndt, Sonja I.; Bidlingmaier, Martin; Broer, Linda; Cappola, Anne; Ceda, Gian Paolo; Chanock, Stephen; Chen, Ming‐Huei; Chen, Tai C.; Chen, Yii‐Der Ida; Chung, Jonathan; Del Greco Miglianico, Fabiola; Eriksson, Joel; Ferrucci, Luigi; Friedrich, Nele; Gnewuch, Carsten; Goodarzi, Mark O.; Grarup, Niels; Guo, Tingwei; Hammer, Elke; Hayes, Richard B.; Hicks, Andrew A.; Hofman, Albert; Houwing‐Duistermaat, Jeanine J.; Hu, Frank; Hunter, David J.; Husemoen, Lise L.; Isaacs, Aaron; Jacobs, Kevin B.; Janssen, Joop A. M. J. L.; Jansson, John‐Olov; Jehmlich, Nico; Johnson, Simon; Juul, Anders; Karlsson, Magnus; Kilpelainen, Tuomas O.; Kovacs, Peter; Kraft, Peter; Li, Chao; Linneberg, Allan; Liu, Yongmei; Loos, Ruth J. F.; Lorentzon, Mattias; Lu, Yingchang; Maggio, Marcello; Magi, Reedik; Meigs, James; Mellström, Dan; Nauck, Matthias; Newman, Anne B.; Pollak, Michael N.; Pramstaller, Peter P.; Prokopenko, Inga; Psaty, Bruce M.; Reincke, Martin; Rimm, Eric B.; Rotter, Jerome I.; Saint Pierre, Aude; Schurmann, Claudia; Seshadri, Sudha; Sjögren, Klara; Slagboom, P. Eline; Strickler, Howard D.; Stumvoll, Michael; Suh, Yousin; Sun, Qi; Zhang, Cuilin; Svensson, Johan; Tanaka, Toshiko; Tare, Archana; Tönjes, Anke; Uh, Hae‐Won; van Duijn, Cornelia M.; van Heemst, Diana; Vandenput, Liesbeth; Vasan, Ramachandran S.; Völker, Uwe; Willems, Sara M.; Ohlsson, Claes; Wallaschofski, Henri; Kaplan, Robert C. (John Wiley and Sons Inc., 2016)
      Summary The growth hormone/insulin‐like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF‐related proteins including IGF‐I and IGF‐binding protein‐3 (IGFBP‐3) have also been implicated ...

    • Genomewide Pattern of Synonymous Nucleotide Substitution in Two Complete Genomes of Mycobacterium tuberculosis 

      Hughes, Austin L.; Friedman, Robert; Murray, Megan Blanche (Centers for Disease Control and Prevention, 2002)
      Comparison of the pattern of synonymous nucleotide substitution between two complete genomes of Mycobacterium tuberculosis at 3,298 putatively orthologous loci showed a mean percent difference per synonymous site of 0.000328 ...

    • Genomewide screens for Escherichia coli genes affecting growth of T7 bacteriophage 

      Qimron, Udi; Marintcheva, Boriana; Tabor, Stanley; Richardson, Charles C. (National Academy of Sciences, 2006)
      Use of bacteriophages as a therapy for bacterial infection has been attempted over the last century. Such an endeavor requires the elucidation of basic aspects of the host-virus interactions and the resistance mechanisms ...

    • Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer 

      Kimmelman, Alec C.; Hezel, Aram F.; Aguirre, Andrew J.; Zheng, Hongwu; Paik, Ji-hye; Ying, Haoqiang; Chu, Gerald C.; Zhang, Jean X.; Sahin, Ergun; Yeo, Giminna; Ponugoti, Aditya; Nabioullin, Roustem; Deroo, Scott; Yang, Shenghong; Wang, Xiaoxu; McGrath, John P.; Protopopova, Marina; Ivanova, Elena; Zhang, Jianhua; Feng, Bin; Tsao, Ming S.; Redston, Mark; Protopopov, Alexei; Xiao, Yonghong; Futreal, P. Andrew; Hahn, William C.; Klimstra, David S.; Chin, Lynda; DePinho, Ronald A. (National Academy of Sciences, 2008)
      Pancreas ductal adenocarcinoma (PDAC) is a highly lethal cancer that typically presents as advanced, unresectable disease. This invasive tendency, coupled with intrinsic resistance to standard therapies and genome instability, ...

    • Genomic analyses of Neisseria gonorrhoeae reveal an association of the gonococcal genetic island with antimicrobial resistance 

      Harrison, Odile B.; Clemence, Marianne; Dillard, Joseph P.; Tang, Christoph M.; Trees, David; Grad, Yonatan H.; Maiden, Martin C.J. (W.B. Saunders, 2016)
      Summary Objectives: Antimicrobial resistance (AMR) threatens our ability to treat the sexually transmitted bacterial infection gonorrhoea. The increasing availability of whole genome sequence (WGS) data from Neisseria ...

    • Genomic Analysis Identifies Targets of Convergent Positive Selection in Drug Resistant Mycobacterium tuberculosis 

      Farhat, Maha R; Shapiro, B Jesse; Kieser, Karen J; Sultana, Razvan; Jacobson, Karen R; Victor, Thomas C; Warren, Robin M; Streicher, Elizabeth M; Calver, Alistair; Sloutsky, Alex; Kaur, Devinder; Posey, Jamie E; Plikaytis, Bonnie; Oggioni, Marco R; Gardy, Jennifer L; Johnston, James C; Rodrigues, Mabel; Tang, Patrick K C; Kato-Maeda, Midori; Borowsky, Mark L; Muddukrishna, Bhavana; Kreiswirth, Barry N; Kurepina, Natalia; Galagan, James; Gagneux, Sebastien; Birren, Bruce; Rubin, Eric J; Lander, Eric S; Sabeti, Pardis C; Murray, Megan (2013)
      Mycobacterium tuberculosis is successfully evolving antibiotic resistance, threatening attempts at tuberculosis epidemic control. Mechanisms of resistance, including the genetic changes favored by selection in resistant ...

    • Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1 

      Ramkissoon, Lori; Horowitz, Peleg; Craig, Justin; Ramkissoon, Shakti; Rich, Benjamin; Schumacher, Steven; McKenna, Aaron; Lawrence, Michael; Bergthold, Guillaume; Brastianos, Priscilla; Tabak, Barbara; Ducar, Matthew; Van Hummelen, Paul; MacConaill, Laura; Pouissant-Young, Tina; Cho, Yoon-Jae; Taha, Hala; Mahmoud, Madeha; Bowers, Daniel; Margraf, Linda; Tabori, Uri; Hawkins, Cynthia; Packer, Roger; Hill, D. Ashley; Pomeroy, Scott; Eberhart, Charles; Dunn, Ian; Goumnerova, Liliana; Getz, Gad; Chan, Jennifer; Santagata, Sandro; Hahn, William; Stiles, Charles; Ligon, Azra; Kieran, Mark; Beroukhim, Rameen; Ligon, Keith (National Academy of Sciences, 2013)
      Pediatric low-grade gliomas (PLGGs) are among the most common solid tumors in children but, apart from BRAF kinase mutations or duplications in specific subclasses, few genetic driver events are known. Diffuse PLGGs comprise ...

    • Genomic Analysis of LexA Binding Reveals the Permissive Nature of the Escherichia Coli Genome and Identifies Unconventional Target Sites 

      Wade, Joseph T.; Reppas, Nikos B.; Church, George; Struhl, Kevin (Cold Spring Harbor Laboratory, 2005-11-01)

    • Genomic Analysis of Plasma Cell-Free DNA in Patients With Cancer 

      Oxnard, Geoffrey Raymond; Paweletz, Cloud; Sholl, Lynette Marie (American Medical Association (AMA), 2016)
      The increased importance of cancer genotyping in guiding cancer treatment has created a need for efficient methods for genomic analysis of patients’ cancers. This increased dependence on DNA-based tumor genotyping assays ...

    • Genomic Analysis of the Basal Lineage Fungus Rhizopus oryzae Reveals a Whole-Genome Duplication 

      Ma, Li-Jun; Ibrahim, Ashraf S.; Skory, Christopher; Grabherr, Manfred G.; Burger, Gertraud; Butler, Margi; Elias, Marek; Idnurm, Alexander; Lang, B. Franz; Sone, Teruo; Abe, Ayumi; Corrochano, Luis M.; Fu, Jianmin; Hansberg, Wilhelm; Kim, Jung-Mi; Kodira, Chinnappa D.; Koehrsen, Michael J.; Miranda-Saavedra, Diego; O'Leary, Sinead; Ortiz-Castellanos, Lucila; Poulter, Russell; Rodriguez-Romero, Julio; Ruiz-Herrera, José; Shen, Yao-Qing; Zeng, Qiandong; Birren, Bruce W.; Cuomo, Christina A.; Wickes, Brian L.; Calvo, Sarah E; Engels, Reinhard; Galagan, James E; Liu, Bo (Public Library of Science, 2009)
      Rhizopus oryzae is the primary cause of mucormycosis, an emerging, life-threatening infection characterized by rapid angioinvasive growth with an overall mortality rate that exceeds 50%. As a representative of the paraphyletic ...

    • Genomic Analysis of the Evolution of Fluoroquinolone Resistance in Mycobacterium tuberculosis Prior to Tuberculosis Diagnosis 

      Zhang, Danfeng; Gomez, James; Chien, Jung-Yien; Haseley, Nathan; Desjardins, Christopher; Earl, Ashlee; Hsueh, Po-Ren; Hung, Deborah (American Society for Microbiology, 2016)
      Fluoroquinolones (FQs) are effective second-line drugs for treating antibiotic-resistant tuberculosis (TB) and are being considered for use as first-line agents. Because FQs are used to treat a range of infections, in a ...

    • Genomic Analysis of the Hydrocarbon-Producing, Cellulolytic, Endophytic Fungus Ascocoryne sarcoides 

      Sboner, Andrea; Kodira, Chinnappa; Egholm, Michael; Church, George McDonald; Gianoulis, Tara A.; Griffin, Meghan A.; Spakowicz, Daniel J.; Dunican, Brian F.; Alpha, Cambria J.; Sismour, A. Michael; Gerstein, Mark B.; Strobel, Scott A. (Public Library of Science, 2012)
      The microbial conversion of solid cellulosic biomass to liquid biofuels may provide a renewable energy source for transportation fuels. Endophytes represent a promising group of organisms, as they are a mostly untapped ...

    • Genomic and Clinical Effects Associated with a Relaxation Response Mind-Body Intervention in Patients with Irritable Bowel Syndrome and Inflammatory Bowel Disease 

      Kuo, Braden; Bhasin, Manoj; Jacquart, Jolene; Scult, Matthew A.; Slipp, Lauren; Riklin, Eric Isaac Kagan; Lepoutre, Veronique; Comosa, Nicole; Norton, Beth-Ann; Dassatti, Allison; Rosenblum, Jessica; Thurler, Andrea H.; Surjanhata, Brian C.; Hasheminejad, Nicole N.; Kagan, Leslee; Slawsby, Ellen; Rao, Sowmya R.; Macklin, Eric A.; Fricchione, Gregory L.; Benson, Herbert; Libermann, Towia A.; Korzenik, Joshua; Denninger, John W. (Public Library of Science, 2015)
      Introduction: Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD) can profoundly affect quality of life and are influenced by stress and resiliency. The impact of mind-body interventions (MBIs) on IBS and ...

    • A genomic and evolutionary approach reveals non-genetic drug resistance in malaria 

      Herman, Jonathan D; Rice, Daniel P; Ribacke, Ulf; Silterra, Jacob; Deik, Amy A; Moss, Eli L; Broadbent, Kate M; Neafsey, Daniel E; Desai, Michael M; Clish, Clary B; Mazitschek, Ralph; Wirth, Dyann F (BioMed Central, 2014)
      Background: Drug resistance remains a major public health challenge for malaria treatment and eradication. Individual loci associated with drug resistance to many antimalarials have been identified, but their epistasis ...

    • Genomic and functional analyses of Mycobacterium tuberculosis strains implicate ald in D-cycloserine resistance 

      Desjardins, Christopher A.; Cohen, Keira A.; Munsamy, Vanisha; Abeel, Thomas; Maharaj, Kashmeel; Walker, Bruce J.; Shea, Terrance P.; Almeida, Deepak V.; Manson, Abigail L.; Salazar, Alex; Padayatchi, Nesri; O’Donnell, Max R.; Mlisana, Koleka P.; Wortman, Jennifer; Birren, Bruce W.; Grosset, Jacques; Earl, Ashlee M.; Pym, Alexander S. (2016)
      A more complete understanding of the genetic basis of drug resistance in Mycobacterium tuberculosis is critical for prompt diagnosis and optimal treatment, particularly for toxic second-line drugs like D-cycloserine. Here, ...

    • Genomic and Functional Analysis of ICEPdaSpa1, a Fish-Pathogen-Derived SXT-Related Integrating Conjugative Element That Can Mobilize a Virulence Plasmid 

      Osorio, Carlos R.; Marrero, Joeli; Wozniak, Rachel F.; Lemos, Manuel L.; Burrus, Vincent; Waldor, Matthew K. (American Society for Microbiology, 2008)
      Integrating conjugative elements (ICEs) are self-transmissible mobile elements that transfer between bacteria via conjugation and integrate into the host chromosome. SXT and related ICEs became prevalent in Asian Vibrio ...

    • A genomic case study of mixed fibrolamellar hepatocellular carcinoma 

      Griffith, O. L.; Griffith, M.; Krysiak, K.; Magrini, V.; Ramu, A.; Skidmore, Z. L.; Kunisaki, J.; Austin, R.; McGrath, S.; Zhang, J.; Demeter, R.; Graves, T.; Eldred, J. M.; Walker, J.; Larson, D. E.; Maher, C. A.; Lin, Y.; Chapman, W.; Mahadevan, A.; Miksad, R.; Nasser, I.; Hanto, D. W.; Mardis, E. R. (Oxford University Press, 2016)
      Background: Mixed fibrolamellar hepatocellular carcinoma (mFL-HCC) is a rare liver tumor defined by the presence of both pure FL-HCC and conventional HCC components, represents up to 25% of cases of FL-HCC, and has been ...

    • Genomic characterization of non-O1, non-O139 Vibrio cholerae reveals genes for a type III secretion system 

      Dziejman, Michelle; Serruto, Davide; Tam, Vincent C.; Sturtevant, Derek; Diraphat, Pornphan; Faruque, Shah M.; Rahman, M. Hasibur; Heidelberg, John F.; Decker, Jeremy; Li, Li; Montgomery, Kate T.; Grills, George; Kucherlapati, Raju; Mekalanos, John J. (National Academy of Sciences, 2005)
      Non-O1, non-O139 Vibrio cholerae can cause gastroenteritis and extraintestinal infections, but, unlike O1 and O139 strains of V. cholerae, little is known about the virulence gene content of non-O1, non-O139 strains and ...