Now showing items 7144-7163 of 17918

    • Getting a Head Start: The Importance of Personal Genetics Education in High Schools 

      Kung, Johnny Tsun-Yi; Gelbart, Marnie E. (Yale School of Medicine, 2012)
      With advances in sequencing technology, widespread and affordable genome sequencing will soon be a reality. However, studies suggest that “genetic literacy” of the general public is inadequate to prepare our society for ...
    • Getting Tie(2)d up in angiogenesis 

      Ramsauer, Markus; D'Amore, Patricia Ann (American Society for Clinical Investigation, 2002)
      Angiogenesis, the growth of new vessels from pre-existing blood vessels, requires complex signaling pathways and a high degree of spatial and temporal coordination among various cell types, multiple pro- and anti-angiogenic ...
    • Getting under the Skin: Report from the International Psoriasis Council Workshop on the Role of Stress in Psoriasis 

      Schwartz, Julia; Evers, Andrea W. M.; Bundy, Christine; Kimball, Alexandra B. (Frontiers Media S.A., 2016)
      Psoriasis is a chronic inflammatory skin condition with significant physical and psychosocial comorbidity. A workshop of leading experts in dermatology and psychology with the purpose of better understanding the current ...
    • GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo 

      Bach, Erika A.; Ekas, Laura A.; Ayala-Camargo, Aidee; Flaherty, Maria Sol; Lee, Haeryun; Perrimon, Norbert; Baeg, Gyeong-Hun (Elsevier, 2007)
    • GGPPS1 predicts the biological character of hepatocellular carcinoma in patients with cirrhosis 

      Yu, De-cai; Liu, Jia; Chen, Jun; Shao, Jiao-jiao; Shen, Xiao; Xia, Hong-guang; Li, Chao-jun; Xue, Bin; Ding, Yi-tao (BioMed Central, 2014)
      Background: Hepatocellular carcinoma (HCC) has been associated with diabetes and obesity, but a possible connection with the metabolic syndrome (MetS) and its potential interaction with hepatitis and cirrhosis are open to ...
    • Ghana randomized air pollution and health study (GRAPHS): study protocol for a randomized controlled trial 

      Jack, Darby W.; Asante, Kwaku Poku; Wylie, Blair J.; Chillrud, Steve N.; Whyatt, Robin M.; Ae-Ngibise, Kenneth A.; Quinn, Ashlinn K.; Yawson, Abena Konadu; Boamah, Ellen Abrafi; Agyei, Oscar; Mujtaba, Mohammed; Kaali, Seyram; Kinney, Patrick; Owusu-Agyei, Seth (BioMed Central, 2015)
      Background: Household air pollution exposure is a major health risk, but validated interventions remain elusive. Methods/Design The Ghana Randomized Air Pollution and Health Study (GRAPHS) is a cluster-randomized trial ...
    • Ghrelin 

      Müller, T.D.; Nogueiras, R.; Andermann, M.L.; Andrews, Z.B.; Anker, S.D.; Argente, J.; Batterham, R.L.; Benoit, S.C.; Bowers, C.Y.; Broglio, F.; Casanueva, F.F.; D'Alessio, D.; Depoortere, I.; Geliebter, A.; Ghigo, E.; Cole, P.A.; Cowley, M.; Cummings, D.E.; Dagher, A.; Diano, S.; Dickson, S.L.; Diéguez, C.; Granata, R.; Grill, H.J.; Grove, K.; Habegger, K.M.; Heppner, K.; Heiman, M.L.; Holsen, L.; Holst, B.; Inui, A.; Jansson, J.O.; Kirchner, H.; Korbonits, M.; Laferrère, B.; LeRoux, C.W.; Lopez, M.; Morin, S.; Nakazato, M.; Nass, R.; Perez-Tilve, D.; Pfluger, P.T.; Schwartz, T.W.; Seeley, R.J.; Sleeman, M.; Sun, Y.; Sussel, L.; Tong, J.; Thorner, M.O.; van der Lely, A.J.; van der Ploeg, L.H.T.; Zigman, J.M.; Kojima, M.; Kangawa, K.; Smith, R.G.; Horvath, T.; Tschöp, M.H. (Elsevier, 2015)
      Background: The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the ...
    • Ghrelin Modulates Physiologic and Pathologic Retinal Angiogenesis through GHSR-1a 

      Zaniolo, Karine; Sapieha, Przemyslaw; Shao, Zhuo; Stahl, Andreas; Zhu, Tang; Tremblay, Sophie; Picard, Emilie; Madaan, Ankush; Blais, Martine; Lachapelle, Pierre; Mancini, Joseph; Hardy, Pierre; Smith, Lois Elaine Hodgson; Ong, Huy; Chemtob, Sylvain (Association for Research in Vision and Ophthalmology (ARVO), 2011)
      PURPOSE: Vascular degeneration and the ensuing abnormal vascular proliferation are central to proliferative retinopathies. Given the metabolic discordance associated with these diseases, the authors explored the role of ...
    • Giant Adrenal Myelolipoma Masquerading as Heart Failure 

      Joy, Parijat S.; Marak, Creticus P.; Nashed, Nadia S.; Guddati, Achuta K. (S. Karger AG, 2014)
      Adrenal myelolipomas are rare benign tumors of the adrenal cortex composed of adipose and hematopoietic cells. They have been postulated to arise from repeated stimulation by stress, inflammation and ACTH oversecretion. ...
    • Giant mesenteric lymphatic malformation presenting as small bowel volvulus 

      Cauley, Christy E.; Spencer, Philip J.; Sagar, Pallavi; Goldstein, Allan M. (Oxford University Press, 2013)
      Abdominal pain with bilious emesis is an ominous clinical presentation with many possible causes. We describe a previously healthy 4-year-old boy who presented with these symptoms and ultrasound findings of fluid throughout ...
    • Giant Pyogenic Granuloma in a Patient with Chronic Lymphocytic Leukemia 

      Plovanich, Molly; Tsibris, Hillary C.; Lian, Christine G.; Mostaghimi, Arash (S. Karger AG, 2014)
      Pyogenic granuloma, also known as lobular capillary hemangioma, is a common benign vascular proliferative lesion that can present at any age on the skin or mucous membranes. Most lesions do not exceed 2 cm, but there are ...
    • Gibbon genome and the fast karyotype evolution of small apes 

      Carbone, Lucia; Harris, R. Alan; Gnerre, Sante; Veeramah, Krishna R.; Lorente-Galdos, Belen; Huddleston, John; Meyer, Thomas J.; Herrero, Javier; Roos, Christian; Aken, Bronwen; Anaclerio, Fabio; Archidiacono, Nicoletta; Baker, Carl; Barrell, Daniel; Batzer, Mark A.; Beal, Kathryn; Blancher, Antoine; Bohrson, Craig L.; Brameier, Markus; Campbell, Michael S.; Capozzi, Oronzo; Casola, Claudio; Chiatante, Giorgia; Cree, Andrew; Damert, Annette; de Jong, Pieter J.; Dumas, Laura; Fernandez-Callejo, Marcos; Flicek, Paul; Fuchs, Nina V.; Gut, Marta; Gut, Ivo; Hahn, Matthew W.; Hernandez-Rodriguez, Jessica; Hillier, LaDeana W.; Hubley, Robert; Ianc, Bianca; Izsvák, Zsuzsanna; Jablonski, Nina G.; Johnstone, Laurel M.; Karimpour-Fard, Anis; Konkel, Miriam K.; Kostka, Dennis; Lazar, Nathan H.; Lee, Sandra L.; Lewis, Lora R.; Liu, Yue; Locke, Devin P.; Mallick, Swapan; Mendez, Fernando L.; Muffato, Matthieu; Nazareth, Lynne V.; Nevonen, Kimberly A.; O,Bleness, Majesta; Ochis, Cornelia; Odom, Duncan T.; Pollard, Katherine S.; Quilez, Javier; Reich, David; Rocchi, Mariano; Schumann, Gerald G.; Searle, Stephen; Sikela, James M.; Skollar, Gabriella; Smit, Arian; Sonmez, Kemal; Hallers, Boudewijn ten; Terhune, Elizabeth; Thomas, Gregg W.C.; Ullmer, Brygg; Ventura, Mario; Walker, Jerilyn A.; Wall, Jeffrey D.; Walter, Lutz; Ward, Michelle C.; Wheelan, Sarah J.; Whelan, Christopher W.; White, Simon; Wilhelm, Larry J.; Woerner, August E.; Yandell, Mark; Zhu, Baoli; Hammer, Michael F.; Marques-Bonet, Tomas; Eichler, Evan E.; Fulton, Lucinda; Fronick, Catrina; Muzny, Donna M.; Warren, Wesley C.; Worley, Kim C.; Rogers, Jeffrey; Wilson, Richard K.; Gibbs, Richard A. (2014)
      Gibbons are small arboreal apes that display an accelerated rate of evolutionary chromosomal rearrangement and occupy a key node in the primate phylogeny between Old World monkeys and great apes. Here we present the assembly ...
    • GiniClust: detecting rare cell types from single-cell gene expression data with Gini index 

      Jiang, Lan; Chen, Huidong; Pinello, Luca; Yuan, Guo-Cheng (BioMed Central, 2016)
      High-throughput single-cell technologies have great potential to discover new cell types; however, it remains challenging to detect rare cell types that are distinct from a large population. We present a novel computational ...
    • GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers 

      Mermel, Craig H.; Schumacher, Steven E.; Hill, Barbara; Meyerson, Matthew L.; Beroukhim, Rameen; Getz, Gad (BMC, 2011)
      We describe methods with enhanced power and specificity to identify genes targeted by somatic copy-number alterations (SCNAs) that drive cancer growth. By separating SCNA profiles into underlying arm-level and focal ...
    • GJB2 mutation spectrum in 2063 Chinese patients with nonsyndromic hearing impairment 

      Dai, Pu; Yu, Fei; Liu, Xuezhong; Wang, Guojian; Yuan, Yongyi; Huang, Deliang; Kang, Dongyang; Yuan, Huijun; Yao, Kun; Hao, Jinsheng; He, Yong; Wang, Youqin; Ye, Qing; Yu, Youjun; Lin, Hongyan; Liu, Lijia; Deng, Wei; Zhu, Xiuhui; You, Yiwen; Cui, Jinghong; Hou, Nongsheng; Xu, Xuehai; Song, Rendong; Lin, Yongjun; Sun, Shuanzhu; Zhang, Ruining; Ma, Yuebing; Zhu, Shanxiang; Han, Dongyi; Wong, Lee-Jun C; Wu, Bai-Lin; Han, Bing; Li, Qi; Liu, Xin; Zhang, Xin; He, Jia; Zhang, Jin; Tang, Liang; Wu, Hao (BioMed Central, 2009)
      Background: Mutations in GJB2 are the most common molecular defects responsible for autosomal recessive nonsyndromic hearing impairment (NSHI). The mutation spectra of this gene vary among different ethnic groups. Methods: ...
    • Glatiramer Acetate (Copaxone) Modulates Platelet Activation and Inhibits Thrombin-Induced Calcium Influx: Possible Role of Copaxone in Targeting Platelets during Autoimmune Neuroinflammation 

      Starossom, Sarah C.; Veremeyko, Tatyana; Dukhinova, Marina; Yung, Amanda W. Y.; Ponomarev, Eugene D. (Public Library of Science, 2014)
      Background: Glatiramer acetate (GA, Copaxone, Copolymer-1) is an FDA approved drug for the treatment of MS and it is very effective in suppressing neuroinflammation in experimental autoimmune encephalitis (EAE), an animal ...
    • Glaucoma Screening in the Haitian Afro-Caribbean Population of South Florida 

      Bokman, Christine L.; Pasquale, Louis R.; Parrish, Richard K.; Lee, Richard K. (Public Library of Science, 2014)
      Objective: To evaluate the presence of clinical signs consistent with suspected glaucoma in Haitian Afro-Caribbean individuals residing in South Florida who do not receive regular eye examinations. Design: Retrospective, ...
    • Glc-TOR signalling leads transcriptome reprogramming and meristem activation 

      Xiong, Yan; McCormack, Matthew; Li, Lei; Hall, Qi; Xiang, Chengbin; Sheen, Jen (2013)
      Meristems encompass stem/progenitor cells that sustain postembryonic growth of all plant organs. How meristems are activated and sustained by nutrient signalling remains enigmatic in photosynthetic plants. Combining chemical ...
    • Glenohumeral Joint Kinematics following Clavicular Fracture and Repairs 

      Rosso, Claudio; Nasr, Michael; Walley, Kempland C.; Harlow, Ethan R.; Haghpanah, Babak; Vaziri, Ashkan; Ramappa, Arun J.; Nazarian, Ara; DeAngelis, Joseph P. (Public Library of Science, 2017)
      Background: The purpose of this biomechanical study was to determine the effect of shortened clavicle malunion on the center of rotation of the glenohumeral (GH) joint, and the capacity of repair to restore baseline ...
    • Glial activation colocalizes with structural abnormalities in amyotrophic lateral sclerosis 

      Alshikho, Mohamad J.; Zürcher, Nicole R.; Loggia, Marco L.; Cernasov, Paul; Chonde, Daniel B.; Izquierdo Garcia, David; Yasek, Julia E.; Akeju, Oluwaseun; Catana, Ciprian; Rosen, Bruce R.; Cudkowicz, Merit E.; Hooker, Jacob M.; Atassi, Nazem (Lippincott Williams & Wilkins, 2016)
      Objective: In this cross-sectional study, we aimed to evaluate brain structural abnormalities in relation to glial activation in the same cohort of participants. Methods: Ten individuals with amyotrophic lateral sclerosis ...