Now showing items 7153-7172 of 17918

    • Giant mesenteric lymphatic malformation presenting as small bowel volvulus 

      Cauley, Christy E.; Spencer, Philip J.; Sagar, Pallavi; Goldstein, Allan M. (Oxford University Press, 2013)
      Abdominal pain with bilious emesis is an ominous clinical presentation with many possible causes. We describe a previously healthy 4-year-old boy who presented with these symptoms and ultrasound findings of fluid throughout ...
    • Giant Pyogenic Granuloma in a Patient with Chronic Lymphocytic Leukemia 

      Plovanich, Molly; Tsibris, Hillary C.; Lian, Christine G.; Mostaghimi, Arash (S. Karger AG, 2014)
      Pyogenic granuloma, also known as lobular capillary hemangioma, is a common benign vascular proliferative lesion that can present at any age on the skin or mucous membranes. Most lesions do not exceed 2 cm, but there are ...
    • Gibbon genome and the fast karyotype evolution of small apes 

      Carbone, Lucia; Harris, R. Alan; Gnerre, Sante; Veeramah, Krishna R.; Lorente-Galdos, Belen; Huddleston, John; Meyer, Thomas J.; Herrero, Javier; Roos, Christian; Aken, Bronwen; Anaclerio, Fabio; Archidiacono, Nicoletta; Baker, Carl; Barrell, Daniel; Batzer, Mark A.; Beal, Kathryn; Blancher, Antoine; Bohrson, Craig L.; Brameier, Markus; Campbell, Michael S.; Capozzi, Oronzo; Casola, Claudio; Chiatante, Giorgia; Cree, Andrew; Damert, Annette; de Jong, Pieter J.; Dumas, Laura; Fernandez-Callejo, Marcos; Flicek, Paul; Fuchs, Nina V.; Gut, Marta; Gut, Ivo; Hahn, Matthew W.; Hernandez-Rodriguez, Jessica; Hillier, LaDeana W.; Hubley, Robert; Ianc, Bianca; Izsvák, Zsuzsanna; Jablonski, Nina G.; Johnstone, Laurel M.; Karimpour-Fard, Anis; Konkel, Miriam K.; Kostka, Dennis; Lazar, Nathan H.; Lee, Sandra L.; Lewis, Lora R.; Liu, Yue; Locke, Devin P.; Mallick, Swapan; Mendez, Fernando L.; Muffato, Matthieu; Nazareth, Lynne V.; Nevonen, Kimberly A.; O,Bleness, Majesta; Ochis, Cornelia; Odom, Duncan T.; Pollard, Katherine S.; Quilez, Javier; Reich, David; Rocchi, Mariano; Schumann, Gerald G.; Searle, Stephen; Sikela, James M.; Skollar, Gabriella; Smit, Arian; Sonmez, Kemal; Hallers, Boudewijn ten; Terhune, Elizabeth; Thomas, Gregg W.C.; Ullmer, Brygg; Ventura, Mario; Walker, Jerilyn A.; Wall, Jeffrey D.; Walter, Lutz; Ward, Michelle C.; Wheelan, Sarah J.; Whelan, Christopher W.; White, Simon; Wilhelm, Larry J.; Woerner, August E.; Yandell, Mark; Zhu, Baoli; Hammer, Michael F.; Marques-Bonet, Tomas; Eichler, Evan E.; Fulton, Lucinda; Fronick, Catrina; Muzny, Donna M.; Warren, Wesley C.; Worley, Kim C.; Rogers, Jeffrey; Wilson, Richard K.; Gibbs, Richard A. (2014)
      Gibbons are small arboreal apes that display an accelerated rate of evolutionary chromosomal rearrangement and occupy a key node in the primate phylogeny between Old World monkeys and great apes. Here we present the assembly ...
    • GiniClust: detecting rare cell types from single-cell gene expression data with Gini index 

      Jiang, Lan; Chen, Huidong; Pinello, Luca; Yuan, Guo-Cheng (BioMed Central, 2016)
      High-throughput single-cell technologies have great potential to discover new cell types; however, it remains challenging to detect rare cell types that are distinct from a large population. We present a novel computational ...
    • GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers 

      Mermel, Craig H.; Schumacher, Steven E.; Hill, Barbara; Meyerson, Matthew L.; Beroukhim, Rameen; Getz, Gad (BMC, 2011)
      We describe methods with enhanced power and specificity to identify genes targeted by somatic copy-number alterations (SCNAs) that drive cancer growth. By separating SCNA profiles into underlying arm-level and focal ...
    • GJB2 mutation spectrum in 2063 Chinese patients with nonsyndromic hearing impairment 

      Dai, Pu; Yu, Fei; Liu, Xuezhong; Wang, Guojian; Yuan, Yongyi; Huang, Deliang; Kang, Dongyang; Yuan, Huijun; Yao, Kun; Hao, Jinsheng; He, Yong; Wang, Youqin; Ye, Qing; Yu, Youjun; Lin, Hongyan; Liu, Lijia; Deng, Wei; Zhu, Xiuhui; You, Yiwen; Cui, Jinghong; Hou, Nongsheng; Xu, Xuehai; Song, Rendong; Lin, Yongjun; Sun, Shuanzhu; Zhang, Ruining; Ma, Yuebing; Zhu, Shanxiang; Han, Dongyi; Wong, Lee-Jun C; Wu, Bai-Lin; Han, Bing; Li, Qi; Liu, Xin; Zhang, Xin; He, Jia; Zhang, Jin; Tang, Liang; Wu, Hao (BioMed Central, 2009)
      Background: Mutations in GJB2 are the most common molecular defects responsible for autosomal recessive nonsyndromic hearing impairment (NSHI). The mutation spectra of this gene vary among different ethnic groups. Methods: ...
    • Glatiramer Acetate (Copaxone) Modulates Platelet Activation and Inhibits Thrombin-Induced Calcium Influx: Possible Role of Copaxone in Targeting Platelets during Autoimmune Neuroinflammation 

      Starossom, Sarah C.; Veremeyko, Tatyana; Dukhinova, Marina; Yung, Amanda W. Y.; Ponomarev, Eugene D. (Public Library of Science, 2014)
      Background: Glatiramer acetate (GA, Copaxone, Copolymer-1) is an FDA approved drug for the treatment of MS and it is very effective in suppressing neuroinflammation in experimental autoimmune encephalitis (EAE), an animal ...
    • Glaucoma Screening in the Haitian Afro-Caribbean Population of South Florida 

      Bokman, Christine L.; Pasquale, Louis R.; Parrish, Richard K.; Lee, Richard K. (Public Library of Science, 2014)
      Objective: To evaluate the presence of clinical signs consistent with suspected glaucoma in Haitian Afro-Caribbean individuals residing in South Florida who do not receive regular eye examinations. Design: Retrospective, ...
    • Glc-TOR signalling leads transcriptome reprogramming and meristem activation 

      Xiong, Yan; McCormack, Matthew; Li, Lei; Hall, Qi; Xiang, Chengbin; Sheen, Jen (2013)
      Meristems encompass stem/progenitor cells that sustain postembryonic growth of all plant organs. How meristems are activated and sustained by nutrient signalling remains enigmatic in photosynthetic plants. Combining chemical ...
    • Glenohumeral Joint Kinematics following Clavicular Fracture and Repairs 

      Rosso, Claudio; Nasr, Michael; Walley, Kempland C.; Harlow, Ethan R.; Haghpanah, Babak; Vaziri, Ashkan; Ramappa, Arun J.; Nazarian, Ara; DeAngelis, Joseph P. (Public Library of Science, 2017)
      Background: The purpose of this biomechanical study was to determine the effect of shortened clavicle malunion on the center of rotation of the glenohumeral (GH) joint, and the capacity of repair to restore baseline ...
    • Glial activation colocalizes with structural abnormalities in amyotrophic lateral sclerosis 

      Alshikho, Mohamad J.; Zürcher, Nicole R.; Loggia, Marco L.; Cernasov, Paul; Chonde, Daniel B.; Izquierdo Garcia, David; Yasek, Julia E.; Akeju, Oluwaseun; Catana, Ciprian; Rosen, Bruce R.; Cudkowicz, Merit E.; Hooker, Jacob M.; Atassi, Nazem (Lippincott Williams & Wilkins, 2016)
      Objective: In this cross-sectional study, we aimed to evaluate brain structural abnormalities in relation to glial activation in the same cohort of participants. Methods: Ten individuals with amyotrophic lateral sclerosis ...
    • Glioblastoma adaptation traced through decline of an IDH1 clonal driver and macro-evolution of a double-minute chromosome 

      Favero, F.; McGranahan, N.; Salm, M.; Birkbak, N. J.; Sanborn, J. Z.; Benz, S. C.; Becq, J.; Peden, J. F.; Kingsbury, Z.; Grocok, R. J.; Humphray, S.; Bentley, D.; Spencer-Dene, B.; Gutteridge, A.; Brada, M.; Roger, S.; Dietrich, P.-Y.; Forshew, T.; Gerlinger, M.; Rowan, A.; Stamp, G.; Eklund, A. C.; Szallasi, Z.; Swanton, C. (Oxford University Press, 2015)
      Background: Glioblastoma (GBM) is the most common malignant brain cancer occurring in adults, and is associated with dismal outcome and few therapeutic options. GBM has been shown to predominantly disrupt three core pathways ...
    • Glioblastoma Mimicking an Arteriovenous Malformation 

      Khanna, Arjun; Venteicher, Andrew S.; Walcott, Brian P.; Kahle, Kristopher T.; Mordes, Daniel A.; William, Christopher M.; Ghogawala, Zoher; Ogilvy, Christopher S. (Frontiers Media S.A., 2013)
      Abnormal cerebral vasculature can be a manifestation of a vascular malformation or a neoplastic process. We report the case of a patient with angiography-negative subarachnoid hemorrhage (SAH) who re-presented 3 years later ...
    • Glioblastoma Recurrence after Cediranib Therapy in Patients: Lack of "Rebound" Revascularization as Mode of Escape 

      di Tomaso, E.; Snuderl, M.; Kamoun, W. S.; Duda, Dan Gabriel; Auluck, P. K.; Fazlollahi, L.; Andronesi, Ovidiu C; Frosch, Matthew P.; Wen, Patrick Yung Chih; Plotkin, Scott Randall; Hedley-Whyte, E. Tessa; Sorensen, A; Batchelor, Tracy Todd; Jain, Radhika (American Association for Cancer Research (AACR), 2011)
      Recurrent glioblastomas (rGBM) invariably relapse after initial response to anti-VEGF therapy. There are two prevailing hypotheses on how these tumors escape antiangiogenic therapy: switch to VEGF-independent angiogenic ...
    • Global and Regional Effects of Type 2 Diabetes on Brain Tissue Volumes and Cerebral Vasoreactivity 

      Last, David; Alsop, David; Abduljalil, Amir; Marquis, Robert P.; de Bazelaire, Cedric; Hu, Kun; Cavallerano, Jerry; Novak, Vera (American Diabetes Association, 2007-02-08)
      OBJECTIVE—The aim of this study was to evaluate the regional effects of type 2 diabetes and associated conditions on cerebral tissue volumes and cerebral blood flow (CBF) regulation. RESEARCH DESIGN AND METHODS—CBF was ...
    • A global approach to HIV-1 vaccine development 

      Stephenson, Kathryn E; Barouch, Dan H (John Wiley & Sons Ltd., 2013)
      Summary A global human immunodeficiency virus-1 (HIV-1) vaccine will have to elicit immune responses capable of providing protection against a tremendous diversity of HIV-1 variants. In this review, we first describe the ...
    • Global Burden of HIV among Men Who Engage in Transactional Sex: A Systematic Review and Meta-Analysis 

      Oldenburg, Catherine E.; Perez-Brumer, Amaya G.; Reisner, Sari L.; Mattie, Jason; Bärnighausen, Till; Mayer, Kenneth H.; Mimiaga, Matthew J. (Public Library of Science, 2014)
      Background: Men who engage in transactional sex, the exchange of sex for money, goods, or other items of value, are thought to be at increased risk of HIV, but there have been no systematic attempts to characterize HIV ...
    • Global Chemical Impact of the Microbiome Includes Novel Bile Acid Conjugations 

      Quinn, Robert; Melnik, Alexey; Vrbanac, Alison; Patras, Kathryn; Christy, Mitchell; Zsolt, Bodai; Belda-Ferre, Pedro; Tripathi, Anupriya; Chung, Lawton; Quinn, Melissa; Humphrey, Greg; Panitchpakdi, Morgan; Weldon, Kelly; Aksenov, Alexander; da Silva, Ricardo; Avila-Pacheco, Julian; Clish, Clary; Bae, Sena; Mallick, Himel; Franzosa, Eric; Lloyd-Price, Jason; Bussell, Robert; Thron, Taren; Nelson, Andrew; Wang, Mingxun; Leszczynski, Eric; Vargas, Fernando; Gauglitz, Julia; Meehan, Michael; Gentry, Emily; Arthur, Timothy; Downes, Michael; Fu, Ting; Welch, Ryan; Komor, Alexis; Poulsen, Orit; Boland, Brigid; Chang, John; Sandborn, William; Lim, Meerana; Garg, Neha; Lumeng, Julie; Xavier, Ramnik; Kazmierczak, Barbara; Jain, Ruchi; Egan, Marie; Rhee, Kyung; Ferguson, David; Evans, Ronald; Raffatellu, Manuela; Vlamakis, Hera; Haddad, Gabriel; Siegel, Dionicio; Huttenhower, Curtis; Mazmanian, Sarkis; Nizet, Victor; Knight, Rob; Dorrestein, Pieter (Springer Nature, 2020-02-26)
      A mosaic of cross-phyla chemical interactions occurs between all metazoans and their microbiomes. In humans, the gut harbors the heaviest microbial load, but many organs, particularly those with a mucosal surface, associate ...
    • A global compendium of human Crimean-Congo haemorrhagic fever virus occurrence 

      Messina, Jane P; Pigott, David M; Duda, Kirsten A; Brownstein, John S; Myers, Monica F; George, Dylan B; Hay, Simon I (Nature Publishing Group, 2015)
      In order to map global disease risk, a geographic database of human Crimean-Congo haemorrhagic fever virus (CCHFV) occurrence was produced by surveying peer-reviewed literature and case reports, as well as informal online ...
    • A global compendium of human dengue virus occurrence 

      Messina, Jane P; Brady, Oliver J; Pigott, David M; Brownstein, John S; Hoen, Anne G; Hay, Simon I (Nature Publishing Group, 2014)
      A global geographic database of human dengue virus occurrence was produced to generate a global risk map and associated burden estimates1. Herein we present the database, which comprises occurrence data linked to point or ...