Now showing items 7207-7226 of 17918

    • A Glucose Fuel Cell for Implantable Brain–Machine Interfaces 

      Rapoport, Benjamin Isaac; Kedzierski, Jakub T.; Sarpeshkar, Rahul (Public Library of Science, 2012)
      We have developed an implantable fuel cell that generates power through glucose oxidation, producing 3.4 \(\mu\)W cm\(^{-2}\) steady-state power and up to 180 \(\mu\)W cm\(^{-2}\) peak power. The fuel cell is manufactured ...
    • Glucose transporter 3 is a rab11-dependent trafficking cargo and its transport to the cell surface is reduced in neurons of CAG140 Huntington’s disease mice 

      McClory, Hollis; Williams, Dana; Sapp, Ellen; Gatune, Leah W; Wang, Ping; DiFiglia, Marian; Li, Xueyi (BioMed Central, 2014)
      Huntington’s disease (HD) disturbs glucose metabolism in the brain by poorly understood mechanisms. HD neurons have defective glucose uptake, which is attenuated upon enhancing rab11 activity. Rab11 regulates numerous ...
    • Glutamate Excitoxicity Is the Key Molecular Mechanism Which Is Influenced by Body Temperature during the Acute Phase of Brain Stroke 

      Campos, Francisco; Pérez-Mato, María; Agulla, Jesús; Blanco, Miguel; Barral, David; Almeida, Ángeles; Brea, David; Waeber, Christian; Castillo, José; Ramos-Cabrer, Pedro (Public Library of Science, 2012)
      Glutamate excitotoxicity, metabolic rate and inflammatory response have been associated to the deleterious effects of temperature during the acute phase of stroke. So far, the association of temperature with these mechanisms ...
    • Glutamate Transporter: An Unexpected Target for Some Antibiotics 

      Mao, Jianren (BioMed Central, 2005)
      Glutamate transporter (GT) plays a major role in the mechanisms of glutamate homeostasis. Can this transporter system be a therapeutic target for glutamate-mediated neurological disorders? In January's edition of Nature, ...
    • Glutamatergic Regulation of the p70S6 Kinase in Primary Mouse Neurons 

      Lenz, Guido; Avruch, Joseph (American Society for Biochemistry and Molecular Biology, 2005)
    • Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway 

      Son, Jaekyoung; Lyssiotis, Costas A.; Ying, Haoqiang; Wang, Xiaoxu; Hua, Sujun; Ligorio, Matteo; Perera, Rushika M.; Ferrone, Cristina R.; Mullarky, Edouard; Shyh-Chang, Ng; Kang, Ya’an; Fleming, Jason B.; Bardeesy, Nabeel; Asara, John M.; Haigis, Marcia C.; DePinho, Ronald A.; Cantley, Lewis C.; Kimmelman, Alec C. (2013)
      Cancer cells exhibit metabolic dependencies that distinguish them from their normal counterparts1. Among these addictions is an increased utilization of the amino acid glutamine (Gln) to fuel anabolic processes2. Indeed, ...
    • Glutathione biosynthesis is a metabolic vulnerability in PI3K/Akt-driven breast cancer 

      Lien, Evan C.; Lyssiotis, Costas A.; Juvekar, Ashish; Hu, Hai; Asara, John M.; Cantley, Lewis C.; Toker, Alex (2016)
      Cancer cells often select for mutations that enhance signaling through pathways that promote anabolic metabolism1. Although the PI3K/Akt signaling pathway, which is frequently dysregulated in breast cancer2, is a ...
    • Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration 

      Carlson, Bradley A.; Tobe, Ryuta; Yefremova, Elena; Tsuji, Petra A.; Hoffmann, Victoria J.; Schweizer, Ulrich; Gladyshev, Vadim N.; Hatfield, Dolph L.; Conrad, Marcus (Elsevier, 2016)
      The selenoenzyme glutathione peroxidase 4 (Gpx4) is an essential mammalian glutathione peroxidase, which protects cells against detrimental lipid peroxidation and governs a novel form of regulated necrotic cell death, ...
    • Glutathione Peroxidase-1 Regulates Mitochondrial Function to Modulate Redox-dependent Cellular Responses 

      Handy, Diane E.; Lubos, Edith; Yang, Yi; Galbraith, John D.; Kelly, Neil; Zhang, Ying-Yi; Leopold, Jane A.; Loscalzo, Joseph (American Society for Biochemistry and Molecular Biology, 2009)
      Glutathione peroxidase-1 (GPx-1) is a selenocysteine-containing enzyme that plays a major role in the reductive detoxification of peroxides in cells. In permanently transfected cells with approximate 2-fold overexpression ...
    • Glutathione S-Transferase Polymorphisms, Passive Smoking, Obesity, and Heart Rate Variability in Nonsmokers 

      Probst-Hensch, Nicole M.; Imboden, Medea; Dietrich, Denise Felber; Barthélemy, Jean-Claude; Ackermann-Liebrich, Ursula; Berger, Wolfgang; Gaspoz, Jean-Michel; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2008)
      Background: Disturbances of heart rate variability (HRV) may represent one pathway by which second-hand smoke (SHS) and air pollutants affect cardiovascular morbidity and mortality. The mechanisms are poorly understood. ...
    • The glutathione synthesis inhibitor buthionine sulfoximine synergistically enhanced melphalan activity against preclinical models of multiple myeloma 

      Tagde, Ashujit; Singh, Harshabad; Kang, M H; Reynolds, C P (Nature Publishing Group, 2014)
      Melphalan (L-PAM) has been an integral part of multiple myeloma (MM) treatment as a conditioning regimen before stem cell transplant (SCT). After initial response, most treated patients experience relapse with an aggressive ...
    • The Gly2019Ser Mutation in LRRK2 is not Fully Penetrant in Familial Parkinson's Disease: The GenePD Study 

      Latourelle, Jeanne C; Lew, Mark F; Suchowersky, Oksana; Klein, Christine; Golbe, Lawrence I; Mark, Margery H; Wooten, G Frederick; Watts, Ray L; Guttman, Mark; Racette, Brad A; Perlmutter, Joel S; Ahmed, Anwar; Shill, Holly A; Singer, Carlos; Goldwurm, Stefano; Pezzoli, Gianni; Zini, Michela; Saint-Hilaire, Marie H; Hendricks, Audrey E; Williamson, Sally; Nagle, Michael W; Wilk, Jemma B; Massood, Tiffany; Huskey, Karen W; Laramie, Jason M; DeStefano, Anita L; Baker, Kenneth B; Itin, Ilia; Litvan, Irene; Nicholson, Garth; Corbett, Alastair; Nance, Martha; Drasby, Edward; Isaacson, Stuart; Burn, David J; Chinnery, Patrick F; Pramstaller, Peter P; Al-hinti, Jomana; Moller, Anette T; Ostergaard, Karen; Roxburgh, Richard; Snow, Barry; Slevin, John T; Cambi, Franca; Growdon, John Herbert; Gusella, James Francis; Sun, Mei; Sherman, Scott J; Myers, Richard Hepworth (BioMed Central, 2008)
      Background: We report age-dependent penetrance estimates for leucine-rich repeat kinase 2 (LRRK2)-related Parkinson's disease (PD) in a large sample of familial PD. The most frequently seen LRRK2 mutation, Gly2019Ser ...
    • Glycated LDL increases monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated chemotaxis 

      Isoda, Kikuo; Folco, Eduardo; Marwali, M. Reza; Ohsuzu, Fumitaka; Libby, Peter (Elsevier BV, 2008)
      Background Previous reports have suggested that levels of advanced glycation end product-modified LDL (AGE-LDL) increase in patients with diabetes due to elevated plasma glucose. However, understanding of the mechanisms ...
    • Glycemic Control and Cardiovascular Mortality in Hemodialysis Patients With Diabetes 

      Ricks, Joni; Molnar, Miklos Z.; Kovesdy, Csaba P.; Shah, Anuja; Nissenson, Allen R.; Williams, Mark Edward; Kalantar-Zadeh, Kamyar (American Diabetes Association, 2012)
      Previous observational studies using differing methodologies have yielded inconsistent results regarding the association between glycemic control and outcomes in diabetic patients receiving maintenance hemodialysis (MHD). ...
    • Glycerol Phosphate Shuttle Enzyme GPD2 Regulates Macrophage Inflammatory Responses 

      Nambu, Aya; Shibata, Munehiko; Lei, Jiahui; Xu, Peining; Jiang, Helen; Horng, Tiffany; Langston, Kent; Jung, Jonathan; Aksoylar, Halil-Ibrahim; Doan, Mary; MacArthur, Michael; Gao, Xia; Kong, Yong; Chouchani, Edward; Locasale, Jason; Snyder, Nathaniel (Springer Science and Business Media LLC, 2019-08-05)
      Macrophages are activated during microbial infection to coordinate inflammatory responses and host defense. Here we find that in macrophages activated by bacterial lipopolysaccharide (LPS), mitochondrial glycerol 3-phosphate ...
    • Glycoconjugate vaccine using a genetically modified O antigen induces protective antibodies to Francisella tularensis 

      Stefanetti, Giuseppe; Okan, Nihal; Fink, Avner; Gardner, Erica; Kasper, Dennis (Proceedings of the National Academy of Sciences, 2019-03-14)
      Francisella tularensis is the causative agent of tularemia, a category A bioterrorism agent. The lipopolysaccharide (LPS) O antigen (OAg) of F. tularensis has been considered for use in a glycoconjugate vaccine, but conjugate ...
    • Glycogen Synthase Kinase3 Beta Phosphorylates Serine 33 of p53 and Activates p53's Transcriptional Activity 

      Turenne, Gaetan A; Price, Brendan D. (BioMed Central, 2001)
      Background: The p53 protein is activated by genotoxic stress, oncogene expression and during senescence, p53 transcriptionally activates genes involved in growth arrest and apoptosis. p53 activation is regulated by ...
    • Glycogene Expression in Conjunctiva of Patients with Dry Eye: Downregulation of Notch Signaling 

      Mantelli, Flavio; Schaffer, Lana; Dana, Reza; Head, Steven R.; Argu¨eso, Pablo (Association for Research in Vision and Ophthalmology (ARVO), 2009)
      purpose. Glycoconjugates regulate a variety of biological events in mucosal surfaces, such as differentiation of postmitotic epithelial cells and maintenance of the wet-surfaced phenotype. This study aimed to identify the ...
    • Glycolytic regulation of cell rearrangement in angiogenesis 

      Cruys, Bert; Wong, Brian W.; Kuchnio, Anna; Verdegem, Dries; Cantelmo, Anna Rita; Conradi, Lena-Christin; Vandekeere, Saar; Bouché, Ann; Cornelissen, Ivo; Vinckier, Stefan; Merks, Roeland M. H.; Dejana, Elisabetta; Gerhardt, Holger; Dewerchin, Mieke; Bentley, Katie; Carmeliet, Peter (Nature Publishing Group, 2016)
      During vessel sprouting, endothelial cells (ECs) dynamically rearrange positions in the sprout to compete for the tip position. We recently identified a key role for the glycolytic activator PFKFB3 in vessel sprouting by ...
    • Glycopeptide Analogues of PSGL-1 Inhibit P-Selectin In Vitro and In Vivo 

      Krishnamurthy, Venkata R; Sardar, Mohammed Y. R.; Yu, Ying; Song, Xuezheng; Haller, Carolyn; Dai, Erbin; Wang, Xiacong; Hanjaya-Putra, Donny; Sun, Lijun; Morikis, Vasilios; Simon, Scott I.; Woods, Robert; Cummings, Richard D.; Chaikof, Elliot L. (2015)
      Blockade of P-selectin/PSGL-1 interactions holds significant potential for treatment of disorders of innate immunity, thrombosis, and cancer. Current inhibitors remain limited due to low binding affinity or by the recognized ...