Browsing HMS Scholarly Articles by Title
Now showing items 7333-7352 of 17922
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Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence
(Nature Pub. Group, 2015)Although BRCA1 function is essential for maintaining genomic integrity in all cell types, it is unclear why increased risk of cancer in individuals harbouring deleterious mutations in BRCA1 is restricted to only a select ... -
Haploinsufficiency for p190B RhoGAP Inhibits MMTV-Neu Tumor Progression
(BioMed Central, 2009)Introduction: Rho signaling regulates key cellular processes including proliferation, survival, and migration, and it has been implicated in the development of many types of cancer including breast cancer. P190B Rho GTPase ... -
Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression
(National Academy of Sciences, 2002)Flap endonuclease (Fen1) is required for DNA replication and repair, and defects in the gene encoding Fen1 cause increased accumulation of mutations and genome rearrangements. Because mutations in some genes involved in ... -
Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring
(BioMed Central, 2015)Background: The HHIP gene, encoding Hedgehog interacting protein, has been implicated in chronic obstructive pulmonary disease (COPD) by genome-wide association studies (GWAS), and our subsequent studies identified a ... -
Haploinsufficiency, but Not Defective Paternal 5mC Oxidation, Accounts for the Developmental Defects of Maternal Tet3 Knockouts
(Elsevier BV, 2015)Paternal DNA demethylation in mammalian zygotes is achieved through Tet3-mediated iterative oxidation of 5-methylcytosine (5mC) coupled with replication-dependent dilution. Tet3-mediated paternal DNA demethylation is ... -
Haploinsufficient Bmp4 Ocular Phenotypes Include Anterior Segment Dysgenesis with Elevated Intraocular Pressure
(BioMed Central, 2001)Background: Glaucoma is a blinding disease usually associated with high intraocular pressure (IOP). In some families, abnormal anterior segment development contributes to glaucoma. The genes causing anterior segment ... -
Haplotype Phasing and Inheritance of Copy Number Variants in Nuclear Families
(Public Library of Science, 2015)DNA copy number variants (CNVs) that alter the copy number of a particular DNA segment in the genome play an important role in human phenotypic variability and disease susceptibility. A number of CNVs overlapping with genes ... -
Haplotype Structure of the ENPP1 Gene and Nominal Association of the K121Q Missense Single Nucleotide Polymorphism With Glycemic Traits in the Framingham Heart Study
(American Diabetes Association, 2008)OBJECTIVE—A recent meta-analysis demonstrated a nominal association of the ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) K→Q missense single nucleotide polymorphism (SNP) at position 121 with type 2 diabetes. ... -
Haplotypes of the D-Amino Acid Oxidase Gene Are Significantly Associated with Schizophrenia and Its Neurocognitive Deficits
(Public Library of Science, 2016)D-amino acid oxidase (DAO) has been reported to be associated with schizophrenia. This study aimed to search for genetic variants associated with this gene. The genomic regions of all exons, highly conserved regions of ... -
The Happy Older Latinos are Active (HOLA) health promotion and prevention study: study protocol for a pilot randomized controlled trial
(BioMed Central, 2015)Background: Results of previous studies attest to the greater illness burden of common mental disorders (anxiety and depression) in older Latinos and the need for developing preventive interventions that are effective, ... -
Haptic Identification of Remote Environment Properties
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Harnessing Electronic Health Records for Public Health Surveillance
(University of Illinois at Chicago Library, 2011)Electronic medical record (EMR) systems are a rich potential source for detailed, timely, and efficient surveillance of large populations. We created the Electronic medical record Support for Public Health (ESP) system to ... -
Harnessing of the Nucleosome Remodeling Deacetylase complex controls lymphocyte development and prevents leukemogenesis
(2013)Cell fate decisions depend on the interplay between chromatin regulators and transcription factors. Here we show that activity of the Mi-2β nucleosome remodeling and deacetylase (NuRD) complex was controlled by the Ikaros ... -
Harnessing Poverty Alleviation to Reduce the Stigma of HIV in Sub-Saharan Africa
(Public Library of Science, 2013)Alexander Tsai and colleagues highlight the complex relationship between poverty and HIV stigma in sub-Saharan Africa, and discuss possible ways to break the cycle. Please see later in the article for the Editors' Summary -
Harnessing RNA interference to prevent or treat HSV-2 and HIV
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Harnessing RNAi-based nanomedicines for therapeutic gene silencing in B-cell malignancies
(National Academy of Sciences, 2016)Despite progress in systemic small interfering RNA (siRNA) delivery to the liver and to solid tumors, systemic siRNA delivery to leukocytes remains challenging. The ability to silence gene expression in leukocytes has great ... -
Harnessing the Medicaid Analytic eXtract (MAX) to Evaluate Medications in Pregnancy: Design Considerations
(Public Library of Science, 2013)Background: In the absence of clinical trial data, large post-marketing observational studies are essential to evaluate the safety and effectiveness of medications during pregnancy. We identified a cohort of pregnancies ... -
Harnessing the power of dividing cardiomyocytes
(Bloomsbury Qatar Foundation Journals, 2013)Lower vertebrates, such as newt and zebrafish, retain a robust cardiac regenerative capacity following injury. Recently, our group demonstrated that neonatal mammalian hearts have a remarkable regenerative potential in the ... -
HARP preferentially co-purifies with RPA bound to DNA-PK and blocks RPA phosphorylation
(Landes Bioscience, 2014)The HepA-related protein (HARP/SMARCAL1) is an ATP-dependent annealing helicase that is capable of rewinding DNA structures that are stably unwound due to binding of the single-stranded DNA (ssDNA)-binding protein Replication ... -
Harsh discipline relates to internalizing problems and cognitive functioning: findings from a cross-sectional study with school children in Tanzania
(BioMed Central, 2016)Background: Child maltreatment poses a risk to children and adolescents’ mental health and may also affect cognitive functioning. Also harsh discipline has been frequently associated with mental health problems. However, ...