Browsing HMS Scholarly Articles by Title

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    • Hemopexin in severe inflammation and infection: mouse models and human diseases 

      Lin, Tian; Maita, Dayana; Thundivalappil, Sujatha R; Riley, Frank E; Hambsch, Jasmin; Van Marter, Linda J; Christou, Helen A; Berra, Lorenzo; Fagan, Shawn; Christiani, David C; Warren, H Shaw (BioMed Central, 2015)
      Introduction: Cell-free plasma hemoglobin is associated with poor outcome in patients with sepsis. Extracellular hemoglobin and secondarily released heme amplify inflammation in the presence of microbial TLR ligands and/or ...

    • Hemorrhage from Extra-Antral Gastric Antral Vascular Ectasia in a Patient with Duodenal Heterotopic Gastric Mucosa 

      Gubatan, John; Raines, Nathan; Khosravi, Hasan; Challies, Tracy L.; Berzin, Tyler M. (Hindawi Publishing Corporation, 2016)
      Gastric antral vascular ectasias (GAVE) have been increasingly recognized as an uncommon cause of chronic gastrointestinal bleeding and anemia, although their underlying pathogenesis is not completely well understood. ...

    • Hemorrhagic Stroke Probably Caused by Exercise Combined With a Sports Supplement Containing β-Methylphenyl-ethylamine (BMPEA): A Case Report 

      Cohen, Pieter; Zeijlon, Rickard; Nardin, Rachel; Keizers, Peter H.J.; Venhuis, Bastiaan (American College of Physicians, 2015-06-16)

    • Heparan sulfate proteoglycan modulation of developmental signaling in Drosophila 

      Nybakken, Kent; Perrimon, Norbert (Elsevier, 2002)

    • Heparan Sulfate Regrowth Profiles Under Laminar Shear Flow Following Enzymatic Degradation 

      Giantsos-Adams, Kristina M.; Koo, Andrew Jia-An; Song, Sukhyun; Sakai, Jiro; Sankaran, Jagadish; Shin, Jennifer H.; Garcia-Cardena, Guillermo; Dewey, C. Forbes (Springer US, 2013)
      The local hemodynamic shear stress waveforms present in an artery dictate the endothelial cell phenotype. The observed decrease of the apical glycocalyx layer on the endothelium in atheroprone regions of the circulation ...

    • Heparan sulphate proteoglycans: the sweet side of development 

      Häcker, Udo; Nybakken, Kent; Perrimon, Norbert (Nature Research (part of Springer Nature), 2005)
      Pattern formation during development is controlled to a great extent by a small number of conserved signal transduction pathways that are activated by extracellular ligands such as Hedgehog, Wingless or Decapentaplegic. ...

    • Heparin affinity purification of extracellular vesicles 

      Balaj, Leonora; Atai, Nadia A.; Chen, Weilin; Mu, Dakai; Tannous, Bakhos A.; Breakefield, Xandra O.; Skog, Johan; Maguire, Casey A. (Nature Publishing Group, 2015)
      Extracellular vesicles (EVs) are lipid membrane vesicles released by cells. They carry active biomolecules including DNA, RNA, and protein which can be transferred to recipient cells. Isolation and purification of EVs from ...

    • Heparin requirements for full anticoagulation are higher for patients on dabigatran than for those on warfarin – a model-based study 

      Edrich, Thomas; Frendl, Gyorgy; Michaud, Gregory; Paschalidis, Ioannis Ch (Dove Medical Press, 2015)
      Purpose Dabigatran (D) is increasingly used for chronic anticoagulation in place of warfarin (W). These patients may present for catheter-based procedures requiring full anticoagulation with heparin. This study compares ...

    • Heparin-induced cis- and trans-Dimerization Modes of the Thrombospondin-1 N-terminal Domain 

      Tan, Kemin; Duquette, Mark; Liu, Jin-huan; Shanmugasundaram, Kumaran; Joachimiak, Andrzej; Gallagher, John T.; Rigby, Alan C.; Wang, Jia-huai; Lawler, Jack (American Society for Biochemistry and Molecular Biology, 2008)
      Through its interactions with proteins and proteoglycans, thrombospondin-1 (TSP-1) functions at the interface of the cell membrane and the extracellular matrix to regulate matrix structure and cellular phenotype. We have ...

    • Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury 

      Pyzik, Michal; Rath, Timo; Kuo, Timothy; Win, Sanda; Baker, Kristi; Hubbard, Jonathan; Grenha, Rosa; Gandhi, Amit; Krämer, Thomas D.; Mezo, Adam; Taylor, Zachary; McDonnell, Kevin; Nienaber, Vicki; Andersen, Jan Terje; Mizoguchi, Atsushi; Blumberg, Laurence; Purohit, Shalaka; Jones, Susan; Christianson, Greg; Lencer, Wayne; Sandlie, Inger; Kaplowitz, Neil; Roopenian, Derry; Blumberg, Richard (National Academy of Sciences, 2017)
      The neonatal crystallizable fragment receptor (FcRn) is responsible for maintaining the long half-life and high levels of the two most abundant circulating proteins, albumin and IgG. In the latter case, the protective ...

    • Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal Permeability 

      Luther, Jay; Garber, John J.; Khalili, Hamed; Dave, Maneesh; Bale, Shyam Sundhar; Jindal, Rohit; Motola, Daniel L.; Luther, Sanjana; Bohr, Stefan; Jeoung, Soung Won; Deshpande, Vikram; Singh, Gurminder; Turner, Jerrold R.; Yarmush, Martin L.; Chung, Raymond T.; Patel, Suraj J. (2015)
      BACKGROUND & AIMS Emerging data suggest that changes in intestinal permeability and increased gut microbial translocation contribute to the inflammatory pathway involved in nonalcoholic steatohepatitis (NASH) development. ...

    • Hepatic Steatosis is Associated with Lower Levels of Physical Activity Measured via Accelerometry 

      Long, Michelle T.; Pedley, Alison; Massaro, Joseph M.; Hoffmann, Udo; Esliger, Dale W.; Vasan, Ramachandran S.; Fox, Caroline S.; Murabito, Joanne M. (2015)
      Objective: Prior studies on the association of physical activity (PA) and non-alcoholic fatty liver disease are limited by reliance on subjective measures of PA. We examined the association between objectively measured PA ...

    • Hepatic tissue engineering: from transplantation to customized cell-based liver directed therapies from the laboratory 

      Fiegel, Henning C; Kaufmann, Peter M; Bruns, Helge; Kluth, Dietrich; Horch, Raymund E; Vacanti, Joseph P; Kneser, Ulrich (Blackwell Publishing Ltd, 2008)
      Abstract Today, liver transplantation is still the only curative treatment for liver failure due to end-stage liver diseases. Donor organ shortage, high cost and the need of immunosuppressive medications are still the major ...

    • Hepatitis B: Prevalence, Hope 

      Hedley-Whyte, John; Milamed, Debra (Ulster Medical Society, 2019-05)

    • The Hepatitis C Cascade of Care: Identifying Priorities to Improve Clinical Outcomes 

      Linas, Benjamin P.; Barter, Devra M.; Leff, Jared A.; Assoumou, Sabrina A.; Salomon, Joshua A.; Weinstein, Milton C.; Kim, Arthur Y.; Schackman, Bruce R. (Public Library of Science, 2014)
      Background: As highly effective hepatitis C virus (HCV) therapies emerge, data are needed to inform the development of interventions to improve HCV treatment rates. We used simulation modeling to estimate the impact of ...

    • Hepatitis C Virus and Hepatocarcinogenesis 

      Jeong, Soung Won; Jang, Jae Young; Chung, Raymond Taeyong (The Korean Association for the Study of the Liver, 2012)
      Hepatitis C virus (HCV) is an RNA virus that is unable to integrate into the host genome. However, its proteins interact with various host proteins and induce host responses. The oncogenic process of HCV infection is slow ...

    • Hepatitis C Virus Cell-Cell Transmission and Resistance to Direct-Acting Antiviral Agents 

      Xiao, Fei; Fofana, Isabel; Heydmann, Laura; Barth, Heidi; Soulier, Eric; Habersetzer, François; Doffoël, Michel; Bukh, Jens; Patel, Arvind H.; Zeisel, Mirjam B.; Baumert, Thomas F. (Public Library of Science, 2014)
      Hepatitis C virus (HCV) is transmitted between hepatocytes via classical cell entry but also uses direct cell-cell transfer to infect neighboring hepatocytes. Viral cell-cell transmission has been shown to play an important ...

    • Hepatitis C Virus Infection Protein Network 

      de Chassey, B; Navratil, V; Tafforeau, L; Hiet, M S; Aublin-Gex, A; Agaugué, S; Meiffren, G; Pradezynski, F; Faria, B F; Chantier, T; Le Breton, M; Pellet, J; Davoust, N; Mangeot, P E; Chaboud, A; Penin, F; Jacob, Y; Vidalain, P O; Vidal, Marc; André, P; Rabourdin-Combe, C; Lotteau, V (Nature Publishing Group, 2008)
      A proteome-wide mapping of interactions between hepatitis C virus (HCV) and human proteins was performed to provide a comprehensive view of the cellular infection. A total of 314 protein–protein interactions between HCV ...

    • Hepatitis C virus NS3‐4A inhibits the peroxisomal MAVS‐dependent antiviral signalling response 

      Ferreira, Ana R.; Magalhães, Ana C.; Camões, Fátima; Gouveia, Ana; Vieira, Marta; Kagan, Jonathan C.; Ribeiro, Daniela (John Wiley and Sons Inc., 2016)
      Abstract Hepatitis C virus (HCV) is the cause of one of the most prevalent viral infections worldwide. Upon infection, the HCV genome activates the RIG‐I‐MAVS signalling pathway leading to the production of direct antiviral ...

    • Hepatocellular Carcinoma in Non-alcoholic Fatty Liver Disease: Epidemiology, Pathogenesis, and Prevention 

      Baffy, György (XIA & HE Publishing Ltd, 2013)
      Hepatocellular cancer (HCC) is the fifth most prevalent cancer worldwide and the third leading cause of cancer-related deaths. Non-alcoholic fatty liver disease (NAFLD), a spectrum of hepatic disorders associated with ...