Browsing HMS Scholarly Articles by Title

Now showing items 7714-7733 of 17922

    • HIV-Derived ssRNA Binds to TLR8 to Induce Inflammation-Driven Macrophage Foam Cell Formation 

      Bernard, Mark A.; Han, Xinbing; Inderbitzin, Sonya; Agbim, Ifunanya; Zhao, Hui; Koziel, Henry; Tachado, Souvenir D. (Public Library of Science, 2014)
      Even though combined anti-retroviral therapy (cART) dramatically improves patient survival, they remain at a higher risk of being afflicted with non-infectious complications such as cardiovascular disease (CVD). This ...

    • HIV-exposed children account for more than half of 24-month mortality in Botswana 

      Zash, Rebecca; Souda, Sajini; Leidner, Jean; Ribaudo, Heather; Binda, Kelebogile; Moyo, Sikhulile; Powis, Kathleen M.; Petlo, Chipo; Mmalane, Mompati; Makhema, Joe; Essex, Max; Lockman, Shahin; Shapiro, Roger (BioMed Central, 2016)
      Background: The contribution of HIV-exposure to childhood mortality in a setting with widespread antiretroviral treatment (ART) availability has not been determined. Methods: From January 2012 to March 2013, mothers were ...

    • HIV-Free Survival among Nine- to 24-Month-Old Children Born to HIV-Positive Mothers in the Rwandan National PMTCT Programme: A Community-Based Household Survey 

      Ruton, Hinda; Mugwaneza, Placidie; Shema, Nadine; Lyambabaje, Alexandre; Bizimana, Jean de Dieu; Tsague, Landry; Nyankesha, Elevanie; Wagner, Claire M; Mutabazi, Vincent; Nyemazi, Jean Pierre; Nsanzimana, Sabin; Karema, Corine; Binagwaho, Agnes (BioMed Central, 2012)
      Background: Operational effectiveness of large-scale national programmes for the prevention of mother to child transmission (PMTCT) of HIV in sub-Saharan Africa remains limited. We report on HIV-free survival among nine- ...

    • HIV-infected T cells are migratory vehicles for viral dissemination 

      Murooka, Thomas; Deruaz, Maud; Marangoni, Francesco; Vrbanac, Vladimir; Seung, Edward N.; Von Andrian, Ulrich H.; Tager, Andrew Martin; Luster, Andrew David; Mempel, Thorsten Roman (2012)
      After host entry through mucosal surfaces, HIV-1 disseminates to lymphoid tissues to establish a generalized infection of the immune system. The mechanisms by which this virus spreads among permissive target cells locally ...

    • HIV-related Stigma in Rural and Tribal Communities of Maharashtra, India 

      Vlassoff, Carol; Weiss, Mitchell Gralnick; Rao, Shobha; Ali, Firdaus; Prentice, Tracey (Springer Science + Business Media, 2013)
      Stigma is a recognized barrier to early detection of HIV and causes great suffering for those affected. This paper examines HIV-related stigma in rural and tribal communities of Maharashtra, an area of relatively high HIV ...

    • HIV-Specific CD4 T Cell Responses to Different Viral Proteins Have Discordant Associations with Viral Load and Clinical Outcome 

      Ranasinghe, Srinika; Flanders, Michael; Cutler, Sam; Soghoian, Damien Z.; Ghebremichael, Musie; Davis, Isaiah; Lindqvist, Madelene; Pereyra, Florencia; Walker, Bruce D.; Heckerman, David; Streeck, Hendrik (American Society for Microbiology, 2012)
      A successful prophylactic vaccine is characterized by long-lived immunity, which is critically dependent on CD4 T cell-mediated helper signals. Indeed, most licensed vaccines induce antigen-specific CD4 T cell responses, ...

    • HIVBrainSeqDB: A Database of Annotated HIV Envelope Sequences from Brain and Other Anatomical Sites 

      Holman, Alexander G; Mefford, Megan E.; O'Connor, Niall; Gabuzda, Dana Helga (BioMed Central, 2010)
      Background: The population of HIV replicating within a host consists of independently evolving and interacting sub-populations that can be genetically distinct within anatomical compartments. HIV replicating within the ...

    • HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1 

      Kalife, Elizabeth T; Qi, Ying; Johnston, Mary N; Burgett, Nicole; Swartz, Martha E; Yang, Amy; Rockstroh, Juergen K; Jessen, Heiko; Carrington, Mary; Altfeld, Marcus; Streeck, Hendrik; Lichterfeld, Mathias; Alter, Galit; Yu, Xu; Meier, Angela; Allen, Todd; Rosenberg, Eric Scott; Walker, Bruce David (Public Library of Science, 2006)
      Background: Very little is known about the immunodominance patterns of HIV-1-specific T cell responses during primary HIV-1 infection and the reasons for human lymphocyte antigen (HLA) modulation of disease progression. ...

    • HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors 

      Ishigaki, Kazuyoshi; Lagattuta, Kaitlyn; Luo, Yang; James, Eddie; Buckner, Jane; Raychaudhuri, Soumya (Cold Spring Harbor Laboratory, 2020-11-12)

    • HLA Class I and Class II Conserved Extended Haplotypes and Their Fragments or Blocks in Mexicans: Implications for the Study of Genetic Diversity in Admixed Populations 

      Zúñiga, Joaquín; Yu, Neng; Barquera, Rodrigo; Alosco, Sharon; Ohashi, Marina; Lebedeva, Tatiana; Acuña-Alonzo, Víctor; Yunis, María; Granados-Montiel, Julio; Cruz-Lagunas, Alfredo; Vargas-Alarcón, Gilberto; Rodríguez-Reyna, Tatiana S.; Fernandez-Viña, Marcelo; Granados, Julio; Yunis, Edmond J. (Public Library of Science, 2013)
      Major histocompatibility complex (MHC) genes are highly polymorphic and informative in disease association, transplantation, and population genetics studies with particular importance in the understanding of human population ...

    • HLA Class I and II Blocks Are Associated to Susceptibility, Clinical Subtypes and Autoantibodies in Mexican Systemic Sclerosis (SSc) Patients 

      Rodriguez-Reyna, Tatiana S.; Mercado-Velázquez, Pamela; Yu, Neng; Alosco, Sharon; Ohashi, Marina; Lebedeva, Tatiana; Cruz-Lagunas, Alfredo; Núñez-Álvarez, Carlos; Cabiedes-Contreras, Javier; Vargas-Alarcón, Gilberto; Granados, Julio; Zúñiga, Joaquin; Yunis, Edmond (Public Library of Science, 2015)
      Introduction: Human leukocyte antigen (HLA) polymorphism studies in Systemic Sclerosis (SSc) have yielded variable results. These studies need to consider the genetic admixture of the studied population. Here we used our ...

    • HLA class I downregulation is associated with enhanced NK‐cell killing of melanoma cells with acquired drug resistance to BRAF inhibitors 

      Sottile, Rosa; Pangigadde, Pradeepa N.; Tan, Thomas; Anichini, Andrea; Sabbatino, Francesco; Trecroci, Francesca; Favoino, Elvira; Orgiano, Laura; Roberts, James; Ferrone, Soldano; Kärre, Klas; Colucci, Francesco; Carbone, Ennio (John Wiley and Sons Inc., 2015)
      The frequent development of drug resistance to targeted therapies in cancer patients has stimulated interest in strategies counteracting resistance. Combining immunotherapies with targeted therapies is one such strategy. ...

    • HLA Class I Supertypes: A Revised and Updated Classification 

      Sidney, John; Peters, Bjoern; Frahm, Nicole; Brander, Christian; Sette, Alessandro (BioMed Central, 2008)
      Background: Class I major histocompatibility complex (MHC) molecules bind, and present to T cells, short peptides derived from intracellular processing of proteins. The peptide repertoire of a specific molecule is to a ...

    • The HLA Class II Allele DRB1*1501 Is Over-Represented in Patients with Idiopathic Pulmonary Fibrosis 

      Xue, Jianmin; Gochuico, Bernadette R.; Alawad, Ahmad Samer; Feghali-Bostwick, Carol A.; Noth, Imre; Nathan, Steven D.; Dacic, Sanja; Ocak, Iclal; Fuhrman, Carl R.; Cuenco, Karen T.; Jacobs, Susan S.; Zeevi, Adriana; Morel, Penelope A.; Pilewski, Joseph M.; Valentine, Vincent G.; Gibson, Kevin F.; Kaminski, Naftali; Sciurba, Frank C.; Zhang, Yingze; Rosen, Glenn David; Rosas, Ivan O.; Smith, Mary A.; Duncan, Steven R. (Public Library of Science, 2011)
      Background: Idiopathic pulmonary fibrosis (IPF) is a progressive and medically refractory lung disease with a grim prognosis. Although the etiology of IPF remains perplexing, abnormal adaptive immune responses are evident ...

    • HLA-A is a Predictor of Hepatitis B e Antigen Status in HIV-Positive African Adults 

      Matthews, Philippa C.; Carlson, Jonathan M.; Beloukas, Apostolos; Malik, Amna; Jooste, Pieter; Ogwu, Anthony; Shapiro, Roger; Riddell, Lynn; Chen, Fabian; Luzzi, Graz; Jesuthasan, Gerald; Jeffery, Katie; Jojic, Nebojsa; Ndung'u, Thumbi; Carrington, Mary; Goulder, Philip J. R.; Geretti, Anna Maria; Klenerman, Paul (Oxford University Press, 2015)
      Outcomes of chronic infection with hepatitis B virus (HBV) are varied, with increased morbidity reported in the context of human immunodeficiency virus (HIV) coinfection. The factors driving different outcomes are not well ...

    • HLA-B*35-Px–mediated Acceleration of HIV-1 Infection by Increased Inhibitory Immunoregulatory Impulses 

      Goedert, James J.; Sundberg, Eric J.; Cung, Thai Duong Hong; Burke, Patrick S.; Preiss, Liliana; Lifson, Jeffrey; Carrington, Mary; Huang, Jinghe; Martin, Maureen P.; Lichterfeld, Mathias; Yu, Xu (The Rockefeller University Press, 2009)
      A subset of HLA-B*35 alleles, B*35-Px, are strongly associated with accelerated HIV-1 disease progression for reasons that are not understood. Interestingly, the alternative set of B*35 subtypes, B*35-PY, have no detectable ...

    • HLA-Mismatched Renal Transplantation without Maintenance Immunosuppression 

      Kawai, Tatsuo; Cosimi, A. Benedict; Spitzer, Thomas Richard; Tolkoff-Rubin, Nina Ellen; Suthanthiran, Manikkam; Saidman, Susan L.; Shaffer, Juanita; Preffer, Frederic Ira; Ding, Ruchuang; Sharma, Vijay; Fishman, Jay Alan; Dey, Bimalangshu; Ko, Dicken S.C.; Hertl, Martin; Goes, Nelson B.; Wong, Waichi; Williams, Winfred Woodrow; Colvin, Robert Barnes; Sykes, Megan; Sachs, David H. (New England Journal of Medicine (NEJM/MMS), 2008)
      Five patients with end-stage renal disease received combined bone marrow and kidney transplants from HLA single-haplotype mismatched living related donors, with the use of a nonmyeloablative preparative regimen. Transient ...

    • The HMCES DNA-protein cross-link functions as an intermediate in DNA interstrand cross-link repair 

      Semlow, Daniel R.; MacKrell, Victoria A.; Walter, Johannes (Springer Science and Business Media LLC, 2022-05)
      The HMCES protein forms a covalent DNA-protein cross-link (DPC) with abasic (AP) sites in ssDNA, and the resulting HMCES-DPC is thought to suppress double-strand break formation in S phase. However, the dynamics of HMCES ...

    • HMG CoA Reductase Inhibitors Reduce Plasminogen Activator Inhibitor-1 Expression by Human Vascular Smooth Muscle and Endothelial Cells 

      Bourcier, Todd; Libby, Peter (American Heart Association, 2000)
      The clinical benefit of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) may derive from a qualitative, functional change in atherosclerotic lesions in addition to their lipid-lowering properties. We ...

    • HMG2 Interacts with the Nucleosome Assembly Protein SET and Is a Target of the Cytotoxic T-Lymphocyte Protease Granzyme A 

      Fan, Zusen; Beresford, Paul J.; Zhang, Dong; Lieberman, Judy (American Society for Microbiology, 2002)
      The cytotoxic T-lymphocyte protease granzyme A induces caspase-independent cell death in which DNA single-stranded nicking is observed instead of oligonucleosomal fragmentation. A 270- to 420-kDa endoplasmic reticulum-associated ...