Browsing HMS Scholarly Articles by Title
Now showing items 7788-7807 of 17922
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Household Transmission of Vibrio cholerae in Bangladesh
(Public Library of Science, 2014)Background: Vibrio cholerae infections cluster in households. This study's objective was to quantify the relative contribution of direct, within-household exposure (for example, via contamination of household food, water, ... -
How Accurate Can Genetic Predictions Be?
(BioMed Central, 2012)Background: Pre-symptomatic prediction of disease and drug response based on genetic testing is a critical component of personalized medicine. Previous work has demonstrated that the predictive capacity of genetic testing ... -
How and Why Community Hospital Clinicians Document a Positive Screen for Intimate Partner Violence: A Cross-sectional Study
(BioMed Central, 2005)Background: This two-part study examines primary care clinicians' chart documentation and attitudes when confronted by a positive waiting room screen for intimate partner violence (IPV). Methods: Patients at community ... -
How behavioral economics can help to avoid ‘The last mile problem’ in whole genome sequencing
(BioMed Central, 2015)Editorial summary Failure to consider lessons from behavioral economics in the case of whole genome sequencing may cause us to run into the ‘last mile problem’ - the failure to integrate newly developed technology, on which ... -
How Changes in Extracellular Matrix Mechanics and Gene Expression Variability Might Combine to Drive Cancer Progression
(Public Library of Science, 2013)Changes in extracellular matrix (ECM) structure or mechanics can actively drive cancer progression; however, the underlying mechanism remains unknown. Here we explore whether this process could be mediated by changes in ... -
How common are ALS plateaus and reversals?
(Lippincott Williams & Wilkins, 2015)Objective: To determine the frequency of amyotrophic lateral sclerosis (ALS) plateaus and reversals in the Pooled Resource Open-Access ALS Clinical Trials (PRO-ACT) database. Methods: We analyzed Amyotrophic Lateral Sclerosis ... -
How consistent are associations between stunting and child development? Evidence from a meta-analysis of associations between stunting and multidimensional child development in fifteen low- and middle-income countries
(Cambridge University Press, 2016)Objective: Despite documented associations between stunting and cognitive development, few population-level studies have measured both indicators in individual children or assessed stunting's associations with other ... -
How cortical neurons help us see: visual recognition in the human brain
(American Society for Clinical Investigation, 2010)Through a series of complex transformations, the pixel-like input to the retina is converted into rich visual perceptions that constitute an integral part of visual recognition. Multiple visual problems arise due to damage ... -
How Deep Is Deep enough for RNA-Seq Profiling of Bacterial Transcriptomes?
(BioMed Central, 2012)Background: High-throughput sequencing of cDNA libraries (RNA-Seq) has proven to be a highly effective approach for studying bacterial transcriptomes. A central challenge in designing RNA-Seq-based experiments is estimating ... -
How do changes to the built environment influence walking behaviors? a longitudinal study within a university campus in Hong Kong
(BioMed Central, 2014)Background: Previous studies testing the association between the built environment and walking behavior have been largely cross-sectional and have yielded mixed results. This study reports on a natural experiment in which ... -
How Do Clinicians Prefer Cultural Competence Training? Findings from the DSM-5 Cultural Formulation Interview Field Trial
(Springer Science and Business Media LLC, 2016-08)Objective This study’s objective is to analyze training methods clinicians reported as most and least helpful during the DSM-5 Cultural Formulation Interview field trial, reasons why, and associations between demographic ... -
How do Medical Societies Select Science for Conference Presentation? How Should They?
(Department of Emergency Medicine, University of California, Irvine School of Medicine, 2015)Introduction: Nothing has been published to describe the practices of medical societies in choosing abstracts for presentations at their annual meetings. We surveyed medical societies to determine their practices, and also ... -
How do we learn about improving health care: a call for a new epistemological paradigm
(Oxford University Press, 2016)Purpose The field of improving health care has been achieving more significant results in outcomes at scale in recent years. This has raised legitimate questions regarding the rigor, attribution, generalizability and ... -
How Does Medical Device Regulation Perform in the United States and the European Union? A Systematic Review
(Public Library of Science, 2012)Background: Policymakers and regulators in the United States (US) and the European Union (EU) are weighing reforms to their medical device approval and post-market surveillance systems. Data may be available that identify ... -
How drug resistance takes shape
(eLife Sciences Publications, Ltd, 2016)Mutations in a hormone receptor can lead to therapeutic resistance by making it less able to bind and respond to hormone blocking drugs and by making it active, even when the hormome is not present. -
How genetically engineered systems are helping to define, and in some cases redefine, the neurobiological basis of sleep and wake
(Taylor & Francis, 2015)The advent of genetically engineered systems, including transgenic animals and recombinant viral vectors, has facilitated a more detailed understanding of the molecular and cellular substrates regulating brain function. ... -
How home HIV testing and counselling with follow-up support achieves high testing coverage and linkage to treatment and prevention: a qualitative analysis from Uganda
(International AIDS Society, 2016)Introduction: The successes of HIV treatment scale-up and the availability of new prevention tools have raised hopes that the epidemic can finally be controlled and ended. Reduction in HIV incidence and control of the ... -
How mothers with borderline personality disorder relate to their year-old infants
(Royal College of Psychiatrists, 2009)Background Women with borderline personality disorder have conflictual interpersonal relations that may extend to disrupted patterns of interaction with their infants. Aims To assess how women with borderline personality ... -
How prevalent and morbid are subthreshold manifestations of major depression in adolescents? A literature review
(Elsevier BV, 2017-03)Major Depressive Disorder (MDD) among youth is a public health concern. Our aim was to examine the current body of knowledge to better characterize the prevalence and morbidity associated with subthreshold forms of MDD ...