Browsing HMS Scholarly Articles by Title

Now showing items 780-799 of 17922

    • Analysis of schizophrenia-related genes and electrophysiological measures reveals ZNF804A association with amplitude of P300b elicited by novel sounds 

      del Re, E C; Bergen, S E; Mesholam-Gately, R I; Niznikiewicz, M A; Goldstein, J M; Woo, T U; Shenton, Martha E.; Seidman, L J; McCarley, R W; Petryshen, T L (Nature Publishing Group, 2014)
      Several genes have recently been identified as risk factors for schizophrenia (SZ) by genome-wide association studies (GWAS), including ZNF804A which is thought to function in transcriptional regulation. However, the ...

    • Analysis of Sequence Conservation at Nucleotide Resolution 

      Asthana, Saurabh; Roytberg, Mikhail; Stamatoyannopoulos, John; Sunyaev, Shamil R. (Public Library of Science, 2007)
      One of the major goals of comparative genomics is to understand the evolutionary history of each nucleotide in the human genome sequence, and the degree to which it is under selective pressure. Ascertainment of selective ...

    • The analysis of social network data: an exciting frontier for statisticians 

      O'Malley, James James (Blackwell Publishing Ltd, 2013)
      The catalyst for this paper is the recent interest in the relationship between social networks and an individual's health, which has arisen following a series of papers by Nicholas Christakis and James Fowler on person- ...

    • Analysis of Somatic Microsatellite Indels Identifies Driver Events in Human Tumors 

      Maruvka, Yosef; Mouw, Kent; Karlic, Rosa; Parasuraman, Prasanna; Kamburov, Atanas; Polak, Paz; Haradhvala, Nicholas; Hess, Julian; Rheinbay, Esther; Brody, Yehuda; Koren, Amnon; Braunstein, Lior; D'Andrea, Alan; Lawrence, Michael; Bass, Adam; Bernards, Andre; Michor, Franziska; Getz, Gad (Springer Science and Business Media LLC, 2017-09-11)
      Microsatellites (MSs) are tracts of variable-length repeats of short DNA motifs that exhibit high rates of mutation in the form of insertions or deletions (indels) of the repeated motif. Despite their prevalence, the ...

    • Analysis of somatic retrotransposition in human cancers 

      Lee, Eunjung; Iskow, Rebecca; Yang, Lixing; Gokcumen, Omer; Haseley, Psalm; Luquette, Lovelace J.; Lohr, Jens Guenter; Harris, Christopher C; Ding, Li; Wilson, Richard K.; Wheeler, David A.; Gibbs, Richard A; Kucherlapati, Raju; Lee, Charles; Kharchenko, Peter Vasili; Park, Peter J. (BioMed Central, 2012)

    • Analysis of Surgical Errors in Closed Malpractice Claims at 4 Liability Insurers 

      Rogers, Selwyn O.; Gawande, Atul; Kwaan, Mary; Puopolo, Ann Louise; Yoon, Catherine; Brennan, Troyen A.; Studdert, David M. (2006)

    • Analysis of the 10q11 Cancer Risk Locus Implicates MSMB and NCOA4 in Human Prostate Tumorigenesis 

      Chanock, Stephen J.; Schafer, Eric J.; Tabernero, Josep; Baselga, José; Oh, William K.; Pomerantz, Mark M; Shrestha, Yashaswi; Flavin, Richard John; Regan, Meredith Margaret; Penney, Kathryn Lee; Mucci, Lorelei Ann; Stampfer, Meir; Hunter, David J.; Chan, Jennifer Ang; Richardson, Andrea Lynn; Loda, Massimo; Kantoff, Philip Wayne; Hahn, William C.; Freedman, Matthew Lawrence (Public Library of Science, 2010)
      Genome-wide association studies (GWAS) have established a variant, rs10993994, on chromosome 10q11 as being associated with prostate cancer risk. Since the variant is located outside of a protein-coding region, the target ...

    • Analysis of the African coelacanth genome sheds light on tetrapod evolution 

      Amemiya, Chris T.; Alföldi, Jessica; Lee, Alison P.; Fan, Shaohua; Philippe, Hervé; MacCallum, Iain; Braasch, Ingo; Manousaki, Tereza; Schneider, Igor; Rohner, Nicolas; Organ, Chris; Chalopin, Domitille; Smith, Jeramiah J.; Robinson, Mark; Dorrington, Rosemary A.; Gerdol, Marco; Aken, Bronwen; Biscotti, Maria Assunta; Barucca, Marco; Baurain, Denis; Berlin, Aaron M.; Blatch, Gregory L.; Buonocore, Francesco; Burmester, Thorsten; Campbell, Michael S.; Canapa, Adriana; Cannon, John P.; Christoffels, Alan; De Moro, Gianluca; Edkins, Adrienne L.; Fan, Lin; Fausto, Anna Maria; Feiner, Nathalie; Forconi, Mariko; Gamieldien, Junaid; Gnerre, Sante; Gnirke, Andreas; Goldstone, Jared V.; Haerty, Wilfried; Hahn, Mark E.; Hesse, Uljana; Hoffmann, Steve; Johnson, Jeremy; Karchner, Sibel I.; Kuraku, Shigehiro; Lara, Marcia; Levin, Joshua Z.; Litman, Gary W.; Mauceli, Evan; Miyake, Tsutomu; Mueller, M. Gail; Nelson, David R.; Nitsche, Anne; Olmo, Ettore; Ota, Tatsuya; Pallavicini, Alberto; Panji, Sumir; Picone, Barbara; Ponting, Chris P.; Prohaska, Sonja J.; Przybylski, Dariusz; Saha, Nil Ratan; Ravi, Vydianathan; Ribeiro, Filipe J.; Sauka-Spengler, Tatjana; Scapigliati, Giuseppe; Searle, Stephen M. J.; Sharpe, Ted; Simakov, Oleg; Stadler, Peter F.; Stegeman, John J.; Sumiyama, Kenta; Tabbaa, Diana; Tafer, Hakim; Turner-Maier, Jason; van Heusden, Peter; White, Simon; Williams, Louise; Yandell, Mark; Brinkmann, Henner; Volff, Jean-Nicolas; Tabin, Clifford J.; Shubin, Neil; Schartl, Manfred; Jaffe, David; Postlethwait, John H.; Venkatesh, Byrappa; Di Palma, Federica; Lander, Eric S.; Meyer, Axel; Lindblad-Toh, Kerstin (2013)
      It was a zoological sensation when a living specimen of the coelacanth was first discovered in 1938, as this lineage of lobe-finned fish was thought to have gone extinct 70 million years ago. The modern coelacanth looks ...

    • Analysis of the Association of the Human Cytomegalovirus DNA Polymerase Subunit UL44 with the Viral DNA Replication Factor UL84 

      Strang, Blair L.; Sinigalia, Elisa; Silva, Laurie A.; Coen, Donald M.; Loregian, Arianna (American Society for Microbiology, 2009)
      The central enzyme responsible for human cytomegalovirus (HCMV) DNA synthesis is a virally encoded DNA polymerase that includes a catalytic subunit, UL54, and a homodimeric accessory subunit, UL44, the presumptive HCMV DNA ...

    • Analysis of the Definition and Utility of Personal Health Records Using Q Methodology 

      Kim, Jeongeun; Bates, David W (JMIR Publications Inc., 2011-11-29)
      Background: Personal health records (PHRs) remain a relatively new technology and concept in practice even though they have been discussed in the literature for more than 50 years. There is no consensus on the definition ...

    • Analysis of the dynamic co-expression network of heart regeneration in the zebrafish 

      Rodius, Sophie; Androsova, Ganna; Götz, Lou; Liechti, Robin; Crespo, Isaac; Merz, Susanne; Nazarov, Petr V.; de Klein, Niek; Jeanty, Céline; González-Rosa, Juan M.; Muller, Arnaud; Bernardin, Francois; Niclou, Simone P.; Vallar, Laurent; Mercader, Nadia; Ibberson, Mark; Xenarios, Ioannis; Azuaje, Francisco (Nature Publishing Group, 2016)
      The zebrafish has the capacity to regenerate its heart after severe injury. While the function of a few genes during this process has been studied, we are far from fully understanding how genes interact to coordinate heart ...

    • Analysis of the molecular features of rectal carcinoid tumors to identify new biomarkers that predict biological malignancy 

      Mitsuhashi, Kei; Yamamoto, Itaru; Kurihara, Hiroyoshi; Kanno, Shinichi; Ito, Miki; Igarashi, Hisayoshi; Ishigami, Keisuke; Sukawa, Yasutaka; Tachibana, Mami; Takahashi, Hiroaki; Tokino, Takashi; Maruyama, Reo; Suzuki, Hiromu; Imai, Kohzoh; Shinomura, Yasuhisa; Yamamoto, Hiroyuki; Nosho, Katsuhiko (Impact Journals LLC, 2015)
      Although gastrointestinal carcinoid tumors are relatively rare in the digestive tract, a quarter of them are present in the rectum. In the absence of specific tumor biomarkers, lymphatic or vascular invasion is generally ...

    • An Analysis of the Relationship Between Metabolism, Developmental Schedules, and Longevity Using Phylogenetic Independent Contrasts 

      Costa, Joana; Church, George; de Magalhães, João Pedro (Gerontological Society of America, 2007-02)
      Comparative studies of aging are often difficult to interpret because of the different factors that tend to correlate with longevity. We used the AnAge database to study these factors, particularly metabolism and developmental ...

    • An Analysis of the Role of the Indigenous Microbiota in Cholesterol Gallstone Pathogenesis 

      Fremont-Rahl, Jacqueline J.; Ge, Zhongming; Umana, Carlos; Whary, Mark T.; Taylor, Nancy S.; Muthupalani, Sureshkumar; Carey, Martin C.; Fox, James G.; Maurer, Kirk J. (Public Library of Science, 2013)
      Background and Aims Cholesterol gallstone disease is a complex process involving both genetic and environmental variables. No information exists regarding what role if any the indigenous gastrointestinal microbiota may ...

    • Analysis of the Yeast Arginine Methyltransferase Hmt1p/rmt1p and Its in Vivo Function. Cofactor Binding and Substrate Interactions 

      McBride, Anne E.; Weiss, Valerie H.; Kim, Heidi K.; Hogle, James M.; Silver, Pamela A. (American Society for Biochemistry and Molecular Biology, 2000)
      Many eukaryotic RNA-binding proteins are modified by methylation of arginine residues. The yeast Saccharomyces cerevisiae contains one major arginine methyltransferase, Hmt1p/Rmt1p, which is not essential for normal cell ...

    • Analysis of Thyroid Response Element Activity During Retinal Development 

      Billings, Nathan; Emerson, Mark Monroe; Cepko, Connie (Public Library of Science, 2010)
      Thyroid hormone (TH) signaling components are expressed during retinal development in dynamic spatial and temporal patterns. To probe the competence of retinal cells to mount a transcriptional response to TH, reporters ...

    • Analytical Complexity in Detection of Gene Variant-by-Environment Exposure Interactions in High-Throughput Genomic and Exposomic Research 

      Patel, Chirag J. (Springer International Publishing, 2016)
      It seems intuitive that disease risk is influenced by the interaction between inherited genetic variants and environmental exposure factors; however, we have few documented interactions between variants and exposures. ...

    • Analyzing Adjuvant Radiotherapy Suggests a Non Monotonic Radio-Sensitivity Over Tumor Volumes 

      Yang, Jack Y; Yang, Mary Qu; Deng, Youping; Niemierko, Andrzej (BioMed Central, 2008)
      Background: Adjuvant Radiotherapy (RT) after surgical removal of tumors proved beneficial in long-term tumor control and treatment planning. For many years, it has been well concluded that radio-sensitivities of tumors ...

    • Analyzing historical trends in breast cancer biomarker expression: a feasibility study (1947–2009) 

      Krieger, Nancy; Habel, Laurel A; Waterman, Pamela D; Shabani, Melina; Ellison-Loschmann, Lis; Achacoso, Ninah S; Acton, Luana; Schnitt, Stuart J (2016)
      BACKGROUND/OBJECTIVES Determining long-term trends in tumor biomarker expression is essential for understanding aspects of tumor biology amenable to change. Limiting the availability of such data, currently used assays for ...

    • Analyzing networks of phenotypes in complex diseases: methodology and applications in COPD 

      Chu, Jen-hwa; Hersh, Craig P; Castaldi, Peter J; Cho, Michael H; Raby, Benjamin A; Laird, Nan; Bowler, Russell; Rennard, Stephen; Loscalzo, Joseph; Quackenbush, John; Silverman, Edwin K (BioMed Central, 2014)
      Background: The investigation of complex disease heterogeneity has been challenging. Here, we introduce a network-based approach, using partial correlations, that analyzes the relationships among multiple disease-related ...