Browsing HMS Scholarly Articles by Title
Now showing items 7834-7853 of 17922
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Human adaptation and population differentiation in the light of ancient genomes
(Nature Publishing Group, 2016)The influence of positive selection sweeps in human evolution is increasingly debated, although our ability to detect them is hampered by inherent uncertainties in the timing of past events. Ancient genomes provide snapshots ... -
The Human Ageing Genomic Resources: Online Databases and Tools for Biogerontologists
(Wiley, 2009-02)Ageing is a complex, challenging phenomenon that will require multiple, interdisciplinary approaches to unravel its puzzles. To assist basic research on ageing, we developed the Human Ageing Genomic Resources (HAGR). This ... -
Human and Murine Clonal CD8+ T Cell Expansions Arise during Tuberculosis Because of TCR Selection
(Public Library of Science, 2015)The immune system can recognize virtually any antigen, yet T cell responses against several pathogens, including Mycobacterium tuberculosis, are restricted to a limited number of immunodominant epitopes. The host factors ... -
Human anti-CAIX antibodies mediate immune cell inhibition of renal cell carcinoma in vitro and in a humanized mouse model in vivo
(BioMed Central, 2015)Background: Carbonic anhydrase (CA) IX is a surface-expressed protein that is upregulated by the hypoxia inducible factor (HIF) and represents a prototypic tumor-associated antigen that is overexpressed on renal cell ... -
Human Anti-CCR4 Minibody Gene Transfer for the Treatment of Cutaneous T-Cell Lymphoma
(Public Library of Science, 2012)Background: Although several therapeutic options have become available for patients with Cutaneous T-cell Lymphoma (CTCL), no therapy has been curative. Recent studies have demonstrated that CTCL cells overexpress the CC ... -
Human B-cell Ontogeny in Humanized NOD/SCID γc\(^{null}\) Mice Generates a Diverse Yet Auto/Poly- and HIV-1 Reactive Antibody Repertoire
(Nature Publishing Group, 2012)Characterization of the human antibody (Ab) repertoire in mouse models of the human immune system is essential to establish their relevance in translational studies. Single human B-cells were sorted from bone marrow and ... -
Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells
(Cold Spring Harbor Laboratory Press, 2001) -
Human Breast Cancer Tumor Models: Molecular Imaging of Drug Susceptibility and Dosing during HER2/neu-targeted Therapy
(Radiological Society of North America, 2008)Purpose: To use near-infrared (NIR) optical imaging to assess the therapeutic susceptibility and drug dosing of orthotopic human breast cancers implanted in mice treated with molecularly targeted therapy.Materials and ... -
Human Cathepsin F. Molecular Cloning, Functional Expression, Tissue Localization, and Enzymatic Characterization
(American Society for Biochemistry and Molecular Biology, 1998) -
Human CD4+ Memory T Cells Can Become CD4+IL-9+ T Cells
(Public Library of Science, 2010)Background: IL-9 is a growth factor for T- and mast-cells that is secreted by human Th2 cells. We recently reported that IL-4+TGF-β directs mouse CD4+CD25−CD62L+ T cells to commit to inflammatory IL-9 producing CD4+ T ... -
Human Cerebrospinal Fluid Contains CD4+ Memory T Cells Expressing Gut- or Skin-Specific Trafficking Determinants: Relevance for Immunotherapy
(BioMed Central, 2006)Background: Circulating memory T cells can be divided into tissue-specific subsets, which traffic through distinct tissue compartments during physiologic immune surveillance, based on their expression of adhesion molecules ... -
A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance
(Springer Science and Business Media LLC, 2020-01-20)Mucociliary clearance, the physiological process by which mammalian conducting airways expel pathogens and unwanted surface materials from the respiratory tract, depends on the coordinated function of multiple specialized ... -
Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation
(National Academy of Sciences, 2004)Claspin is a homolog of Mrc1, a checkpoint protein required for the DNA replication checkpoint in yeast. In Xenopus, phosphorylated Claspin binds to xChk1 and regulates xChk1 activation in response to replication stress. ... -
Human colostrum oligosaccharides modulate major immunologic pathways of immature human intestine
(2014)The immature neonatal intestinal immune system hyperreacts to newly colonizing unfamiliar bacteria. The hypothesis that human milk oligosaccharides from colostrum (cHMOS) can directly modulate the signaling pathways of the ... -
Human Cytomegalovirus Protein Kinase UL97 Forms a Complex with the Tegument Phosphoprotein pp65
(American Society for Microbiology, 2007)UL97 is a protein kinase encoded by human cytomegalovirus (HCMV) and is an important target for antiviral drugs against this ubiquitous herpesvirus, which is a major cause of life-threatening opportunistic infections in ... -
Human Cytomegalovirus UL44 Concentrates at the Periphery of Replication Compartments, the Site of Viral DNA Synthesis
(American Society for Microbiology, 2012)The formation of replication compartments, the subnuclear structures in which the viral DNA genome is replicated, is a hallmark of hapesvirus infections. The localization of proteins and viral DNA within human cytomegalovirus ... -
Human Cytomegalovirus UL50 and UL53 Recruit Viral Protein Kinase UL97, Not Protein Kinase C, for Disruption of Nuclear Lamina and Nuclear Egress in Infected Cells
(American Society for Microbiology, 2014)Herpesvirus nucleocapsids traverse the nuclear envelope into the cytoplasm in a process called nuclear egress that includes disruption of the nuclear lamina. In several herpesviruses, a key player in nuclear egress is a ... -
Human Cytomegalovirus UL97 Phosphorylates the Viral Nuclear Egress Complex
(American Society for Microbiology, 2015)Herpesvirus nucleocapsids exit the host cell nucleus in an unusual process known as nuclear egress. The human cytomegalovirus (HCMV) UL97 protein kinase is required for efficient nuclear egress, which can be explained by ... -
A Human Cytomegalovirus-Encoded microRNA Regulates Expression of Multiple Viral Genes Involved in Replication
(Public Library of Science, 2007)Although multiple studies have documented the expression of over 70 novel virus-encoded microRNAs (miRNAs), the targets and functions of most of these regulatory RNA species are unknown. In this study a comparative ... -
Human DDX3 Functions in Translation and Interacts with the Translation Initiation Factor eIF3
(Oxford University Press, 2008)The conserved RNA helicase DDX3 is of major medical importance due to its involvement in numerous cancers, human hepatitis C virus (HCV) and HIV. Although DDX3 has been reported to have a wide variety of cellular functions, ...