Now showing items 8017-8036 of 17918

    • Identification of a Protein Subset of the Anthrax Spore Immunome in Humans Immunized with the Anthrax Vaccine Adsorbed Preparation 

      Kudva, Indira T.; Griffin, Robert W.; Garren, Jeonifer M.; Calderwood, Stephen B.; John, Manohar (American Society for Microbiology, 2005)
      We identified spore targets of Anthrax Vaccine Adsorbed (AVA)-induced immunity in humans by screening recombinant clones of a previously generated, limited genomic Bacillus anthracis Sterne (pXO1(+), pXO2(-)) expression ...
    • Identification of a Rare Coding Variant in Complement 3 Associated with Age-related Macular Degeneration 

      Zhan, Xiaowei; Larson, David E.; Wang, Chaolong; Koboldt, Daniel C.; Sergeev, Yuri V.; Fulton, Robert S.; Fulton, Lucinda L.; Fronick, Catrina C.; Branham, Kari E.; Bragg-Gresham, Jennifer; Jun, Goo; Hu, Youna; Kang, Hyun Min; Liu, Dajiang; Othman, Mohammad; Brooks, Matthew; Ratnapriya, Rinki; Boleda, Alexis; Grassmann, Felix; von Strachwitz, Claudia; Olson, Lana M.; Buitendijk, Gabriëlle H.S.; Hofman, Albert; van Duijn, Cornelia M.; Cipriani, Valentina; Moore, Anthony T.; Shahid, Humma; Jiang, Yingda; Conley, Yvette P.; Morgan, Denise J.; Kim, Ivana K.; Johnson, Matthew P.; Cantsilieris, Stuart; Richardson, Andrea J.; Guymer, Robyn H.; Luo, Hongrong; Ouyang, Hong; Licht, Christoph; Pluthero, Fred G.; Zhang, Mindy M.; Zhang, Kang; Baird, Paul N.; Blangero, John; Klein, Michael L.; Farrer, Lindsay A.; DeAngelis, Margaret M.; Weeks, Daniel E.; Gorin, Michael B.; Yates, John R.W.; Klaver, Caroline C.W.; Pericak-Vance, Margaret A.; Haines, Jonathan L.; Weber, Bernhard H.F.; Wilson, Richard K.; Heckenlively, John R.; Chew, Emily Y.; Stambolian, Dwight; Mardis, Elaine R.; Swaroop, Anand; Abecasis, Goncalo R. (2013)
      Macular degeneration is a common cause of blindness in the elderly. To identify rare coding variants associated with a large increase in risk of age-related macular degeneration (AMD), we sequenced 2,335 cases and 789 ...
    • Identification of a Signature Motif in Target mRNAs of RNA-binding Protein AUF1 

      Mazan-Mamczarz, Krystyna; Kuwano, Yuki; Zhan, Ming; White, Elizabeth; Martindale, Jennifer; Lal, Ashish; Gorospe, Myriam (Oxford University Press, 2009)
      The ubiquitous RNA-binding protein AUF1 promotes the degradation of some target mRNAs, but increases the stability and translation of other targets. Here, we isolated AUF1-associated mRNAs by immunoprecipitation of (AUF1–RNA) ...
    • Identification of a Small Molecule that Increases Hemoglobin Oxygen Affinity and Reduces SS Erythrocyte Sickling 

      Nakagawa, Akito; Lui, Francine E.; Wassaf, Dina; Yefidoff-Freedman, Revital; Casalena, Dominick; Palmer, Michelle A.; Meadows, Jacqueline; Mozzarelli, Andrea; Ronda, Luca; Abdulmalik, Osheiza; Bloch, Kenneth D.; Safo, Martin K.; Zapol, Warren M. (American Chemical Society, 2014)
      Small molecules that increase the oxygen affinity of human hemoglobin may reduce sickling of red blood cells in patients with sickle cell disease. We screened 38 700 compounds using small molecule microarrays and identified ...
    • Identification of a Unique TGF-β Dependent Molecular and Functional Signature in Microglia 

      Butovsky, Oleg; Jedrychowski, Mark P.; Moore, Craig S.; Cialic, Ron; Lanser, Amanda J.; Gabriely, Galina; Koeglsperger, Thomas; Dake, Ben; Wu, Pauline M.; Doykan, Camille E.; Fanek, Zain; Liu, LiPing; Chen, Zhuoxun; Rothstein, Jeffrey D.; Ransohoff, Richard M.; Gygi, Steven P.; Antel, Jack P.; Weiner, Howard L. (2014)
      Microglia are myeloid cells of the central nervous system (CNS) that participate both in normal CNS function and disease. We investigated the molecular signature of microglia and identified 239 genes and 8 microRNAs that ...
    • Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2 

      Wang, Zhiwei; Inuzuka, Hiroyuki; Zhong, Jiateng; Liu, Pengda; Sarkar, Fazlul H.; Sun, Yi; Wei, Wenyi (Impact Journals LLC, 2012)
      The Skp2 (S-phase kinase associated protein 2) oncoprotein is often highly expressed in various types of human cancers. However, the mechanistic basis of its oncogenic function, as well as the upstream regulatory pathway(s) ...
    • Identification of adult midgut precursors in Drosophila 

      Micchelli, Craig A.; Sudmeier, Lisa; Perrimon, Norbert; Tang, Shan; Beehler-Evans, Ryan (Elsevier, 2011)
      The adult Drosophila midgut is thought to arise from an endodermal rudiment specified during embryogenesis. Previous studies have reported the presence of individual cells termed adult midgut precursors (AMPs) as well as ...
    • Identification of ALK Gene Alterations in Urothelial Carcinoma 

      Bellmunt, Joaquim; Selvarajah, Shamini; Rodig, Scott; Salido, Marta; de Muga, Silvia; Costa, Irmgard; Bellosillo, Beatriz; Werner, Lillian; Mullane, Stephanie; Fay, André P.; O'Brien, Robert; Barretina, Jordi; Minoche, André E.; Signoretti, Sabina; Montagut, Clara; Himmelbauer, Heinz; Berman, David M.; Kantoff, Philip; Choueiri, Toni K.; Rosenberg, Jonathan E. (Public Library of Science, 2014)
      Background: Anaplastic lymphoma kinase (ALK) genomic alterations have emerged as a potent predictor of benefit from treatment with ALK inhibitors in several cancers. Currently, there is no information about ALK gene ...
    • Identification of Altered Metabolomic Profiles Following a Panchakarma-based Ayurvedic Intervention in Healthy Subjects: The Self-Directed Biological Transformation Initiative (SBTI) 

      Peterson, Christine Tara; Lucas, Joseph; John-Williams, Lisa St.; Thompson, J. Will; Moseley, M. Arthur; Patel, Sheila; Peterson, Scott N.; Porter, Valencia; Schadt, Eric E.; Mills, Paul J.; Tanzi, Rudolph E.; Doraiswamy, P. Murali; Chopra, Deepak (Nature Publishing Group, 2016)
      The effects of integrative medicine practices such as meditation and Ayurveda on human physiology are not fully understood. The aim of this study was to identify altered metabolomic profiles following an Ayurveda-based ...
    • Identification of an Antimicrobial Agent Effective against Methicillin-Resistant Staphylococcus aureus Persisters Using a Fluorescence-Based Screening Strategy 

      Kim, Wooseong; Conery, Annie L.; Rajamuthiah, Rajmohan; Fuchs, Beth Burgwyn; Ausubel, Frederick M.; Mylonakis, Eleftherios (Public Library of Science, 2015)
      Persisters are a subpopulation of normal bacterial cells that show tolerance to conventional antibiotics. Persister cells are responsible for recalcitrant chronic infections and new antibiotics effective against persisters ...
    • Identification of an Evolutionarily Conserved Domain in Human Lens Epithelium-derived Growth Factor/Transcriptional Co-activator p75 (LEDGF/p75) That Binds HIV-1 Integrase 

      Cherepanov, Peter; Devroe, Eric; Silver, Pamela A.; Engelman, Alan (American Society for Biochemistry and Molecular Biology, 2004)
      Human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) protein was recently identified as a binding partner for HIV-1 integrase (IN) in human cells. In this work, we used biochemical and ...
    • Identification of Angiogenesis/Metastases Genes Predicting Chemoradiotherapy Response in Patients With Laryngopharyngeal Carcinoma 

      Ganly, Ian; Talbot, Simon George; Carlson, Diane; Viale, Agnes; Maghami, Ellie; Osman, Iman; Sherman, Eric; Pfister, David; Chuai, Shaokun; Shaha, Ashok R.; Kraus, Dennis; Shah, Jatin P.; Socci, Nicholas D.; Singh, Bhuvanesh (American Society of Clinical Oncology (ASCO), 2007)
      Purpose To identify genes related to angiogenesis/metastasis that predict locoregional failure in patients with laryngopharyngeal cancer (LPC) undergoing chemoradiotherapy (CRT) treatment. Methods Tumor tissue was ...
    • Identification of Anti-virulence Compounds That Disrupt Quorum-Sensing Regulated Acute and Persistent Pathogenicity 

      Starkey, Melissa; Lepine, Francois; Maura, Damien; Bandyopadhaya, Arunava; Lesic, Biljana; He, Jianxin; Kitao, Tomoe; Righi, Valeria; Milot, Sylvain; Tzika, Aria; Rahme, Laurence (Public Library of Science, 2014)
      Etiological agents of acute, persistent, or relapsing clinical infections are often refractory to antibiotics due to multidrug resistance and/or antibiotic tolerance. Pseudomonas aeruginosa is an opportunistic Gram-negative ...
    • Identification of Antifungal Compounds Active against Candida albicans Using an Improved High-Throughput Caenorhabditis elegans Assay 

      Okoli, Ikechukwu; Tempakakis, Emmanouil; Holson, Edward; Wagner, Florence; Conery, Annie L.; Larkins-Ford, Jonah; Stern, Andy; Coleman, Jeffrey James; An, W. Frank; Wu, Gang; Ausubel, Frederick M.; Mylonakis, Eleftherios (Public Library of Science, 2009)
      Candida albicans, the most common human pathogenic fungus, can establish a persistent lethal infection in the intestine of the microscopic nematode Caenorhabditis elegans. The C. elegans–C. albicans infection model was ...
    • Identification of Anziaic Acid, a Lichen Depside from Hypotrachyna sp., as a New Topoisomerase Poison Inhibitor 

      Cheng, Bokun; Cao, Shugeng; Vasquez, Victor; Annamalai, Thirunavukkarasu; Tamayo-Castillo, Giselle; Clardy, Jon C.; Tse-Dinh, Yuk-Ching (Public Library of Science, 2013)
      Topoisomerase inhibitors are effective for antibacterial and anticancer therapy because they can lead to the accumulation of the intermediate DNA cleavage complex formed by the topoisomerase enzymes, which trigger cell ...
    • Identification of Associations Between Prescribed Medications and Cancer: A Nationwide Screening Study 

      Pottegård, Anton; Friis, Søren; Christensen, René dePont; Habel, Laurel A.; Gagne, Joshua J.; Hallas, Jesper (Elsevier, 2016)
      Purpose We present a systematic screening for identifying associations between prescribed drugs and cancer risk using the high quality Danish nationwide health registries. Methods: We identified all patients (cases) with ...
    • Identification of Autoimmune Gene Signatures in Autism 

      Jung, J-Y; Kohane, Isaac Samuel; Wall, Dennis Paul Paul (Nature Publishing Group, 2011)
      The role of the immune system in neuropsychiatric diseases, including autism spectrum disorder (ASD), has long been hypothesized. This hypothesis has mainly been supported by family cohort studies and the immunological ...
    • Identification of BACE1 Cleavage Sites in Human Voltage-Gated Sodium Channel Beta 2 Subunit 

      Gersbacher, Manuel T; Kim, Doo Yeon; Bhattacharyya, Raja; Kovacs, Dora M. (BioMed Central, 2010)
      Background: The voltage-gated sodium channel β2 subunit (Navβ2) is a physiological substrate of BACE1 (β-site APP cleaving enzyme) and γ-secretase, two proteolytic enzymes central to Alzheimer's disease pathogenesis. ...
    • Identification of broadly neutralizing antibody epitopes in the HIV-1 envelope glycoprotein using evolutionary models 

      Lacerda, Miguel; Moore, Penny L; Ngandu, Nobubelo K; Seaman, Michael; Gray, Elin S; Murrell, Ben; Krishnamoorthy, Mohan; Nonyane, Molati; Madiga, Maphuti; Wibmer, Constantinos Kurt; Sheward, Daniel; Bailer, Robert T; Gao, Hongmei; Greene, Kelli M; Karim, Salim S Abdool; Mascola, John R; Korber, Bette TM; Montefiori, David C; Morris, Lynn; Williamson, Carolyn; Seoighe, Cathal (BioMed Central, 2013)
      Background: Identification of the epitopes targeted by antibodies that can neutralize diverse HIV-1 strains can provide important clues for the design of a preventative vaccine. Methods: We have developed a computational ...
    • Identification of bromodomain-containing protein-4 as a novel marker and epigenetic target in mast cell leukemia 

      Wedeh, Ghaith; Cerny-Reiterer, Sabine; Eisenwort, Gregor; Hermann, Harald; Blatt, Katharina; Hadzijusufovic, Emir; Sadovnik, Irina; Müllauer, Leonhard; Schwaab, Juliana; Hoffmann, Thomas; Bradner, James Elliott; Radia, Deepti; Sperr, Wolfgang R.; Hoermann, Gregor; Reiter, Andreas; Horny, Hans-Peter; Zuber, Johannes; Arock, Michel; Valent, Peter (Nature Publishing Group, 2015)
      Advanced systemic mastocytosis (SM) is a life-threatening neoplasm characterized by uncontrolled growth and accumulation of neoplastic mast cells (MCs) in various organs and a poor survival. So far, no curative treatment ...