Browsing HMS Scholarly Articles by Title
Now showing items 844-863 of 17917
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Ankle impingement
(BioMed Central, 2016)Ankle impingement is a syndrome that encompasses a wide range of anterior and posterior joint pathology involving both osseous and soft tissue abnormalities. In this review, the etiology, pathoanatomy, diagnostic workup, ... -
ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3
(2013)Nephronophthisis (NPH) is an autosomal recessive cystic kidney disease that leads to renal failure in childhood or adolescence. Most NPHP gene products form molecular networks. We have identified ANKS6 as a new NPHP family ... -
ANKS6 is the critical activator of NEK8 kinase in embryonic situs determination and organ patterning
(2015)The ciliary kinase NEK8 plays a critical role in situs determination and cystic kidney disease, yet its exact function remains unknown. In this study we identify ANKS6 as a target and activator of NEK8. ANKS6 requires NEK8 ... -
Ankyrin 3: Genetic Association with Bipolar Disorder and Relevance to Disease Pathophysiology
(BioMed Central, 2012)Bipolar disorder (BD) is a multi-factorial disorder caused by genetic and environmental influences. It has a large genetic component, with heritability estimated between 59-93%. Recent genome-wide association studies (GWAS) ... -
Ankyrin-G Regulates Neurogenesis and Wnt Signaling by Altering the Subcellular Localization of β-catenin
(2014)Ankyrin-G is a scaffolding protein required for the formation of the axon initial segment in neurons. Recent genome-wide association studies and whole-exome sequencing have identified ANK3, the gene coding for ankyrin-G, ... -
Annexin A1–containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair
(American Society for Clinical Investigation, 2015)Epithelial restitution is an essential process that is required to repair barrier function at mucosal surfaces following injury. Prolonged breaches in epithelial barrier function result in inflammation and further damage; ... -
Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics
(2014)Genome-wide association studies (GWAS) have identified thousands of loci associated wtih complex traits, but it is challenging to pinpoint causal genes in these loci and to exploit subtle association signals. We used ... -
Annual Ambient Black Carbon Associated with Shorter Telomeres in Elderly Men: Veterans Affairs Normative Aging Study
(National Institute of Environmental Health Sciences, 2010)Background: Telomere length reflects biological age and is inversely associated with risk of cardiovascular disease (CVD). Ambient air pollution is associated with CVD, but its effect on telomere length is unknown. Objective: ... -
Anomalous origin of the coronary artery arising from the opposite sinus: prevalence and outcomes in patients undergoing coronary CTA
(Oxford University Press (OUP), 2016)Aims The impact of coronary computed tomographic angiography (CTA) on management of anomalous origin of the coronary artery arising from the opposite sinus (ACAOS) remains uncertain. We examined the prevalence, anatomical ... -
Antagonism Between Smad1 and Smad2 Signaling Determines the Site of Distal Visceral Endoderm Formation in the Mouse Embryo
(Rockefeller University Press, 2009)The anterior–posterior axis of the mouse embryo is established by formation of distal visceral endoderm (DVE) and its subsequent migration. The precise mechanism of DVE formation has remained unknown, however. Here we show ... -
Antecedent Hypoglycemia Impairs Autonomic Cardiovascular Function
(American Diabetes Association, 2009)OBJECTIVE—Glycemic control decreases the incidence and progression of diabetic complications but increases the incidence of hypoglycemia. Hypoglycemia can impair hormonal and autonomic responses to subsequent hypoglycemia. ... -
Antecedent Treatment with Different Antibiotic Agents as a Risk Factor for Vancomycin-Resistant Enterococcus
(Centers for Disease Control and Prevention, 2002)We conducted a matched case-control study to compare the effect of antecedent treatment with various antibiotics on subsequent isolation of vancomycin-resistant Enterococcus (VRE); 880 in-patients; 233 VRE cases, and 647 ... -
Anterior limb of the internal capsule in schizophrenia: a diffusion tensor tractography study
(Springer Science + Business Media, 2012)Thalamo-cortical feedback loops play a key role in the processing and coordination of processing and integration of perceptual inputs and outputs, and disruption in this connection has long been hypothesized to contribute ... -
Anterior Urethral Stricture Disease Negatively Impacts the Quality of Life of Family Members
(Hindawi Publishing Corporation, 2016)Purpose. To quantify the quality of life (QoL) distress experienced by immediate family members of patients with urethral stricture via a questionnaire given prior to definitive urethroplasty. The emotional, social, and ... -
Anterior uveitis secondary to type II essential cryoglobulinemia
(Springer, 2013)Background: The purpose of this report is to describe the association of severe anterior uveitis with type II essential cryoglobulinemia. Findings: A 40-year-old male with a history of psoriatic arthritis presented with ... -
Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors
(National Academy of Sciences, 2011) -
Anthrax Toxin Receptor 2 Determinants that Dictate the pH Threshold of Toxin Pore Formation
(Public Library of Science, 2007)The anthrax toxin receptors, ANTXR1 and ANTXR2, act as molecular clamps to prevent the protective antigen (PA) toxin subunit from forming pores until exposure to low pH. PA forms pores at pH ∼6.0 or below when it is bound ... -
Anthrax Toxin Receptor 2-Dependent Lethal Toxin Killing In Vivo
(Public Library of Science, 2006)Anthrax toxin receptors 1 and 2 (ANTXR1 and ANTXR2) have a related integrin-like inserted (I) domain which interacts with a metal cation that is coordinated by residue D683 of the protective antigen (PA) subunit of anthrax ... -
Anthrax Toxins Regulate Pain Signaling and Can Deliver Molecular Cargoes Into ANTXR2+ DRG Sensory Neurons
(Springer Science and Business Media LLC, 2021-12-20)Bacterial products can act on neurons to alter signaling and function. In the present study, we found that dorsal root ganglion (DRG) sensory neurons are enriched for ANTXR2, the high-affinity receptor for anthrax toxins. ... -
Anthrax Vaccine Design: Strategies to Achieve Comprehensive Protection Against Spore, Bacillus, and Toxin
(BioMed Central, 2005)The successful use of Bacillus anthracis as a lethal biological weapon has prompted renewed research interest in the development of more effective vaccines against anthrax. The disease consists of three critical components: ...