Browsing HMS Scholarly Articles by Title
Now showing items 8570-8589 of 17922
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In vitro models of cancer stem cells and clinical applications
(BioMed Central, 2016)Cancer cells, stem cells and cancer stem cells have for a long time played a significant role in the biomedical sciences. Though cancer therapy is more effective than it was a few years ago, the truth is that still none ... -
In Vitro Priming Recapitulates In Vivo HIV-1 Specific T Cell Responses, Revealing Rapid Loss of Virus Reactive CD4+ T Cells in Acute HIV-1 Infection
(Public Library of Science, 2009)Background: The requirements for priming of HIV-specific T cell responses initially seen in infected individuals remain to be defined. Activation of T cell responses in lymph nodes requires cell-cell contact between T cells ... -
In Vitro Validation of an Artefact Suppression Algorithm in X-Ray Phase-Contrast Computed Tomography
(Public Library of Science, 2015)X-ray phase-contrast tomography can significantly increase the contrast-resolution of conventional attenuation-contrast imaging, especially for soft-tissue structures that have very similar attenuation. Just as in ... -
In Vivo Analysis of Lrig Genes Reveals Redundant and Independent Functions in the Inner Ear
(Public Library of Science, 2013)Lrig proteins are conserved transmembrane proteins that modulate a variety of signaling pathways from worm to humans. In mammals, there are three family members – Lrig1, Lrig2, and Lrig3 – that are defined by closely related ... -
In Vivo Analysis of the Notch Receptor S1 Cleavage
(Public Library of Science, 2009)A ligand-independent cleavage (S1) in the extracellular domain of the mammalian Notch receptor results in what is considered to be the canonical heterodimeric form of Notch on the cell surface. The in vivo consequences and ... -
In vivo analysis of the pivot shift phenomenon during computer navigated ACL reconstruction
(Springer Nature, 2008)Abstract ACL insufficiency can be documented clinically with the pivot shift maneuver, but the specific pathologic kinematics of the pivot shift is difficult to quantify. Navi- gation provides an opportunity to analyze in ... -
In Vivo and In Vitro Dynamics of Undifferentiated Embryonic Cell Transcription Factor 1
(Elsevier, 2014)Summary Pluripotent stem cells retain the ability to differentiate into the three germ layers and germline. As a result, there is a major interest in characterizing regulators that establish and maintain pluripotency. The ... -
In Vivo Anti-HIV Activity of the Heparin-Activated Serine Protease Inhibitor Antithrombin III Encapsulated in Lymph-Targeting Immunoliposomes
(Public Library of Science, 2012)Endogenous serine protease inhibitors (serpins) are anti-inflammatory mediators with multiple biologic functions. Several serpins have been reported to modulate HIV pathogenesis, or exhibit potent anti-HIV activity in ... -
In Vivo Brillouin Analysis of the Aging Crystalline Lens
(The Association for Research in Vision and Ophthalmology, 2016)Purpose To analyze the age dependence of the longitudinal modulus of the crystalline lens in vivo using Brillouin scattering data in healthy subjects. Methods: Brillouin scans were performed along the crystalline lens in ... -
In vivo Brillouin optical microscopy of the human eye
(Optical Society of America, 2012)We report the first Brillouin measurement of the human eye in vivo. We constructed a Brillouin optical scanner safe for human use by employing continuous-wave laser light at 780 nm at a low power of 0.7 mW. With a single ... -
In vivo cell cycle profiling in xenograft tumors by quantitative intravital microscopy
(2015)Quantification of cell-cycle state at a single-cell level is essential to understand fundamental three-dimensional biological processes such as tissue development and cancer. Analysis of 3D in vivo images, however, is very ... -
In Vivo Chemical Screening for Modulators of Hematopoiesis and Hematological Diseases
(Hindawi Publishing Corporation, 2012)In vivo chemical screening is a broadly applicable approach not only for dissecting genetic pathways governing hematopoiesis and hematological diseases, but also for finding critical components in those pathways that may ... -
In vivo co-localization of enzymes on RNA scaffolds increases metabolic production in a geometrically dependent manner
(Oxford University Press, 2014)Co-localization of biochemical processes plays a key role in the directional control of metabolic fluxes toward specific products in cells. Here, we employ in vivo scaffolds made of RNA that can bind engineered proteins ... -
In vivo coherent Raman imaging of the melanomagenesis-associated pigment pheomelanin
(Nature Publishing Group, 2016)Melanoma is the most deadly form of skin cancer with a yearly global incidence over 232,000 patients. Individuals with fair skin and red hair exhibit the highest risk for developing melanoma, with evidence suggesting the ... -
In Vivo Detection of Amyloid-\(\beta\) Deposits Using Heavy Chain Antibody Fragments in a Transgenic Mouse Model for Alzheimer's Disease
(Public Library of Science, 2012)This study investigated the in vivo properties of two heavy chain antibody fragments (V\(_H\)H), ni3A and pa2H, to differentially detect vascular or parenchymal amyloid-\(\beta\) deposits characteristic for Alzheimer's ... -
In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation
(Nature Research, 2011)Coagulase-positive Staphylococcus aureus (S. aureus) is the major causal pathogen of acute endocarditis, a rapidly progressing, destructive infection of the heart valves. Bacterial colonization occurs at sites of endothelial ... -
In vivo Ebola virus infection leads to a strong innate response in circulating immune cells
(BioMed Central, 2016)Background: Ebola virus is the causative agent of a severe syndrome in humans with a fatality rate that can approach 90 %. During infection, the host immune response is thought to become dysregulated, but the mechanisms ... -
In vivo evaluation of chemical biopersistence of nonfibrous inorganic particles.
(1994)The lung's response to deposited particles may depend upon the physical-chemical properties of the particles, the amount initially deposited, and the persistence of the particles. Clearance involves mucociliary transport ... -
In vivo evaluation of edge-loading in metal-on-metal hip resurfacing patients with pseudotumours
(British Editorial Society of Bone and Joint Surgery, 2012)Objectives: Pseudotumours (abnormal peri-prosthetic soft-tissue reactions) following metal-on-metal hip resurfacing arthroplasty (MoMHRA) have been associated with elevated metal ion levels, suggesting that excessive wear ... -
In Vivo Expansion of Regulatory T Cells by Low-Dose Interleukin-2 Treatment Increases Allograft Survival in Corneal Transplantation
(Ovid Technologies (Wolters Kluwer Health), 2016)Background Corneal allograft survival dramatically decreases in hosts with inflamed or vascularized recipient beds. We have previously shown that in rejected corneal allografts regulatory T cells (Tregs) demonstrate ...