Browsing HMS Scholarly Articles by Title
Now showing items 8619-8638 of 17922
-
In Vivo Volume and Hemoglobin Dynamics of Human Red Blood Cells
(Public Library of Science, 2014)Human red blood cells (RBCs) lose ∼30% of their volume and ∼20% of their hemoglobin (Hb) content during their ∼100-day lifespan in the bloodstream. These observations are well-documented, but the mechanisms for these volume ... -
In-Home Solid Fuel Use and Cardiovascular Disease: A Cross-Sectional Analysis of the Shanghai Putuo Study
(BioMed Central, 2012)Background: Although recent research evidence suggests an association between household air pollution from solid fuel use, such as coal or biomass, and cardiovascular events such as hypertension, little epidemiologic data ... -
In-hospital measurement of left ventricular ejection fraction and one-year outcomes in acute coronary syndromes: results from the IMMEDIATE Trial
(BioMed Central, 2016)Background: In patients with acute coronary syndrome (ACS), reduced left ventricular ejection fraction (LVEF) is a known marker for increased mortality. However, the relationship between LVEF measured during index ACS ... -
In-vivo glenohumeral translation and ligament elongation during abduction and abduction with internal and external rotation
(BioMed Central, 2012)Study Design: Basic Science. To investigate humeral head translations and glenohumeral ligament elongation with a dual fluoroscopic imaging system. Background: The glenohumeral ligaments are partially responsible for ... -
Inactivation and Disassembly of the Anaphase-Promoting Complex during Human Cytomegalovirus Infection Is Associated with Degradation of the APC5 and APC4 Subunits and Does Not Require UL97-Mediated Phosphorylation of Cdh1
(American Society for Microbiology, 2010)Infection of quiescent cells by human cytomegalovirus (HCMV) elicits severe cell cycle deregulation, resulting in a G(1)/S arrest, which can be partly attributed to the inactivation of the anaphase-promoting complex (APC). ... -
Inactivation of Drosophila Huntingtin Affects Long-Term Adult Functioning and the Pathogenesis of a Huntington's Disease Model
(The Company of Biologists, 2009-05)A polyglutamine expansion in the huntingtin (HTT) gene causes neurodegeneration in Huntington’s disease (HD), but the in vivo function of the native protein (Htt) is largely unknown. Numerous biochemical and in vitro studies ... -
Inactivation of GSK3β and activation of NF-κB pathway via Axl represents an important mediator of tumorigenesis in esophageal squamous cell carcinoma
(The American Society for Cell Biology, 2015)The receptor tyrosine kinase Axl has been described as an oncogene, and its deregulation has been implicated in the progression of several human cancers. While the role of Axl in esophageal adenocarcinoma has been addressed, ... -
Inactivation of Retinoblastoma Protein Does Not Overcome the Requirement for Human Cytomegalovirus UL97 in Lamina Disruption and Nuclear Egress
(American Society for Microbiology, 2013)Human cytomegalovirus (HCMV) encodes one conventional protein kinase, UL97. During infection, UL97 phosphorylates the retinoblastoma tumor suppressor protein (pRb) on sites ordinarily phosphorylated by cyclin-dependent ... -
Inactivation of the Huntington's Disease Gene (Hdh) Impairs Anterior Streak Formation and Early Patterning of the Mouse Embryo
(BioMed Central, 2005)Background: Huntingtin, the HD gene encoded protein mutated by polyglutamine expansion in Huntington's disease, is required in extraembryonic tissues for proper gastrulation, implicating its activities in nutrition or ... -
Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression
(The Rockefeller University Press, 2013)Thymic involution during aging is a major cause of decreased production of T cells and reduced immunity. Here we show that inactivation of Rb family genes in young mice prevents thymic involution and results in an enlarged ... -
Inadequate Prescription-Drug Coverage for Medicare Enrollees — A Call to Action
(New England Journal of Medicine (NEJM/MMS), 1999)The demise of both the Medicare Catastrophic Coverage Act of 19881 and the 1993 Clinton plan for health care reform2,3 resulted in missed opportunities to correct a glaring defect in the American health care system — ... -
Inadvertent Percutaneous Endoscopic Gastrostomy Tube Placement through the Transverse Colon to the Stomach Causing Intractable Diarrhea: A Case Report
(Hindawi Publishing Corporation, 2011)Background: Among patients with chronic disease, percutaneous endoscopic gastrostomy (PEG) tubes are a common mechanism to deliver enteral feedings to patients unable to feed by mouth. While several cases in the literature ... -
Incidence and patterns of polydrug use and craving for ecstasy in regular ecstasy users: An ecological momentary assessment study
(Elsevier BV, 2006)Background: Previous studies employing retrospective assessments methods found that regular ecstasy users frequently use alcohol, marihuana and other drugs in combination with ecstasy. Methods: Twenty-two participants (13 ... -
Incidence and Predictors of Pregnancy among a Cohort of HIV-Positive Women Initiating Antiretroviral Therapy in Mbarara, Uganda
(Public Library of Science, 2013)Objective: Many people living with HIV in sub-Saharan Africa desire biological children. Implementation of HIV prevention strategies that support the reproductive goals of people living with HIV while minimizing HIV ... -
Incidence and prevalence of idiopathic inflammatory myopathies among commercially insured, Medicare supplemental insured, and Medicaid enrolled populations: an administrative claims analysis
(BioMed Central, 2012)Background: Idiopathic inflammatory myopathies (IIMs) are a rare group of autoimmune syndromes characterized by chronic muscle inflammation and muscle weakness with no known cause. Little is known about their incidence and ... -
Incidence and Preventability of Adverse Drug Events Among Older Persons in the Ambulatory Setting
(American Medical Association (AMA), 2003-03-05)Context: Adverse drug events, especially those that may be preventable, are among the most serious concerns about medication use in older persons cared for in the ambulatory clinical setting. Objective: To assess the ... -
Incidence and Remission of Parasomnias among Adolescent Children in the Tucson Children’s Assessment of Sleep Apnea
(Arizona, New Mexico and Colorado Thoracic Societies, 2011)Background: Longitudinal assessments of parasomnias in the adolescent population are scarce. This analysis aims to identify the incidence and remission of parasomnias in the adolescent age group.Methods: The TuCASA study ... -
Incidence and Remission of Sleep-Disordered Breathing and Related Symptoms in 6- to 17-Year Old Children—The Tucson Children's Assessment of Sleep Apnea Study
(Elsevier BV, 2010-07)Objective To determine the incidence and remission of sleep disordered breathing in adolescent children. Study design 319 children completed two home polysomnograms approximately 5 years apart. Sleep disordered breathing ... -
Incidence and Risk Factors of Ventricular Fibrillation Before Primary Angioplasty in Patients With First ST‐Elevation Myocardial Infarction: A Nationwide Study in Denmark
(Blackwell Publishing Ltd, 2014)Background: We aimed to investigate the incidence and risk factors for ventricular fibrillation (VF) before primary percutaneous coronary intervention (PPCI) among patients with ST‐segment elevation myocardial infarction ... -
Incidence of Adverse Drug Events and Potential Adverse Drug Events
(American Medical Association (AMA), 1995-07-05)Objectives. —To assess incidence and preventability of adverse drug events (ADEs) and potential ADEs. To analyze preventable events to develop prevention strategies. Design. —Prospective cohort study. Participants. ...