Browsing HMS Scholarly Articles by Title
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Antibody Derived Peptides for Detection of Ebola Virus Glycoprotein
(Public Library of Science, 2015)Background: Current Ebola virus (EBOV) detection methods are costly and impractical for epidemic scenarios. Different immune-based assays have been reported for the detection and quantification of Ebola virus (EBOV) proteins. ... -
Antibody Engineering & Therapeutics 2016: The Antibody Society's annual meeting, December 11–15, 2016, San Diego, CA
(Taylor & Francis, 2016)ABSTRACT Antibody Engineering & Therapeutics, the largest meeting devoted to antibody science and technology and the annual meeting of The Antibody Society, will be held in San Diego, CA on December 11-15, 2016. Each of ... -
Antibody Responses After Analytic Treatment Interruption in Human Immunodeficiency Virus-1-Infected Individuals on Early Initiated Antiretroviral Therapy
(Oxford University Press, 2016)The examination of antibody responses in human immunodeficiency virus (HIV)-1-infected individuals in the setting of antiretroviral treatment (ART) interruption can provide insight into the evolution of antibody responses ... -
Antibody Responses after Intravaginal Immunisation with Trimeric HIV-1CN54 clade C gp140 in Carbopol Gel are Augmented by Systemic Priming or Boosting with an Adjuvanted Formulation
(Elsevier Science, 2011)Optimum strategies to elicit and maintain antibodies at mucosal portals of virus entry are critical for the development of vaccines against human immunodeficiency virus (HIV). Here we show in non-human primates that a novel ... -
Antibody Secreting Cell Responses following Vaccination with Bivalent Oral Cholera Vaccine among Haitian Adults
(Public Library of Science, 2016)Background: The bivalent whole-cell (BivWC) oral cholera vaccine (Shanchol) is effective in preventing cholera. However, evaluations of immune responses following vaccination with BivWC have been limited. To determine ... -
An Antibody-Based Leukocyte-Capture Microarray for the Diagnosis of Systemic Lupus Erythematosus
(Public Library of Science, 2013)The diagnosis of Systemic Lupus Erythematosus (SLE) is challenging due to its heterogeneous clinical presentation and the lack of robust biomarkers to distinguish it from other autoimmune diseases. Further, currently used ... -
Antibody-Mediated Immunity to the Obligate Intracellular Bacterial Pathogen Coxiella burnetii is Fc Receptor- and Complement-Independent
(BioMed Central, 2009)Background: The obligate intracellular bacterial pathogen Coxiella burnetii causes the zoonosis Q fever. The intracellular niche of C. burnetii has led to the assumption that cell-mediated immunity is the most important ... -
Antibody-Secreting Cell Responses after Vibrio cholerae O1 Infection and Oral Cholera Vaccination in Adults in Bangladesh
(American Society for Microbiology, 2013)Infection with Vibrio cholerae and oral cholera vaccines (OCVs) induce transient circulating plasmablast responses that peak within approximately 7 days after infection or vaccination. We previously demonstrated that ... -
Anticancer Activity of an Extract from Needles and Twigs of Taxus cuspidata and Its Synergistic Effect as a Cocktail with 5-Fluorouracil
(BioMed Central, 2011)Background: Botanical medicines are increasingly combined with chemotherapeutics as anticancer drug cocktails. This study aimed to assess the chemotherapeutic potential of an extract of Taxus cuspidata (TC) needles and ... -
Anticancer Effect of Fucoidan in Combination with Tyrosine Kinase Inhibitor Lapatinib
(Hindawi Publishing Corporation, 2014)Background:. Despite a number of in vitro and in vivo studies reporting the efficacy of fucoidan in treating various cancers, few studies have measured the efficacy of dietary fucoidan (DF) in combination with cancer drugs. ... -
Anticipation of Monetary Reward Can Attenuate the Vigilance Decrement
(Public Library of Science, 2016)Motivation and reward can have differential effects on separate aspects of sustained attention. We previously demonstrated that continuous reward/punishment throughout a sustained attention task improves overall performance, ... -
Anticoagulants and Statins As Pharmacological Agents in Free Flap Surgery: Current Rationale
(Open Science Company, LLC, 2015)Microvascular free flaps are key components of reconstructive surgery, but despite their common use and usual reliability, flap failures still occur. Many pharmacological agents have been utilized to minimize risk of flap ... -
An Antifouling Coating That Enables Affinity-Based Electrochemical Biosensing in Complex Biological Fluids
(Springer Science and Business Media LLC, 2019-11-11)Affinity-based electrochemical detection in complex biological fluids could enable multiplexed point-of-care (POC) diagnostics for home healthcare; however, commercialisation of POC devices has been limited by rapid loss ... -
Antigen Cross-Presentation of Immune Complexes
(Frontiers Media S.A., 2014)The ability of dendritic cells (DCs) to cross-present tumor antigens has long been a focus of interest to physicians, as well as basic scientists, that aim to establish efficient cell-based cancer immune therapy. A ... -
Antigen identification and high-throughput interaction mapping by reprogramming viral entry
(Springer Science and Business Media LLC, 2022-04)Deciphering immune recognition is critical to understanding a broad range of diseases, and to develop effective vaccines and immunotherapies. Efforts to do so are limited by a lack of technologies capable of simultaneously ... -
Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1–Specific CD8+ T Cells
(Public Library of Science, 2008)Background: Virus-specific CD8+ T lymphocytes play a key role in the initial reduction of peak viremia during acute viral infections, but display signs of increasing dysfunction and exhaustion under conditions of chronic ... -
Antigen-mediated T cell expansion regulated by parallel pathways of death
(National Academy of Sciences, 2008)T cells enigmatically require caspase-8, an inducer of apoptosis, for antigen-driven expansion and effective antiviral responses, and yet the pathways responsible for this effect have been elusive. A defect in caspase-8 ... -
Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination
(Public Library of Science, 2016)Antibody effector functions, such as antibody-dependent cellular cytotoxicity, complement deposition, and antibody-dependent phagocytosis, play a critical role in immunity against multiple pathogens, particularly in the ... -
Antigen-Specific Immunoglobulin a Antibodies Secreted from Circulating B Cells Are an Effective Marker for Recent Local Immune Responses in Patients with Cholera: Comparison to Antibody-Secreting Cell Responses and Other Immunological Markers
(American Society for Microbiology, 2003)Gut-derived lymphocytes transiently migrate through the peripheral circulation before homing back to mucosal sites and can be detected using an ELISPOT-based antibody secreting cell (ASC) assay. Alternatively, transiently ... -
Antigen-Specific Memory B-Cell Responses in Bangladeshi Adults after One- or Two-Dose Oral Killed Cholera Vaccination and Comparison with Responses in Patients with Naturally Acquired Cholera
(American Society for Microbiology, 2011)The mediators of protective immunity against cholera are currently unknown, but memory B-cell responses may play a central role in facilitating long-term and anamnestic responses against Vibrio cholerae, the cause of ...