Browsing HMS Scholarly Articles by Title

Now showing items 901-920 of 17922

    • Antigen Cross-Presentation of Immune Complexes 

      Platzer, Barbara; Stout, Madeleine; Fiebiger, Edda (Frontiers Media S.A., 2014)
      The ability of dendritic cells (DCs) to cross-present tumor antigens has long been a focus of interest to physicians, as well as basic scientists, that aim to establish efficient cell-based cancer immune therapy. A ...

    • Antigen identification and high-throughput interaction mapping by reprogramming viral entry 

      Dobson, Connor; Reich, Anna; Gaglione, Stephanie; Smith, Blake; Kim, Ellen; Dong, Jiayi; Ronsard, Larance; Okonkwo, Vintus; Lingwood, Daniel; Dougan, Michael; Dougan, Stephanie; Brinbaum, Michael (Springer Science and Business Media LLC, 2022-04)
      Deciphering immune recognition is critical to understanding a broad range of diseases, and to develop effective vaccines and immunotherapies. Efforts to do so are limited by a lack of technologies capable of simultaneously ...

    • Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1–Specific CD8+ T Cells 

      Brumme, Zabrina L; Anastario, Michael; Cohen, Kristin W; Jolin, Jonathan S; Brumme, Chanson J; Streeck, Hendrik; Meier, Angela; Rosenberg, Eric Scott; Alter, Galit; Allen, Todd; Walker, Bruce David; Altfeld, Marcus (Public Library of Science, 2008)
      Background: Virus-specific CD8+ T lymphocytes play a key role in the initial reduction of peak viremia during acute viral infections, but display signs of increasing dysfunction and exhaustion under conditions of chronic ...

    • Antigen-mediated T cell expansion regulated by parallel pathways of death 

      Ch'en, Irene L.; Beisner, Daniel R.; Degterev, Alexei; Lynch, Candace; Yuan, Junying; Hoffmann, Alexander; Hedrick, Stephen M. (National Academy of Sciences, 2008)
      T cells enigmatically require caspase-8, an inducer of apoptosis, for antigen-driven expansion and effective antiviral responses, and yet the pathways responsible for this effect have been elusive. A defect in caspase-8 ...

    • Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination 

      Mahan, Alison E.; Jennewein, Madeleine F.; Suscovich, Todd; Dionne, Kendall; Tedesco, Jacquelynne; Chung, Amy W.; Streeck, Hendrik; Pau, Maria; Schuitemaker, Hanneke; Francis, Don; Fast, Patricia; Laufer, Dagna; Walker, Bruce D.; Baden, Lindsey; Barouch, Dan H.; Alter, Galit (Public Library of Science, 2016)
      Antibody effector functions, such as antibody-dependent cellular cytotoxicity, complement deposition, and antibody-dependent phagocytosis, play a critical role in immunity against multiple pathogens, particularly in the ...

    • Antigen-Specific Immunoglobulin a Antibodies Secreted from Circulating B Cells Are an Effective Marker for Recent Local Immune Responses in Patients with Cholera: Comparison to Antibody-Secreting Cell Responses and Other Immunological Markers 

      Qadri, Firdausi; Ryan, Edward T.; Faruque, A. G.; Ahmed, Firoz; Khan, Ashraful Islam; Islam, M. Monirul; Akramuzzaman, Syed M.; Sack, David. A.; Calderwood, Stephen B. (American Society for Microbiology, 2003)
      Gut-derived lymphocytes transiently migrate through the peripheral circulation before homing back to mucosal sites and can be detected using an ELISPOT-based antibody secreting cell (ASC) assay. Alternatively, transiently ...

    • Antigen-Specific Memory B-Cell Responses in Bangladeshi Adults after One- or Two-Dose Oral Killed Cholera Vaccination and Comparison with Responses in Patients with Naturally Acquired Cholera 

      Alam, Mohammad Murshid; Riyadh, M. Asrafuzzaman; Fatema, Kaniz; Rahman, Mohammad Arif; Akhtar, Nayeema; Ahmed, Tanvir; Chowdhury, Mohiul Islam; Chowdhury, Fahima; Calderwood, Stephen B.; Harris, Jason B.; Ryan, Edward T.; Qadri, Firdausi (American Society for Microbiology, 2011)
      The mediators of protective immunity against cholera are currently unknown, but memory B-cell responses may play a central role in facilitating long-term and anamnestic responses against Vibrio cholerae, the cause of ...

    • Antigen-Specific Memory B-cell Responses to Enterotoxigenic Escherichia coli Infection in Bangladeshi Adults 

      Alam, Mohammad Murshid; Aktar, Amena; Afrin, Sadia; Rahman, Mohammad Arif; Aktar, Sarmin; Uddin, Taher; Rahman, M. Arifur; Mahbuba, Deena Al; Chowdhury, Fahima; Khan, Ashraful Islam; Bhuiyan, Taufiqur Rahman; Begum, Yasmin Ara; Ryan, Edward T.; Calderwood, Stephen B.; Svennerholm, Ann-Mari; Qadri, Firdausi (Public Library of Science, 2014)
      Background: Multiple infections with diverse enterotoxigenic E. coli (ETEC) strains lead to broad spectrum protection against ETEC diarrhea. However, the precise mechanism of protection against ETEC infection is still ...

    • Antigen-Specific Memory B-Cell Responses to Vibrio cholerae O1 Infection in Bangladesh 

      Harris, Aaron M.; Bhuiyan, M. Saruar; Chowdhury, Fahima; Khan, Ashraful I.; Hossain, Azim; Kendall, Emily A.; Rahman, Atiqur; LaRocque, Regina C.; Wrammert, Jens; Ryan, Edward T.; Qadri, Firdausi; Calderwood, Stephen B.; Harris, Jason B. (American Society for Microbiology, 2009)
      Cholera, caused by Vibrio cholerae, is a noninvasive dehydrating enteric disease with a high mortality rate if untreated. Infection with V. cholerae elicits long-term protection against subsequent disease in countries where ...

    • Antigen-Specific Memory T Cell Responses after Vaccination with an Oral Killed Cholera Vaccine in Bangladeshi Children and Comparison to Responses in Patients with Naturally Acquired Cholera 

      Arifuzzaman, Mohammad; Rashu, Rasheduzzaman; Leung, Daniel T.; Hosen, M. Ismail; Bhuiyan, Taufiqur Rahman; Bhuiyan, M. Saruar; Rahman, Mohammad Arif; Khanam, Farhana; Saha, Amit; Charles, Richelle C.; LaRocque, Regina C.; Weil, Ana A.; Clements, John D.; Holmes, Randall K.; Calderwood, Stephen B.; Harris, Jason B.; Ryan, Edward T.; Qadri, Firdausi (American Society for Microbiology, 2012)
      Young children, older children, and adults develop comparable levels and durations of immunity following cholera. In comparison, young children receiving oral killed cholera vaccines (OCV) develop a lower level and shorter ...

    • Antigen-specific NK cell memory in rhesus macaques 

      Reeves, R. Keith; Li, Haiying; Jost, Stephanie; Blass, Eryn; Li, Hualin; Schafer, Jamie L.; Varner, Valerie; Manickam, Cordelia; Eslamizar, Leila; Altfeld, Marcus; von Andrian, Ulrich H.; Barouch, Dan H. (2015)
      Natural killer (NK) cells have traditionally been considered nonspecific components of innate immunity, but recent studies have shown features of antigen-specific memory in murine NK cells. However, it has remained unclear ...

    • Antigenic Characterization of the HCMV gH/gL/gO and Pentamer Cell Entry Complexes Reveals Binding Sites for Potently Neutralizing Human Antibodies 

      Ciferri, Claudio; Chandramouli, Sumana; Leitner, Alexander; Donnarumma, Danilo; Cianfrocco, Michael A.; Gerrein, Rachel; Friedrich, Kristian; Aggarwal, Yukti; Palladino, Giuseppe; Aebersold, Ruedi; Norais, Nathalie; Settembre, Ethan C.; Carfi, Andrea (Public Library of Science, 2015)
      Human Cytomegalovirus (HCMV) is a major cause of morbidity and mortality in transplant patients and in fetuses following congenital infection. The glycoprotein complexes gH/gL/gO and gH/gL/UL128/UL130/UL131A (Pentamer) are ...

    • Antigenicity-defined conformations of an extremely neutralization-resistant HIV-1 envelope spike 

      Cai, Yongfei; Karaca-Griffin, Selen; Chen, Jia; Tian, Sai; Fredette, Nicholas; Linton, Christine; Rits-Volloch, Sophia; Lu, Jianming; Wagh, Kshitij; Theiler, James; Korber, Bette; Seaman, Michael; Harrison, Stephen; Carfi, Andrea; Chen, Bing (National Academy of Sciences, 2017)
      The extraordinary genetic diversity of the HIV-1 envelope spike [Env; trimeric (gp160)(3), cleaved to (gp120/gp41)(3)] poses challenges for vaccine development. Envs of different clinical isolates exhibit different ...

    • Antihyperalgesia by α2-GABAA Receptors Occurs Via a Genuine Spinal Action and Does Not Involve Supraspinal Sites 

      Paul, Jolly; Yévenes, Gonzalo E; Benke, Dietmar; Lio, Alessandra Di; Ralvenius, William T; Witschi, Robert; Scheurer, Louis; Cook, James M; Rudolph, Uwe; Fritschy, Jean-Marc; Zeilhofer, Hanns Ulrich (Nature Publishing Group, 2014)
      Drugs that enhance GABAergic inhibition alleviate inflammatory and neuropathic pain after spinal application. This antihyperalgesia occurs mainly through GABAA receptors (GABAARs) containing α2 subunits (α2-GABAARs). ...

    • Antiinflammatory cAMP signaling and cell migration genes co-opted by the anthrax bacillus 

      Kim, Chun; Wilcox-Adelman, Sarah; Sano, Yasuyo; Tang, Wei-Jen; Collier, R. John; Park, Jin Mo (National Academy of Sciences, 2008)
      Bacillus anthracis, the etiologic agent of anthrax, avoids immune surveillance and commandeers host macrophages as a vehicle for lymphatic spreading. Here, we show that B. anthracis edema toxin (ET), via its adenylyl cyclase ...

    • Antileukemic Activity of Nuclear Export Inhibitors that Spare Normal Hematopoietic Cells 

      Etchin, Julia; Sun, Q; Kentsis, Alex; Farmer, A; Zhang, Z C; Sanda, Takaomi; Mansour, M R; Barcelo, C; McCauley, D; Kauffman, M; Shacham, S; Christie, A L; Kung, A L; Rodig, Scott J.; Chook, Y M; Look, A. Thomas (Nature Publishing Group, 2013)
      Drugs that target the chief mediator of nuclear export, chromosome region maintenance 1 protein (CRM1) have potential as therapeutics for leukemia, but existing CRM1 inhibitors show variable potencies and a broad range of ...

    • Antimicrobial and Efflux Pump Inhibitory Activity of Caffeoylquinic Acids from Artemisia absinthium Against Gram-Positive Pathogenic Bacteria 

      Fiamegos, Yiannis C.; Kastritis, Panagiotis L.; Exarchou, Vassiliki; Han, Haley; Bonvin, Alexandre M. J. J.; Vervoort, Jacques; Lewis, Kim; Hamblin, Michael; Tegos, George (Public Library of Science, 2011)
      Background: Traditional antibiotics are increasingly suffering from the emergence of multidrug resistance amongst pathogenic bacteria leading to a range of novel approaches to control microbial infections being investigated ...

    • Antimicrobial Chemicals Are Associated with Elevated Antibiotic Resistance Genes in the Indoor Dust Microbiome 

      Hartmann, Erica M.; Hickey, Roxana; Hsu, Tiffany; Betancourt Román, Clarisse M.; Chen, Jing; Schwager, Randall; Kline, Jeff; Brown, G. Z.; Halden, Rolf U.; Huttenhower, Curtis; Green, Jessica L. (American Chemical Society, 2016)
      Antibiotic resistance is increasingly widespread, largely due to human influence. Here, we explore the relationship between antibiotic resistance genes and the antimicrobial chemicals triclosan, triclocarban, and methyl-, ...

    • An Antimicrobial Peptidomimetic Induces Mucorales Cell Death through Mitochondria-Mediated Apoptosis 

      Barbu, E. Magda; Shirazi, Fazal; McGrath, Danielle M.; Albert, Nathaniel; Sidman, Richard L.; Pasqualini, Renata; Arap, Wadih; Kontoyiannis, Dimitrios P. (Public Library of Science, 2013)
      The incidence of mucormycosis has dramatically increased in immunocompromised patients. Moreover, the array of cellular targets whose inhibition results in fungal cell death is rather limited. Mitochondria have been ...

    • Antimicrobial Photodynamic Inactivation Inhibits Candida albicans Virulence Factors and ReducesIn VivoPathogenicity 

      Kato, Ilka Tiemy; Prates, Renato Araujo; Sabino, Caetano Padial; Tegos, George P.; Mylonakis, Eleftherios; Ribeiro, Martha Simões; Hamblin, Michael; Fuchs, Beth Burgwyn (American Society for Microbiology, 2012-11-05)
      The objective of this study was to evaluate whether Candida albicans exhibits altered pathogenicity characteristics following sublethal antimicrobial photodynamic inactivation (APDI) and if such alterations are maintained ...