Browsing HMS Scholarly Articles by Title

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    • Ischemic Stroke Activates Hematopoietic Bone Marrow Stem Cells 

      Courties, Gabriel; Herisson, Fanny; Sager, Hendrik; Heidt, Timo; Ye, Yuxiang; Wei, Ying; Sun, Yuan; Severe, Nicolas; Dutta, Partha; Scharff, Jennifer; Scadden, David; Weissleder, Ralph; Swirski, Filip; Moskowitz, Michael; Nahrendorf, Matthias (American Heart Association, 2015)
      Rationale: The mechanisms leading to an expanded neutrophil and monocyte supply after stroke are incompletely understood. Objective: To test the hypothesis that transient middle cerebral artery occlusion (tMCAO) in mice ...

    • The Islet Estrogen Receptor-α Is Induced by Hyperglycemia and Protects Against Oxidative Stress-Induced Insulin-Deficient Diabetes 

      Kilic, Gamze; Alvarez-Mercado, Ana I.; Zarrouki, Bader; Opland, Darren; Liew, Chong Wee; Alonso, Laura C.; Myers, Martin G.; Jonas, Jean-Christophe; Poitout, Vincent; Kulkarni, Rohit N.; Mauvais-Jarvis, Franck (Public Library of Science, 2014)
      The female steroid, 17β-estradiol (E2), is important for pancreatic β-cell function and acts via at least three estrogen receptors (ER), ERα, ERβ, and the G-protein coupled ER (GPER). Using a pancreas-specific ERα knockout ...

    • Islet Oxygen Consumption Rate (OCR) Dose Predicts Insulin Independence in Clinical Islet Autotransplantation 

      Papas, Klearchos K.; Bellin, Melena D.; Sutherland, David E. R.; Suszynski, Thomas M.; Kitzmann, Jennifer P.; Avgoustiniatos, Efstathios S.; Gruessner, Angelika C.; Mueller, Kathryn R.; Beilman, Gregory J.; Balamurugan, Appakalai N.; Loganathan, Gopalakrishnan; Colton, Clark K.; Koulmanda, Maria; Weir, Gordon C.; Wilhelm, Josh J.; Qian, Dajun; Niland, Joyce C.; Hering, Bernhard J. (Public Library of Science, 2015)
      Background: Reliable in vitro islet quality assessment assays that can be performed routinely, prospectively, and are able to predict clinical transplant outcomes are needed. In this paper we present data on the utility ...

    • Islet β cell mass in diabetes and how it relates to function, birth, and death 

      Weir, Gordon C; Bonner-Weir, Susan (Blackwell Publishing Ltd, 2013)
      In type 1 diabetes (T1D) β cell mass is markedly reduced by autoimmunity. Type 2 diabetes (T2D) results from inadequate β cell mass and function that can no longer compensate for insulin resistance. The reduction of β cell ...

    • Islets in Type 2 Diabetes: In Honor of Dr. Robert C. Turner 

      Bonner-Weir, Susan; O'Brien, Timothy D. (American Diabetes Association, 2008)

    • Isoflurane-Induced Apoptosis: A Potential Pathogenic Link Between Delirium and Dementia 

      Xie, Zhongcong; Dong, Y.; Maeda, U.; Moir, Robert D.; Inouye, Sharon; Culley, Deborah Jean; Crosby, Gregory; Tanzi, Rudolph Emile (Oxford University Press (OUP), 2006)
      Background. Dementia and delirium have been postulated to share common pathophysiologic mechanisms; however, identification of these unifying mechanisms has remained elusive. The inhalation anesthetic isoflurane has been ...

    • Isolated cell behavior drives the evolution of antibiotic resistance 

      Artemova, Tatiana; Gerardin, Ylaine; Dudley, Carmel; Vega, Nicole M; Gore, Jeff (John Wiley & Sons, Ltd, 2015)
      Bacterial antibiotic resistance is typically quantified by the minimum inhibitory concentration (MIC), which is defined as the minimal concentration of antibiotic that inhibits bacterial growth starting from a standard ...

    • Isolating Live Cells After High-Throughput, Long-Term, Time-Lapse Microscopy 

      Luro, Scott; Potvin-Trottier, Laurent; Okumus, Burak; Paulsson, Johan (Springer Science and Business Media LLC, 2019-11-25)
      Single-cell genetic screens can be incredibly powerful, but current high-throughput platforms do not track dynamics, and even for non-dynamic properties they struggle to separate mutants of interest from phenotypic outliers ...

    • Isolation and Characterization of Distal Lung Progenitor Cells 

      Driscoll, Barbara; Kikuchi, Alex; Lau, Allison N.; Lee, Jooeun; Reddy, Raghava; Jesudason, Edwin; Kim, Carla; Warburton, David (Humana Press, 2012-04-14)
      The majority of epithelial cells in the distal lung of rodents and humans are quiescent in vivo, yet certain cell populations retain an intrinsic capacity to proliferate and differentiate in response to lung injury or in ...

    • Isolation and characterization of novel RECK tumor suppressor gene splice variants 

      Trombetta-Lima, Marina; Winnischofer, Sheila Maria Brochado; Demasi, Marcos Angelo Almeida; Filho, Renato Astorino; Carreira, Ana Claudia Oliveira; Wei, Beiyang; de Assis Ribas, Thais; Konig, Michelle Silberspitz; Bowman-Colin, Christian; Oba-Shinjo, Sueli Mieko; Marie, Suely Kazue Nagahashi; Stetler-Stevenson, William; Sogayar, Mari Cleide (Impact Journals LLC, 2015)
      Glioblastoma multiforme is the most common and lethal of the central nervous system glial-derived tumors. RECK suppresses tumor invasion by negatively regulating at least three members of the matrix metalloproteinase family: ...

    • Isolation and co-culture of rat parenchymal and non-parenchymal liver cells to evaluate cellular interactions and response 

      Bale, Shyam Sundhar; Geerts, Sharon; Jindal, Rohit; Yarmush, Martin L. (Nature Publishing Group, 2016)
      The liver is a central organ in the human body, and first line of defense between host and external environment. Liver response to any external perturbation is a collective reaction of resident liver cells. Most of the ...

    • Isolation and Culture of Post-Natal Mouse Cerebellar Granule Neuron Progenitor Cells and Neurons 

      Lee, Hae Young; Greene, Lloyd A.; Mason, Carol A.; Manzini, Maria Chiara (Journal of Visualized Experiments, 2009)
      The cerebellar cortex is a well described structure that provides unique opportunities for studying neuronal properties and development. Of the cerebellar neuronal types (granule cells, Purkinje cells and inhibitory ...

    • Isolation and Synthesis of a Bacterially Produced Inhibitor of Rosette Development in Choanoflagellates 

      Cantley, Alexandra M.; Woznica, Arielle; Beemelmanns, Christine; King, Nicole; Clardy, Jon (American Chemical Society, 2016)
      The choanoflagellate Salpingoeca rosetta is a microbial marine eukaryote that can switch between unicellular and multicellular states. As one of the closest living relatives of animals, this organism has become a model for ...

    • Isolation of a novel basic FGF-binding peptide with potent antiangiogenetic activity 

      Wu, Xiaoping; Yan, Qiuxia; Huang, Yadong; Huang, Huixian; Su, Zhijian; Xiao, Jian; Zeng, Yaoying; Wang, Yi; Nie, Changjun; Yang, Yongguang; Li, Xiaokun (Blackwell Publishing Ltd, 2008)
      Abstract Basic fibroblast growth factor (bFGF), which plays an important role in tumour angiogenesis and progression, provides a potential target for cancer therapy. Here we screened a phage display heptapeptide library ...

    • Isolation of Monoclonal Antibodies with Predetermined Conformational Epitope Specificity 

      Sholukh, Anton M.; Mukhtar, Muhammad Mahmood; Humbert, Michael; Essono, Sosthène S.; Watkins, Jennifer D.; Vyas, Hemant Kumar; Shanmuganathan, Vivekanandan; Hemashettar, Girish; Kahn, Maria; Hu, Shiu-Lok; Montefiori, David C.; Polonis, Victoria R.; Schur, Peter Henry; Ruprecht, Ruth Margrit (Public Library of Science, 2012)
      Existing technologies allow isolating antigen-specific monoclonal antibodies (mAbs) from B cells. We devised a direct approach to isolate mAbs with predetermined conformational epitope specificity, using epitope mimetics ...

    • Isolation of peptide aptamers that inhibit intracellular processes 

      Blum, Jonathan H.; Dove, Simon L.; Hochschild, Ann; Mekalanos, John J. (National Academy of Sciences, 2000)

    • Isolation of Progenitors that Exhibit Myogenic/Osteogenic Bipotency In Vitro by Fluorescence-Activated Cell Sorting from Human Fetal Muscle 

      Castiglioni, Alessandra; Hettmer, Simone; Lynes, Matthew D.; Rao, Tata Nageswara; Tchessalova, Daria; Sinha, Indranil; Lee, Bernard T.; Tseng, Yu-Hua; Wagers, Amy J. (Elsevier, 2014)
      Summary Fluorescence-activated cell sorting (FACS) strategies to purify distinct cell types from the pool of fetal human myofiber-associated (hMFA) cells were developed. We demonstrate that cells expressing the satellite ...

    • Isolation, Characterization, and Aggregation of a Structured Bacterial Matrix Precursor 

      Chai, Liraz; Romero, Diego; Kayatekin, Can; Akabayov, Barak; Vlamakis, Hera; Losick, Richard; Kolter, Roberto (American Society for Biochemistry and Molecular Biology, 2013)
      Biofilms are surface-associated groups of microbial cells that are embedded in an extracellular matrix (ECM). The ECM is a network of biopolymers, mainly polysaccharides, proteins, and nucleic acids. ECM proteins serve a ...

    • Isolation, Characterization, and Multipotent Differentiation of Mesenchymal Stem Cells Derived from Meniscal Debris 

      Fu, Weili; Xie, Xing; Li, Qi; Chen, Gang; Zhang, Chenghao; Tang, Xin; Li, Jian (Hindawi Publishing Corporation, 2016)
      This study aimed to culture and characterize mesenchymal stem cells derived from meniscal debris. Cells in meniscal debris from patients with meniscal injury were isolated by enzymatic digestion, cultured in vitro to the ...

    • The Isolation, Differentiation, and Survival In Vivo of Multipotent Cells from the Postnatal Rat filum terminale 

      Jha, Ruchira M.; Chrenek, Ryan; Magnotti, Laura M.; Cardozo, David L. (Public Library of Science, 2013)
      Neural stem cells (NSCs) are undifferentiated cells in the central nervous system (CNS) that are capable of self-renewal and can be induced to differentiate into neurons and glia. Current sources of mammalian NSCs are ...