Browsing HMS Scholarly Articles by Title
Now showing items 933-952 of 17922
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Antitumor activity and mechanisms of action of total glycosides from aerial part of Cimicifuga dahurica targeted against hepatoma
(BioMed Central, 2007)Background: Medicinal plant is a main source of cancer drug development. Some of the cycloartane triterpenoids isolated from the aerial part of Cimicifuga dahurica showed cytotoxicity in several cancer cell lines. It is ... -
Antitumor Activity of Crizotinib in Lung Cancers Harboring a MET Exon 14 Alteration
(Springer Science and Business Media LLC, 2020-01)MET exon 14 alterations are oncogenic drivers of non-small cell lung cancers (NSCLCs).1 These alterations are associated with increased MET activity and preclinical sensitivity to MET inhibition.2 Crizotinib is a multikinase ... -
Antiviral Resistance and the Control of Pandemic Influenza
(Public Library of Science, 2007)Background: The response to the next influenza pandemic will likely include extensive use of antiviral drugs (mainly oseltamivir), combined with other transmission-reducing measures. Animal and in vitro studies suggest ... -
Anti–PD-1–Related Pneumonitis during Cancer Immunotherapy
(New England Journal of Medicine (NEJM/MMS), 2015)The use of antibodies against programmed cell death 1 (PD-1), which block inhibitory T-cell checkpoints, is a promising new therapy for advanced cancers.1 Recent trials have shown substantial clinical activity of anti–PD-1 ... -
Aortic stiffening and its impact on left atrial volumes and function in patients after successful coarctation repair: a multiparametric cardiovascular magnetic resonance study
(BioMed Central, 2016)Background: The increased cardiovascular morbidity of adults with late repair of aortic coarctation (CoA) has been well documented. In contrast, successful CoA repair in early childhood has a generally good prognosis, ... -
AOSSM Early Sport Specialization Consensus Statement
(SAGE Publications, 2016)Background: Early sport specialization is not a requirement for success at the highest levels of competition and is believed to be unhealthy physically and mentally for young athletes. It also discourages unstructured free ... -
Apc inhibition of Wnt signaling regulates supernumerary tooth formation during embryogenesis and throughout adulthood
(Company of Biologists, 2009)The ablation of Apc function or the constitutive activation of beta-catenin in embryonic mouse oral epithelium results in supernumerary tooth formation, but the underlying mechanisms and whether adult tissues retain this ... -
An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination
(2012)The Anaphase-Promoting Complex/Cyclosome (APC) is a ubiquitin ligase required for exit from mitosis. We previously showed that Tosyl Arginine Methyl Ester (TAME) inhibits APC-dependent proteolysis by competing with the ... -
Apicobasal polarization: epithelial form and function
(Elsevier, 2003)The structure and function of epithelial sheets generally depend on apicobasal polarization, which is achieved and maintained by linking asymmetrically distributed intercellular junctions to the cytoskeleton of individual ... -
APOBEC3G Polymorphism as a Selective Barrier to Cross-Species Transmission and Emergence of Pathogenic SIV and AIDS in a Primate Host
(Public Library of Science, 2013)Cellular restriction factors, which render cells intrinsically resistant to viruses, potentially impose genetic barriers to cross-species transmission and emergence of viral pathogens in nature. One such factor is APOBEC3G. ... -
ApoC-III and visceral adipose tissue contribute to paradoxically normal triglyceride levels in insulin-resistant African-American women
(BioMed Central, 2013)Background: African-Americans are more insulin-resistant than whites but have lower triglyceride (TG) concentrations. The metabolic basis for this is unknown. Our goal was to determine in a cross-sectional study the effect ... -
Apocrine-Eccrine Carcinomas: Molecular and Immunohistochemical Analyses
(Public Library of Science, 2012)Apocrine-eccrine carcinomas are rare and associated with poor prognosis. Currently there is no uniform treatment guideline. Chemotherapeutic drugs that selectively target cancer-promoting pathways may complement conventional ... -
APOE Status Modulates the Changes in Network Connectivity Induced by Brain Stimulation in Non-Demented Elders
(Public Library of Science, 2012)Behavioral consequences of a brain insult represent an interaction between the injury and the capacity of the rest of the brain to adapt to it. We provide experimental support for the notion that genetic factors play a ... -
Apolipoprotein C-III and the Metabolic Basis for Hypertriglyceridemia and the Dense Low-Density Lipoprotein Phenotype
(Ovid Technologies (Wolters Kluwer Health), 2010)BACKGROUND: Here, we aim to identify defects of apolipoprotein (apo) B lipoprotein metabolism that characterize hypertriglyceridemia, focusing on apoC-III and apoE. METHODS AND RESULTS: We studied the transport of plasma ... -
Apolipoprotein C-III as a Potential Modulator of the Association Between HDL-Cholesterol and Incident Coronary Heart Disease
(Blackwell Publishing Ltd, 2012)Background: High-density lipoproteins (HDL) are structurally and metabolically heterogeneous and subclasses with differential effects on coronary heart disease (CHD) might exist. Apolipoprotein (apo) C-III, a small ... -
Apolipoprotein E in VLDL and LDL With Apolipoprotein C‐III is Associated With a Lower Risk of Coronary Heart Disease
(Blackwell Publishing Ltd, 2013)Background: Low‐density lipoprotein (LDL) with apolipoprotein C‐III (apoC‐III) is the lipoprotein species that most strongly predicts initial and recurring coronary heart disease (CHD) events in several cohorts. Thus, a ... -
Apolipoprotein(a) Size and Lipoprotein(a) Concentration and Future Risk of Angina Pectoris with Evidence of Severe Coronary Atherosclerosis in Men: The Physicians' Health Study
(American Association for Clinical Chemistry (AACC), 2004)The relationship of lipoprotein (a) [Lp(a)] concentrations with risk of coronary heart disease needs clarification, especially for threshold values for increased risk and for possible interactions with LDL-cholesterol ... -
Apoptosis, autophagy, necroptosis, and cancer metastasis
(BioMed Central, 2015)Metastasis is a crucial hallmark of cancer progression, which involves numerous factors including the degradation of the extracellular matrix (ECM), the epithelial-to-mesenchymal transition (EMT), tumor angiogenesis, the ... -
ApoSense: A Novel Technology for Functional Molecular Imaging of Cell Death in Models of Acute Renal Tubular Necrosis
(Springer Verlag, 2005)Purpose: Acute renal tubular necrosis (ATN), a common cause of acute renal failure, is a dynamic, rapidly evolving clinical condition associated with apoptotic and necrotic tubular cell death. Its early identification is ... -
APP Gene Copy Number Changes Reflect Exogenous Contamination
(Springer Science and Business Media LLC, 2020-08-19)Various types of somatic mutations occur in cells of the human body and cause human diseases including cancer and some neurological disorders1. Recently, Lee et al.2 (hereafter “the Lee study”) reported somatic copy number ...