Browsing HMS Scholarly Articles by Title
Now showing items 9348-9367 of 17918
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It’s Big Surgery: Preoperative Expressions of Risk, Responsibility, and Commitment to Treatment after High-risk Operations
(Ovid Technologies (Wolters Kluwer Health), 2014)Objective To identify the processes surgeons use to establish patient buy-in to postoperative treatments. Background Surgeons generally believe they confirm the patient's commitment to an operation and all ensuing ... -
It’s MORe exciting than mu: crosstalk between mu opioid receptors and glutamatergic transmission in the mesolimbic dopamine system
(Frontiers Media S.A., 2014)Opioids selective for the G protein-coupled mu opioid receptor (MOR) produce potent analgesia and euphoria. Heroin, a synthetic opioid, is considered one of the most addictive substances, and the recent exponential rise ... -
Ivermectin Inhibits Growth of Chlamydia trachomatis in Epithelial Cells
(Public Library of Science, 2012)Ivermectin is currently approved for treatment of both clinical and veterinary infections by nematodes, including Onchocerca cervicalis in horses and Onchocerca volvulus in humans. However, ivermectin has never been shown ... -
IVIg for apparently autoimmune small-fiber polyneuropathy: first analysis of efficacy and safety
(SAGE Publications, 2018)Objectives: Small-fiber polyneuropathy (SFPN) has various underlying causes, including associations with systemic autoimmune conditions. We have proposed a new cause; small-fiber-targeting autoimmune diseases akin to ... -
Iwr1 Protein Is Important for Preinitiation Complex Formation by All Three Nuclear RNA Polymerases in \(Saccharomyces\) \(cerevisiae\)
(Public Library of Science, 2011)Background: Iwr1, a protein conserved throughout eukaryotes, was originally identified by its physical interaction with RNA polymerase (Pol) II. Principal Findings: Here, we identify Iwr1 in a genetic screen designed to ... -
Izumo1 and Juno: the evolutionary origins and coevolution of essential sperm–egg binding partners
(The Royal Society Publishing, 2015)Reproductive proteins are among the most rapidly evolving classes of proteins. For a subset of these, rapid evolution is driven by positive Darwinian selection despite vital, well-conserved, reproductive functions. Izumo1 ... -
JAK2-STAT5 signaling: A novel mechanism of resistance to targeted PI3K/mTOR inhibition
(Landes Bioscience, 2013)A recent article published by Britschgi et al. in Cancer Cell, “JAK2/STAT5 Inhibition Circumvents Resistance to PI3K/mTOR Blockade: A Rationale for Cotargeting These Pathways in Metastatic Breast Cancer,” describes a ... -
Japanese Encephalitis Accompanied by Cerebral Venous Sinus Thrombosis: a Case Report
(BioMed Central, 2012)Background: Cerebral venous sinus thrombosis (CVST) is a relatively rare cerebrovascular condition which accounts for 0.5% of all strokes. Risk of CVST has been documented in patients with numerous conditions including ... -
A Jaw-Dropping Predicament
(Open Science Company, LLC, 2012) -
JC Polyomavirus Abundance and Distribution in Progressive Multifocal Leukoencephalopathy (PML) Brain Tissue Implicates Myelin Sheath in Intracerebral Dissemination of Infection
(Public Library of Science, 2016)Over half of adults are seropositive for JC polyomavirus (JCV), but rare individuals develop progressive multifocal leukoencephalopathy (PML), a demyelinating JCV infection of the central nervous system. Previously, PML ... -
Je pense donc je fais: transcranial direct current stimulation modulates brain oscillations associated with motor imagery and movement observation
(Frontiers Media S.A., 2013)Motor system neural networks are activated during movement imagery, observation and execution, with a neural signature characterized by suppression of the Mu rhythm. In order to investigate the origin of this neurophysiological ... -
Jetset: Selecting the Optimal Microarray Probe Set to Represent a Gene
(BioMed Central, 2011)Background: Interpretation of gene expression microarrays requires a mapping from probe set to gene. On many Affymetrix gene expression microarrays, a given gene may be detected by multiple probe sets, which may deliver ... -
JNER: A Forum to Discuss How Neuroscience and Biomedical Engineering are Reshaping Physical Medicine & Rehabilitation
(BioMed Central, 2004)Advances in neuroscience and biomedical engineering deeply affect the clinical practice of physical medicine & rehabilitation. New research findings and engineering tools are continuously made available that have the ... -
JNK Activation is Responsible for Mucus Overproduction in Smoke Inhalation Injury
(BioMed Central, 2010)Background: Increased mucus secretion is one of the important characteristics of the response to smoke inhalation injuries. We hypothesized that gel-forming mucins may contribute to the increased mucus production in a smoke ... -
Job Requirements Compared to Medical School Education: Differences between Graduates from Problem-Based Learning and Conventional Curricula
(BioMed Central, 2010)Background: Problem-based Learning (PBL) has been suggested as a key educational method of knowledge acquisition to improve medical education. We sought to evaluate the differences in medical school education between ... -
Job Strain, Job Insecurity, and Incident Cardiovascular Disease in the Women’s Health Study: Results from a 10-Year Prospective Study
(Public Library of Science, 2012)Objectives: Research about work-related stressors and cardiovascular disease (CVD) has produced mixed findings. Moreover, a paucity of data exists regarding the long-term associations between job strain and job insecurity ... -
Joint Coupling of Awake EEG Frequency Activity and MRI Gray Matter Volumes in the Psychosis Dimension: A BSNIP Study
(Frontiers Media S.A., 2015)Background: Many studies have examined either electroencephalogram (EEG) frequency activity or gray matter volumes (GMV) in various psychoses [including schizophrenia (SZ), schizoaffective (SZA), and psychotic bipolar ... -
Joint Effect of Genotypic and Phenotypic Features of Reproductive Factors on Endometrial Cancer Risk
(Nature Publishing Group, 2015)Prolonged estrogen exposure is believed to be the major cause of endometrial cancer. As possible markers of estrogen exposure, various menstrual and reproductive features, e.g., ages at menarche and menopause, are found ... -
Joint Effect of Multiple Common SNPs Predicts Melanoma Susceptibility
(Public Library of Science, 2013)Single genetic variants discovered so far have been only weakly associated with melanoma. This study aims to use multiple single nucleotide polymorphisms (SNPs) jointly to obtain a larger genetic effect and to improve the ... -
Joint Effects of Colorectal Cancer Susceptibility Loci, Circulating 25-Hydroxyvitamin D and Risk of Colorectal Cancer
(Public Library of Science, 2014)Background: Genome wide association studies (GWAS) have identified several SNPs associated with colorectal cancer (CRC) susceptibility. Vitamin D is also inversely associated with CRC risk. Methods: We examined main and ...