Browsing HMS Scholarly Articles by Title
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Apicobasal polarization: epithelial form and function
(Elsevier, 2003)The structure and function of epithelial sheets generally depend on apicobasal polarization, which is achieved and maintained by linking asymmetrically distributed intercellular junctions to the cytoskeleton of individual ... -
APOBEC3G Polymorphism as a Selective Barrier to Cross-Species Transmission and Emergence of Pathogenic SIV and AIDS in a Primate Host
(Public Library of Science, 2013)Cellular restriction factors, which render cells intrinsically resistant to viruses, potentially impose genetic barriers to cross-species transmission and emergence of viral pathogens in nature. One such factor is APOBEC3G. ... -
ApoC-III and visceral adipose tissue contribute to paradoxically normal triglyceride levels in insulin-resistant African-American women
(BioMed Central, 2013)Background: African-Americans are more insulin-resistant than whites but have lower triglyceride (TG) concentrations. The metabolic basis for this is unknown. Our goal was to determine in a cross-sectional study the effect ... -
Apocrine-Eccrine Carcinomas: Molecular and Immunohistochemical Analyses
(Public Library of Science, 2012)Apocrine-eccrine carcinomas are rare and associated with poor prognosis. Currently there is no uniform treatment guideline. Chemotherapeutic drugs that selectively target cancer-promoting pathways may complement conventional ... -
APOE Status Modulates the Changes in Network Connectivity Induced by Brain Stimulation in Non-Demented Elders
(Public Library of Science, 2012)Behavioral consequences of a brain insult represent an interaction between the injury and the capacity of the rest of the brain to adapt to it. We provide experimental support for the notion that genetic factors play a ... -
Apolipoprotein C-III and the Metabolic Basis for Hypertriglyceridemia and the Dense Low-Density Lipoprotein Phenotype
(Ovid Technologies (Wolters Kluwer Health), 2010)BACKGROUND: Here, we aim to identify defects of apolipoprotein (apo) B lipoprotein metabolism that characterize hypertriglyceridemia, focusing on apoC-III and apoE. METHODS AND RESULTS: We studied the transport of plasma ... -
Apolipoprotein C-III as a Potential Modulator of the Association Between HDL-Cholesterol and Incident Coronary Heart Disease
(Blackwell Publishing Ltd, 2012)Background: High-density lipoproteins (HDL) are structurally and metabolically heterogeneous and subclasses with differential effects on coronary heart disease (CHD) might exist. Apolipoprotein (apo) C-III, a small ... -
Apolipoprotein E in VLDL and LDL With Apolipoprotein C‐III is Associated With a Lower Risk of Coronary Heart Disease
(Blackwell Publishing Ltd, 2013)Background: Low‐density lipoprotein (LDL) with apolipoprotein C‐III (apoC‐III) is the lipoprotein species that most strongly predicts initial and recurring coronary heart disease (CHD) events in several cohorts. Thus, a ... -
Apolipoprotein(a) Size and Lipoprotein(a) Concentration and Future Risk of Angina Pectoris with Evidence of Severe Coronary Atherosclerosis in Men: The Physicians' Health Study
(American Association for Clinical Chemistry (AACC), 2004)The relationship of lipoprotein (a) [Lp(a)] concentrations with risk of coronary heart disease needs clarification, especially for threshold values for increased risk and for possible interactions with LDL-cholesterol ... -
Apoptosis, autophagy, necroptosis, and cancer metastasis
(BioMed Central, 2015)Metastasis is a crucial hallmark of cancer progression, which involves numerous factors including the degradation of the extracellular matrix (ECM), the epithelial-to-mesenchymal transition (EMT), tumor angiogenesis, the ... -
ApoSense: A Novel Technology for Functional Molecular Imaging of Cell Death in Models of Acute Renal Tubular Necrosis
(Springer Verlag, 2005)Purpose: Acute renal tubular necrosis (ATN), a common cause of acute renal failure, is a dynamic, rapidly evolving clinical condition associated with apoptotic and necrotic tubular cell death. Its early identification is ... -
APP Gene Copy Number Changes Reflect Exogenous Contamination
(Springer Science and Business Media LLC, 2020-08-19)Various types of somatic mutations occur in cells of the human body and cause human diseases including cancer and some neurological disorders1. Recently, Lee et al.2 (hereafter “the Lee study”) reported somatic copy number ... -
App Store for EHRs and Patients Both
(American Medical Informatics Association, 2013)The Substitutable Medical Applications, Reusable Technologies (SMART) Platforms project ( www.smartplatforms.org ) seeks to develop an iPhone-like health information technology platform with substitutable apps constructed ... -
APP-BP1 Inhibits Aβ42 Levels by Interacting with Presenilin-1
(BioMed Central, 2007)Background: The β-amyloid precursor protein (APP) is sequentially cleaved by the β- and then γ-secretase to generate the amyloid β-peptides Aβ40 and Aβ42. Increased Aβ42/Aβ40 ratios trigger amyloid plaque formations in ... -
Appearance and disappearance of the mRNA signature characteristic of T-reg cells in visceral adipose tissue: Age, diet, and PPAR gamma effects
(National Academy of Sciences, 2015) -
Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit
(eLife Sciences Publications, Ltd, 2016)The nucleus of the solitary tract (NTS) is a key gateway for meal-related signals entering the brain from the periphery. However, the chemical mediators crucial to this process have not been fully elucidated. We reveal ... -
APPL1 Potentiates Insulin Sensitivity by Facilitating the Binding of IRS1/2 to the Insulin Receptor
(2014)SUMMARY Binding of insulin receptor substrate proteins 1 and 2 (IRS1/2) to the insulin receptor (IR) is essential for the regulation of insulin sensitivity and energy homeostasis. However, the mechanism of IRS1/2 recruitment ... -
Application of a synthetic human proteome to autoantigen discovery through PhIP-Seq
(2011)In this study, we improve on current autoantigen discovery approaches by creating a synthetic representation of the complete human proteome, the T7 “peptidome” phage display library (T7-Pep), and use it to profile the ... -
Application of change point analysis to daily influenza-like illness emergency department visits
(BMJ Group, 2012)Background: The utility of healthcare utilization data from US emergency departments (EDs) for rapid monitoring of changes in influenza-like illness (ILI) activity was highlighted during the recent influenza A (H1N1) ... -
Application of combined omics platforms to accelerate biomedical discovery in diabesity
(Blackwell Publishing Ltd, 2013)Diabesity has become a popular term to describe the specific form of diabetes that develops late in life and is associated with obesity. While there is a correlation between diabetes and obesity, the association is not ...