Browsing HMS Scholarly Articles by Title

Now showing items 9671-9690 of 17922

    • Linkage to HIV, TB and Non-Communicable Disease Care from a Mobile Testing Unit in Cape Town, South Africa 

      Govindasamy, Darshini; Kranzer, Katharina; van Schaik, Nienke; Noubary, Farzad; Wood, Robin; Walensky, Rochelle P.; Freedberg, Kenneth A.; Bassett, Ingrid V.; Bekker, Linda-Gail (Public Library of Science, 2013)
      Background: HIV counseling and testing may serve as an entry point for non-communicable disease screening. Objectives: To determine the yield of newly-diagnosed HIV, tuberculosis (TB) symptoms, diabetes and hypertension, ...

    • The Linked CENTURY Study: linking three decades of clinical and public health data to examine disparities in childhood obesity 

      Hawkins, Summer Sherburne; Gillman, Matthew W.; Rifas-Shiman, Sheryl L.; Kleinman, Ken P.; Mariotti, Megan; Taveras, Elsie M. (BioMed Central, 2016)
      Background: Despite the need to identify the causes of disparities in childhood obesity, the existing epidemiologic studies of early life risk factors have several limitations. We report on the construction of the Linked ...

    • Linking abnormal mitosis to the acquisition of DNA damage 

      Ganem, Neil J.; Pellman, David (The Rockefeller University Press, 2012)
      Cellular defects that impair the fidelity of mitosis promote chromosome missegregation and aneuploidy. Increasing evidence reveals that errors in mitosis can also promote the direct and indirect acquisition of DNA damage ...

    • Linking prenatal experience to the emerging musical mind 

      Ullal-Gupta, Sangeeta; Vanden Bosch der Nederlanden, Christina M.; Tichko, Parker; Lahav, Amir; Hannon, Erin E. (Frontiers Media S.A., 2013)
      The musical brain is built over time through experience with a multitude of sounds in the auditory environment. However, learning the melodies, timbres, and rhythms unique to the music and language of one’s culture begins ...

    • Lipid Body–Phagosome Interaction in Macrophages during Infectious Diseases: Host Defense or Pathogen Survival Strategy? 

      Melo, Rossana C. N.; Dvorak, Ann Marie (Public Library of Science, 2012)
      Phagocytosis of invading microorganisms by specialized cells such as macrophages and neutrophils is a key component of the innate immune response. These cells capture and engulf pathogens and subsequently destroy them in ...

    • Lipid droplets go nuclear 

      Farese, Robert V.; Walther, Tobias C. (The Rockefeller University Press, 2016)
      Lipid droplets (LDs) are sometimes found in the nucleus of some cells. In this issue, Ohsaki et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201507122) show that the nuclear membrane, promyelocytic leukemia bodies, ...

    • Lipid interaction of the C terminus and association of the transmembrane segments facilitate atlastin-mediated homotypic endoplasmic reticulum fusion 

      Liu, Tina Y.; Bian, Xin; Sun, Sha; Hu, Xiaoyu; Klemm, Robin W.; Prinz, William A.; Rapoport, Tom A.; Hu, Junjie (National Academy of Sciences, 2012)
      The homotypic fusion of endoplasmic reticulum (ER) membranes is mediated by atlastin (ATL), which consists of an N-terminal cytosolic domain containing a GTPase module and a three-helix bundle followed by two transmembrane ...

    • A Lipid Mediator Hepoxilin A3 Is a Natural Inducer of Neutrophil Extracellular Traps in Human Neutrophils 

      Douda, David N.; Grasemann, Hartmut; Pace-Asciak, Cecil; Palaniyar, Nades (Hindawi Publishing Corporation, 2015)
      Pulmonary exacerbations in cystic fibrosis airways are accompanied by inflammation, neutrophilia, and mucous thickening. Cystic fibrosis sputum contains a large amount of uncleared DNA contributed by neutrophil extracellular ...

    • Lipid Mediator Informatics and Proteomics in Inflammation-Resolution 

      Lu, Yan; Hong, Song; Gotlinger, Katherine; Serhan, Charles (Wiley, 2006)
      Lipid mediator informatics is an emerging area denoted to the identification of bioactive lipid mediators (LMs) and their biosynthetic profiles and pathways. LM informatics and proteomics applied to inflammation, systems ...

    • Lipid mediator-induced expression of bactericidal/ permeability-increasing protein (BPI) in human mucosal epithelia 

      Canny, Geraldine; Levy, Ofer; Furuta, Glenn T.; Narravula-Alipati, Sailaja; Sisson, Richard B.; Serhan, Charles N.; Colgan, Sean P. (National Academy of Sciences, 2002)
      Epithelial cells which line mucosal surfaces are the first line of defense against bacterial invasion and infection. Recent studies have also indicated that epithelial cells contribute significantly to the orchestration ...

    • Lipid Mediators in Innate Immunity Against Tuberculosis: Opposing Roles of PGE2 and LXA4 in the Induction of Macrophage Death 

      Chen, Minjian; Divangahi, Maziar; Gan, Huixian; Shin, Daniel S.J.; Hong, Song; Lee, David Marvin; Serhan, Charles Nicholas; Behar, Samuel M; Remold, Heinz G (Rockefeller University Press, 2008)
      Virulent Mycobacterium tuberculosis (Mtb) induces a maladaptive cytolytic death modality, necrosis, which is advantageous for the pathogen. We report that necrosis of macrophages infected with the virulent Mtb strains H37Rv ...

    • Lipid metabolites in the pathogenesis and treatment of neovascular eye disease 

      Stahl, A; Krohne, T. U.; Sapieha, P.; Chen, Jing; Hellstrom, A.; Chew, E.; Holz, F. G.; Smith, Lois Elaine Hodgson (BMJ, 2011)
      Lipids and lipid metabolites have long been known to play biological roles that go beyond energy storage and membrane structure. In age-related macular degeneration and diabetes, for example, dysregulation of lipid metabolism ...

    • Lipidome in colorectal cancer 

      Yan, Guifang; Li, Liqi; Zhu, Bo; Li, Yongsheng (Impact Journals LLC, 2016)
      Colorectal cancer (CRC) is the second leading cause of cancer-related deaths. Understanding its pathophysiology is essential for developing efficient strategies to treat this disease. Lipidome, the sum of total lipids, ...

    • Lipidomic Analysis Links Mycobactin Synthase K to Iron Uptake and Virulence in M. tuberculosis 

      Madigan, Cressida A.; Martinot, Amanda Jezek; Wei, Jun-Rong; Madduri, Ashoka; Cheng, Tan-Yun; Young, David C.; Layre, Emilie; Murry, Jeffrey P.; Rubin, Eric J.; Moody, D. Branch (Public Library of Science, 2015)
      The prolonged survival of Mycobacterium tuberculosis (M. tb) in the host fundamentally depends on scavenging essential nutrients from host sources. M. tb scavenges non-heme iron using mycobactin and carboxymycobactin ...

    • Lipidomics Reveals Early Metabolic Changes in Subjects with Schizophrenia: Effects of Atypical Antipsychotics 

      McEvoy, Joseph; Baillie, Rebecca A.; Zhu, Hongjie; Buckley, Peter; Keshavan, Matcheri S.; Nasrallah, Henry A.; Dougherty, George G.; Yao, Jeffrey K.; Kaddurah-Daouk, Rima (Public Library of Science, 2013)
      There is a critical need for mapping early metabolic changes in schizophrenia to capture failures in regulation of biochemical pathways and networks. This information could provide valuable insights about disease mechanisms, ...

    • Lipocalin 2 expression is associated with aggressive features of endometrial cancer 

      Mannelqvist, Monica; Stefansson, Ingunn M; Wik, Elisabeth; Kusonmano, Kanthida; Raeder, Maria B; Øyan, Anne M; Kalland, Karl-Henning; Moses, Marsha; Salvesen, Helga B; Akslen, Lars A (BioMed Central, 2012)
      Background: Increased expression of lipocalin 2 (LCN2) has been observed in several cancers. The aim of the present study was to investigate LCN2 in endometrial cancer in relation to clinico-pathologic phenotype, angiogenesis, ...

    • Lipochoristoma of the Internal Auditory Canal 

      Scangas, George; Remenschneider, Aaron; Santos, Felipe (Georg Thieme Verlag KG, 2015)
      Objective: Lipochoristomas comprise 0.1% of all cerebellopontine angle tumors and may be misdiagnosed as vestibular schwannomas. We describe a lipochoristoma of the internal auditory canal (IAC) and present the salient ...

    • Lipodystrophy, Diabetes and Normal Serum Insulin in PPARγ-Deficient Neonatal Mice 

      O’Donnell, Peter E.; Ye, Xiu Zhen; DeChellis, Melissa A.; Davis, Vannessa M.; Duan, Sheng Zhong; Mortensen, Richard M.; Milstone, David S. (Public Library of Science, 2016)
      Peroxisome proliferator activated receptor gamma (PPARγ) is a pleiotropic ligand activated transcription factor that acts in several tissues to regulate adipocyte differentiation, lipid metabolism, insulin sensitivity and ...

    • Lipoprotein Lipase Bound to Apolipoprotein B Lipoproteins Accelerates Clearance of Postprandial Lipoproteins in Humans 

      Zheng, Chunyu; Murdoch, Susan J.; Brunzell, John D.; Sacks, Frank (Ovid Technologies (Wolters Kluwer Health), 2006-04)
      Objectives Experiments in cells and animal models show that lipoprotein lipase (LpL) bound to apolipoprotein (apo)B lipoproteins enhances their uptake by receptor mediated pathways. It is unknown whether this pathway is ...

    • Lipoprotein metabolism in nonalcoholic fatty liver disease 

      Jiang, Zhenghui Gordon; Robson, Simon Christopher; Yao, Zemin (Editorial Department of Journal of Biomedical Research, 2013)
      Nonalcoholic fatty liver disease (NAFLD), an escalating health problem worldwide, covers a spectrum of pathologies characterized by fatty accumulation in hepatocytes in early stages, with potential progression to liver ...