Browsing HMS Scholarly Articles by Issue Date

Now showing items 21-40 of 17920

    • How to Edit a Manuscript with Assistance of ChatGPT 

      Tran, Nghi V; Nguyen, Doan Ngoc Chau; Nguyen, Duc; Nguyen, Hien Q; Nguyen, Van Tuong; Trinh, Huong; Pham, Thien; Pham, Nam; Vu, Loc T; Nguyen, Thinh; Nguyen, Thang; Nguyen, Dien T; Nguyen, Thach (Tan Tao University, 2023-08-22)
      This research article investigates the efficacy of ChatGPT, an AI-based language model developed by OpenAI, as a manuscript editing tool. The study’s design and methodology used to evaluate ChatGPT’s usefulness in editing ...

    • Thyroiditis – A Clinical Update and Review 

      Singer, Peter; Nguyen, Caroline; Nguyen, Thach (Tan Tao University, 2023-08-22)
      Purpose: Thyroiditis refers to a set of inflammatory disorders involving the destruction of normal thyroid follicular tissue. Each disorder has distinctive histology and pathology. Understanding each condition in the ...

    • Utilizing ChatGPT in the Process of Crafting a Research Paper: A Comprehensive Guide 

      Tran, Nghi V; Nguyen, Doan Ngoc Chau; Nguyen, Duc; Pham, Nam; Nguyen, Dien T; Nguyen, Thach (Tan Tao University, 2023-08-22)
      The rapid advancement of artificial intelligence (AI) and natural language processing (NLP) technologies has paved the way for innovative tools, such as ChatGPT, to enhance various aspects of academic research. This ...

    • Photodynamic Therapy Applications in Cancer, Infections and Cardiovascular Disease 

      F Isaac-Lam, Meden; Nguyen, Thach (Tan Tao University, 2023-08-22)
      Photodynamic therapy (PDT) or light treatment is a procedure to treat certain types of diseases that uses a photosensitizer (PS) which upon light activation produces cytotoxic oxygen species destroying tumor cells. PDT is ...

    • New Techniques of Recording and Interpretation of Dynamic Coronary Angiography 

      Nguyen, Thach; Nguyen, Duc; Vu, Loc T; Nguyen, Hien Q; Le, Tu NH; Kieu, Thai N; Dinh, Hoang VK; Le, Linh K; Nguyen, Nguyen T; Nguyen, Thinh; Nguyen, Thang; Pham, Tran H; Tran, Khoa; Nguyen, Hao Thuy; Vo, Huy K; Bui, Nhan; Le, Thien C; Mihas, Imran; Singh, Mankirth; Talarico, Ernest; Zuin, Marco; Rigatelli, Gianluca; Nanjundappa, Aravinda; Gibson, Michael (Tan Tao University, 2023-08-15)
      In the study of coronary artery disease (CAD), the mechanism of plaque formation and development was still the subject of continuing debate. The limitation of the current coronary angiogram (CAG) is that it can only show ...

    • HIV-1 Preferentially Targets Genes Regulated by PAF-1 and U2 snRNP for Integration 

      Singh, Parmit; Annamalai, Arun; Kvaratkshelia, Mamuka; Engelman, Alan (2023-08-04)
      Pre-mRNA splicing is coupled with promoter-proximal Pol II pausing and alternative polyadenylation (APA). Splicing inhibitors increase pausing and the use of proximal polyadenylation sites (PAS) in intron rich genes by ...

    • Situation of HDV Infection in Adult Hepatitis B Patients at The Outpatient Clinic of Pasteur Institute in Ho Chi Minh City 

      Nguyen, Thi Thu Huong; Dinh, Thoi Van; Nguyen, Minh Ngoc; Nguyen, Phuong Lan Thi; Nguyen, Thu Thuy Thi; Hoang, Tuong Giao; Do, Hai Hoang Hanh; Lam, My Linh; Nguyen, Hoai Thu Mong; Pham, Duy Quang; Tran, Nghi V; Nguyen, Duc; Nguyen, Thach (Tan Tao University, 2023-08-01)
      Hepatitis D virus (HDV) infection, also known as delta virus, has been identified as a crucial risk factor contributing to severe complications among hepatitis B patients. Such complications arise as HDV accelerates the ...

    • Is aggressive treatment of smoldering myeloma the path to curing myeloma? 

      Chakraborty, Rajshekar; Al Hadidi, Samer; Cliff, Edward; Mohyuddin, Ghulam Rehman (American Society of Hematology, 2023-07-27)
      Smoldering multiple myeloma (SMM) is an asymptomatic condition that precedes newly diagnosed multiple myeloma (ND MM) and is present in ~1 of 200 individuals (0.5%) aged >40 years.1 The optimal management of patients with ...

    • H3K36 methylation maintains cell identity by regulating opposing lineage programmes 

      Hoetker, Michael; Yagi, Masaki; Di Stefano, Bruno; Langerman, Justin; Cristea, Simona; Wong, Lai Ping; Huebner, Aaron J; Charlton, Jocelyn; Deng, Weixian; Haggerty, Chuck; Sadreyev, Ruslan I; Meissner, Alexander; Michor, Franziska; Plath, Kathrin; Hochedlinger, Konrad (Springer Science and Business Media LLC, 2023-07-17)
      The epigenetic mechanisms that maintain differentiated cell states remain largely unexplored. Here, we employed histone mutants to uncover a crucial role for H3K36-methylation in the maintenance of cell identities across ...

    • Significance analysis for clustering with single-cell RNA-sequencing data 

      Grabski, Isabella N.; Street, Kelly; Irizarry, Rafael (Springer Science and Business Media LLC, 2023-07-10)
      Unsupervised clustering of single-cell RNA-sequencing data enables the identification and discovery of distinct cell populations. However, the most widely used clustering algorithms are heuristic and do not formally account ...

    • Cancer aneuploidies are shaped primarily by effects on tumour fitness 

      Shih, Juliann; Sarmashghi, Shahab; Zhakula-Kostadinova, Nadja; Georgis, Yohanna; Hoyt, Stephanie H.; Cuoco, Michael S.; Gao, Galen F.; Spurr, Liam F.; Berger, Ashton C.; Ha, Gavin; Rendo, Veronica; Shen, Hui; Meyerson, Matthew; Cherniack, Andrew D.; Taylor, Alison M.; Beroukhim, Rameen (Springer Science and Business Media LLC, 2023-06-28)
      Aneuploidies—whole-chromosome or whole-arm imbalances—are the most prevalent alteration in cancer genomes1,2. However, it is still debated whether their prevalence is due to selection or because they are readily generated ...

    • Oxycodone withdrawal induces HDAC1/HDAC2-dependent transcriptional maladaptations in the reward pathway in a mouse model of peripheral nerve injury 

      Pryce, Kerri D.; Serafini, Randal A.; Ramakrishnan, Aarthi; Nicolais, Andrew; Giosan, Ilinca M.; Polizu, Claire; Torres-Berrío, Angélica; Vuppala, Sreeya; Kronman, Hope; Ruiz, Anne; Gaspari, Sevasti; Peña, Catherine J.; Sakloth, Farhana; Mitsi, Vasiliki; van Duzer, John; Mazitschek, Ralph; Jarpe, Matthew; Shen, Li; Nestler, Eric J.; Zachariou, Venetia (Springer Science and Business Media LLC, 2023-06-08)
      The development of physical dependence and addiction disorders due to misuse of opioid analgesics is a major concern with pain therapeutics. In this study, we developed a mouse model of oxycodone exposure to gain insight ...

    • Lower Ghrelin Levels Are Associated With Higher Anxiety Symptoms in Adolescents and Young Adults With Avoidant/Restrictive Food Intake Disorder 

      Chovel Sella, Aluma; Hadaway, Natalia; Stern, Casey; Becker, Kendra R.; Holsen, Laura M.; Eddy, Kamryn T.; Micali, Nadia; Misra, Madhusmita; Thomas, Jennifer J.; Lawson, Elizabeth A. (Physicians Postgraduate Press, Inc, 2023-05-03)
      Objective: Avoidant/restrictive food intake disorder (ARFID) is associated with increased risk for anxiety, which may adversely affect prognosis. The appetite-stimulating hormone, ghrelin, increases in response to stress, ...

    • Complete integration of carbene-transfer chemistry into biosynthesis 

      Huang, Jing; Quest, Andrew; Cruz-Morales, Pablo; Deng, Kai; Pereira, Jose Henrique; Van Cura, Devon; Kakumanu, Ramu; Baidoo, Edward E. K.; Dan, Qingyun; Chen, Yan; Petzold, Christopher J.; Northen, Trent R.; Adams, Paul D.; Clark, Douglas S.; Balskus, Emily; Hartwig, John F.; Mukhopadhyay, Aindrila; Keasling, Jay D. (Springer Science and Business Media LLC, 2023-05-03)

    • CPSF6 LICENSES HIV-1 INTEGRATION INTO POL II-PAUSED GENES REGULATED by P-TEFb and U2 snRNP 

      Singh, Parmit; Annamalai, Arun; Kvaratskhelia, Mamuka; Engelman, Alan (2023-05)
      Pre-mRNA splicing regulates promoter-proximal Pol II pausing and alternative polyadenylation (APA). Splicing inhibitors increase pausing and use of proximal polyadenylation sites (PAS) for comparatively long (>4 introns) ...

    • Spinal artery syndrome following kyphoplasty in the setting of a non-compressive extradural cement extravasation: a case report 

      Striano, Brendan; Goh, Brian; Ziino, Chason; Kim, Saechin (Springer Science and Business Media LLC, 2023-04-25)
      INTRODUCTION: Cement extravasation (CE) during vertebroplasty or kyphoplasty for vertebral compression fracture (VCF) is not uncommon, though neurological deficits occur rarely and when paraparesis occurs severe cord ...

    • CRISPR-Cas-amplified urinary biomarkers for multiplexed and portable cancer diagnostics 

      Hao, Liangliang; Zhao, Renee T.; Welch, Nicole; Tan, Edward Kah Wei; Zhong, Qian; Harzallah, Nour Saida; Ngambenjawong, Chayanon; Ko, Henry; Fleming, Heather E.; Sabeti, Pardis C.; Bhatia, Sangeeta N. (Springer Science and Business Media LLC, 2023-04-24)
      Synthetic biomarkers, exogenous probes that generate molecular reporters, represent an emerging paradigm in precision diagnostics with applications across infectious and noncommunicable diseases. These methods use multiplexing ...

    • PI3Kβ controls immune evasion in PTEN-deficient breast tumours 

      Bergholz, Johann; Wang, Qiwei; Wang, Qi; Ramseier, Michelle; Prakadan, Sanjay; Wang, Weihua; Fang, Rong; Kabraji, Sheheryar; Zhou, Qian; Gray, G. Kenneth; Abell-Hart, Kayley; Xie, Shaozhen; Guo, Xiaocan; Gu, Hao; Von, Thanh; Jiang, Tao; Tang, Shuang; Freeman, Gordon J.; Kim, Hye-Jung; Shalek, Alex K.; Roberts, Thomas M.; Zhao, Jean J. (Springer Science and Business Media LLC, 2023-04-19)
      Loss of the PTEN tumor suppressor is one of the most common oncogenic drivers across all cancer types. PTEN is the major negative regulator of phosphoinositide-3 kinase (PI3K) signaling. Notably, the PI3Kβ isoform has been ...

    • Spatiotemporally resolved transcriptomics reveals the subcellular RNA kinetic landscape 

      Ren, Jingyi; Zhou, Haowen; Zeng, Hu; Wang, Connie Kangni; Huang, Jiahao; Qiu, Xiaojie; Sui, Xin; Li, Qiang; Wu, Xunwei; Lin, Zuwan; Lo, Jennifer A.; Maher, Kamal; He, Yichun; Tang, Xin; Lam, Judson; Chen, Hongyu; Li, Brian; Fisher, David E.; Liu, Jia; Wang, Xiao (Springer Science and Business Media LLC, 2023-04-10)
      <jats:title>Abstract</jats:title><jats:p>Spatiotemporal regulation of the cellular transcriptome is crucial for proper protein expression and cellular function. However, the intricate subcellular dynamics of RNA remain ...

    • Trends in Medicare Spending on Oral Drugs for Chronic Lymphocytic Leukemia From 2014 to 2020 

      Cliff, Edward; Kesselheim, Aaron S.; Rome, Benjamin N.; Feldman, William B. (American Medical Association (AMA), 2023-04-07)
      <jats:p>This cross-sectional study analyzes trends in Medicare Part D use and spending on oral-targeted drugs for chronic lymphocytic leukemia from 2014 to 2020.</jats:p>