Browsing HMS Scholarly Articles by Issue Date

Now showing items 41-60 of 17922

    • Spatiotemporally resolved transcriptomics reveals the subcellular RNA kinetic landscape 

      Ren, Jingyi; Zhou, Haowen; Zeng, Hu; Wang, Connie Kangni; Huang, Jiahao; Qiu, Xiaojie; Sui, Xin; Li, Qiang; Wu, Xunwei; Lin, Zuwan; Lo, Jennifer A.; Maher, Kamal; He, Yichun; Tang, Xin; Lam, Judson; Chen, Hongyu; Li, Brian; Fisher, David E.; Liu, Jia; Wang, Xiao (Springer Science and Business Media LLC, 2023-04-10)
      <jats:title>Abstract</jats:title><jats:p>Spatiotemporal regulation of the cellular transcriptome is crucial for proper protein expression and cellular function. However, the intricate subcellular dynamics of RNA remain ...

    • Trends in Medicare Spending on Oral Drugs for Chronic Lymphocytic Leukemia From 2014 to 2020 

      Cliff, Edward; Kesselheim, Aaron S.; Rome, Benjamin N.; Feldman, William B. (American Medical Association (AMA), 2023-04-07)
      <jats:p>This cross-sectional study analyzes trends in Medicare Part D use and spending on oral-targeted drugs for chronic lymphocytic leukemia from 2014 to 2020.</jats:p>

    • Bacteria hijack a meningeal neuroimmune axis to facilitate brain invasion 

      Pinho-Ribeiro, Felipe A.; Deng, Liwen; Neel, Dylan V.; Erdogan, Ozge; Basu, Himanish; Yang, Daping; Choi, Samantha; Walker, Alec J.; Carneiro-Nascimento, Simone; He, Kathleen; Wu, Glendon; Stevens, Beth; Doran, Kelly S.; Levy, Dan; Chiu, Isaac (Springer Science and Business Media LLC, 2023-03-01)
      The meninges are densely innervated by nociceptive sensory neurons that mediate pain and headache1,2. How pain and neuroimmune interactions impact meningeal host defense is unclear. Bacterial meningitis causes life-threatening ...

    • A NPAS4–NuA4 complex couples synaptic activity to DNA repair 

      Pollina, Elizabeth; Gilliam, Daniel; Landau, Andrew T.; Lin, Cindy; Pajarillo, Naomi; Davis, Christopher P.; Harmin, David A.; Yap, Ee-Lynn; Vogel, Ian; Nagy, M. Aurel; Ling, Emi; Griffith, Eric C.; Duffy, Erin E.; Weitz, Charles J.; Sabatini, Bernardo L.; Greenberg, Michael E. (Springer Science and Business Media LLC, 2023-02-15)
      Neuronal activity is critical for adaptive circuit remodeling but poses an inherent risk to the stability of the genome across the long lifespan of post-mitotic neurons1-5. Whether neurons have acquired specialized genome ...

    • Mono- and Biallelic Variant Effects on Disease at Biobank Scale 

      Heyne, Henrike; Karjalainen, Juha; Karczewski, Konrad; Lemmelä, Susanna; Zhou, Wei; Havulinna, Aki S.; Kurki, Mitja; Rehm, Heidi; Palotie, Aarno; Daly, Mark (Springer Science and Business Media LLC, 2023-01-18)
      Identifying causal factors for Mendelian and common diseases is an ongoing challenge in medical genetics 1 . Population bottleneck events, such as in the Finnish population history, enrich some homozygous variants to ...

    • Metabolic Regulation of Species-Specific Developmental Rates 

      Diaz Cuadros, Margarete; Miettinen, Teemu; Skinner, Owen; Sheedy, Dylan; Diaz Garcia, Carlos; Gapon, Svetlana; Hubaud, Alexis; Yellen, Gary; Manalis, Scott R.; Oldham, William; Pourquie, Olivier (Nature Publishing Group, 2023-01-04)
      Animals display significant inter-species variation in the rate of embryonic development despite broad conservation of the overall sequence of developmental events. Differences in biochemical reaction speeds, including the ...

    • Fiber-specific structural properties relate to reading skills in children and adolescents 

      Meisler, Steven Lee; Gabrieli, John (eLife Sciences Publications, Ltd, 2022-12-28)
      Recent studies suggest that the cross-sectional relationship between reading skills and white matter microstructure, as indexed by fractional anisotropy, is not as robust as previously thought. Fixel-based analyses yield ...

    • Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies 

      Li, Xihao; Quick, Corbin; Zhou, Hufeng; Gaynor, Sheila M.; Liu, Yaowu; Dey, Rounak; Li, Zilin; Lin, Xihong (Springer Science and Business Media LLC, 2022-12-23)
      Meta-analysis of whole-genome/exome sequencing (WGS/WES) studies provides an attractive solution to obtain large sample sizes from multiple studies for discovering rare variants associated with complex phenotypes. Existing ...

    • Reconstruction and deconstruction of human somitogenesis in vitro 

      Miao, Yuchuan; Djeffal, Yannis; De Simone, Alessandro; Zhu, Kongju; Lee, Jong Gwan; Lu, Ziqi; Silberfeld, Andrew; Rao, Jyoti; Tarazona, Oscar A.; Mongera, Alessandro; Rigoni, Pietro; Diaz-Cuadros, Margarete; Song, Laura Min Sook; Di Talia, Stefano; Pourquie, Olivier (Springer Science and Business Media LLC, 2022-12-21)
      <jats:title>Abstract</jats:title><jats:p>The body of vertebrates displays a segmental organization which is most conspicuous in the periodic organization of the vertebral column and peripheral nerves. This metameric ...

    • Training the Machine Learning Programs to Measure the Arterial Phase and Identify the Types of Coronary Flow 

      Vu, Tri Loc; Nguyen, Thach; Nguyen, Hien; Mihas, Imran; Cao, Van Thinh; Zuin, Marco; Rigatelli, Gianluca (Tan Tao University, 2022-10-09)
      Coronary artery disease (CAD) is one of the most common and severe medical conditions worldwide. The current research focused on investigating the mechanisms and prevention of the detrimental effects of CAD. Recently, the ...

    • Applications of Computational Fluid Dynamics in Cardiovascular Disease 

      Rigatelli, Gianluca; Zuin, Marco; Agarwal, Sarthak; Nguyen, Vivian; Nguyen, Cardy; Agarwal, Sanyaa; Nguyen, Thach (Tan Tao University, 2022-10-09)
      Computational fluid dynamics (CFD), alone or coupled with the most advanced imaging tools, allows for the assessment of blood flow patterns in cardiovascular disease to both understand their pathophysiology and anticipate ...

    • Precise DNA cleavage using CRISPR-SpRYgests 

      Christie, Kathleen A.; Guo, Jimmy A.; Silverstein, Rachel A.; Doll, Roman M.; Mabuchi, Megumu; Stutzman, Hannah E.; Lin, Jiecong; Ma, Linyuan; Walton, Russell T.; Pinello, Luca; Robb, G. Brett; Kleinstiver, Benjamin (Springer Science and Business Media LLC, 2022-10-06)

    • Measuring the Size and Expansion of the Common Femoral Vein as A New Method of Detection and Stratification of Heart Failure 

      Nguyen, Thach; H Nguyen, Duc; Nguyen, Bao; Nguyen, Nga; Chung, Duy; Ngo, Luan; Tran, Hadrian; Mihas, Imran; Agarwal, Sarthak; Nguyen, Cardy; Nguyen, Vivian; Ho, Thuong Dung; Nanjundappa, Aravinda; Vu, Tri Loc; Agarwal, Sanyaa; Talarico, Ernest Jr.; Zuin, Marco; Rigatelli, Gianluca; Michael Gibson, C. (Tan Tao University, 2022-10)
      Heart Failure (HF) is on the end stage of the disease spectrum with many confounders and thus no specific symptoms and signs. There is a need for a test that can effectively confirm the diagnosis of volume overload in HF ...

    • Unmasking Syndrome X 

      Nguyen, Thach; Ngo, Tra; H Nguyen, Duc; Nguyen, Bao; Nguyen, Nga; Chung, Duy; Ngo, Luan; Tran, Hadrian; Mihas, Imran; Agarewal, Sarthak; Nguyen, Cardy; Thuong Ho, Dung; Nanjundappa, Aravinda; T Vu, Loc; Agarwal, Sanyaa; Talarico, Ernest; Zuin, Marco; Rigatelli, Gianluca; Gibson, Michael (Tan Tao University, 2022-10)
      <jats:p>Background. The differential diagnosis of chest pain in women is complex, ranging from atypical angina to chest pain in the absence of coronary artery disease (i.e., Syndrome X). The mechanism of these conditions ...

    • High-throughput continuous evolution of compact Cas9 variants targeting single-nucleotide-pyrimidine PAMs 

      Huang, Tony P.; Heins, Zachary J.; Miller, Shannon M.; Wong, Brandon G.; Balivada, Pallavi A.; Wang, Tina; Khalil, Ahmad S.; Liu, David R.; Liu, David (Springer Science and Business Media LLC, 2022-09-08)
      Despite the availability of Cas9 variants with varied protospacer-adjacent motif (PAM) compatibilities, some genomic loci—especially those with pyrimidine-rich PAM sequences—remain inaccessible by high-activity Cas9 proteins. ...

    • Omega-3 Fatty Acids for Major Depressive Disorder With High Inflammation 

      Mischoulon, David; Dunlop, Boadie W.; Kinkead, Becky; Schettler, Pamela J.; Lamon-Fava, Stefania; Rakofsky, Jeffrey J.; Nierenberg, Andrew; Clain, Alisabet J.; Crowe, Tanja Mletzko; Wong, Andrea; Felger, Jennifer C.; Sangermano, Lisa; Ziegler, Thomas R.; Cusin, Cristina; Fisher, Lauren B.; Fava, Maurizio; Rapaport, Mark Hyman (Physicians Postgraduate Press, Inc, 2022-08-22)
      Objective: We compared the impact of three eicosapentaenoic acid (EPA) doses versus placebo on inflammatory biomarkers and depressive symptoms. Methods: We randomized 61 unmedicated adults (75% female; 45.5 ± 13.8 years) ...

    • At-home COVID-19 testing and the estimated true incidence of confirmed Omicron BA.2 in the United States 

      Rader, Benjamin; Gertz, Autumn; Brownstein, John (2022-08-09)

    • Very Low-Level Transcranial Photobiomodulation for Major Depressive Disorder 

      Iosifescu, Dan V.; Norton, Richard J.; Tural, Umit; Mischoulon, David; Collins, Katherine; McDonald, Erin; Taboada, Luis De; Foster, Simmie; Cusin, Cristina; Yeung, Albert; Clain, Alisabet; Schoenfeld, David; Hamblin, Michael R.; Cassano, Paolo (Physicians Postgraduate Press, Inc, 2022-08-08)
      Background: Transcranial photobiomodulation (t-PBM) with near-infrared (NIR) light might represent a treatment for major depressive disorder (MDD). However, the dosimetry of administered t-PBM varies widely. We tested the ...

    • Allosteric Integrase Inhibitor Influences on HIV-1 Integration and Roles of LEDGF/p75 and HDGFL2 Host Factors 

      Singh, Parmit; Li, Wen; Bedwell, Gregory J.; Fadel, Hind J.; Poeschla, Eric M.; Engelman, Alan N. (MDPI, 2022-08)
      Allosteric integrase (IN) inhibitors (ALLINIs), which are promising preclinical compounds that engage the lens epithelium-derived growth factor (LEDGF)/p75 binding site on IN, can inhibit different aspects of human ...

    • Drug addiction mutations unveil a repressive methylation ceiling in EZH2-mutant lymphoma 

      Kwok, Hui Si; Freedy, Allyson M.; Siegenfeld, Allison P.; Morriss, Julia; Waterbury, Amanda L.; Kissler, Stephen; Liau, Brian B. (Research Square Platform LLC, 2022-07-22)
      Drug addiction, a phenomenon where cancer cells paradoxically depend on continuous drug treatment for survival, has uncovered cell signaling mechanisms and cancer co-dependencies. Here, we discover mutations that confer ...